TW202525844A - 工程改造鉸鏈區以驅動抗體二聚化 - Google Patents

工程改造鉸鏈區以驅動抗體二聚化 Download PDF

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Publication number
TW202525844A
TW202525844A TW114109900A TW114109900A TW202525844A TW 202525844 A TW202525844 A TW 202525844A TW 114109900 A TW114109900 A TW 114109900A TW 114109900 A TW114109900 A TW 114109900A TW 202525844 A TW202525844 A TW 202525844A
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Taiwan
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TW114109900A
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English (en)
Chinese (zh)
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費南多 加瑟斯
祖倫 王
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美商安進公司
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Publication of TW202525844A publication Critical patent/TW202525844A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
TW114109900A 2019-05-30 2020-05-29 工程改造鉸鏈區以驅動抗體二聚化 TW202525844A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962854907P 2019-05-30 2019-05-30
US62/854,907 2019-05-30

Publications (1)

Publication Number Publication Date
TW202525844A true TW202525844A (zh) 2025-07-01

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TW109118067A TWI879770B (zh) 2019-05-30 2020-05-29 工程改造鉸鏈區以驅動抗體二聚化
TW114109900A TW202525844A (zh) 2019-05-30 2020-05-29 工程改造鉸鏈區以驅動抗體二聚化

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US (1) US20220235148A1 (enExample)
EP (1) EP3976643A2 (enExample)
JP (2) JP7500619B2 (enExample)
KR (1) KR20220016139A (enExample)
CN (2) CN119431599A (enExample)
AU (1) AU2020283890A1 (enExample)
CA (1) CA3141690A1 (enExample)
EA (1) EA202193322A1 (enExample)
MX (1) MX2021014534A (enExample)
SG (1) SG11202112926YA (enExample)
TW (2) TWI879770B (enExample)
WO (1) WO2020243477A2 (enExample)

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CN110669137B (zh) * 2019-10-24 2021-07-16 高新 一种多特异性抗体及其制备方法和用途
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JP2025524024A (ja) * 2022-07-22 2025-07-25 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 多重特異性抗体の重鎖及び軽鎖の相同対合を促進する変異体
CN115232214A (zh) * 2022-08-16 2022-10-25 广州市拜沃思生物科技有限公司 一种双特异性抗体及其制备方法和应用
TW202506725A (zh) * 2023-04-07 2025-02-16 美商麥迪紐有限責任公司 三特異性工程化抗體
WO2024242490A1 (ko) * 2023-05-24 2024-11-28 삼성바이오로직스 주식회사 Ch3 도메인 변이체 또는 이를 포함하는 이중 특이적 항체
WO2025167974A1 (zh) * 2024-02-07 2025-08-14 上海齐鲁制药研究中心有限公司 多特异性抗体或抗原结合片段

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Publication number Publication date
TWI879770B (zh) 2025-04-11
WO2020243477A3 (en) 2021-01-07
JP2022534901A (ja) 2022-08-04
US20220235148A1 (en) 2022-07-28
WO2020243477A2 (en) 2020-12-03
CN114174344A (zh) 2022-03-11
AU2020283890A1 (en) 2021-12-16
EP3976643A2 (en) 2022-04-06
MX2021014534A (es) 2022-02-11
JP7500619B2 (ja) 2024-06-17
KR20220016139A (ko) 2022-02-08
CA3141690A1 (en) 2020-12-03
JP2024113040A (ja) 2024-08-21
CN119431599A (zh) 2025-02-14
EA202193322A1 (ru) 2022-03-10
TW202110877A (zh) 2021-03-16
CN114174344B (zh) 2024-11-22
SG11202112926YA (en) 2021-12-30

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