KR20220032607A - 항암제를 스크리닝하는 방법 및 췌장암 치료를 위한 키나아제 억제제의 조합 의약 - Google Patents

항암제를 스크리닝하는 방법 및 췌장암 치료를 위한 키나아제 억제제의 조합 의약 Download PDF

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KR20220032607A
KR20220032607A KR1020227004728A KR20227004728A KR20220032607A KR 20220032607 A KR20220032607 A KR 20220032607A KR 1020227004728 A KR1020227004728 A KR 1020227004728A KR 20227004728 A KR20227004728 A KR 20227004728A KR 20220032607 A KR20220032607 A KR 20220032607A
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inhibitor
gene
nucleic acid
uas
test substance
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마사히로 소노시타
쇼 세키야
사토시 히라노
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국립대학법인 홋가이도 다이가쿠
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    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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    • A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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KR1020227004728A 2020-02-27 2021-03-01 항암제를 스크리닝하는 방법 및 췌장암 치료를 위한 키나아제 억제제의 조합 의약 Ceased KR20220032607A (ko)

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JP2020032112 2020-02-27
JPJP-P-2020-032112 2020-02-27
PCT/JP2021/007651 WO2021172582A1 (ja) 2020-02-27 2021-03-01 抗がん剤をスクリーニングする方法及び膵がんの治療のためのキナーゼ阻害剤の組み合わせ医薬

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US (1) US20220387630A1 (https=)
EP (1) EP4115907B1 (https=)
JP (1) JP7761939B2 (https=)
KR (1) KR20220032607A (https=)
CN (1) CN114207437B (https=)
AU (1) AU2021226119B2 (https=)
CA (1) CA3151403A1 (https=)
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JP2019528279A (ja) 2016-08-17 2019-10-10 アイカーン スクール オブ メディシン アット マウント サイナイ キナーゼ阻害物質化合物、組成物、及びがんの治療方法

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CN102216775B (zh) * 2008-08-18 2014-04-16 马克斯·普朗克科学促进协会 对hsp90-抑制剂的易感性
AR086656A1 (es) * 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
CA2846496C (en) * 2011-09-02 2020-07-14 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
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JP7761939B2 (ja) 2025-10-29
US20220387630A1 (en) 2022-12-08
CA3151403A1 (en) 2021-09-02
EP4115907B1 (en) 2026-05-06
AU2021226119A1 (en) 2022-03-24
EP4115907A1 (en) 2023-01-11
JPWO2021172582A1 (https=) 2021-09-02
CN114207437B (zh) 2024-05-28
WO2021172582A1 (ja) 2021-09-02
CN114207437A (zh) 2022-03-18
EP4115907A4 (en) 2024-07-03
AU2021226119B2 (en) 2024-04-18

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