KR20220066291A - Nef-함유 t 세포 및 이의 제조 방법 - Google Patents

Nef-함유 t 세포 및 이의 제조 방법 Download PDF

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KR20220066291A
KR20220066291A KR1020227010201A KR20227010201A KR20220066291A KR 20220066291 A KR20220066291 A KR 20220066291A KR 1020227010201 A KR1020227010201 A KR 1020227010201A KR 20227010201 A KR20227010201 A KR 20227010201A KR 20220066291 A KR20220066291 A KR 20220066291A
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cmsd
modified
itam
cell
seq
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샤오후 판
윈청 자오
빙 왕
다웨이 위
신 황
핑옌 왕
추촨 좡
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난징 레전드 바이오테크 씨오., 엘티디.
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Priority to KR1020227043340A priority Critical patent/KR20230004898A/ko
Publication of KR20220066291A publication Critical patent/KR20220066291A/ko
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PL3896091T3 (pl) 2016-08-10 2024-04-29 Legend Biotech Ireland Limited Chimeryczne receptory antygenowe nakierowane na bcma i sposoby ich zastosowania
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WO2022174172A1 (en) * 2021-02-15 2022-08-18 H. Lee Moffitt Cancer Center And Research Institute Inc. Customized chimeric antigen receptor polypeptides
US20230303655A1 (en) * 2021-10-18 2023-09-28 Kite Pharma, Inc. Signaling domains for chimeric antigen receptors
IL320312A (en) * 2022-10-25 2025-06-01 Kyverna Therapeutics Inc Methods for treating lupus nephritis using anti-cd19 car-t cell therapies
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