KR20220154791A - (1r,3s)-3-(5-시아노-4-페닐-1,3-티아졸-2-일카바모일)사이클로펜탄 카복실산의 공결정 - Google Patents

(1r,3s)-3-(5-시아노-4-페닐-1,3-티아졸-2-일카바모일)사이클로펜탄 카복실산의 공결정 Download PDF

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Publication number
KR20220154791A
KR20220154791A KR1020227035871A KR20227035871A KR20220154791A KR 20220154791 A KR20220154791 A KR 20220154791A KR 1020227035871 A KR1020227035871 A KR 1020227035871A KR 20227035871 A KR20227035871 A KR 20227035871A KR 20220154791 A KR20220154791 A KR 20220154791A
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KR
South Korea
Prior art keywords
crystal
cyano
phenyl
ylcarbamoyl
thiazol
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KR1020227035871A
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English (en)
Korean (ko)
Inventor
라리아 훌리오 카스트로 팔로미노
고메즈 후안 까마초
Original Assignee
팔로바이오파마, 에스.엘.
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Publication of KR20220154791A publication Critical patent/KR20220154791A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/02—Salts; Complexes; Addition compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227035871A 2020-03-16 2021-03-15 (1r,3s)-3-(5-시아노-4-페닐-1,3-티아졸-2-일카바모일)사이클로펜탄 카복실산의 공결정 Pending KR20220154791A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20382194.7A EP3882240A1 (en) 2020-03-16 2020-03-16 Cocrystals of (1r,3s)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcabamoyl)cyclopentane carboxylic acid
EP20382194.7 2020-03-16
PCT/EP2021/056506 WO2021185748A1 (en) 2020-03-16 2021-03-15 Cocrystals of (1r,3s)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcabamoyl)cyclopentane carboxylic acid

Publications (1)

Publication Number Publication Date
KR20220154791A true KR20220154791A (ko) 2022-11-22

Family

ID=69953938

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227035871A Pending KR20220154791A (ko) 2020-03-16 2021-03-15 (1r,3s)-3-(5-시아노-4-페닐-1,3-티아졸-2-일카바모일)사이클로펜탄 카복실산의 공결정

Country Status (21)

Country Link
US (1) US12384754B2 (https=)
EP (2) EP3882240A1 (https=)
JP (1) JP7779846B2 (https=)
KR (1) KR20220154791A (https=)
CN (1) CN115298169B (https=)
AU (1) AU2021237686B2 (https=)
BR (1) BR112022018449A2 (https=)
CA (1) CA3171894C (https=)
DK (1) DK4121419T3 (https=)
ES (1) ES3002084T3 (https=)
FI (1) FI4121419T3 (https=)
HR (1) HRP20241515T1 (https=)
HU (1) HUE068886T2 (https=)
LT (1) LT4121419T (https=)
MX (1) MX2022011530A (https=)
PL (1) PL4121419T3 (https=)
PT (1) PT4121419T (https=)
RS (1) RS66214B1 (https=)
SI (1) SI4121419T1 (https=)
WO (1) WO2021185748A1 (https=)
ZA (1) ZA202211247B (https=)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2331220B1 (es) 2007-10-02 2010-09-23 Palobiofarma, S.L. Nuevos compuestos como antagonistas de los receptores a1 de adenosina.
US8779146B2 (en) 2010-04-28 2014-07-15 Nuformix Limited Cilostazol cocrystals and compositions
LT3592734T (lt) 2017-03-06 2021-07-26 Palobiofarma, S.L. (1r,3s)-3-(5-ciano-4-fenil-1,3-tiazol-2-ilkarbamoil)ciklopentankarboksirūgšties amino druska

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Publication number Publication date
ES3002084T3 (en) 2025-03-06
JP7779846B2 (ja) 2025-12-03
MX2022011530A (es) 2022-10-13
HUE068886T2 (hu) 2025-02-28
EP4121419A1 (en) 2023-01-25
CN115298169A (zh) 2022-11-04
FI4121419T3 (fi) 2024-11-04
US12384754B2 (en) 2025-08-12
LT4121419T (lt) 2024-11-25
CA3171894C (en) 2025-03-11
EP3882240A1 (en) 2021-09-22
WO2021185748A1 (en) 2021-09-23
CN115298169B (zh) 2024-11-19
US20230183195A1 (en) 2023-06-15
DK4121419T3 (da) 2024-10-28
ZA202211247B (en) 2023-12-20
AU2021237686A1 (en) 2022-10-06
BR112022018449A2 (pt) 2022-11-01
AU2021237686B2 (en) 2026-04-09
HRP20241515T1 (hr) 2025-01-03
PL4121419T3 (pl) 2025-02-17
CA3171894A1 (en) 2021-09-23
EP4121419B1 (en) 2024-08-14
PT4121419T (pt) 2024-11-18
SI4121419T1 (sl) 2025-02-28
RS66214B1 (sr) 2024-12-31
JP2023517722A (ja) 2023-04-26

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