KR20210050033A - A composition for improving, preventing and treating of gastrointestinal disease - Google Patents

Abstract

The present invention relates to a composition for prevention, treatment or alleviation of gastric diseases caused by Helicobacter pylori, which contains a mixed extract consisting of Cirsium japonicum and Taraxacum platycarpum; an extract of Brassica oleracea; honey; Zingiber officinale juice; and stevia as active ingredients, and thus, has excellent effects on gastric diseases caused by Helicobacter pylori and is non-toxic to be consumed in the form of food for a user to alleviate, prevent or treat the gastric diseases caused by the Helicobacter pylori in the long term through the diet and lifestyle of daily life.

Description

A composition for improving, preventing and treating gastrointestinal disease caused by Helicobacter pylori containing a mixture consisting of milk thistle, dandelion, cabbage, honey and ginger {A composition for improving, preventing and treating of gastrointestinal disease}

The present invention relates to a composition for preventing, treating or improving gastric diseases caused by Helicobacter pylori containing a mixture consisting of thistle, dandelion, cabbage, honey and ginger.

Digestive diseases include liver-related diseases such as hepatitis and cirrhosis, and stomach and intestinal diseases such as colitis, colon cancer, gastroenteritis, gastric cancer, functional gastrointestinal disorder, and enteritis. The situation is not decreasing.

Particularly, the causes of gastric diseases can be classified largely as factors due to bacterial diseases such as Helicobacter pyrone, physical factors such as stress, and chemical factors such as ethanol.

The Helicobacter bacteria are mainly infected in the gastrointestinal mucosa and are a direct cause of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, and gastric lymphoma.If chronic gastritis caused by Helicobacter bacteria continues, an atrophic change occurs in the gastrointestinal mucosa. Environmental and genetic factors are known to increase the incidence of gastric adenocarcinoma. Therefore, Helicobacter bacteria were warned by the World Health Organization (WHO) as a first-degree cancer-causing factor in 1994.

Helicobacter infection is very common among Korean people, and the infection rate is 46.6% of the total population and 69.4% of adults. It is estimated that such a high carrier ratio of Helicobacter bacteria is the cause of the high incidence of gastric adenocarcinoma in the Korean people. Antibiotics are used to treat Helicobacter bacteria, and the commonly used first-line treatment for Helicobacter is composed of three types of drugs, including two antibiotics and one type of gastric acid inhibitor. If you take this for 7-14 days, Helicobacter bacteria are cured with a 70-80% probability. However, due to the recent increase in antibiotic resistance of Helicobacter bacteria, there are many cases in which the bacteria do not disappear even after treatment, which is a problem, and the recommended guidelines on which patients should be sterilized are not clear. In addition, there is increasing interest in the development of food or natural product extracts. In particular, according to the 2007 Maastricht III consensus report, it was mentioned that probiotics may be a tool for treating H. pylori infection.

In addition, it has been reported that co-administration of lactic acid bacteria during the first antibacterial treatment of Helicobacter bacteria using antibiotics can improve the eradication rate and reduce complications caused by the use of an eradication treatment [Sun Hee Roh. 2011. The Effect of Probiotics for Helicobacter pylori. The Korean Journal of Helicobacter and Upper Gastrointestinal Research. 11(1); 26-36].

In order to continuously treat gastric diseases caused by Helicobacter pylori, there is a need for a therapeutic agent using natural products that have less side effects than chemical drugs and have secured stability.

Korean Registered Patent No. 1902932 Korean Patent Registration No. 1984129

An object of the present invention is to provide a food composition capable of preventing or improving gastric diseases caused by Helicobacter pylori bacteria by containing a mixture consisting of thistle, dandelion, cabbage, honey and ginger.

In addition, another object of the present invention is to provide a method of preparing a food composition capable of preventing or improving gastric diseases caused by Helicobacter pylori.

In addition, another object of the present invention is to provide a food composition capable of preventing or treating gastric diseases caused by Helicobacter pylori by containing a mixture consisting of thistle, dandelion, cabbage, honey and ginger.

The food composition for preventing or improving gastric diseases caused by Helicobacter pylori of the present invention for achieving the above object comprises: a mixed extract obtained by extracting a mixture consisting of thistle and dandelion; Cabbage extract; honey; Ginger juice; And it may contain a mixture consisting of stevia as an active ingredient.

The mixed extract may be an extract extracted at 80 to 100° C. by mixing thistle and dandelion in a weight ratio of 1: 0.2-1.

With respect to 100 parts by weight of the mixed extract, 1 to 30 parts by weight of cabbage extract, 0.5 to 10 parts by weight of honey, 0.1 to 5 parts by weight of ginger juice, and 0.1 to 5 parts by weight of stevia may be mixed.

