CN115667283A - Rna指导的千碱基规模基因组重组工程 - Google Patents

Rna指导的千碱基规模基因组重组工程 Download PDF

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CN115667283A
CN115667283A CN202180033011.8A CN202180033011A CN115667283A CN 115667283 A CN115667283 A CN 115667283A CN 202180033011 A CN202180033011 A CN 202180033011A CN 115667283 A CN115667283 A CN 115667283A
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ala
glu
sequence
leu
protein
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丛乐
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Leland Stanford Junior University
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CN202180033011.8A 2020-03-03 2021-03-02 Rna指导的千碱基规模基因组重组工程 Pending CN115667283A (zh)

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US202062984618P 2020-03-03 2020-03-03
US62/984,618 2020-03-03
US202163146447P 2021-02-05 2021-02-05
US63/146,447 2021-02-05
PCT/US2021/020513 WO2021178432A1 (en) 2020-03-03 2021-03-02 Rna-guided genome recombineering at kilobase scale

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US (1) US20230091242A1 (OSRAM)
EP (1) EP4114845A4 (OSRAM)
JP (1) JP2023515670A (OSRAM)
KR (1) KR20220151175A (OSRAM)
CN (1) CN115667283A (OSRAM)
AU (1) AU2021231769A1 (OSRAM)
BR (1) BR112022017196A2 (OSRAM)
CA (1) CA3173526A1 (OSRAM)
IL (1) IL296057A (OSRAM)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117025670A (zh) * 2023-03-13 2023-11-10 苏州金唯智生物科技有限公司 一种检测CRISPR-Cas产生的DNA双链断裂位点的方法
CN120555441A (zh) * 2025-05-29 2025-08-29 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024002482A (es) * 2021-09-01 2024-09-19 Univ Leland Stanford Junior Recombinacion del genoma guiada por arn en escala de kilobase.
WO2023154892A1 (en) * 2022-02-10 2023-08-17 Possible Medicines Llc Rna-guided genome recombineering at kilobase scale
WO2023154877A2 (en) * 2022-02-10 2023-08-17 The Board Of Trustees Of The Leland Stanford Junior University Rna-guided genome recombineering at kilobase scale
WO2024168265A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Aav delivery of rna guided recombination system
WO2024168253A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Delivery of an rna guided recombination system

Family Cites Families (9)

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DE69841340D1 (de) * 1997-12-05 2010-01-07 Europ Lab Molekularbiolog Neue Methode zur Klonierung DNS unter Anwendung des E. coli RecE/RecT Rekombinationssystems
US9388430B2 (en) * 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
WO2016022363A2 (en) * 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
JP6817215B2 (ja) * 2015-03-03 2021-01-20 ザ ジェネラル ホスピタル コーポレイション 変更ＰＡＭ特異性を有する遺伝子操作ＣＲＩＳＰＲ−Ｃａｓ９ヌクレアーゼ
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
JP7044373B2 (ja) * 2015-07-15 2022-03-30 ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
WO2019089910A1 (en) * 2017-11-01 2019-05-09 Ohio State Innovation Foundation Highly compact cas9-based transcriptional regulators for in vivo gene regulation
KR102098915B1 (ko) * 2017-12-22 2020-04-09 (주)지플러스 생명과학 키메라 게놈 조작 분자 및 방법
MX2024002482A (es) * 2021-09-01 2024-09-19 Univ Leland Stanford Junior Recombinacion del genoma guiada por arn en escala de kilobase.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117025670A (zh) * 2023-03-13 2023-11-10 苏州金唯智生物科技有限公司 一种检测CRISPR-Cas产生的DNA双链断裂位点的方法
CN120555441A (zh) * 2025-05-29 2025-08-29 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

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MX2022010835A (es) 2022-09-29
EP4114845A1 (en) 2023-01-11
KR20220151175A (ko) 2022-11-14
US20230091242A1 (en) 2023-03-23
EP4114845A4 (en) 2024-03-06
JP2023515670A (ja) 2023-04-13
IL296057A (en) 2022-10-01
WO2021178432A1 (en) 2021-09-10
AU2021231769A1 (en) 2022-09-29
BR112022017196A2 (pt) 2022-10-25
WO2021178432A9 (en) 2021-10-28

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