KR20220170340A - Oral disintegrating film comprising paracress having dry mouth relief and bad breath removal ability through stimulation of salivary glands - Google Patents

Abstract

The present invention relates to an oral disintegrating film comprising an Acmella oleracea extract. The present invention is the oral disintegrating film characterized in that the orally disintegrating film further comprises pullulan, and comprises 50 to 99 parts by weight of pullulan based on 100 parts by weight of the Acmella oleracea extract. A composition, the oral disintegrating film, a food composition, and a pharmaceutical composition of the present invention use ingredients of natural origin and do not have significant side effects.

Description

Oral disintegrating film containing paracress having oral dryness relieving ability and bad breath removal ability through salivary gland stimulation

The present invention relates to an oral disintegrating film comprising Paracress having an ability to relieve dry mouth and remove bad breath by stimulating the salivary glands.

On average, a person produces 0.001 to 0.2 mL of saliva per minute, and 1 to 1.5 L of saliva is secreted per day for adults. The reason why the human body produces a large amount of saliva is because saliva is an essential element in the human body. Saliva is secreted from the 'salivary glands' called the 'salivary glands'. The three major salivary glands, the parotid glands (parotid glands) located under both left and right ears, are the largest of the salivary glands and are secreted from both cheeks. Under the chin, there is a submandibular gland (submandibular gland), the size of a walnut, of about 15 g. Under the mucous membrane of the bottom of the tongue, there is a 'sublingual island (sublingual gland).' spit until In particular, saliva helps digest food, melts food gently to reduce friction when swallowing food, and helps us to taste the taste by washing the taste organs on the surface of the tongue. In addition, it contains immunoglobulin and lactoferrin, which have antibacterial action, so it has an immune function that prevents bacterial infection, which is very important. So, when the secretion of saliva is reduced and the mouth is dry, many people suffer from severe discomfort.

When saliva is reduced and the mouth is rapidly dry, xerostomia occurs. When the mouth is dry, the first thing to smell is bad, and the smell gets worse as the saliva that acts as hygiene decreases. In addition, since saliva plays a big role in the sense of taste, it is difficult to feel the taste of food, and the mucous membrane of the tongue cracks and becomes sensitive to stimuli. Tongue burns and pain persists. Dry mouth is not a simple disease, periodontal disease, and in severe cases, oral bacteria can enter the blood and cause systemic diseases.

Therefore, products for stimulating the salivary glands are being studied. For example, Korean Patent Publication No. 10-2017-0099384 discloses an oral spray for preventing and treating xerostomia caused by diabetes, which contains an extract of S. ) and licorice (Glychrrhiza uralensis Fischer), a pharmaceutical composition for preventing or treating xerostomia is disclosed.

An object of the present invention is to provide an oral disintegrating film having an ability to alleviate dry mouth and remove bad breath by stimulating the salivary glands.

In order to achieve the above object, the present invention provides an orally disintegrating film containing a Paracress extract.

The composition, orally disintegrating film, food composition and pharmaceutical composition of the present invention have the ability to relieve dry mouth and remove bad breath. In addition, the composition, orally disintegrating film, food composition and pharmaceutical composition of the present invention have the ability to prevent, improve and/or treat xerostomia disease. In addition, the composition, orally disintegrating film, food composition, and pharmaceutical composition of the present invention use ingredients of natural origin and do not have significant side effects.

the present invention

It relates to an orally disintegrating film containing a Paracress extract.

Also, the present invention

It relates to a food composition comprising a Paracress extract.

Also, the present invention

It relates to a pharmaceutical composition comprising a Paracress extract.

Hereinafter, the present invention will be described in detail.

Paracress Extract

The present invention relates to an orally disintegrating film, food composition and/or pharmaceutical composition comprising a Paracress extract. Paracress (Spilanthes Acmella, Paracress) is a perennial plant of the Asteraceae family that is cultivated for medicinal and edible purposes all over the world. Spilantol, an active ingredient, numbs the senses in the gums and mouth, and is an herb with a pungent taste that burns the mouth.

