KR20210015291A - Dandruff Relieving Scalp Cleansing Composition - Google Patents

Dandruff Relieving Scalp Cleansing Composition Download PDF

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KR20210015291A
KR20210015291A KR1020190093917A KR20190093917A KR20210015291A KR 20210015291 A KR20210015291 A KR 20210015291A KR 1020190093917 A KR1020190093917 A KR 1020190093917A KR 20190093917 A KR20190093917 A KR 20190093917A KR 20210015291 A KR20210015291 A KR 20210015291A
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dandruff
scalp
weight
present
comparative example
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KR1020190093917A
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Korean (ko)
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이재광
조시형
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애경산업(주)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23Sulfur; Selenium; Tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair

Abstract

The present invention relates to a scalp cleansing composition capable of alleviating dandruff on the scalp, comprising polyquaternium-52, ethanol and a dandruff reliever. The present invention, more specifically, relates to a scalp cleansing composition for alleviating dandruff, capable of effectively implementing a dandruff care effect even with a small content of dandruff alleviating materials.

Description

비듬 완화 두피 세정용 조성물{Dandruff Relieving Scalp Cleansing Composition}Dandruff Relieving Scalp Cleansing Composition

본 발명은 폴리쿼터늄-52, 에탄올 및 비듬완화 성분을 사용하여 두피의 비듬을 완화시켜줄 수 있는 비듬 완화 두피 세정용 조성물에 관한 것이다.The present invention relates to a composition for cleaning the scalp, which can relieve dandruff of the scalp by using polyquaternium-52, ethanol, and a dandruff-relieving component.

피부의 표피층은 지속적으로 교체되는데, 세포가 서서히 바깥쪽으로 밀려나 죽은 후 조각조각 떨어져 나가게 된다. 두피도 마찬가지로 약 1 개월의 주기로 새로운 세포로 치환되는데, 대부분의 사람들은 이 피부 조각의 크기는 너무 작아서 눈에 띄지 않는다. 그러나, 각질세포가 과다하게 생성되어 각질세포 덩어리가 눈에 보일 정도로 뭉쳐 두피에서 벗겨지는 경우가 있는데 이를 비듬이라고 한다.The epidermal layer of the skin is constantly replaced, and the cells are gradually pushed outward and die, then fall apart. Likewise, the scalp is replaced with new cells every about a month, and for most people, the size of this piece of skin is too small to be noticeable. However, there are cases in which the keratinocytes are excessively produced and the keratinocyte masses are visible and peeled off the scalp, which is called dandruff.

비듬은 크게 증상이 가벼운 일반 비듬(Common dandruff), 인설(Scurf)이 많이 박리되는 건선성 비듬(Psoriasis), 과도한 피지분비와 함께 인설이 두피에 축적되는 지루성 비듬(Seborrheic-dandruff)으로 나눌 수 있다. 이러한 가려움이나 비듬은 신체의 내외적인 요인에서 비롯되는 것으로, 이러한 요인으로 인해 발생되는 가려움이나 비듬에서 벗어나기 위해 항비듬용 의약품, 의약부외품, 화장품 등의 피부처리제(Topical treatment)를 사용하고 있다.Dandruff can be divided into common dandruff, which has mild symptoms, psoriasis, where scurf is severely exfoliated, and seborrheic-dandruff, in which scales accumulate in the scalp with excessive sebum secretion. . These itchiness and dandruff are caused by internal and external factors of the body, and in order to get rid of itchiness or dandruff caused by these factors, topical treatments such as anti-dandruff drugs, quasi-drugs, and cosmetics are used.

지금까지 알려진 항비듬 물질로는 징크피리치온(Zinc-Pyrithione), 피록톤올아민(Pirotone olamine), 황(Sulfur), 클림바졸(Climbazole), 살리실산 등이 있다.Anti-dandruff substances known so far include zinc-pyrithione, pyrotone olamine, sulfur, climbazole, and salicylic acid.

현재 일반적인 비듬방지용 제품에 사용되고 있는 항비듬제 대부분은 말라세지아에 대한 강한 살균력을 특징으로 하는 물질로써, 대부분 피부에 대한 자극 및 독성이 있어 일정량 이상 사용하기 어려우며, 이러한 이유로 국내는 물론 해외에서도 법률적으로 그 함량을 규제하고 있다. 따라서, 피부에 대한 안정성을 확보하면서도 우수한 비듬완화 효능을 구현할 수 있는 조성물에 대한 연구가 요구된다.Most of the anti-dandruff drugs currently used in general anti-dandruff products are substances characterized by a strong sterilizing power against Malassezia, and most of them are irritating and toxic to the skin, making it difficult to use more than a certain amount. Its content is regulated locally. Therefore, there is a need for a study on a composition capable of realizing excellent dandruff relieving efficacy while securing the stability to the skin.

