KR20220156930A - 무정형 3,4-디페닐-4,5-디하이드로-1h-피라졸 유도체의 고체 분산체, 이를 포함하는 조성물 및 칸나비노이드 cb1 수용체 억제제로서의 이의 용도 - Google Patents

무정형 3,4-디페닐-4,5-디하이드로-1h-피라졸 유도체의 고체 분산체, 이를 포함하는 조성물 및 칸나비노이드 cb1 수용체 억제제로서의 이의 용도 Download PDF

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KR20220156930A
KR20220156930A KR1020227036821A KR20227036821A KR20220156930A KR 20220156930 A KR20220156930 A KR 20220156930A KR 1020227036821 A KR1020227036821 A KR 1020227036821A KR 20227036821 A KR20227036821 A KR 20227036821A KR 20220156930 A KR20220156930 A KR 20220156930A
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optionally substituted
solid dispersion
compound
disease
solid
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프랑수아즈 라벤넬
노렐리스 발데스
에이메스터 오. 베탄코트
패트릭 고슬린
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인베르사고 파마 인코포레이티드
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    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1629—Organic macromolecular compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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KR1020227036821A 2020-03-24 2021-03-24 무정형 3,4-디페닐-4,5-디하이드로-1h-피라졸 유도체의 고체 분산체, 이를 포함하는 조성물 및 칸나비노이드 cb1 수용체 억제제로서의 이의 용도 Pending KR20220156930A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062993775P 2020-03-24 2020-03-24
US62/993,775 2020-03-24
PCT/CA2021/050385 WO2021189141A1 (en) 2020-03-24 2021-03-24 Solid dispersions of amorphous 3, 4-diphenyl-4, 5-dihydro- 1h-pyrazole derivatives, compositions comprising them and uses thereof as cannabinoid cb1 receptor inhibitors

Publications (1)

Publication Number Publication Date
KR20220156930A true KR20220156930A (ko) 2022-11-28

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KR1020227036821A Pending KR20220156930A (ko) 2020-03-24 2021-03-24 무정형 3,4-디페닐-4,5-디하이드로-1h-피라졸 유도체의 고체 분산체, 이를 포함하는 조성물 및 칸나비노이드 cb1 수용체 억제제로서의 이의 용도

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US (1) US20230174493A1 (https=)
EP (1) EP4126822A4 (https=)
JP (1) JP2023518529A (https=)
KR (1) KR20220156930A (https=)
CN (1) CN115335361A (https=)
AU (1) AU2021242808A1 (https=)
CA (1) CA3169753A1 (https=)
MX (1) MX2022011899A (https=)
WO (1) WO2021189141A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4482490A4 (en) * 2022-02-24 2025-08-20 Novo Nordisk As METHODS OF TREATING SUBJECTS WITH HYPERTRIGLYCERIDEMIA, ABDOMINAL OBESITY AND/OR ALTERED GLUCOSE
WO2025040089A1 (zh) * 2023-08-21 2025-02-27 德睿智药(苏州)新药研发有限公司 用于选择性调节大麻素cb1功能的新型杂环类化合物
WO2025103493A1 (zh) * 2023-11-16 2025-05-22 西藏海思科制药有限公司 一种大麻素受体1拮抗剂及其应用
WO2025257151A1 (en) 2024-06-10 2025-12-18 Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical composition for treating ciliopathies

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EP2083799A1 (en) * 2006-10-20 2009-08-05 Solvay Pharmaceuticals B.V. Micellar nanoparticles of chemical substances
CN104884057B (zh) * 2012-11-13 2019-08-20 美国政府(由卫生和人类服务部的部长所代表) 大麻素受体介导的化合物
CA2955510C (en) * 2014-07-25 2018-09-04 Allen-Vanguard Corporation System and method for ultra wideband radio frequency scanning and signal generation
WO2016196646A1 (en) * 2015-06-04 2016-12-08 The United States Of America, As Represented By The Secretary, Departmet Of Health & Human Services Cannabinoid receptor mediating compounds
US12286405B2 (en) * 2019-05-17 2025-04-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Scalable synthesis of dual-target inhibitor of cannabinoid-1 receptor and inducible nitric oxide synthase

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EP4126822A1 (en) 2023-02-08
EP4126822A4 (en) 2024-07-03
WO2021189141A1 (en) 2021-09-30
CA3169753A1 (en) 2021-09-30
JP2023518529A (ja) 2023-05-01
MX2022011899A (es) 2023-01-04
CN115335361A (zh) 2022-11-11
US20230174493A1 (en) 2023-06-08
AU2021242808A1 (en) 2022-10-06
AU2021242808A8 (en) 2022-10-27

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