The gastric disease caused by Helicobacter pylori may be at least one gastric disease selected from the group consisting of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastric cancer and gastric lymphoma caused by Helicobacter pylori.

The thistle may be a mixture of flowers of thistle, a mixture of stems and leaves, and roots in a weight ratio of 1: 14-25: 0.1-0.9.

In addition, a method for preparing a food composition for preventing or improving gastric diseases caused by Helicobacter pylori to achieve the other object described above includes the steps of (A) obtaining a mixed extract by mixing and extracting thistle and dandelion; (B) adding and mixing cabbage extract and ginger juice to the mixed extract; And (C) adding and mixing honey and stevia to the mixture of the cabbage extract and ginger juice.

In addition, the pharmaceutical composition for the prevention or treatment of gastric diseases caused by Helicobacter pylori of the present invention for achieving the another object described above is a mixed extract obtained by extracting a mixture consisting of thistle and dandelion; Cabbage extract; honey; Ginger juice; And it may contain a mixture consisting of stevia as an active ingredient.

The composition for preventing, treating or improving gastric diseases caused by Helicobacter pylori of the present invention is selected from the group consisting of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastric cancer and gastric lymphoma by inhibiting the growth of Helicobacter pylori. It can prevent, treat or ameliorate gastric diseases caused by one or more Helicobacter pylori, and since it is not toxic, it can be consumed in the form of food.

The present invention relates to a composition for preventing, treating or improving gastric diseases caused by Helicobacter pylori containing a mixture consisting of thistle, dandelion, cabbage honey and ginger.

The gastric disease caused by Helicobacter pylori may be at least one gastric disease selected from the group consisting of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastric cancer and gastric lymphoma caused by Helicobacter pylori.

Hereinafter, the present invention will be described in detail.

The composition for preventing, treating, or improving gastric diseases caused by Helicobacter pylori of the present invention comprises: a mixed extract obtained by extracting a mixture consisting of thistle and dandelion; Cabbage extract; honey; Ginger juice; And a mixture consisting of stevia as an active ingredient.

Thistle

The thistle used in the present invention may be white-patterned thistle (Silybum marianum (L.) Gaertn.), spiny thistle (Cirsium japonicum Fisch ex DC. var. spinossimum Kitam.), or a mixture thereof, preferably white-patterned thistle. It is to use thistle alone.

The white-patterned thistle (Silybum marianum (L.) Gaertn.) is a deep, shiny green plant with milky white veins, and is a long, elongated plant divided into root-leaves with wavy patterns and thorns at the edges. It is mainly found in levee fences and in abandoned land. Useful parts of plants are whole herbs, roots, leaves, seeds, and shells, and thistle seeds contain a flavonoid compound known as silymarin. Thistle seed extract contains 70-80% silymarin.

Thistle according to the present invention is a mixed extract of a thistle flower, a mixture of stems and leaves, and a mixture of roots.

The flowers of thistle are purple or red corolla and 19-24 mm in length, and it is preferable to use only those having a length of 10 to 15 mm and not use those with a length longer than that.

In addition, the thistle stem and leaves are used by mixing in a weight ratio of 1: 1-4, preferably in a weight ratio of 1: 2-3. If the content of leaves based on the stem is less than the lower limit, the bitter taste may be strong, and if the content of the leaves is greater than the upper limit, it is not preferable for the prevention, treatment, or improvement of gastric diseases caused by Helicobacter pylori.

In addition, the thistle root is harvested once every three years, unlike flowers, stems, and leaves that are harvested twice a year, so it is preferable to use it after drying.

The flower of thistle, a mixture of stems and leaves, and roots are mixed in a weight ratio of 1: 14-25: 0.1-0.9, preferably 1: 16-19: 0.4-0.8. If the content of stem and leaf mixture and root based on flowers is less than the lower limit, the effect on preventing, treating, or improving gastric diseases caused by Helicobacter pylori may not be excellent, and if it exceeds the upper limit. There is a strong bitter taste, and the effect on the prevention, treatment, or improvement of gastric diseases caused by Helicobacter pylori may be reduced.

The mixed extract of thistle of the present invention is an extract extracted for 20 to 30 hours, preferably 24 to 28 hours at 80 to 100 ℃. When the extraction temperature and time are less than the lower limit, the active ingredient may not be extracted, and when the extraction temperature and time exceed the upper limit, the tan taste may be strong and the nutrient component may be destroyed. In addition, when extraction is performed in other ways, such as organic solvent extraction, in addition to the water bath extraction, the effect of preventing, treating or improving gastric diseases caused by Helicobacter pylori bacteria may be insignificant, and a strong bitter taste may occur. .