상기와 같은 문제점을 해결하기 위한 본 발명의 목적은, 피부에 자극을 줄 수 있는 비듬 완화 성분을 낮은 함량 포함하고도, 비듬케어 효과를 향상시킬 수 있는 비듬 완화 두피 세정용 조성물을 제공하는 것이다. An object of the present invention for solving the above problems is to provide a dandruff-relieving scalp cleaning composition that contains a low content of a dandruff-relieving component that can irritate the skin and improves the dandruff care effect.

상기 목적을 달성하고자 본 발명의 양상은, Aspects of the present invention to achieve the above object,

폴리쿼터늄-52 0.01 내지 1 중량%, 에탄올 함량 0.1 내지 1 중량% 및 비듬완화 성분 0.01 내지 1 중량%를 함유하는 비듬 완화 두피 세정용 조성물을 제공한다. Polyquaternium-52 provides a composition for cleaning the scalp to relieve dandruff containing 0.01 to 1% by weight, an ethanol content of 0.1 to 1% by weight, and 0.01 to 1% by weight of a dandruff relief component.

본 발명의 비듬 완화 두피 세정제 조성물은, 사용 시 효과적으로 비듬완화 성분을 전달하여 적은 함량의 비듬완화 성분을 함유해도 우수한 비듬 완화 효과를 갖는다.The dandruff-relieving scalp cleaner composition of the present invention effectively delivers a dandruff-relieving component when used and has an excellent dandruff relief effect even if it contains a small amount of the dandruff-relieving component.

이하, 당업자가 용이하게 실시할 수 있도록 본 발명을 상세히 설명한다. 그러나 이는 본 발명의 설명을 위한 것으로, 본 발명의 범위를 제한하는 방향으로 해석되어서는 안 된다.Hereinafter, the present invention will be described in detail so that those skilled in the art can easily implement it. However, this is for the purpose of describing the present invention and should not be construed in the direction of limiting the scope of the present invention.

본 발명의 일 실시예에 의하면, 본 발명의 비듬 완화 두피 세정용 조성물은 폴리쿼터늄-52, 에탄올, 비듬완화 성분 및 계면활성제를 포함한다. 또한 상기 비듬 완화 두피 세정용 조성물은, 두피 세정용 조성물 분야에서 통상적으로 사용되는, 예를 들어, 점도 조절제, pH 조절제, 컨디셔닝제, 향료, 방부제, 단백질 등의 첨가제를 선택적으로 포함할 수 있다. 또한 상기 비듬 완화 두피 세정용 조성물은, 잔부의 물, 예를 들어, 정제수를 더 포함할 수 있다. According to an embodiment of the present invention, the composition for cleaning the scalp to relieve dandruff of the present invention includes polyquaternium-52, ethanol, a dandruff relief component, and a surfactant. In addition, the dandruff relief scalp cleaning composition may optionally include additives commonly used in the field of scalp cleaning compositions, for example, viscosity modifiers, pH modifiers, conditioning agents, fragrances, preservatives, proteins, and the like. In addition, the dandruff relief scalp cleaning composition may further include water, for example, purified water in the balance.

양이온 폴리머Cationic polymer

본 발명의 일 실시예에 있어서, 상기 양이온 폴리머는 가교형 폴리머 구조를 가지고 있어 제형 내 점도 형성 및 안정성에 도움을 주며, 가교형 네트워크 구조 특성상 효능성분의 딜리버리에 도움을 준다. 일례로, 상기 양이온 폴리머는 폴리쿼터늄-52 일 수 있다. In one embodiment of the present invention, the cationic polymer has a crosslinkable polymer structure, which helps to form viscosity and stability in the formulation, and aids in delivery of an effective ingredient due to the characteristics of a crosslinked network structure. For example, the cationic polymer may be polyquaternium-52.