The Paracress extract of the present invention may be a Paracress hot water extract. For example, after adding distilled water to Paracress at a weight ratio of 1:30 to 70, hot water extraction was performed at 110 to 130 °C for 1 to 6 hours, followed by filtration, and the filtered Paracres hot water extract was concentrated under reduced pressure at 60 to 65 °C to obtain a concentrate. Obtained, and freeze-dried the concentrate to prepare a Paracress extract powder, which can be used as the Paracress extract of the present invention.

composition

The present invention relates to a composition comprising a Paracress extract. The composition may further include pullulan. The composition may further include modified starch. The composition may further include pectin. The composition may further include propylene glycol. The composition may further include glycerin. The composition may further include D-sorbitol. The composition may further include polysorbate 80. The composition may further include a glycerin fatty acid ester. The composition may further include xylitol. The composition may further include a synthetic fragrance. The composition may further include a steviol glycoside. The composition may further include DL-malic acid. The composition may further include L-menthol. The composition may further include vitamin C. The composition may further include sucralose.

Preferably, pullulan may be included in an amount of 50 to 99 parts by weight, more preferably 55 to 85 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the modified starch may be included in an amount of 5 to 13 parts by weight, and more preferably in an amount of 6 to 11 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, pectin may be included in an amount of 15 to 35 parts by weight, more preferably 18 to 28 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, propylene glycol may be included in an amount of 1 to 10 parts by weight, and more preferably in an amount of 2 to 7 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, glycerin may be included in an amount of 4 to 17 parts by weight, more preferably 6 to 12 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, D-sorbitol may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, polysorbate 80 may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the glycerin fatty acid ester may be included in an amount of 2 to 10 parts by weight, and more preferably in an amount of 3 to 8 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 10 to 23 parts by weight of xylitol may be included, more preferably 13 to 20 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the synthetic fragrance may be included in an amount of 6 to 19 parts by weight, and more preferably in an amount of 8 to 16 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, steviol glycosides may be included in an amount of 3 to 13 parts by weight, more preferably 5 to 10 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, DL-malic acid may be included in an amount of 4 to 15 parts by weight, more preferably 6 to 13 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 3 parts by weight of L-menthol may be included, more preferably 0.3 to 2.5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 2 parts by weight of vitamin C may be included with respect to 100 parts by weight of the Paracress extract, and more preferably 0.3 to 1.5 parts by weight. Preferably, sucralose may be included in an amount of 0.1 to 2 parts by weight, more preferably 0.3 to 1.5 parts by weight, based on 100 parts by weight of the Paracress extract.

The composition of the present invention can be used for the prevention and treatment of xerostomia disease by stimulating the salivary glands to enhance secretion. In addition, the composition of the present invention has a function of stimulating the salivary glands to promote salivary secretion to moisten the mouth and remove bad breath. In addition, the composition of the present invention may be formulated according to conventional methods such as oral dispersible film preparations, powders, granules, tablets, capsules, suspensions, syrups, etc. and used. Preferably, the composition of the present invention may be an orally disintegrating film, a food composition and/or a pharmaceutical composition.

In one embodiment of the present invention, the composition of the present invention contains 35.17% by weight of Paracress extract powder, 26.38% by weight of pullulan, 8.79% by weight of pectin, 5.86% by weight of xylitol, 4.69% by weight of synthetic fragrance, 3.52% by weight of DL-malic acid, Glycerin 2.94 wt%, modified starch 2.93 wt%, steviol glycoside 2.93 wt%, glycerin fatty acid ester 1.76 wt%, propylene glycol 1.76 wt%, D-sorbitol 1.17 wt%, polysorbate 80 1.17 wt%, L-menthol 0.35% by weight, 0.29% by weight of vitamin C, 0.29% by weight of sucralose, and the remaining components may be purified water.

Oral Disintegrating Film

The present invention relates to an orally disintegrating film comprising a Paracress extract. The orally disintegrating film may further include pullulan. The orally disintegrating film may further include modified starch. The orally disintegrating film may further include pectin. The orally disintegrating film may further include propylene glycol. The orally disintegrating film may further include glycerin. The orally disintegrating film may further include D-sorbitol. The orally disintegrating film may further include polysorbate 80. The orally disintegrating film may further include a glycerin fatty acid ester. The orally disintegrating film may further include xylitol. The orally disintegrating film may further include a synthetic flavoring agent. The orally disintegrating film may further include a steviol glycoside. The orally disintegrating film may further include DL-malic acid. The orally disintegrating film may further include L-menthol. The orally disintegrating film may further include vitamin C. The orally disintegrating film may further include sucralose.