Specifically, the mixed extract of thistle is mixed with flowers, and a mixture of stems and leaves, followed by extraction with a bath, and separate roots are extracted with a bath, followed by mixing. Unlike the present invention, in the case of extracting the bath by mixing flowers, a mixture of stems and leaves, and roots, the bitter taste is strong, and the effect on the prevention, treatment, or improvement of gastric diseases caused by Helicobacter pylori bacteria may be lowered. .

Specifically, the method of preparing the mixed thistle extract includes the steps of: (a) mixing a mixture of flowers of thistle, and a mixture of stems and leaves, and extracting the extract by boiling water at 80 to 100° C. to obtain an extract; (b) extracting the roots of thistle in a bath at 80 to 100° C. to obtain an extract; And (c) lyophilizing and powdering the extracts obtained in steps (a) and (b), respectively, and mixing them. In addition, after the step (c), (d) drying and pulverizing the residue extracted in the step (b); And (e) mixing 100 parts by weight of the powder mixed in step (c) with 0.1 to 3 parts by weight of the powder in step (d).

Unlike steps (a) and (b) above, in the case of mixing flowers, a mixture of stems and leaves, and all of the roots and extracting the bath, the bitter taste is strong, but rather, the prevention, treatment or improvement of gastric diseases caused by Helicobacter pylori The effect on may be reduced; When the flowers, the mixture of stems and leaves, and the roots are all extracted in a bath, the yield may decrease.

When the root residue powder prepared in step (D) is added, the effect on diseases can be significantly improved compared to the case where the root residue powder is not added.

dandelion

The dandelion (Taraxacum platycarpum) is also referred to as Geumjamcho, Jeongji, Pogongyeong, Pogongcho, Anjilbang, and also has the nickname of Satbang. Leaves or stems evenly contain proteins, carbohydrates, fats, ash, minerals, and vitamins. Young shoots are used as herbs or soup. In oriental medicine, the roots and outposts before flowering are said to be effective in antipyretic, anti-inflammatory, diuretic, and dry stomach. Use.

In the present invention, thistle and dandelion are mixed in a weight ratio of 1:0.2-1, preferably 1:0.4-0.6.

If the content of dandelion based on thistle is less than the above lower limit, the effect of preventing, treating, or improving gastric diseases caused by Helicobacter pylori may be lower than when each substance is used alone, and if it exceeds the upper limit, It may have little effect to prevent, treat, or ameliorate gastric diseases caused by Helicobacter pylori.

The mixed extract of thistle and dandelion of the present invention is a mixture of thistle and dandelion and an extraction solvent in a weight ratio of 1: 1 to 100, preferably 1: 5 to 20, at 80 to 100° C. and 40 to 50 Extract for an hour to prepare an extract. When the weight ratio of the mixture and the extraction solvent is out of the above range, the active ingredient of thistle and dandelion mixture may be extracted in a small amount in the extract.

The extraction solvent for extracting the extract is water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. The extraction solvent is not particularly limited, but the extract extracted with water exhibits an excellent effect.

Cabbage extract

Cabbage has thick leaves, no hair, turns white like a powder, irregular serrations at the edges, wrinkles, and overlaps each other, and the innermost leaves are round and hard like a ball, and are effective in helping health, preventing cancer, It is effective in improving blood circulation, detoxification, and constipation.

The cabbage extract is used in an amount of 1 to 30 parts by weight, preferably 5 to 15 parts by weight, based on 100 parts by weight of the mixed extract. If the content of cabbage extract is less than the lower limit, the effect of preventing, treating, or improving gastric diseases caused by Helicobacter pylori may be reduced, and if it exceeds the upper limit, the organoleptic is lowered and is caused by Helicobacter pylori. The effect of preventing, treating or ameliorating gastric diseases may be lower than when each substance is used alone.

Cabbage extract of the present invention is a mixture of cabbage and extraction solvent in a weight ratio of 1: 1 to 100, preferably 1: 5 to 20, at 80 to 100 °C for 8 to 15 hours, preferably 10 to 12 hours It is prepared by extracting from the bath. When the weight ratio of the mixture and the extraction solvent is out of the above range, the active ingredient of cabbage may be extracted in a small amount in the extract.

The extraction solvent for extracting the extract is water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. The extraction solvent is not particularly limited, but the extract extracted with water exhibits an excellent effect.

Ginger juice

The ginger is a rootstock, grows sideways, is fleshy, lumps, yellow, has a spicy taste and a fragrant smell. Ginger cures chills, fever, headache, vomiting, seawater, and phlegm caused by colds. It is also effective for abdominal pain, diarrhea and stomach caused by food poisoning. As pharmacological action, gastric juice secretion promotion, digestion enhancement, heart excitation, blood circulation promotion, and inhibition have been reported.