상기 폴리쿼터늄-52 함량은 상기 두피 세정제 조성물 총 중량에 대하여 0.01 내지 1 중량%, 예를 들어, 0.05 내지 0.5 중량%로 포함될 수 있다. 상기 폴리쿼터늄-52 함량이 0.01 중량% 미만일 경우 효능성분 딜리버리 효과가 발생하지 않으며, 1 중량%를 초과할 경우 음이온과의 콤플렉스 형성으로 제형 구현이 힘들어지며 점도가 너무 높게 형성되고, 항비듬 특성이 열악하며 피부에 자극 정도가 심해진다.The polyquaternium-52 content may be included in an amount of 0.01 to 1% by weight, for example, 0.05 to 0.5% by weight, based on the total weight of the scalp cleaning composition. When the content of the polyquaternium-52 is less than 0.01% by weight, the delivery effect of the effective ingredient does not occur, and when it exceeds 1% by weight, it is difficult to implement the formulation due to the formation of a complex with an anion, and the viscosity is formed too high, and anti-dandruff properties This is poor and the degree of irritation to the skin becomes severe.

에탄올ethanol

본 발명의 일 실시예에 있어서, 상기 에탄올은 초기 발포 및 사용 후 두피의 깔끔한 사용감을 부여할 수 있다. 상기 에탄올의 함량은 상기 두피 세정제 조성물 총 중량에 대하여 0.1 내지 1 중량%로 포함되는 것이 바람직하다.In one embodiment of the present invention, the ethanol may impart a clean feeling of use of the scalp after initial foaming and use. The content of ethanol is preferably contained in an amount of 0.1 to 1% by weight based on the total weight of the scalp cleaning composition.

상기 에탄올 함량이 0.1 중량% 미만일 경우 초기 발포력이 저하된다. 상기 에탄올 함량이 1 중량%를 초과하는 경우 기포 유지력이 불량해지고 점도가 하락하며, 모발의 컨디셔닝 효과가 떨어져 모발 엉킴이 발생한다. 또한 피부에 자극 정도가 심해진다. If the ethanol content is less than 0.1% by weight, the initial foaming power is lowered. When the ethanol content exceeds 1% by weight, the bubble retention is poor, the viscosity decreases, and the conditioning effect of the hair decreases, resulting in hair entanglement. Also, the degree of irritation to the skin becomes severe.

비듬완화 성분Dandruff relief ingredients

본 발명의 일 실시예에 있어서, 상기 비듬완화 성분은 비듬균(예: Malassezia furfur)의 성장을 억제하는 항비듬력을 갖는 것으로, 두피의 과도한 비듬을 관리해 줄 수 있다.In one embodiment of the present invention, the dandruff relief component has anti-dandruff ability to inhibit the growth of dandruff bacteria (eg, Malassezia furfur), and can manage excessive dandruff of the scalp.

상기 비듬완화 성분은 징크피리치온(Zinc-Pyrithione), 피록톤올아민(Pirotone olamine), 황(Sulfur), 클림바졸(Climbazole), 살리실산 으로 이루어진 군으로부터 선택된 1종 이상일 수 있다. 일례로, 상기 비듬완화 성분은 징크피리치온일 수 있다. The dandruff relief component may be at least one selected from the group consisting of zinc-pyrithione, pyrotone olamine, sulfur, climbazole, and salicylic acid. For example, the dandruff relief component may be zinc pyrithione.

상기 비듬완화 성분은 상기 두피 세정제 조성물 총 중량에 대하여 0.01 내지 1 중량%, 예를 들어, 0.05 내지 0.5 중량%으로 함유될 수 있다. 상기 비듬완화 성분 함량이 0.01 중량% 미만일 경우 비듬완화 효과가 떨어진다. 상기 비듬완화 성분 함량이 1 중량%을 초과할 경우, 두피를 포함한 피부에 대하여 자극과 손상의 우려가 발생한다. The dandruff relief component may be contained in an amount of 0.01 to 1% by weight, for example, 0.05 to 0.5% by weight, based on the total weight of the scalp cleaning composition. If the content of the dandruff relief component is less than 0.01% by weight, the dandruff relief effect is inferior. When the content of the dandruff relieving component exceeds 1% by weight, there is a concern of irritation and damage to the skin including the scalp.

계면활성제Surfactants

본 발명의 일 실시예에 있어서, 상기 비듬 완화 두피 세정제 조성물은 양이온성 계면활성제, 음이온성 계면활성제, 양쪽성 계면활성제 및 비이온성 계면활성제로 이루어진 군으로부터 선택된 1종 이상의 계면활성제를 더 포함할 수 있다.In one embodiment of the present invention, the dandruff relief scalp cleaner composition may further include at least one surfactant selected from the group consisting of cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants. have.

