KR20220125232A - Ahr 억제제 및 이의 용도 - Google Patents

Ahr 억제제 및 이의 용도 Download PDF

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Publication number
KR20220125232A
KR20220125232A KR1020227021773A KR20227021773A KR20220125232A KR 20220125232 A KR20220125232 A KR 20220125232A KR 1020227021773 A KR1020227021773 A KR 1020227021773A KR 20227021773 A KR20227021773 A KR 20227021773A KR 20220125232 A KR20220125232 A KR 20220125232A
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KR
South Korea
Prior art keywords
cancer
compound
patient
pharmaceutically acceptable
sdi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
KR1020227021773A
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English (en)
Korean (ko)
Inventor
알프레도 씨. 카스트로
3세 제임스 마틴 놀란
샤오얀 미셸 장
제이슨 세이저
Original Assignee
이케나 온콜로지, 인코포레이티드
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Publication date
Application filed by 이케나 온콜로지, 인코포레이티드 filed Critical 이케나 온콜로지, 인코포레이티드
Publication of KR20220125232A publication Critical patent/KR20220125232A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020227021773A 2019-11-26 2020-11-25 Ahr 억제제 및 이의 용도 Withdrawn KR20220125232A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962940514P 2019-11-26 2019-11-26
US62/940,514 2019-11-26
US202063106530P 2020-10-28 2020-10-28
US63/106,530 2020-10-28
PCT/US2020/062116 WO2021108469A1 (en) 2019-11-26 2020-11-25 Ahr inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
KR20220125232A true KR20220125232A (ko) 2022-09-14

Family

ID=73856333

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227021773A Withdrawn KR20220125232A (ko) 2019-11-26 2020-11-25 Ahr 억제제 및 이의 용도

Country Status (11)

Country Link
US (1) US20230026232A1 (https=)
EP (1) EP4065090A1 (https=)
JP (1) JP2023503167A (https=)
KR (1) KR20220125232A (https=)
CN (1) CN115279347A (https=)
AU (1) AU2020391451A1 (https=)
BR (1) BR112022010143A2 (https=)
CA (1) CA3159315A1 (https=)
IL (1) IL293325A (https=)
MX (1) MX2022006312A (https=)
WO (1) WO2021108469A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019012431A (es) 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
US12570638B2 (en) 2020-05-20 2026-03-10 Sail Biomedicines, Inc. Fused imidazole derivatives as AHR antagonists
CN119768155A (zh) * 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201103837D0 (en) * 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
MX2019012431A (es) * 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
EP3774767B1 (en) * 2018-04-05 2025-10-29 Beth Israel Deaconess Medical Center, Inc. Aryl hydrocarbon receptor modulators and uses thereof
US20220185795A1 (en) * 2019-03-11 2022-06-16 Ptc Therapeutics, Inc. Compound form having enhanced bioavailability and formulations thereof

Also Published As

Publication number Publication date
IL293325A (en) 2022-07-01
BR112022010143A2 (pt) 2022-08-09
US20230026232A1 (en) 2023-01-26
WO2021108469A1 (en) 2021-06-03
CN115279347A (zh) 2022-11-01
AU2020391451A1 (en) 2022-06-16
EP4065090A1 (en) 2022-10-05
CA3159315A1 (en) 2021-06-03
MX2022006312A (es) 2022-06-22
JP2023503167A (ja) 2023-01-26

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