KR20220150947A - 스테로이드의 히드록실화 방법 - Google Patents
스테로이드의 히드록실화 방법 Download PDFInfo
- Publication number
- KR20220150947A KR20220150947A KR1020227034684A KR20227034684A KR20220150947A KR 20220150947 A KR20220150947 A KR 20220150947A KR 1020227034684 A KR1020227034684 A KR 1020227034684A KR 20227034684 A KR20227034684 A KR 20227034684A KR 20220150947 A KR20220150947 A KR 20220150947A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- cholane
- group
- radical
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 19
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- 238000005084 2D-nuclear magnetic resonance Methods 0.000 description 1
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- SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 description 1
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- RPKLZQLYODPWTM-KBMWBBLPSA-N cholanoic acid Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(O)=O)C)[C@@]1(C)CC2 RPKLZQLYODPWTM-KBMWBBLPSA-N 0.000 description 1
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- 238000001704 evaporation Methods 0.000 description 1
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- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
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- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
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- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 238000005817 monooxygenase reaction Methods 0.000 description 1
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
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- 201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- -1 rbs Proteins 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000010157 sclerosing cholangitis Diseases 0.000 description 1
- 239000010822 slaughterhouse waste Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 230000000707 stereoselective effect Effects 0.000 description 1
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- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20161536.6A EP3875596A1 (de) | 2020-03-06 | 2020-03-06 | Verfahren zur hydroxylierung von steroiden |
| EP20161536.6 | 2020-03-06 | ||
| PCT/EP2021/055617 WO2021176068A1 (de) | 2020-03-06 | 2021-03-05 | Verfahren zur hydroxylierung von steroiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220150947A true KR20220150947A (ko) | 2022-11-11 |
Family
ID=69780052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227034684A Pending KR20220150947A (ko) | 2020-03-06 | 2021-03-05 | 스테로이드의 히드록실화 방법 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12305212B2 (https=) |
| EP (2) | EP3875596A1 (https=) |
| JP (1) | JP7783187B2 (https=) |
| KR (1) | KR20220150947A (https=) |
| WO (1) | WO2021176068A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3875597A1 (de) * | 2020-03-06 | 2021-09-08 | Annikki GmbH | Verfahren zur hydroxylierung von steroiden |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005512532A (ja) | 2001-08-03 | 2005-05-12 | ディヴァーサ コーポレイション | Ｐ４５０酵素、それらをコードした核酸及びそれらの作製と使用 |
-
2020
- 2020-03-06 EP EP20161536.6A patent/EP3875596A1/de not_active Withdrawn
-
2021
- 2021-03-05 KR KR1020227034684A patent/KR20220150947A/ko active Pending
- 2021-03-05 JP JP2022552739A patent/JP7783187B2/ja active Active
- 2021-03-05 US US17/908,507 patent/US12305212B2/en active Active
- 2021-03-05 WO PCT/EP2021/055617 patent/WO2021176068A1/de not_active Ceased
- 2021-03-05 EP EP21709988.6A patent/EP4114929A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7783187B2 (ja) | 2025-12-09 |
| WO2021176068A1 (de) | 2021-09-10 |
| US20240240221A1 (en) | 2024-07-18 |
| JP2023520307A (ja) | 2023-05-17 |
| EP3875596A1 (de) | 2021-09-08 |
| US12305212B2 (en) | 2025-05-20 |
| EP4114929A1 (de) | 2023-01-11 |
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