KR20210132661A - Cyp27a1의 발현을 억제하기 위한 방법 및 조성물 - Google Patents

Cyp27a1의 발현을 억제하기 위한 방법 및 조성물 Download PDF

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KR20210132661A
KR20210132661A KR1020217026888A KR20217026888A KR20210132661A KR 20210132661 A KR20210132661 A KR 20210132661A KR 1020217026888 A KR1020217026888 A KR 1020217026888A KR 20217026888 A KR20217026888 A KR 20217026888A KR 20210132661 A KR20210132661 A KR 20210132661A
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South Korea
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artificial sequence
synthetic polynucleotide
oligonucleotide
rna
nucleotides
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Korean (ko)
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우차브 삭세나
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다이서나 파마수이티컬, 인크.
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)

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KR1020217026888A 2019-02-12 2020-02-07 Cyp27a1의 발현을 억제하기 위한 방법 및 조성물 Withdrawn KR20210132661A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962804410P 2019-02-12 2019-02-12
US62/804,410 2019-02-12
PCT/US2020/017129 WO2020167593A1 (en) 2019-02-12 2020-02-07 Methods and compositions for inhibiting expression of cyp27a1

Publications (1)

Publication Number Publication Date
KR20210132661A true KR20210132661A (ko) 2021-11-04

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KR1020217026888A Withdrawn KR20210132661A (ko) 2019-02-12 2020-02-07 Cyp27a1의 발현을 억제하기 위한 방법 및 조성물

Country Status (13)

Country Link
US (1) US20220186229A1 (https=)
EP (1) EP3908661A1 (https=)
JP (1) JP2022520653A (https=)
KR (1) KR20210132661A (https=)
CN (1) CN113692444A (https=)
AU (1) AU2020221892A1 (https=)
BR (1) BR112021015651A2 (https=)
CA (1) CA3128059A1 (https=)
CL (2) CL2021002120A1 (https=)
IL (1) IL285367A (https=)
MX (1) MX2021009754A (https=)
SG (1) SG11202108532RA (https=)
WO (1) WO2020167593A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024269205A1 (en) * 2023-05-11 2025-12-11 Keymed Biosciences (Us) Inc. Dsrna molecules for regulating masp2 gene activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1309726E (pt) 2000-03-30 2010-03-08 Whitehead Biomedical Inst Mediadores de interferência por rna específicos de sequência de rna
AU2002213489A1 (en) * 2000-10-13 2002-04-22 Genaissance Pharmaceuticals, Inc. Haplotypes of the cyp27a1 gene
US20040259247A1 (en) 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
US20050159378A1 (en) 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
JP2005508196A (ja) 2001-11-07 2005-03-31 アプレラ コーポレイション 核酸分析の汎用ヌクレオチド
US20070265220A1 (en) 2004-03-15 2007-11-15 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
WO2007030167A1 (en) 2005-09-02 2007-03-15 Nastech Pharmaceutical Company Inc. Modification of double-stranded ribonucleic acid molecules
JP2012504389A (ja) * 2008-09-22 2012-02-23 ダイセルナ ファーマシューティカルズ， インコーポレイテッド 修飾を有するｄｓＲＮＡによる遺伝子発現の特異的な阻害のための組成物および方法
US8691971B2 (en) 2008-09-23 2014-04-08 Scott G. Petersen Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
US20100249214A1 (en) 2009-02-11 2010-09-30 Dicerna Pharmaceuticals Multiplex dicer substrate rna interference molecules having joining sequences
AU2009336191B2 (en) 2008-12-18 2017-08-24 Novo Nordisk A/S Extended dicer substrate agents and methods for the specific inhibition of gene expression
US8927513B2 (en) 2009-07-07 2015-01-06 Alnylam Pharmaceuticals, Inc. 5′ phosphate mimics
WO2011133871A2 (en) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. 5'-end derivatives
JP2015501155A (ja) 2011-10-25 2015-01-15 アイシス ファーマシューティカルズ， インコーポレーテッド Ｇｃｃｒ発現のアンチセンス調整
EP2928877B1 (en) 2012-12-06 2020-01-22 Merck Sharp & Dohme Corp. Disulfide masked prodrug compositions and methods
JP2017522046A (ja) 2014-06-06 2017-08-10 ソルスティス バイオロジクス，リミティッド 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物
JP7105065B2 (ja) * 2014-12-15 2022-07-22 ダイセルナ ファーマシューティカルズ， インコーポレイテッド リガンド修飾二本鎖核酸
KR101916583B1 (ko) * 2017-04-20 2018-11-07 가천대학교 산학협력단 칼피르조밉을 유효성분으로 함유하는 담석증의 예방 또는 치료용 약학적 조성물

Also Published As

Publication number Publication date
MX2021009754A (es) 2021-09-08
IL285367A (en) 2021-09-30
US20220186229A1 (en) 2022-06-16
AU2020221892A1 (en) 2021-08-19
CL2021002120A1 (es) 2022-04-01
SG11202108532RA (en) 2021-09-29
BR112021015651A2 (pt) 2021-10-05
WO2020167593A1 (en) 2020-08-20
CA3128059A1 (en) 2020-08-20
JP2022520653A (ja) 2022-03-31
CN113692444A (zh) 2021-11-23
CL2023003914A1 (es) 2024-07-12
EP3908661A1 (en) 2021-11-17

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