In the present invention, ginger juice from which solids are removed after the ginger is juiced, and when prepared as an extract and used, the effect of preventing, treating, or improving gastric diseases caused by Helicobacter pylori bacteria may be reduced.

In addition, when used alone, the ginger juice has little effect in preventing, treating or improving gastric diseases caused by Helicobacter pylori, but when used together with the mixed extract of thistle and dandelion and cabbage extract, ginger juice alone or the mixed extract Compared to the case of using alone, it exhibits 1.5 to 20 times superior efficacy.

The ginger juice is used in an amount of 0.1 to 5 parts by weight, preferably 0.5 to 2 parts by weight, based on 100 parts by weight of the mixed extract. When the content of ginger juice is less than the lower limit, the effect of preventing, treating, or improving gastric diseases caused by Helicobacter pylori may be reduced, and when the content of the ginger juice exceeds the upper limit, the organoleptic property may be lowered.

honey

The honey is not effective when used alone, but when used together with the mixed extract of thistle and dandelion, cabbage extract, and ginger juice, it is effective in preventing, treating, or improving gastric diseases caused by Helicobacter pylori.

The honey is used in an amount of 0.5 to 10 parts by weight, preferably 2 to 6 parts by weight, based on 100 parts by weight of the mixed extract. When the content of honey is less than the lower limit, there may be no effect of preventing, treating, or improving gastric diseases caused by Helicobacter pylori, and when it exceeds the upper limit, organoleptic properties may decrease and manufacturing cost may be improved.

Stevia

Stevia ( Stevia rebaudiana ) grows around rivers or wetlands, and has been using stevia leaves as a sweetener from ancient times. Recently, when the harmfulness of saccharin, a synthetic sweetener, became a problem, it attracted attention again. Leaves contain stevioside, a sweetening substance about 6-7% by weight, and the content varies greatly depending on the individual. The sweetening ingredient is 300 times that of sugar, and it is used as a sweetener in soft drinks and as a substitute for tea or chewing gum.

In the present invention, the use of stevia enhances the functionality lowered by the use of ginger juice.

The stevia is used in an amount of 0.1 to 5 parts by weight, preferably 0.2 to 1 parts by weight, based on 100 parts by weight of the mixed extract. If the content of stevia is out of the above range, the functionality may be lowered.

In addition, the present invention provides a method of preparing a composition for preventing, treating or improving gastric diseases caused by Helicobacter pylori.

The method for preparing a composition for preventing, treating, or improving gastric diseases caused by Helicobacter pylori of the present invention comprises the steps of: (A) obtaining a mixed extract by mixing and extracting milk thistle and dandelion; (B) adding and mixing cabbage extract and ginger juice to the mixed extract; And (C) adding and mixing honey and stevia to the mixture of the cabbage extract and ginger juice.

First, in step (A), a mixture of thistle and dandelion is extracted with an extraction solvent to obtain a mixed extract.

The mixing conditions, extraction solvent and extraction conditions of the mixture are the same as those mentioned above.

Next, in step (B), a mixture of cabbage extract and ginger juice is prepared by adding cabbage extract and ginger juice to the mixed extract at room temperature (23-27° C.).

When preparing the mixed extract by mixing thistle and dandelion in step (A), the cabbage extract and ginger juice are not added to extract the extract, but the cabbage extract and ginger juice are added separately to increase the organoleptic properties, and the stomach caused by the Helicobacter pylori bacteria. It is possible to further improve the effect of preventing, treating or ameliorating the disease. In the case of extraction by adding cabbage and ginger to thistle and dandelion, the effect of preventing, treating or improving gastric diseases caused by Helicobacter pylori is not improved compared to the case where cabbage and ginger are not added, so thistle and dandelion are mixed. It is preferable to separately add cabbage extract and ginger juice to one mixed extract.

Next, in the step (C), honey and stevia are added to the mixture of the cabbage extract and ginger juice at room temperature and mixed.

The honey and stevia are added after the cabbage extract and ginger juice are sufficiently mixed with the mixed extract. When the cabbage extract, ginger juice, honey and stevia are added and mixed at the same time, the sensory properties may be significantly reduced.

The form of the composition of the present invention may be prepared in the form of gels, purees, juices, pills, large rings, and granules.

For example, in the case of manufacturing in the form of gel and puree, the mixture of cabbage extract and ginger juice prepared in step (B) is concentrated to a volume of 1/3 to 1/5 of the volume of the mixture with a concentrator. The (C) step is performed using the concentrate. That is, after mixing the concentrate with honey and stevia, agar is added, stirred, and then sterilized to prepare a gel and puree.