Preferably, pullulan may be included in an amount of 50 to 99 parts by weight, more preferably 55 to 85 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the modified starch may be included in an amount of 5 to 13 parts by weight, and more preferably in an amount of 6 to 11 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, pectin may be included in an amount of 15 to 35 parts by weight, more preferably 18 to 28 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, propylene glycol may be included in an amount of 1 to 10 parts by weight, and more preferably in an amount of 2 to 7 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, glycerin may be included in an amount of 4 to 17 parts by weight, more preferably 6 to 12 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, D-sorbitol may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, polysorbate 80 may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the glycerin fatty acid ester may be included in an amount of 2 to 10 parts by weight, and more preferably in an amount of 3 to 8 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 10 to 23 parts by weight of xylitol may be included, more preferably 13 to 20 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the synthetic fragrance may be included in an amount of 6 to 19 parts by weight, and more preferably in an amount of 8 to 16 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, steviol glycosides may be included in an amount of 3 to 13 parts by weight, more preferably 5 to 10 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, DL-malic acid may be included in an amount of 4 to 15 parts by weight, more preferably 6 to 13 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 3 parts by weight of L-menthol may be included, more preferably 0.3 to 2.5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 2 parts by weight of vitamin C may be included with respect to 100 parts by weight of the Paracress extract, and more preferably 0.3 to 1.5 parts by weight. Preferably, sucralose may be included in an amount of 0.1 to 2 parts by weight, more preferably 0.3 to 1.5 parts by weight, based on 100 parts by weight of the Paracress extract.

The orally disintegrating film may have an ability to alleviate dry mouth or remove bad breath. In addition, the orally disintegrating film may be disintegrated in the oral cavity within 40 seconds, preferably for 10 seconds to 40 seconds, and more preferably for 30 seconds to 40 seconds. The oral disintegrating film can be used to prevent, treat, and/or improve xerostomia disease by stimulating the salivary glands to enhance secretion.

The orally disintegrating film of the present invention may include additives commonly used in the field of orally disintegrating films. For example, the oral disintegrating film of the present invention may include a film forming aid, a plasticizer, a colorant, a preservative, and the like.

pharmaceutical composition

The present invention relates to a pharmaceutical composition comprising a Paracress extract. The pharmaceutical composition may further include pullulan. The pharmaceutical composition may further include modified starch. The composition may further include pharmaceutical pectin. The pharmaceutical composition may further include propylene glycol. The pharmaceutical composition may further include glycerin. The pharmaceutical composition may further include D-sorbitol. The pharmaceutical composition may further include polysorbate 80. The pharmaceutical composition may further include a glycerin fatty acid ester. The pharmaceutical composition may further include xylitol. The pharmaceutical composition may further include a synthetic flavoring agent. The pharmaceutical composition may further include a steviol glycoside. The pharmaceutical composition may further include DL-malic acid. The pharmaceutical composition may further include L-menthol. The composition may further include pharmaceutical vitamin C. The pharmaceutical composition may further include sucralose.

Preferably, pullulan may be included in an amount of 50 to 99 parts by weight, more preferably 55 to 85 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the modified starch may be included in an amount of 5 to 13 parts by weight, and more preferably in an amount of 6 to 11 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, pectin may be included in an amount of 15 to 35 parts by weight, more preferably 18 to 28 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, propylene glycol may be included in an amount of 1 to 10 parts by weight, and more preferably in an amount of 2 to 7 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, glycerin may be included in an amount of 4 to 17 parts by weight, more preferably 6 to 12 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, D-sorbitol may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, polysorbate 80 may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the glycerin fatty acid ester may be included in an amount of 2 to 10 parts by weight, and more preferably in an amount of 3 to 8 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 10 to 23 parts by weight of xylitol may be included, more preferably 13 to 20 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the synthetic fragrance may be included in an amount of 6 to 19 parts by weight, and more preferably in an amount of 8 to 16 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, steviol glycosides may be included in an amount of 3 to 13 parts by weight, more preferably 5 to 10 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, DL-malic acid may be included in an amount of 4 to 15 parts by weight, more preferably 6 to 13 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 3 parts by weight of L-menthol may be included, more preferably 0.3 to 2.5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 2 parts by weight of vitamin C may be included with respect to 100 parts by weight of the Paracress extract, and more preferably 0.3 to 1.5 parts by weight. Preferably, sucralose may be included in an amount of 0.1 to 2 parts by weight, more preferably 0.3 to 1.5 parts by weight, based on 100 parts by weight of the Paracress extract.

