KR20210132661A - Cyp27a1의 발현을 억제하기 위한 방법 및 조성물 - Google Patents

Cyp27a1의 발현을 억제하기 위한 방법 및 조성물 Download PDF

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KR20210132661A
KR20210132661A KR1020217026888A KR20217026888A KR20210132661A KR 20210132661 A KR20210132661 A KR 20210132661A KR 1020217026888 A KR1020217026888 A KR 1020217026888A KR 20217026888 A KR20217026888 A KR 20217026888A KR 20210132661 A KR20210132661 A KR 20210132661A
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South Korea
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artificial sequence
synthetic polynucleotide
oligonucleotide
rna
nucleotides
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KR1020217026888A
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Korean (ko)
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우차브 삭세나
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다이서나 파마수이티컬, 인크.
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)

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KR1020217026888A 2019-02-12 2020-02-07 Cyp27a1의 발현을 억제하기 위한 방법 및 조성물 Withdrawn KR20210132661A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962804410P 2019-02-12 2019-02-12
US62/804,410 2019-02-12
PCT/US2020/017129 WO2020167593A1 (en) 2019-02-12 2020-02-07 Methods and compositions for inhibiting expression of cyp27a1

Publications (1)

Publication Number Publication Date
KR20210132661A true KR20210132661A (ko) 2021-11-04

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KR1020217026888A Withdrawn KR20210132661A (ko) 2019-02-12 2020-02-07 Cyp27a1의 발현을 억제하기 위한 방법 및 조성물

Country Status (13)

Country Link
US (1) US20220186229A1 (https=)
EP (1) EP3908661A1 (https=)
JP (1) JP2022520653A (https=)
KR (1) KR20210132661A (https=)
CN (1) CN113692444A (https=)
AU (1) AU2020221892A1 (https=)
BR (1) BR112021015651A2 (https=)
CA (1) CA3128059A1 (https=)
CL (2) CL2021002120A1 (https=)
IL (1) IL285367A (https=)
MX (1) MX2021009754A (https=)
SG (1) SG11202108532RA (https=)
WO (1) WO2020167593A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024269205A1 (en) * 2023-05-11 2025-12-11 Keymed Biosciences (Us) Inc. Dsrna molecules for regulating masp2 gene activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN específicos de secuencias de ARN
WO2002030952A2 (en) * 2000-10-13 2002-04-18 Genaissance Pharmaceuticals, Inc. Haplotypes of the cyp27a1 gene
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
US20050159378A1 (en) 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
WO2003040395A2 (en) 2001-11-07 2003-05-15 Applera Corporation Universal nucleotides for nucleic acid analysis
US20070265220A1 (en) 2004-03-15 2007-11-15 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
WO2007030167A1 (en) 2005-09-02 2007-03-15 Nastech Pharmaceutical Company Inc. Modification of double-stranded ribonucleic acid molecules
DK2341943T3 (en) 2008-09-22 2019-02-25 Dicerna Pharmaceuticals Inc COMPOSITIONS AND METHODS OF SPECIFIC INHIBITION OF DSRNA REPRINT WITH MODIFICATIONS
US8691971B2 (en) 2008-09-23 2014-04-08 Scott G. Petersen Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
US20100249214A1 (en) 2009-02-11 2010-09-30 Dicerna Pharmaceuticals Multiplex dicer substrate rna interference molecules having joining sequences
KR101728655B1 (ko) 2008-12-18 2017-04-19 다이서나 파마수이티컬, 인크. 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
WO2011005860A2 (en) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
WO2011133871A2 (en) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. 5'-end derivatives
AU2012328680A1 (en) 2011-10-25 2014-05-01 Ionis Pharmaceuticals, Inc. Antisense modulation of GCCR expression
EP2928877B1 (en) 2012-12-06 2020-01-22 Merck Sharp & Dohme Corp. Disulfide masked prodrug compositions and methods
CA2950960A1 (en) 2014-06-06 2015-12-10 Solstice Biologics, Ltd. Polynucleotide constructs having bioreversible and non-bioreversible groups
DK3569711T3 (da) * 2014-12-15 2021-02-22 Dicerna Pharmaceuticals Inc Ligandmodificerede dobbeltstrengede nukleinsyrer
KR101916583B1 (ko) * 2017-04-20 2018-11-07 가천대학교 산학협력단 칼피르조밉을 유효성분으로 함유하는 담석증의 예방 또는 치료용 약학적 조성물

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Publication number Publication date
CN113692444A (zh) 2021-11-23
US20220186229A1 (en) 2022-06-16
BR112021015651A2 (pt) 2021-10-05
IL285367A (en) 2021-09-30
MX2021009754A (es) 2021-09-08
WO2020167593A1 (en) 2020-08-20
SG11202108532RA (en) 2021-09-29
CA3128059A1 (en) 2020-08-20
EP3908661A1 (en) 2021-11-17
AU2020221892A1 (en) 2021-08-19
JP2022520653A (ja) 2022-03-31
CL2021002120A1 (es) 2022-04-01
CL2023003914A1 (es) 2024-07-12

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