CA3159315A1 - Ahr inhibitors and uses thereof - Google Patents

Ahr inhibitors and uses thereof Download PDF

Info

Publication number
CA3159315A1
CA3159315A1 CA3159315A CA3159315A CA3159315A1 CA 3159315 A1 CA3159315 A1 CA 3159315A1 CA 3159315 A CA3159315 A CA 3159315A CA 3159315 A CA3159315 A CA 3159315A CA 3159315 A1 CA3159315 A1 CA 3159315A1
Authority
CA
Canada
Prior art keywords
cancer
compound
sdi
detected
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3159315A
Other languages
English (en)
French (fr)
Inventor
Alfredo C. Castro
James Martin Nolan Iii
Xiaoyan Michelle ZHANG
Jason SAGER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImageneBio Inc
Original Assignee
Ikena Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ikena Oncology Inc filed Critical Ikena Oncology Inc
Publication of CA3159315A1 publication Critical patent/CA3159315A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3159315A 2019-11-26 2020-11-25 Ahr inhibitors and uses thereof Pending CA3159315A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962940514P 2019-11-26 2019-11-26
US62/940,514 2019-11-26
US202063106530P 2020-10-28 2020-10-28
US63/106,530 2020-10-28
PCT/US2020/062116 WO2021108469A1 (en) 2019-11-26 2020-11-25 Ahr inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CA3159315A1 true CA3159315A1 (en) 2021-06-03

Family

ID=73856333

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3159315A Pending CA3159315A1 (en) 2019-11-26 2020-11-25 Ahr inhibitors and uses thereof

Country Status (11)

Country Link
US (1) US20230026232A1 (https=)
EP (1) EP4065090A1 (https=)
JP (1) JP2023503167A (https=)
KR (1) KR20220125232A (https=)
CN (1) CN115279347A (https=)
AU (1) AU2020391451A1 (https=)
BR (1) BR112022010143A2 (https=)
CA (1) CA3159315A1 (https=)
IL (1) IL293325A (https=)
MX (1) MX2022006312A (https=)
WO (1) WO2021108469A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019012431A (es) 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
US12570638B2 (en) 2020-05-20 2026-03-10 Sail Biomedicines, Inc. Fused imidazole derivatives as AHR antagonists
CN119768155A (zh) * 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201103837D0 (en) * 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
MX2019012431A (es) * 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
EP3774767B1 (en) * 2018-04-05 2025-10-29 Beth Israel Deaconess Medical Center, Inc. Aryl hydrocarbon receptor modulators and uses thereof
US20220185795A1 (en) * 2019-03-11 2022-06-16 Ptc Therapeutics, Inc. Compound form having enhanced bioavailability and formulations thereof

Also Published As

Publication number Publication date
IL293325A (en) 2022-07-01
BR112022010143A2 (pt) 2022-08-09
US20230026232A1 (en) 2023-01-26
WO2021108469A1 (en) 2021-06-03
CN115279347A (zh) 2022-11-01
AU2020391451A1 (en) 2022-06-16
EP4065090A1 (en) 2022-10-05
MX2022006312A (es) 2022-06-22
KR20220125232A (ko) 2022-09-14
JP2023503167A (ja) 2023-01-26

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