The pharmaceutical composition of the present invention can be used for the prevention and treatment of dry mouth disease.

The pharmaceutical composition of the present invention may include 0.01 to 80% by weight of the Paracress extract, preferably 0.02 to 65% by weight. However, this may be increased or decreased according to the needs of the administering person, and may be appropriately increased or decreased depending on the circumstances such as the age, dietary habits, nutritional status, and progress of the disease of the subject.

The pharmaceutical composition of the present invention can be administered orally or parenterally and can be used in the form of general pharmaceutical preparations. Preferred pharmaceutical preparations include preparations for oral administration such as tablets, hard or soft capsules, solutions, suspensions, and the like, and these pharmaceutical preparations are pharmaceutically acceptable carriers, for example, excipients in the case of preparations for oral administration, It can be prepared using a binder, disintegrant, lubricant, solubilizer, suspending agent, preservative or bulking agent.

The dosage of the pharmaceutical composition containing the Paracress extract of the present invention may be determined by experts according to various factors such as the patient's condition, age, sex, and complications, but is generally 0.1 mg to 10 g per 1 kg of adult, preferably 0.1 mg to 10 g. Preferably, it may be administered in a dose of 10 mg to 5 g. In addition, the daily dose of the pharmaceutical composition per unit dosage form or a dose of 1/2, 1/3 or 1/4 thereof may be contained, and may be administered 1 to 6 times a day. However, in the case of long-term intake for the purpose of health and hygiene or health control, the amount may be less than the above range, and the active ingredient may be used in an amount greater than the above range because there is no problem in terms of safety.

food composition

The present invention relates to a food composition comprising a Paracress extract. The food composition may further include pullulan. The food composition may further include modified starch. The food composition may further include pectin. The food composition may further include propylene glycol. The food composition may further include glycerin. The food composition may further include D-sorbitol. The food composition may further include polysorbate 80. The food composition may further include a glycerin fatty acid ester. The food composition may further include xylitol. The food composition may further include a synthetic flavoring agent. The food composition may further include a steviol glycoside. The food composition may further include DL-malic acid. The food composition may further include L-menthol. The food composition may further include vitamin C. The food composition may further include sucralose.

Preferably, pullulan may be included in an amount of 50 to 99 parts by weight, more preferably 55 to 85 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the modified starch may be included in an amount of 5 to 13 parts by weight, and more preferably in an amount of 6 to 11 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, pectin may be included in an amount of 15 to 35 parts by weight, more preferably 18 to 28 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, propylene glycol may be included in an amount of 1 to 10 parts by weight, and more preferably in an amount of 2 to 7 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, glycerin may be included in an amount of 4 to 17 parts by weight, more preferably 6 to 12 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, D-sorbitol may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, polysorbate 80 may be included in an amount of 1 to 6 parts by weight, more preferably 1.5 to 5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the glycerin fatty acid ester may be included in an amount of 2 to 10 parts by weight, and more preferably in an amount of 3 to 8 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 10 to 23 parts by weight of xylitol may be included, more preferably 13 to 20 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, the synthetic fragrance may be included in an amount of 6 to 19 parts by weight, and more preferably in an amount of 8 to 16 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, steviol glycosides may be included in an amount of 3 to 13 parts by weight, more preferably 5 to 10 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, DL-malic acid may be included in an amount of 4 to 15 parts by weight, more preferably 6 to 13 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 3 parts by weight of L-menthol may be included, more preferably 0.3 to 2.5 parts by weight, based on 100 parts by weight of the Paracress extract. Preferably, 0.1 to 2 parts by weight of vitamin C may be included with respect to 100 parts by weight of the Paracress extract, and more preferably 0.3 to 1.5 parts by weight. Preferably, sucralose may be included in an amount of 0.1 to 2 parts by weight, more preferably 0.3 to 1.5 parts by weight, based on 100 parts by weight of the Paracress extract.

