KR20210098940A - Ebv 관련 암의 치료를 위한 항-lmp2 tcr-t 세포 요법 - Google Patents
Ebv 관련 암의 치료를 위한 항-lmp2 tcr-t 세포 요법 Download PDFInfo
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- KR20210098940A KR20210098940A KR1020217005780A KR20217005780A KR20210098940A KR 20210098940 A KR20210098940 A KR 20210098940A KR 1020217005780 A KR1020217005780 A KR 1020217005780A KR 20217005780 A KR20217005780 A KR 20217005780A KR 20210098940 A KR20210098940 A KR 20210098940A
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- Prior art keywords
- tcr
- cancer
- cells
- seq
- leu
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A61K40/42—Cancer antigens
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- A61K40/46—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—DNA viruses
- C07K16/085—Orthoherpesviridae (F), e.g. pseudorabies virus or Epstein-Barr virus
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- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2510/00—Genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Oncology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862771653P | 2018-11-27 | 2018-11-27 | |
| US62/771,653 | 2018-11-27 | ||
| PCT/US2019/063310 WO2020112815A1 (en) | 2018-11-27 | 2019-11-26 | Anti-lmp2 tcr-t cell therapy for the treatment of ebv-associated cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210098940A true KR20210098940A (ko) | 2021-08-11 |
Family
ID=70854398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217005780A Ceased KR20210098940A (ko) | 2018-11-27 | 2019-11-26 | Ebv 관련 암의 치료를 위한 항-lmp2 tcr-t 세포 요법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12139523B2 (https=) |
| JP (1) | JP2022512538A (https=) |
| KR (1) | KR20210098940A (https=) |
| CN (1) | CN113166224A (https=) |
| SG (1) | SG11202101671PA (https=) |
| TW (1) | TW202039540A (https=) |
| WO (1) | WO2020112815A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113621070A (zh) | 2020-05-06 | 2021-11-09 | 华夏英泰(北京)生物技术有限公司 | 一种t细胞抗原受体、其多聚体复合物及其制备方法和应用 |
| WO2021243695A1 (en) * | 2020-06-05 | 2021-12-09 | Guangdong Tcrcure Biopharma Technology Co., Ltd. | Tcr-t cell therapy targeting epstein-barr virus |
| CN112940108B (zh) * | 2021-03-19 | 2022-10-14 | 河南省肿瘤医院 | 识别ebv抗原的t细胞受体以及该t细胞受体的应用 |
| WO2023092452A1 (zh) * | 2021-11-26 | 2023-06-01 | 上海吉倍生物技术有限公司 | 识别ebv lmp2抗原的t细胞受体及其应用 |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| CN119390814B (zh) * | 2023-10-26 | 2025-06-27 | 上海市第一人民医院 | 一种t细胞受体及其制备方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0917090D0 (en) * | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
| US8834889B2 (en) * | 2011-08-29 | 2014-09-16 | National Tsing Hua University | Antigen presenting composition and use thereof |
| GB201314404D0 (en) | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
| WO2016095783A1 (zh) | 2014-12-17 | 2016-06-23 | 中国科学院广州生物医药与健康研究院 | 识别eb病毒短肽的t细胞受体 |
| EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
| GB201520191D0 (en) * | 2015-11-16 | 2015-12-30 | Cancer Rec Tech Ltd | T-cell receptor and uses thereof |
| GB201522592D0 (en) * | 2015-12-22 | 2016-02-03 | Immunocore Ltd | T cell receptors |
| CN106632659A (zh) * | 2016-08-05 | 2017-05-10 | 武汉赛云博生物科技有限公司 | 一种eb病毒特异性tcr及其重组慢病毒载体与应用 |
| CN110139873A (zh) * | 2016-10-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | Hpv特异性结合分子 |
| CN110582509A (zh) * | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
-
2019
- 2019-11-26 US US17/276,553 patent/US12139523B2/en active Active
- 2019-11-26 SG SG11202101671PA patent/SG11202101671PA/en unknown
- 2019-11-26 JP JP2021510452A patent/JP2022512538A/ja active Pending
- 2019-11-26 CN CN201980056915.5A patent/CN113166224A/zh active Pending
- 2019-11-26 KR KR1020217005780A patent/KR20210098940A/ko not_active Ceased
- 2019-11-26 WO PCT/US2019/063310 patent/WO2020112815A1/en not_active Ceased
- 2019-11-27 TW TW108143260A patent/TW202039540A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022512538A (ja) | 2022-02-07 |
| WO2020112815A1 (en) | 2020-06-04 |
| CN113166224A (zh) | 2021-07-23 |
| SG11202101671PA (en) | 2021-03-30 |
| US12139523B2 (en) | 2024-11-12 |
| TW202039540A (zh) | 2020-11-01 |
| US20220056101A1 (en) | 2022-02-24 |
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