상기 양이온성 계면활성제는 베헨트리모늄클로라이드, 스테아트리모늄클로라이드 및 세트리모늄클로라이드로 이루어진 군으로부터 선택되는 1종 이상의 4급 암모늄 또는 베헨아미도프로필디메칠아민 및 스테아라미도프로필디메칠아민으로 이루어진 군으로부터 선택되는 1종 이상의 3급 아미도아민이거나 이들의 혼합물일 수 있다.The cationic surfactant is at least one quaternary ammonium selected from the group consisting of behentrimonium chloride, stearimonium chloride and cetrimonium chloride, or behenamidopropyldimethylamine and stearamidopropyldimethylamine. It may be one or more tertiary amidoamines selected from the group consisting of, or a mixture thereof.

상기 음이온성 계면활성제는 소듐라우레스설페이트, 소듐코코일이세치오네이트, 디소듐코코암포디아세테이트, 라우릴황산나트륨, 라우릴황산암모늄, 폴리옥시에틸렌 라우릴황산나트륨 및 폴리옥시에틸렌 라우릴 황산암모늄으로 이루어진 군으로부터 선택된 1종 이상일 수 있다.The anionic surfactants include sodium laureth sulfate, sodium cocoyl isethionate, disodium cocoamphodiacetate, sodium lauryl sulfate, ammonium lauryl sulfate, sodium polyoxyethylene lauryl sulfate, and ammonium polyoxyethylene lauryl sulfate. It may be one or more selected from the group consisting of.

상기 양쪽성 계면활성제는 코카미도프로필베타인, 라우라미도프로필베타인, 라우릴베타인, 코코-베타인, 미리스틸베타인, 코코디메틸카복시메틸베타인, 라우릴디메틸카복시메틸베타인, 코카미도프로필하이드록시설테인, 코코-하이드록시설테인, 코코-설테인, 에루카미도프로필하이드록시설테인, 하이드록시설테인, 라우라미도프로필하이드록시설테인, 라우릴하이드록시설테인 및 라우릴설테인으로 이루어진 군으로부터 선택된 1종 이상일 수 있다.The amphoteric surfactants are cocamidopropylbetaine, lauramidopropylbetaine, laurylbetaine, coco-betaine, myristylbetaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, cocamido Propylhydroxysulfatein, coco-hydroxysulfatein, coco-sultein, erucamidopropylhydroxysulfatein, hydroxysulfatein, lauramidopropylhydroxysulfatein, laurylhydroxysulfatein and laurylsultaine It may be one or more selected from the group consisting of tain.

상기 비이온 계면활성제는 코카마이드메칠엠이에이, 코카마이드디이에이, 코카마이드엠이에이 및 라우릴산디이에이로 이루어진 군으로부터 선택된 1종 이상일 수 있다. The nonionic surfactant may be at least one selected from the group consisting of cocamide methylMA, cocamide DIA, cocamide MI, and lauryl acid DIA.

일례로, 상기 계면활성제는 소듐라우레스설페이트 및 코카미도프로필베타인을 포함할 수 있다. 상기 계면활성제는 조성물 총 중량에 대하여 0.5 내지 15 중량%, 예를 들어, 1 내지 10 중량%으로 함유될 수 있다. As an example, the surfactant may include sodium laureth sulfate and cocamidopropyl betaine. The surfactant may be contained in an amount of 0.5 to 15% by weight, for example, 1 to 10% by weight based on the total weight of the composition.

첨가제additive

본 발명의 일 실시예에 있어서, 상기 비듬 완화 두피 세정제 조성물은 통상적으로 사용되는 점도 조절제, pH 조절제, 컨디셔닝제, 향료, 방부제 및 단백질로 이루어진 군으로부터 선택된 1종 이상의 첨가제를 더 포함할 수 있다. 상기 첨가제는 상기 조성물 총 중량에 대하여 각각 0.5 중량% 내지 20중량%으로 함유될 수 있다. In one embodiment of the present invention, the dandruff relief scalp cleaner composition may further include one or more additives selected from the group consisting of commonly used viscosity modifiers, pH modifiers, conditioning agents, flavors, preservatives and proteins. The additives may be contained in an amount of 0.5% to 20% by weight, respectively, based on the total weight of the composition.

이하, 실시예와 비교예를 통하여 본 발명을 보다 상세히 설명한다. 이는 본 발명의 설명을 위한 것일 뿐, 이로 인해 본 발명의 범위가 제한되지 않는다.Hereinafter, the present invention will be described in more detail through examples and comparative examples. This is only for the description of the present invention, and thus the scope of the present invention is not limited.