As another example, when it is prepared in the form of juice, the mixture prepared in step (C) is sterilized and used as it is.

As another example, when prepared in the form of a pill, a stalk, and a granule, the mixture of the cabbage extract and ginger juice prepared in step (B) is used as a concentrator in a volume of 1/5 to 1/7 of the volume of the mixture. After concentration, honey is added to the concentrate, aged for 40 to 50 hours in a water bath at 60 to 70°C, dried, and molded to prepare rings, large rings, and granules.

Mixed extract of the present invention; Cabbage extract; honey; Ginger juice; And stevia; The mixture consisting of a mixed extract in a broad sense; Cabbage extract; honey; Ginger juice; And stevia; a mixed product formulated to be administered to an animal, such as a mixed extract; Cabbage extract; honey; Ginger juice; And Stevia; It has the meaning of including a mixed powder of. Although the mixed extract in the present invention; Cabbage extract; honey; Ginger juice; And stevia; although the experiment was conducted with a mixture consisting of, a mixed extract; Cabbage extract; honey; Ginger juice; And stevia; it will be predictable to those skilled in the art that the desired effect can be achieved even in the same form as the mixed product.

Meanwhile, in the present specification, the term “contained as an active ingredient” is a mixed extract; Cabbage extract; honey; Ginger juice; And stevia; means containing an amount sufficient to achieve the efficacy or activity of a mixture consisting of. For example, the mixed extract; Cabbage extract; honey; Ginger juice; And stevia; the mixture is used in a concentration of 10 to 1500 µg/ml, preferably 100 to 1000 µg/ml. Mixed extract; Cabbage extract; honey; Ginger juice; And Stevia; is a natural product, even if administered in excess, since there is no side effect to the human body, the mixed extract contained in the composition of the present invention; Cabbage extract; honey; Ginger juice; And stevia; the upper limit of the quantity can be selected and carried out by a person skilled in the art within an appropriate range.

The pharmaceutical composition of the present invention may be prepared using a pharmaceutically suitable and physiologically acceptable adjuvant in addition to the active ingredient, and the adjuvants include excipients, disintegrants, sweeteners, binders, coating agents, expanding agents, lubricants, Lubricating agents or flavoring agents can be used.

For administration, the pharmaceutical composition may contain one or more pharmaceutically acceptable carriers in addition to the above-described active ingredients, and may be preferably formulated into a pharmaceutical composition.

The formulation form of the pharmaceutical composition may be granules, powders, tablets, coated tablets, capsules, suppositories, solutions, syrups, juices, suspensions, emulsions, drops, or injectable solutions. For example, for formulation in the form of tablets or capsules, the active ingredient may be combined with an oral, non-toxic pharmaceutically acceptable inert carrier such as ethanol, glycerol, water, and the like. In addition, if desired or necessary, suitable binders, lubricants, disintegrants and coloring agents may also be included in the mixture. Suitable binders are, but are not limited to, natural sugars such as starch, gelatin, glucose or beta-lactose, corn sweeteners, natural and synthetic gums such as acacia, trackcacanth or sodium oleate, sodium stearate, magnesium stearate, sodium Benzoate, sodium acetate, sodium chloride, and the like. Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like.

Acceptable pharmaceutical carriers for compositions formulated as liquid solutions are sterilized and biocompatible, and include saline, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, ethanol, and One or more of these components may be mixed and used, and other conventional additives such as antioxidants, buffers, and bacteriostatic agents may be added as necessary. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to prepare injection formulations such as aqueous solutions, suspensions, emulsions, etc., pills, capsules, granules, or tablets.

Further, it can be preferably formulated according to each disease or ingredient using a method disclosed in Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA as an appropriate method in the field.

The pharmaceutical composition of the present invention may be administered orally or parenterally, and in the case of parenteral administration, it may be administered by intravenous injection, subcutaneous injection, intramuscular injection, intraperitoneal injection, transdermal administration, etc., preferably oral administration. .

A suitable dosage of the pharmaceutical composition of the present invention varies depending on factors such as formulation method, mode of administration, age, weight, sex, pathological condition, food, administration time, route of administration, excretion rate and response sensitivity of the patient, Usually the skilled practitioner can readily determine and prescribe a dosage effective for the desired treatment or prophylaxis. According to a preferred embodiment of the present invention, the daily dosage of the pharmaceutical composition of the present invention is 0.001-10 g/kg.

The pharmaceutical composition of the present invention is prepared in unit dosage form by formulating using a pharmaceutically acceptable carrier and/or excipient according to a method that can be easily carried out by a person having ordinary knowledge in the art. Or it can be prepared by incorporating it into a multi-dose container. In this case, the formulation may be in the form of a solution, suspension or emulsion in an oil or aqueous medium, or may be in the form of an extract, powder, granule, tablet or capsule, and may additionally include a dispersant or a stabilizer.

