KR20220062353A - 아플리베르셉트를 코딩하는 aav2 변이체를 사용하여 안구 신생혈관 질환을 치료하는 방법 - Google Patents

아플리베르셉트를 코딩하는 aav2 변이체를 사용하여 안구 신생혈관 질환을 치료하는 방법 Download PDF

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KR20220062353A
KR20220062353A KR1020227011745A KR20227011745A KR20220062353A KR 20220062353 A KR20220062353 A KR 20220062353A KR 1020227011745 A KR1020227011745 A KR 1020227011745A KR 20227011745 A KR20227011745 A KR 20227011745A KR 20220062353 A KR20220062353 A KR 20220062353A
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South Korea
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unit dose
raav particles
eye
weeks
administration
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KR1020227011745A
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Korean (ko)
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메흐디 가스미
실라드 키스
아론 오스본
아담 터프큐
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애드베룸 바이오테크놀로지스, 인코포레이티드
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Priority claimed from PCT/US2019/062066 external-priority patent/WO2021050094A1/en
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Publication of KR20220062353A publication Critical patent/KR20220062353A/ko
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KR1020227011745A 2019-09-11 2020-09-10 아플리베르셉트를 코딩하는 aav2 변이체를 사용하여 안구 신생혈관 질환을 치료하는 방법 Pending KR20220062353A (ko)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201962899070P 2019-09-11 2019-09-11
US62/899,070 2019-09-11
US201962913648P 2019-10-10 2019-10-10
US62/913,648 2019-10-10
USPCT/US2019/062066 2019-11-18
PCT/US2019/062066 WO2021050094A1 (en) 2019-09-11 2019-11-18 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
US202062959784P 2020-01-10 2020-01-10
US62/959,784 2020-01-10
US202062971835P 2020-02-07 2020-02-07
US62/971,835 2020-02-07
US202063019190P 2020-05-01 2020-05-01
US63/019,190 2020-05-01
US202063030819P 2020-05-27 2020-05-27
US63/030,819 2020-05-27
US202063063203P 2020-08-07 2020-08-07
US63/063,203 2020-08-07
PCT/US2020/050079 WO2021050649A1 (en) 2019-09-11 2020-09-10 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

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Publication Number Publication Date
KR20220062353A true KR20220062353A (ko) 2022-05-16

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EP (2) EP4027983B1 (https=)
JP (2) JP2022547541A (https=)
KR (1) KR20220062353A (https=)
CN (1) CN114375195A (https=)
AU (1) AU2020345915A1 (https=)
BR (1) BR112022004027A2 (https=)
CA (1) CA3148376A1 (https=)
DK (1) DK4027983T3 (https=)
ES (1) ES3063491T3 (https=)
FI (1) FI4027983T3 (https=)
HR (1) HRP20260137T1 (https=)
IL (1) IL291182A (https=)
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PT (1) PT4027983T (https=)
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SM (1) SMT202600070T1 (https=)
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CN118718181A (zh) 2019-06-05 2024-10-01 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
JP7842082B2 (ja) * 2020-07-21 2026-04-07 エフティージェン コーポレーション 眼疾患を処置するための組成物および方法
JP2024515459A (ja) 2021-04-27 2024-04-10 アドヴェラム バイオテクノロジーズ， インコーポレイテッド アフリベルセプトをコードするａａｖ２バリアントを使用する眼疾患の治療方法
MX2023014041A (es) * 2021-05-28 2023-12-15 Shanghai Regenelead Therapies Co Ltd Virus adenoasociado recombinante que tiene una capsida variante y su aplicacion.
WO2023028457A1 (en) * 2021-08-23 2023-03-02 Duke University Compositions for and methods of long-term integration of circuits using connexins
EP4479098A1 (en) * 2022-02-16 2024-12-25 Adverum Biotechnologies, Inc. Method of reducing cst fluctuation in neovascular amd by a recombinant adeno-associated virus
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2025026182A1 (zh) 2023-08-01 2025-02-06 北京因诺惟康医药科技有限公司 融合多肽、包含其编码基因的表达盒、基因递送载体、药物组合物及用途
KR20260004635A (ko) * 2024-07-01 2026-01-09 삼성바이오에피스 주식회사 애플리버셉트를 암호화하는 코돈-최적화된 폴리뉴클레오티드를 포함하는 발현 카세트 및 이를 포함하는 rAAV 생산용 플라스미드

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JP2544136B2 (ja) * 1986-05-23 1996-10-16 第一製薬株式会社 硫酸化多糖体ｄｓ４１５２を含有する血管新生抑制剤及び抗腫瘍剤
TW201105363A (en) * 2009-07-14 2011-02-16 Univ Yamagata Eye drop for macular edema treatment
HRP20171334T1 (hr) 2011-04-22 2017-11-17 The Regents Of The University Of California Virioni adeno-povezanog virusa s kapsid varijantom i postupci njihove upotrebe
AU2014252808A1 (en) * 2013-04-09 2015-11-12 Cresset Biomolecular Discovery Ltd The treatment of inflammatory disorders
DK3471780T3 (da) * 2016-06-16 2020-11-23 Adverum Biotechnologies Inc Behandling af amd med aav2-variant med aflibercept
CN110546257B (zh) 2017-03-17 2024-03-01 阿德夫拉姆生物技术股份有限公司 用于增强基因表达的组合物和方法

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EP4027983A1 (en) 2022-07-20
WO2021050649A1 (en) 2021-03-18
EP4027983B1 (en) 2025-11-19
RS67774B1 (sr) 2026-03-31
BR112022004027A2 (pt) 2022-05-31
CN114375195A (zh) 2022-04-19
AU2020345915A1 (en) 2022-03-24
SMT202600070T1 (it) 2026-03-09
CA3148376A1 (en) 2021-03-18
EP4696318A1 (en) 2026-02-18
DK4027983T3 (da) 2026-02-09
JP2022547541A (ja) 2022-11-14
HRP20260137T1 (hr) 2026-03-13
IL291182A (en) 2022-05-01
LT4027983T (lt) 2026-02-25
JP2025118798A (ja) 2025-08-13
PT4027983T (pt) 2026-02-25
MX2022002961A (es) 2022-04-06
ES3063491T3 (en) 2026-04-16

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