KR20210063319A - 암을 치료하기 위한 항-lypd3 car t-세포 요법 - Google Patents

암을 치료하기 위한 항-lypd3 car t-세포 요법 Download PDF

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KR20210063319A
KR20210063319A KR1020217004654A KR20217004654A KR20210063319A KR 20210063319 A KR20210063319 A KR 20210063319A KR 1020217004654 A KR1020217004654 A KR 1020217004654A KR 20217004654 A KR20217004654 A KR 20217004654A KR 20210063319 A KR20210063319 A KR 20210063319A
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car
amino acid
acid sequence
cells
cancer
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Korean (ko)
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퀴-징 리
시아오-판 왕
멩양 총
루이 첸
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듀크 유니버시티
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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KR1020217004654A 2018-07-20 2019-07-19 암을 치료하기 위한 항-lypd3 car t-세포 요법 Ceased KR20210063319A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862700942P 2018-07-20 2018-07-20
US62/700,942 2018-07-20
PCT/US2019/042707 WO2020018973A1 (en) 2018-07-20 2019-07-19 Anti-lypd3 car t-cell therapy for the treatment of cancer

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KR20210063319A true KR20210063319A (ko) 2021-06-01

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KR1020217004654A Ceased KR20210063319A (ko) 2018-07-20 2019-07-19 암을 치료하기 위한 항-lypd3 car t-세포 요법

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US (1) US20210309711A1 (https=)
EP (1) EP3823992B1 (https=)
JP (1) JP2021530238A (https=)
KR (1) KR20210063319A (https=)
CN (1) CN112955466A (https=)
AU (1) AU2019305223A1 (https=)
CA (1) CA3106967A1 (https=)
SG (1) SG11202100571TA (https=)
WO (1) WO2020018973A1 (https=)

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* Cited by examiner, † Cited by third party
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EP4536278A2 (en) 2022-06-07 2025-04-16 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates

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US7332580B2 (en) * 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
US20130266551A1 (en) * 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
PT2510012T (pt) * 2009-12-09 2017-07-13 Bayer Pharma AG Anticorpos anti-c4.4a e utilizações dos mesmos
WO2014160627A1 (en) * 2013-03-25 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 polypeptides, proteins, and chimeric antigen receptors
CA3289997A1 (en) * 2015-09-20 2026-03-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal Antibodies Specific for Fibroblast Growth Factor Receptor 4 (FGFR4) and Methods of Their Use
CN105132575B (zh) * 2015-09-28 2020-03-27 固安博健生物技术有限公司 骨质疏松症的分子标志物及其应用
GB201518136D0 (en) * 2015-10-14 2015-11-25 Glaxosmithkline Ip Dev Ltd Novel chimeric antigen receptors
EP3454870A4 (en) * 2016-05-12 2020-03-04 Adicet Bio Inc. METHOD FOR SELECTIVE EXPANSION OF GAMMA DELTA T CELL POPULATIONS AND COMPOSITIONS THEREOF
BR112018074453A2 (pt) * 2016-05-27 2019-03-19 Abbvie Biotherapeutics Inc. proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral
CN106119405B (zh) * 2016-08-31 2019-11-12 广州万德基因医学科技有限公司 一种肺癌的预后标记物、使用该标记预测肺癌预后的方法及应用
EP3759225A1 (en) * 2018-03-02 2021-01-06 Sixfold Bioscience Ltd. Compositions for delivery of cargo to cells

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CN112955466A (zh) 2021-06-11
AU2019305223A1 (en) 2021-02-18
CA3106967A1 (en) 2020-01-23
SG11202100571TA (en) 2021-02-25
EP3823992A4 (en) 2022-05-11
JP2021530238A (ja) 2021-11-11
EP3823992A1 (en) 2021-05-26
EP3823992B1 (en) 2023-12-13
WO2020018973A1 (en) 2020-01-23
US20210309711A1 (en) 2021-10-07

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