In addition, the present invention is a mixed extract; Cabbage extract; honey; Ginger juice; And Stevia; It provides a food composition for preventing, treating or improving gastric diseases caused by Helicobacter pylori containing a mixture consisting of as an active ingredient.

The food composition according to the present invention may be formulated in the same manner as the pharmaceutical composition and used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, beverages, alcoholic beverages, confectionery, diet bars, dairy products, meat, chocolate, pizza, ramen, other noodles, gums, ice creams, vitamin complexes, health supplements. Etc.

The food composition of the present invention is a mixed extract as an active ingredient; Cabbage extract; honey; Ginger juice; And stevia; In addition, may include ingredients that are commonly added during food production, and include, for example, proteins, carbohydrates, fats, nutrients, flavoring agents, and flavoring agents. Examples of the aforementioned carbohydrates include monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides, and the like; And polysaccharides, for example, common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents, natural flavoring agents [taumatin, stevia extract (eg, rebaudioside A, glycyrrhizin, etc.]) and synthetic flavoring agents (saccharin, aspartame, etc.) can be used. For example, when the food composition of the present invention is made of drinks and beverages, the mixed extract of the present invention; Pear juice; In addition to honey, citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, and various plant extracts may be further included.

The present invention is the mixed extract; Cabbage extract; honey; Ginger juice; And Stevia; It provides a health functional food comprising a food composition for the prevention, treatment or improvement of gastric diseases caused by Helicobacter pylori containing as an active ingredient. What is a health functional food, mixed extract; Cabbage extract; honey; Ginger juice; And stevia; added to food materials such as beverages, teas, spices, chewing gum, confectionery, etc., or are foods prepared as encapsulated, powdered, or suspended, and when ingested, it means bringing a specific effect on health. Unlike drugs, it has the advantage of not having side effects that may occur when taking drugs for a long time because food is used as a raw material. The health functional food of the present invention obtained in this way is very useful because it can be consumed on a daily basis. Mixed extracts in such health functional foods; Cabbage extract; honey; Ginger juice; And stevia; the amount of addition can not be uniformly defined depending on the type of health functional food to be targeted, but may be added within a range that does not impair the original taste of the food, and is usually 0.01 to 50% by weight, preferably, based on the target food. Is in the range of 0.1 to 20% by weight. In addition, in the case of health functional foods in the form of pills, granules, tablets or capsules, it is usually added in the range of 0.1 to 100% by weight, preferably 0.5 to 80% by weight. In one embodiment, the health functional food of the present invention may be in the form of a pill, tablet, capsule or beverage.

In addition, the present invention is a mixed extract for the manufacture of a drug or food for the prevention, treatment or improvement of gastric diseases caused by Helicobacter pylori; Cabbage extract; honey; Ginger juice; And the use of stevia. Mixed extract as described above; Cabbage extract; honey; Ginger juice; And stevia may be used for gastric diseases caused by Helicobacter pylori.

In addition, the present invention is a mixed extract of an effective amount to a mammal; Cabbage extract; honey; Ginger juice; And it provides a method of improving, preventing or treating gastric diseases caused by Helicobacter pylori comprising administering a mixture of stevia.

The term "mammal" as used herein refers to a mammal that is an object of treatment, observation or experiment, and preferably refers to a human.

The term "effective amount" as used herein refers to the amount of an active ingredient or pharmaceutical composition that induces a biological or medical response in a tissue system, animal or human, which is considered by a researcher, veterinarian, doctor or other clinician, which Includes an amount that induces relief of symptoms of the disease or disorder. It is apparent to those skilled in the art that the effective amount and the number of administrations for the active ingredient of the present invention will vary depending on the desired effect. Therefore, the optimal dosage to be administered can be easily determined by those skilled in the art, and the type of disease, the severity of the disease, the content of active ingredients and other ingredients contained in the composition, the type of formulation, and the age, weight, and general health of the patient. It can be adjusted according to various factors including condition, sex and diet, time of administration, route of administration and rate of secretion of the composition, duration of treatment, and drugs used concurrently. In the prevention, treatment or improvement method of the present invention, in the case of an adult, a mixed extract; Cabbage extract; honey; Ginger juice; And when the mixture consisting of stevia is administered once to several times a day, it is preferable to administer in a dose of 0.001 g/kg to 10 g/kg.

Mixed extract in the treatment method of the present invention; Cabbage extract; honey; Ginger juice; And a composition comprising a mixture consisting of stevia as an active ingredient can be administered in a conventional manner through oral, rectal, intravenous, intraarterial, intraperitoneal, intramuscular, intrasternal, transdermal, topical, intraocular or intradermal routes. have.