[실시예 1-4 및 비교예 1-8][Example 1-4 and Comparative Example 1-8]

하기 표 1의 조성 및 기타 첨가제를 적절히 배합하여 비듬 완화 두피 세정제 조성물을 제조하였다. 하기 표의 단위는 중량%이다.The composition of Table 1 and other additives were appropriately blended to prepare a dandruff relief scalp cleaner composition. The units in the table below are% by weight.

Figure pat00001
Figure pat00001

[시험예 1 : 점도 구현 확인][Test Example 1: Confirmation of viscosity implementation]

상기 표 1에 따른 실시예 1-4 및 비교예 1-8의 두피 세정용 조성물을 배합하여 샴푸를 제조하고, 레오미터(Brookfield Rheometer RVDV-III)를 이용하여 Spindle #4, 10rpm 평가 조건에서 15초 후의 점도 결과를 측정하였다.A shampoo was prepared by blending the scalp cleaning compositions of Examples 1-4 and Comparative Examples 1-8 according to Table 1, and Spindle #4 using a rheometer (Brookfield Rheometer RVDV-III), 15 at 10 rpm evaluation conditions. The viscosity result after second was measured.

실시예Example 비교예Comparative example 1One 22 33 44 55 1One 22 33 44 55 66 77 88 점도(cPs)Viscosity (cPs) 6,5006,500 9,0009,000 7,9007,900 7,0007,000 8,0008,000 5,0005,000 20,00020,000 8,5008,500 2,0002,000 7,0007,000 6,0006,000 6,5006,500 7,0007,000

상기 표 2를 참조하면, 점도 범위가 5,000 내지 10,000cPs 수준에서 형성이 되어야 사용자가 사용하기 용이하다.Referring to Table 2, the viscosity range must be formed at a level of 5,000 to 10,000 cPs to facilitate user use.

실시예 1-5, 비교예 1, 비교예 3 및 비교예 5-8 사용 시 흘러내리지 않아 사용하기 용이한 수준의 점도를 형성한 것을 확인할 수 있다. Example 1-5, Comparative Example 1, Comparative Example 3, and Comparative Example 5-8 When used, it can be seen that the viscosity was formed at a level that was easy to use because it did not flow down.

그러나, 폴리쿼터늄-52 함량이 초과된 비교예 2와 에탄올 함량이 초과된 비교예 4는 점도가 불량한 것으로 나타났다.However, Comparative Example 2 in which the polyquaternium-52 content was exceeded and Comparative Example 4 in which the ethanol content was exceeded were found to have poor viscosity.

[시험예 2 : 항비듬력 평가][Test Example 2: Evaluation of anti-dandruff power]

실시예 2와 비교예 1의 조성물을 배지(Pityrosporum medium)에 희석하여 비듬균 Malassezia furfur (KCTC 7546)에 대한 최소성장억제농도(Minimum Inhibitory Concentration, MIC) 시험을 실시하였다.The compositions of Example 2 and Comparative Example 1 were diluted in a medium (Pityrosporum medium) to perform a Minimum Inhibitory Concentration (MIC) test for the dandruff bacteria Malassezia furfur (KCTC 7546).

※ MIC(최소성장억제농도)의 값이 작을수록 항비듬균력이 우수한 것으로 판단한다.※ The smaller the value of MIC (minimum growth inhibitory concentration), the better the anti-dandruff bacteria are.

  MIC(ppm)MIC(ppm) 실시예 1Example 1 3,125 ~ 6,2503,125-6,250 실시예 2Example 2 390~781390~781 실시예 3Example 3 3,125 ~ 6,2503,125-6,250 실시예 4Example 4 3,125 ~ 6,2503,125-6,250 실시예 5Example 5 781~1,562781-1,562 비교예 1Comparative Example 1 12,500 ~ 25,00012,500 ~ 25,000 비교예 3Comparative Example 3 12,500 ~ 25,00012,500 ~ 25,000 비교예 5Comparative Example 5 50,000 ~ 100,00050,000 ~ 100,000 비교예 6Comparative Example 6 12,500 ~ 25,00012,500 ~ 25,000 비교예 7Comparative Example 7 12,500 ~ 25,00012,500 ~ 25,000

테스트 결과, 본 발명에 따른 실시예 1-5는 비교예 1, 비교예 3, 비교예 5-7 대비 더 우수한 항비듬력 효과를 나타내는 것을 확인하였다.As a result of the test, it was confirmed that Example 1-5 according to the present invention exhibited a better anti-dandruff effect compared to Comparative Example 1, Comparative Example 3, and Comparative Example 5-7.

