KR20220162133A - 항원 표적화된 면역 요법에서 항원 음성 세포 사망의 증강 - Google Patents

항원 표적화된 면역 요법에서 항원 음성 세포 사망의 증강 Download PDF

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KR20220162133A
KR20220162133A KR1020227035400A KR20227035400A KR20220162133A KR 20220162133 A KR20220162133 A KR 20220162133A KR 1020227035400 A KR1020227035400 A KR 1020227035400A KR 20227035400 A KR20227035400 A KR 20227035400A KR 20220162133 A KR20220162133 A KR 20220162133A
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gly
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thr
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카메론 제이. 터틀
살바토레 피오렌자
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프레드 허친슨 캔서 센터
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K38/05—Dipeptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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KR1020227035400A 2020-03-31 2021-03-31 항원 표적화된 면역 요법에서 항원 음성 세포 사망의 증강 Pending KR20220162133A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003209P 2020-03-31 2020-03-31
US63/003,209 2020-03-31
PCT/US2021/025260 WO2021202801A1 (en) 2020-03-31 2021-03-31 Augmenting antigen-negative cell death in antigen-targeted immunotherapies

Publications (1)

Publication Number Publication Date
KR20220162133A true KR20220162133A (ko) 2022-12-07

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KR1020227035400A Pending KR20220162133A (ko) 2020-03-31 2021-03-31 항원 표적화된 면역 요법에서 항원 음성 세포 사망의 증강

Country Status (6)

Country Link
US (1) US20230218669A1 (https=)
EP (1) EP4126016A4 (https=)
JP (1) JP2023519970A (https=)
KR (1) KR20220162133A (https=)
CN (1) CN115361968A (https=)
WO (1) WO2021202801A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022303363A1 (en) * 2021-06-29 2024-01-18 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
WO2023022235A1 (ja) * 2021-08-20 2023-02-23 大塚製薬株式会社 組み合わせ医薬
EP4673161A2 (en) * 2023-03-02 2026-01-07 Case Western Reserve University Oncostatin-m-based chimeric antigen receptor (car)-immune cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7623784B2 (ja) * 2016-10-13 2025-01-29 ジュノー セラピューティクス インコーポレイテッド トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物
CA3048648A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation T cells expressing a chimeric antigen receptor
JP2021500859A (ja) * 2017-09-22 2021-01-14 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Ｎｆｋｂシグナル伝達の増強を伴うキメラ抗原受容体
AU2019215031C1 (en) * 2018-01-31 2026-02-26 Novartis Ag Combination therapy using a chimeric antigen receptor
EP3814369A1 (en) * 2018-06-29 2021-05-05 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Tweak-receptor agonists for use in combination with immunotherapy of a cancer
WO2020028572A2 (en) * 2018-08-01 2020-02-06 Unum Therapeutics Inc. ANTIBODY-COUPLED T CELL RECEPTORS (ACTRs) IN COMBINATION WITH TRANS CO-STIMULATORY MOLECULES AND THERAPEUTIC USES THEREOF

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Publication number Publication date
US20230218669A1 (en) 2023-07-13
CN115361968A (zh) 2022-11-18
EP4126016A4 (en) 2024-07-03
WO2021202801A1 (en) 2021-10-07
JP2023519970A (ja) 2023-05-15
EP4126016A1 (en) 2023-02-08

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