KR20220147642A - Il4r에 결합하는 항체 및 이의 용도 - Google Patents

Il4r에 결합하는 항체 및 이의 용도 Download PDF

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Publication number
KR20220147642A
KR20220147642A KR1020227033367A KR20227033367A KR20220147642A KR 20220147642 A KR20220147642 A KR 20220147642A KR 1020227033367 A KR1020227033367 A KR 1020227033367A KR 20227033367 A KR20227033367 A KR 20227033367A KR 20220147642 A KR20220147642 A KR 20220147642A
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South Korea
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amino acid
seq
ser
antibody
nos
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Pending
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KR1020227033367A
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English (en)
Korean (ko)
Inventor
밍주 첸
웨이 탄
케시 시아오유엔 종
마크 지칭 마
슈카이 시아
젱핑 장
홍지앙 쑤
지지안 루
Original Assignee
치아타이 티안큉 파마수티컬 그룹 주식회사
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Publication of KR20220147642A publication Critical patent/KR20220147642A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020227033367A 2020-02-27 2021-02-25 Il4r에 결합하는 항체 및 이의 용도 Pending KR20220147642A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062982521P 2020-02-27 2020-02-27
US62/982,521 2020-02-27
PCT/CN2021/077784 WO2021170020A1 (en) 2020-02-27 2021-02-25 Antibodies binding il4r and uses thereof

Publications (1)

Publication Number Publication Date
KR20220147642A true KR20220147642A (ko) 2022-11-03

Family

ID=75108091

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227033367A Pending KR20220147642A (ko) 2020-02-27 2021-02-25 Il4r에 결합하는 항체 및 이의 용도

Country Status (12)

Country Link
US (1) US20230105029A1 (https=)
EP (1) EP4110816A1 (https=)
JP (2) JP7711079B2 (https=)
KR (1) KR20220147642A (https=)
CN (4) CN119708231A (https=)
AU (1) AU2021228061A1 (https=)
BR (1) BR112022017174A2 (https=)
CA (1) CA3169479A1 (https=)
MX (1) MX2022010665A (https=)
TW (1) TWI859419B (https=)
WO (1) WO2021170020A1 (https=)
ZA (1) ZA202210628B (https=)

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TW202313692A (zh) * 2021-08-26 2023-04-01 大陸商正大天晴藥業集團股份有限公司 抗ｉｌ４ｒ抗體的藥物組成物及其用途
WO2023235738A1 (en) * 2022-06-02 2023-12-07 Eli Lilly And Company Human interleukin-4 receptor alpha antibody glucocorticoid conjugates
KR20240038841A (ko) * 2022-09-16 2024-03-26 연세대학교 산학협력단 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이의 용도
US20260109758A1 (en) * 2022-09-22 2026-04-23 Biosion, Inc. Recombinant bispecific antibodies targeting tslp and il4r
CN121693518A (zh) * 2023-08-01 2026-03-17 先声药业有限公司 抗il4r抗体及其应用
CN117924490B (zh) * 2023-12-22 2024-10-22 华润生物医药有限公司 抗il-4r抗体及其用途
CN117924491B (zh) * 2023-12-22 2024-10-18 华润生物医药有限公司 抗il-4r抗体及其用途
US20250388685A1 (en) 2024-04-15 2025-12-25 Sanofi Biotechnology Methods for treating chronic rhinosinusitis without nasal polyps by administering an il-4r antagonist
WO2026055687A1 (en) 2024-09-09 2026-03-12 Regeneron Pharmaceuticals, Inc. Methods for treating bullous pemphigoid by administering an il-4r antagonist
WO2026059949A1 (en) 2024-09-10 2026-03-19 Sanofi Biotechnology Methods for treating chronic pruritus of unknown origin (cpuo) by administering an il-4r antagonist

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Publication number Publication date
TWI859419B (zh) 2024-10-21
CN119708230A (zh) 2025-03-28
CN115087673B (zh) 2025-02-18
ZA202210628B (en) 2025-01-29
JP7711079B2 (ja) 2025-07-22
US20230105029A1 (en) 2023-04-06
AU2021228061A1 (en) 2022-10-13
JP2023515223A (ja) 2023-04-12
BR112022017174A2 (pt) 2022-10-18
JP2025157317A (ja) 2025-10-15
WO2021170020A1 (en) 2021-09-02
EP4110816A1 (en) 2023-01-04
CN115087673A (zh) 2022-09-20
CN119708231A (zh) 2025-03-28
TW202140564A (zh) 2021-11-01
CN119859187A (zh) 2025-04-22
MX2022010665A (es) 2022-09-23
CA3169479A1 (en) 2021-09-02

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