KR20220016139A - 항체 이량체화를 유도하기 위한 경첩 영역 조작 - Google Patents

항체 이량체화를 유도하기 위한 경첩 영역 조작 Download PDF

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Publication number
KR20220016139A
KR20220016139A KR1020217042483A KR20217042483A KR20220016139A KR 20220016139 A KR20220016139 A KR 20220016139A KR 1020217042483 A KR1020217042483 A KR 1020217042483A KR 20217042483 A KR20217042483 A KR 20217042483A KR 20220016139 A KR20220016139 A KR 20220016139A
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KR
South Korea
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amino acid
region
antibody
sequence
domain
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KR1020217042483A
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English (en)
Korean (ko)
Inventor
페르난도 가르세스
줄룬 왕
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암젠 인크
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Publication of KR20220016139A publication Critical patent/KR20220016139A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020217042483A 2019-05-30 2020-05-29 항체 이량체화를 유도하기 위한 경첩 영역 조작 Pending KR20220016139A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962854907P 2019-05-30 2019-05-30
US62/854,907 2019-05-30
PCT/US2020/035196 WO2020243477A2 (en) 2019-05-30 2020-05-29 Engineering the hinge region to drive antibody dimerization

Publications (1)

Publication Number Publication Date
KR20220016139A true KR20220016139A (ko) 2022-02-08

Family

ID=72234906

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217042483A Pending KR20220016139A (ko) 2019-05-30 2020-05-29 항체 이량체화를 유도하기 위한 경첩 영역 조작

Country Status (12)

Country Link
US (1) US20220235148A1 (enExample)
EP (1) EP3976643A2 (enExample)
JP (2) JP7500619B2 (enExample)
KR (1) KR20220016139A (enExample)
CN (2) CN114174344B (enExample)
AU (1) AU2020283890A1 (enExample)
CA (1) CA3141690A1 (enExample)
EA (1) EA202193322A1 (enExample)
MX (1) MX2021014534A (enExample)
SG (1) SG11202112926YA (enExample)
TW (2) TW202525844A (enExample)
WO (1) WO2020243477A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024242490A1 (ko) * 2023-05-24 2024-11-28 삼성바이오로직스 주식회사 Ch3 도메인 변이체 또는 이를 포함하는 이중 특이적 항체

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110669137B (zh) * 2019-10-24 2021-07-16 高新 一种多特异性抗体及其制备方法和用途
WO2022223016A1 (en) * 2021-04-23 2022-10-27 Chimagen Biosciences, Ltd Heterodimeric antibodies and antigen-binding fragment thereof
KR20250051674A (ko) * 2022-07-22 2025-04-17 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 다중특이적 항체의 중쇄 및 경쇄의 상동성 페어링을 촉진하는 돌연변이체
CN115232214A (zh) * 2022-08-16 2022-10-25 广州市拜沃思生物科技有限公司 一种双特异性抗体及其制备方法和应用
TW202506725A (zh) * 2023-04-07 2025-02-16 美商麥迪紐有限責任公司 三特異性工程化抗體
WO2025167974A1 (zh) * 2024-02-07 2025-08-14 上海齐鲁制药研究中心有限公司 多特异性抗体或抗原结合片段

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024242490A1 (ko) * 2023-05-24 2024-11-28 삼성바이오로직스 주식회사 Ch3 도메인 변이체 또는 이를 포함하는 이중 특이적 항체

Also Published As

Publication number Publication date
AU2020283890A1 (en) 2021-12-16
TW202110877A (zh) 2021-03-16
MX2021014534A (es) 2022-02-11
TW202525844A (zh) 2025-07-01
US20220235148A1 (en) 2022-07-28
CA3141690A1 (en) 2020-12-03
JP2024113040A (ja) 2024-08-21
CN114174344B (zh) 2024-11-22
WO2020243477A3 (en) 2021-01-07
EA202193322A1 (ru) 2022-03-10
CN114174344A (zh) 2022-03-11
TWI879770B (zh) 2025-04-11
EP3976643A2 (en) 2022-04-06
WO2020243477A2 (en) 2020-12-03
JP2022534901A (ja) 2022-08-04
JP7500619B2 (ja) 2024-06-17
SG11202112926YA (en) 2021-12-30
CN119431599A (zh) 2025-02-14

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