KR20220142441A - Cd3에 결합하는 이중 특이적 항체 - Google Patents

Cd3에 결합하는 이중 특이적 항체 Download PDF

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KR20220142441A
KR20220142441A KR1020227027592A KR20227027592A KR20220142441A KR 20220142441 A KR20220142441 A KR 20220142441A KR 1020227027592 A KR1020227027592 A KR 1020227027592A KR 20227027592 A KR20227027592 A KR 20227027592A KR 20220142441 A KR20220142441 A KR 20220142441A
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South Korea
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amino acid
acid sequence
seq
sequence shown
bispecific antibody
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Korean (ko)
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린페이 니와
신야 오가와
마미 와지마
츠구오 구보타
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쿄와 기린 가부시키가이샤
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

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KR1020227027592A 2020-02-14 2021-02-12 Cd3에 결합하는 이중 특이적 항체 Pending KR20220142441A (ko)

Applications Claiming Priority (3)

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JP2020023855 2020-02-14
JPJP-P-2020-023855 2020-02-14
PCT/JP2021/005276 WO2021162098A1 (ja) 2020-02-14 2021-02-12 Ｃｄ３に結合するバイスペシフィック抗体

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US (1) US20230406926A1 (https=)
EP (1) EP4105330A4 (https=)
JP (1) JP7764361B2 (https=)
KR (1) KR20220142441A (https=)
CN (1) CN115279907A (https=)
AU (1) AU2021220471A1 (https=)
CA (1) CA3167553A1 (https=)
TW (1) TWI888487B (https=)
WO (1) WO2021162098A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2025181189A1 (en) * 2024-03-01 2025-09-04 F. Hoffmann-La Roche Ag Antibodies binding to cd3

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