Hereinafter, a preferred embodiment is presented to aid in the understanding of the present invention, but it is obvious to those skilled in the art that various changes and modifications are possible within the scope of the present invention and the scope of the technical idea, but the following examples are only illustrative of the present invention, It is natural that such modifications and modifications fall within the scope of the appended claims.

Example 1.

Manufacture of thistle

Thistle flower 1 part by weight, a mixture of stem and leaf (stem: leaf = 1:2 weight ratio) 18.6 parts by weight and 45 parts by weight of water were mixed and extracted with water at 95° C. for 24 hours to obtain extract A, and then thistle root 0.4 Part by weight and 45 parts by weight of water were extracted in a bath at 95° C. for 24 hours to obtain extract B, and then freeze-dried to prepare and mix powder A and powder B to prepare a mixed thistle extract powder.

Preparation of cabbage extract

After mixing 10 parts by weight of washed cabbage and 40 parts by weight of water, the cabbage extract was prepared by extracting in a bath for 8 hours at 95°C.

Preparation of mixture

After mixing the prepared thistle and dandelion at a weight ratio of 1:0.42, the mixture and water were mixed at a weight ratio of 1:9 and extracted for 48 hours at 90°C to prepare a mixed extract. 11.2 parts by weight of the cabbage extract and 0.75 parts by weight of ginger juice were added to 100 parts by weight of the mixed extract, mixed for 10 minutes at room temperature, and then 2.5 parts by weight of honey and 0.25 parts by weight of stevia were added, further mixed for 10 minutes at room temperature, and 0.25 parts by weight of agar By adding parts and mixing for another 5 minutes, a mixture consisting of a mixed extract, cabbage extract, honey, ginger juice, and stevia was obtained.

Comparative Example 1. Using only mixed extracts

It was carried out in the same manner as in Example 1, except that cabbage extract, honey, ginger juice, and stevia were not used, and only a mixed extract consisting of thistle and dandelion was used.

Comparative Example 2. Omission of cabbage extract

It was carried out in the same manner as in Example 1, but a mixture was obtained without using the cabbage extract.

Comparative Example 3. Ginger juice omitted

It was carried out in the same manner as in Example 1, but a mixture was obtained without using ginger juice.

Comparative Example 3. Omission of honey

It was carried out in the same manner as in Example 1, but a mixture was obtained without using honey.

Comparative Example 4. Omission of thistle

It was carried out in the same manner as in Example 1, but when preparing the mixed extract, a mixed extract was obtained without using thistle, and then cabbage extract, honey, ginger juice, and stevia were mixed to obtain a mixture.

<Test Example>

Test Example 1. Inhibitory effect of Helicobacter pylori

Antibacterial activity against H. pylori (KCTC5335, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea) was measured by the paper disk method (agar diffusion method). The sample was aseptically absorbed and dried by 50 μL of the test solution prepared on a 10 mm paper disk (ADVANTEC, Japan). H. pylori cultured on agar medium ^{is suspended in sterilized water so that it is 1×10 8} CFU (colony forming unit) or higher to form a strain solution, and 100 μL of each strain solution is plated on agar medium to which antibiotics are not added, and the test solution A paper disk that has been absorbed and dried is placed on the agar medium smeared with H. pylori and attached. After incubation for 72 hours in a microaerobic state in a CO2 incubator, the size (size, mm) of the clear zone formed around the paper disk as H. pylori grew was measured.

division Growth inhibition ring size (mm) 25 ㎍ 50 ㎍ 100 ㎍ Control (distilled water) 0 0 0 Example 1 28 30 or more 30 or more Comparative Example 1 11 12 14 Comparative Example 2 20 22 22 Comparative Example 3 19 19 20 Comparative Example 4 23 25 26 Comparative Example 5 15 16 18

As shown in Table 1 above, it was confirmed that the mixture prepared according to Example 1 of the present invention further inhibited the growth of Helicobacter pyrroli bacteria (KCTC5335) compared to the mixture of the control and Comparative Examples 1 to 5.

Hereinafter, examples of the formulation of the composition containing the powder of the present invention will be described, but the present invention is not intended to limit this, but is intended to be described in detail.

Formulation Example 1. Preparation of powder

500 mg of powder mixture obtained in Example 1

100 mg lactose

10 mg of talc

The above ingredients are mixed and filled in an airtight cloth to prepare a powder.

Formulation Example 2. Preparation of tablets

300 mg of powder mixture obtained in Example 1

100 mg corn starch

100 mg lactose

2 mg of magnesium stearate

After mixing the above ingredients, tablets are prepared by tableting according to a conventional tablet manufacturing method.

