KR20220012278A - 약물 컨쥬게이트 및 이의 사용 방법 - Google Patents

약물 컨쥬게이트 및 이의 사용 방법 Download PDF

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KR20220012278A
KR20220012278A KR1020217041069A KR20217041069A KR20220012278A KR 20220012278 A KR20220012278 A KR 20220012278A KR 1020217041069 A KR1020217041069 A KR 1020217041069A KR 20217041069 A KR20217041069 A KR 20217041069A KR 20220012278 A KR20220012278 A KR 20220012278A
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conjugate
fragment
peptide
drug
heavy chain
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제임스 알. 킨칭
제니퍼 알. 코크란
카이틀린 밀러
Original Assignee
더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티
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Publication of KR20220012278A publication Critical patent/KR20220012278A/ko
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    • C07K2319/00—Fusion polypeptide
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AU2020357806A1 (en) * 2019-09-30 2022-05-26 The Board Of Trustees Of The Leland Stanford Junior University Knottin-immunostimulant conjugates and related compositions and methods
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CA3247329A1 (en) * 2022-02-02 2023-08-10 Cancer Targeted Technology Llc PHOSPHORAMIDATE-BASED SMALL MOLECULE DRUG CONJUGATES TARGETING PSMA
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US10844106B2 (en) * 2010-11-08 2020-11-24 The Board Of Trustees Of The Leland Stanford Junior University Fusion proteins comprising an engineered knottin peptide and uses thereof
KR101972446B1 (ko) * 2011-05-27 2019-04-25 글락소 그룹 리미티드 Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）­결합 단백질
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US9587001B2 (en) * 2012-10-19 2017-03-07 The Board Of Trustees Of The Leland Stanford Junior University Conjugated knottin mini-proteins containing non-natural amino acids
CA2957717C (en) * 2014-08-12 2021-10-19 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
WO2016102679A1 (en) * 2014-12-23 2016-06-30 Nbe-Therapeutics Ag Binding protein drug conjugates comprising anthracycline derivatives
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
CA2987636A1 (en) * 2015-06-26 2016-12-29 Fred Hutchinson Cancer Research Center Therapeutic peptides and methods of use thereof
US10888603B2 (en) * 2016-02-12 2021-01-12 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cancer cells expressing tumor-associated integrins
US10765625B2 (en) * 2016-03-15 2020-09-08 The Board Of Trustees Of The Leland Stanford Junior University Knottin-drug conjugates and methods of using the same
US20190292243A1 (en) * 2016-08-22 2019-09-26 Fred Hutchinson Cancer Research Center Peptides and methods of use thereof
AU2018207303A1 (en) * 2017-01-10 2019-07-25 xCella Biosciences, Inc. Combination tumor treatment with an integrin-binding-Fc fusion protein and immune modulator
AU2018289581C1 (en) * 2017-06-23 2025-01-30 VelosBio Inc. ROR1 antibody immunoconjugates
AU2020357806A1 (en) * 2019-09-30 2022-05-26 The Board Of Trustees Of The Leland Stanford Junior University Knottin-immunostimulant conjugates and related compositions and methods
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