The food of the present invention may be a health supplement, health functional food, functional food, etc., but is not limited thereto, and includes natural food, processed food, and general food materials containing the Paracress extract of the present invention. The food of the present invention can be used for the prevention and improvement of xerostomia disease.

The food composition of the present invention may be added to the Paracress extract of the present invention as it is or used together with other foods or food compositions, and may be appropriately used according to conventional methods. The mixing amount of the active ingredient can be suitably determined depending on the purpose of its use (prevention, improvement or therapeutic treatment). In general, the Paracress extract of the present invention may be added in an amount of 0.1 to 5% by weight, preferably 2 to 3% by weight, based on 100% by weight of the raw material of the food or beverage during production of food or beverage. The effective dose of the Paracress extract of the present invention can be used according to the effective dose of the pharmaceutical composition, but may be less than the above range in the case of long-term intake for the purpose of health and hygiene or health control, However, the active ingredient may be used in an amount greater than the above range because there is no problem in terms of safety.

There is no particular limitation on the type of food. The food composition may be used in the form of formulations for oral administration such as tablets, hard or soft capsules, solutions, suspensions, etc. It can be prepared using a binder, disintegrant, lubricant, solubilizer, suspending agent, preservative or bulking agent.

Examples of foods to which the Paracress extract of the present invention can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups, and beverages , tea, drinks, alcoholic beverages and vitamin complexes, and other nutritional supplements, but is not limited to these types of foods.

Advantages and features of the present invention, and how to achieve them, will become clear with reference to the detailed description of the following embodiments. However, the present invention is not limited to the embodiments disclosed below and will be implemented in various forms different from each other, only these embodiments make the disclosure of the present invention complete, and common knowledge in the art to which the present invention pertains. It is provided to completely inform the person who has the scope of the invention, and the present invention is only defined by the scope of the claims.

<Materials and methods>

Materials in this experimental example were purchased and used commercially available products.

Preparation of Paracress Extract

Paracress was lyophilized. Thereafter, the lyophilized Paracress was pulverized into a powder having a size of 50 mesh or more, distilled water was added to the pulverized Paracress at a weight ratio of 1:50, followed by hot water extraction at 110 to 130° C. for 3 hours, followed by filtration. The filtered hot-water extract of Paracress was concentrated under reduced pressure at 60 to 65° C. to obtain a concentrate, and the concentrate was lyophilized and powdered to be used as an extract powder for Paracress.

<Experimental Example 1>

Purified water, Paracress extract, xylitol, polysorbate 80, stepviol glycoside, and vitamin C were added to crude liquid 1 tank and stirred to completely solubilize the raw materials. Glycerin fatty acid ester was melted by slightly heating and administered to 1 tank of crude liquid. In a separate container 1, glycerin, propylene glycol, and D-sorbitol were put into L-menthol to solubilize. Modified starch was added to purified water in a separate container 2 to gelatinize. In a separate container 3, pectin was dissolved by heating to about 50 degrees and administered. Then, DL-malic acid and sucralose were added and mixed. The contents of container 1, container 2, and container 3 were separately put into crude liquid 1 tank and mixed. Then, pullulan and synthetic fragrance were added to crude liquid 1 tank and stirred. When the crude liquid was sufficiently dispersed, degassing was performed by applying negative pressure. In addition, after confirming the appropriate viscosity, it was injected into an oral disintegrating film formulation molding equipment, and drying conditions were set to apply it thinly on a PE-coated aluminum foil, which is a packaging material, and dried to form a thin film to prepare an oral disintegrating film. Then, the film was slit (horizontally) and cut (vertically) to a size of 2.2 X 3.3 cm, and then sealed and packaged one by one in an aluminum foil pouch. At this time, the composition of each component was according to Table 1, and purified water was used in a weight ratio of 1: 3 with respect to the solid weight of the components used for coating. Table 1 shows parts by weight of each component with respect to 100 parts by weight of the Paracress extract powder, and components whose contents are not described in Table 1 were not used in the preparation of the oral disintegrating film. For example, the orally disintegrating film of Comparative Example 1 was prepared without using pullulan.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Paracress Extract Powder 100 100 100 100 100 100 mechanism pullulan 75 - 75 75 75 75 modified starch 8.3 8.3 - 8.3 8.3 8.3 pectin 25 25 25 - 25 25 plasticizer propylene glycol 5 5 5 5 5 5 glycerin 8.4 8.4 8.4 8.4 8.4 8.4 D-sorbitol 3.3 3.3 3.3 3.3 3.3 3.3 emulsifier polysorbate 80 3.3 3.3 3.3 3.3 - 3.3 emulsifier Glycerin fatty acid ester 5 5 5 5 5 - Sweet sweetener, prevent tooth decay xylitol 16.6 16.6 16.6 16.6 16.6 16.6 incense Synthetic flavor [mandarin flavor] 13.3 13.3 13.3 13.3 13.3 13.3 sweetness, sweetener steviol glycosides 8.3 8.3 8.3 8.3 8.3 8.3 acidity, acidity regulator DL-malic acid 10 10 10 10 10 10 refreshing taste L-Menthol One One One One One One vitamin C 0.8 0.8 0.8 0.8 0.8 0.8 sweetness, sweetener sucralose 0.8 0.8 0.8 0.8 0.8 0.8