Formulation Example 3. Preparation of Capsule

200 mg of powder mixture obtained in Example 1

3 mg of crystalline cellulose

14.8 mg lactose

Magnesium stearate 0.2 mg

According to a conventional capsule preparation method, the above ingredients are mixed and filled into gelatin capsules to prepare a capsule.

Formulation Example 4. Preparation of injection

600 mg of powder mixture obtained in Example 1

Mannitol 180 mg

2974 mg of sterile distilled water for injection

Na ₂ HPO _4, 12H ₂ O 26 mg

It is prepared in the amount of the above ingredients per ampoule according to a conventional injection preparation method.

Formulation Example 5. Preparation of liquid formulation

4 g of powder mixture obtained in Example 1

10 g of isomerized sugar

5 g of mannitol

Purified water appropriate amount

According to the usual preparation method of liquid formulations, add and dissolve each component in purified water, add an appropriate amount of lemon scent, mix the above ingredients, add purified water and add purified water to adjust the total to 100 g, then fill in a brown bottle for sterilization. To prepare a liquid formulation.

Formulation Example 6. Preparation of granules

1,000 mg of powder mixture obtained in Example 1

The right amount of vitamin mixture

Vitamin A acetate 70 ㎍

1.0 mg of vitamin E

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

0.5 mg of vitamin B6

Vitamin B12 0.2 ㎍

10 mg of vitamin C

Biotin 10 ㎍

1.7 mg of nicotinic acid amide

Folic acid 50 ㎍

0.5 mg of calcium pantothenate

Suitable amount of inorganic mixture

Ferrous sulfate 1.75 mg

Zinc oxide 0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dicalcium phosphate 55 mg

90 mg of potassium citrate

100 mg of calcium carbonate

Magnesium chloride 24.8 mg

The composition ratio of the vitamin and mineral mixture is relatively suitable for granules, but it is also possible to arbitrarily modify the mixing ratio. After mixing the above ingredients according to a conventional granule preparation method, granules And, according to a conventional method, it can be used for preparing a health functional food composition.

Formulation Example 7. Preparation of functional beverage

1,000 mg of powder mixture obtained in Example 1

1,000 mg citric acid

100 g oligosaccharides

2 g of plum concentrate

1 g taurine

900 mL total by adding purified water

After mixing the above ingredients according to the normal health drink manufacturing method, stirring and heating the mixture at 85°C for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container, sealed and sterilized, and then stored in a refrigerator. It is used to prepare the functional beverage composition of the present invention.

The composition ratio is a mixture of ingredients suitable for a relatively preferred beverage in a preferred embodiment, but the mixing ratio may be arbitrarily modified according to regional and ethnic preferences such as the demand class, the country of demand, and the purpose of use.

Claims (7)

A mixed extract obtained by extracting a mixture consisting of thistle and dandelion; Cabbage extract; honey; Ginger juice; And a food composition for preventing or improving gastric diseases caused by Helicobacter pylori, characterized in that it contains a mixture consisting of stevia as an active ingredient. The method of claim 1, wherein the mixed extract is an extract obtained by mixing thistle and dandelion at a weight ratio of 1:0.2-1 and extracted at 80 to 100°C. Food composition. The Helicobacter pylori according to claim 1, wherein 1 to 30 parts by weight of cabbage extract, 0.5 to 10 parts by weight of honey, 0.1 to 5 parts by weight of ginger juice, and 0.1 to 5 parts by weight of stevia are mixed with respect to 100 parts by weight of the mixed extract. Food composition for preventing or improving gastric diseases caused by bacteria. The method of claim 1, wherein the gastric disease caused by Helicobacter pylori is at least one gastric disease selected from the group consisting of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastric cancer and gastric lymphoma caused by Helicobacter pylori. Food composition for preventing or improving gastric diseases caused by Helicobacter pylori, characterized in that. The method of claim 1, wherein the thistle is a mixture of thistle flowers, stems and leaves, and roots in a weight ratio of 1: 14-25: 0.1-0.9. Food composition for prevention or improvement. (A) mixing and extracting thistle and dandelion to obtain a mixed extract;
(B) adding and mixing cabbage extract and ginger juice to the mixed extract; And
(C) the step of mixing by adding honey and stevia to the mixture of the cabbage extract and ginger juice; and a method for preparing a food composition for preventing or improving gastric diseases caused by Helicobacter pylori, comprising. A mixed extract obtained by extracting a mixture consisting of thistle and dandelion; Cabbage extract; honey; Ginger juice; And a pharmaceutical composition for preventing or treating gastric diseases caused by Helicobacter pylori, characterized in that it contains a mixture consisting of stevia as an active ingredient.