KR20220151175A - 킬로베이스 스케일에서 rna-가이드된 게놈 재조합 - Google Patents

킬로베이스 스케일에서 rna-가이드된 게놈 재조합 Download PDF

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KR20220151175A
KR20220151175A KR1020227033540A KR20227033540A KR20220151175A KR 20220151175 A KR20220151175 A KR 20220151175A KR 1020227033540 A KR1020227033540 A KR 1020227033540A KR 20227033540 A KR20227033540 A KR 20227033540A KR 20220151175 A KR20220151175 A KR 20220151175A
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glu
sequence
protein
leu
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리 콩
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더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티
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Publication of KR20220151175A publication Critical patent/KR20220151175A/ko
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KR1020227033540A 2020-03-03 2021-03-02 킬로베이스 스케일에서 rna-가이드된 게놈 재조합 Pending KR20220151175A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062984618P 2020-03-03 2020-03-03
US62/984,618 2020-03-03
US202163146447P 2021-02-05 2021-02-05
US63/146,447 2021-02-05
PCT/US2021/020513 WO2021178432A1 (en) 2020-03-03 2021-03-02 Rna-guided genome recombineering at kilobase scale

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KR20220151175A true KR20220151175A (ko) 2022-11-14

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US (1) US20230091242A1 (OSRAM)
EP (1) EP4114845A4 (OSRAM)
JP (1) JP2023515670A (OSRAM)
KR (1) KR20220151175A (OSRAM)
CN (1) CN115667283A (OSRAM)
AU (1) AU2021231769A1 (OSRAM)
BR (1) BR112022017196A2 (OSRAM)
CA (1) CA3173526A1 (OSRAM)
IL (1) IL296057A (OSRAM)
MX (1) MX2022010835A (OSRAM)
WO (1) WO2021178432A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024002482A (es) * 2021-09-01 2024-09-19 Univ Leland Stanford Junior Recombinacion del genoma guiada por arn en escala de kilobase.
WO2023154892A1 (en) * 2022-02-10 2023-08-17 Possible Medicines Llc Rna-guided genome recombineering at kilobase scale
WO2023154877A2 (en) * 2022-02-10 2023-08-17 The Board Of Trustees Of The Leland Stanford Junior University Rna-guided genome recombineering at kilobase scale
WO2024168265A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Aav delivery of rna guided recombination system
WO2024168253A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Delivery of an rna guided recombination system
CN117025670A (zh) * 2023-03-13 2023-11-10 苏州金唯智生物科技有限公司 一种检测CRISPR-Cas产生的DNA双链断裂位点的方法
CN120555441B (zh) * 2025-05-29 2026-04-17 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

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DE69841340D1 (de) * 1997-12-05 2010-01-07 Europ Lab Molekularbiolog Neue Methode zur Klonierung DNS unter Anwendung des E. coli RecE/RecT Rekombinationssystems
US9388430B2 (en) * 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
WO2016022363A2 (en) * 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
JP6817215B2 (ja) * 2015-03-03 2021-01-20 ザ ジェネラル ホスピタル コーポレイション 変更ＰＡＭ特異性を有する遺伝子操作ＣＲＩＳＰＲ−Ｃａｓ９ヌクレアーゼ
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
JP7044373B2 (ja) * 2015-07-15 2022-03-30 ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
WO2019089910A1 (en) * 2017-11-01 2019-05-09 Ohio State Innovation Foundation Highly compact cas9-based transcriptional regulators for in vivo gene regulation
KR102098915B1 (ko) * 2017-12-22 2020-04-09 (주)지플러스 생명과학 키메라 게놈 조작 분자 및 방법
MX2024002482A (es) * 2021-09-01 2024-09-19 Univ Leland Stanford Junior Recombinacion del genoma guiada por arn en escala de kilobase.

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CA3173526A1 (en) 2021-09-10
MX2022010835A (es) 2022-09-29
EP4114845A1 (en) 2023-01-11
US20230091242A1 (en) 2023-03-23
CN115667283A (zh) 2023-01-31
EP4114845A4 (en) 2024-03-06
JP2023515670A (ja) 2023-04-13
IL296057A (en) 2022-10-01
WO2021178432A1 (en) 2021-09-10
AU2021231769A1 (en) 2022-09-29
BR112022017196A2 (pt) 2022-10-25
WO2021178432A9 (en) 2021-10-28

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