<Experimental Example 2> Gum forming ability and gum shape retention ability

For Example 1 and Comparative Examples 1 to 5, the ability to form a gum and the ability to maintain a gum shape were evaluated. The specific method is as follows.

The examples and comparative examples were evaluated by 5 researchers through visual and sensory evaluation, and were stored for 3 months under accelerated conditions of 40 degrees and 75% relative humidity, and the state was checked.

The results are shown in Table 2.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 gum forming ability very good bad good good good good Ability to maintain sword shape very good bad good good bad bad

<Experimental Example 3> Evaluation of oral disintegration time

Oral disintegration time was evaluated for Example 1 and Comparative Examples 1 to 5. The specific method is as follows.

Using a disintegration tester, 200 ml of distilled water was put into a 300 ml beaker, Examples and Comparative Examples were added, and the time required for complete disintegration of the film was measured by stirring at a constant speed.

The results are shown in Table 3.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Oral disintegration time (seconds) 36 60 45 40 46 43

<Experimental Example 4> Bad breath removal ability

The ability to remove bad breath was evaluated for Example 1 and Comparative Examples 1 to 5. The specific method is as follows.

Halitosis was measured using a portable halitosis monitor, and halitosis was indicated as 5 levels: 0 level very good, 1 level normal, 2 level not bad, 3 level bad, and 4 level very bad. After ingestion of Examples and Comparative Examples, measurement was performed 5 minutes later.

The results are shown in Table 4.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Bad breath removal ability 0 One One One One One

<Experimental Example 5> Saliva secretion promoting ability

Saliva secretion promoting ability was evaluated for Example 1 and Comparative Examples 1 to 5. The specific method is as follows.

The amount of saliva secretion refers to the total amount of saliva secreted from bovine salivary glands distributed in the parotid, sublingual, and submandibular glands and the globular mucosa, lips, and tongue, and the total amount of saliva produced by combining moisture from the gums. Irritating saliva secreted from the parotid, sublingual, and submandibular glands measured using gauze is defined as the amount of salivary secretion. Minutes of irritant saliva was collected. The amount of collected saliva was compared and analyzed by group.

The results are shown in Table 5.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Saliva secretion promoting ability (mg) 4.07 3.52 3.73 3.92 4.10 3.69

Claims (8)

An orally disintegrating film containing Paracress extract.
According to claim 1,
The orally disintegrating film further comprises pullulan,
An orally disintegrating film comprising 50 to 99 parts by weight of pullulan based on 100 parts by weight of the Paracress extract.
According to claim 1,
An oral disintegrating film further comprising xylitol.
According to claim 1,
Orally disintegrating film characterized by having bad breath removal ability.
According to claim 1,
An oral disintegrating film characterized in that it disintegrates within 40 seconds in the oral cavity.
According to claim 1,
An oral disintegrating film characterized in that it has an ability to alleviate dryness of the mouth or promote saliva secretion.
According to claim 1,
Orally disintegrating film, characterized in that it further comprises a modified starch.
According to claim 1,
An oral disintegrating film further comprising a glycerin fatty acid ester.