[시험예 3 : 사용감 평가][Test Example 3: Evaluation of feeling of use]

사용감 평가를 하기 위하여 성인남녀 30명을 선정하여 실시예 3 내지 4와 비교예 3 내지 4의 두피 세정제 조성물을 사용하게 한 후 하기 설문에 5점 척도로 평가하였으며 그 결과를 하기 표 4에 나타내었다.In order to evaluate the feeling of use, 30 adult men and women were selected to use the scalp cleaner compositions of Examples 3 to 4 and Comparative Examples 3 to 4, and then evaluated on a 5-point scale in the following questionnaire, and the results are shown in Table 4 below. .

- 평가기준 : 매우 나쁨(1), 나쁨(2), 보통(3), 좋음(4), 매우 좋음(5)-Evaluation criteria: Very bad (1), bad (2), fair (3), good (4), very good (5)

설문항목Survey item 실시예 3Example 3 실시예 4Example 4 비교예 3Comparative Example 3 비교예 4Comparative Example 4 거품이 쉽게 일어난다Bubbles easily occur 4.04.0 4.34.3 3.53.5 4.34.3 두피가 깔끔하다The scalp is clean 4.04.0 4.54.5 3.63.6 4.44.4 사용 후 자극이 없다No irritation after use 4.34.3 4.24.2 4.34.3 3.53.5

상기 표 4의 결과에서 볼 수 있듯이 실시예 3 및 4는 비교예 3 및 4 대비 초기 발포가 우수하며, 사용 후 두피가 깔끔하고 자극이 없는 것을 확인하였다.As can be seen from the results of Table 4, it was confirmed that Examples 3 and 4 had superior initial foaming compared to Comparative Examples 3 and 4, and the scalp was clean and irritated after use.

[시험예 4 : 인체 첩포 시험- 자극평가][Test Example 4: Human patch test-stimulation evaluation]

상기 표 1, 2에 나타난 실시예 1 내지 4 및 비교예 2 및 4의 두피 세정제 조성물의 자극 정도를 평가하기 위하여 성인남녀 30명을 선정하였다. In order to evaluate the degree of irritation of the scalp cleaner compositions of Examples 1 to 4 and Comparative Examples 2 and 4 shown in Tables 1 and 2, 30 adult men and women were selected.

상기 모발 세정제 조성물을 챔버(Chamber)에 로딩(loading)한 후 팔의 상박 안쪽에 도포한다. 패치(Patch)를 부착한지 24시간 후에 탈착하여 1시간 후와 24시간 후의 자극 정도를 판정하였다.After loading the hair cleaner composition into a chamber, it is applied to the inside of the upper arm of the arm. The patch was detached 24 hours after attaching, and the degree of stimulation 1 hour and 24 hours later was determined.

설문항목Survey item 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 비교예 2Comparative Example 2 비교예4Comparative Example 4 비교예 8Comparative Example 8 판정Judgment 경자극Light stimulation 경자극Light stimulation 경자극Light stimulation 경자극Light stimulation 경자극Light stimulation 중자극Heavy stimulation 강자극Strong stimulation 강자극Strong stimulation

상기 표 5의 결과에서 볼 수 있듯이 실시예 1-5는, 에탄올, 폴리쿼터늄-52, 비듬완화성분이 다량 포함된 비교예 2, 비교예 4 및 비교예 8 대비 피부 자극 정도가 낮은 것을 확인할 수 있었다.As can be seen from the results of Table 5, in Example 1-5, it was confirmed that the degree of skin irritation was low compared to Comparative Examples 2, 4 and 8 containing a large amount of ethanol, polyquaternium-52, and dandruff alleviating components. Could

Claims (2)

폴리쿼터늄-52 0.01 내지 1 중량%, 에탄올 함량 0.1 내지 1 중량% 및 비듬완화 성분 0.01 내지 1 중량% 를 함유하는 비듬 완화 두피 세정용 조성물.Polyquaternium-52 0.01 to 1% by weight, an ethanol content of 0.1 to 1% by weight, and a dandruff relief scalp cleaning composition containing 0.01 to 1% by weight of a dandruff relief component. 제1항에 있어서,
상기 비듬완화 성분은 징크피리치온(Zinc-Pyrithione), 피록톤올아민(Pirotone olamine), 황(Sulfur), 클림바졸(Climbazole), 살리실산 등으로부터 선택된 1종 이상을 포함하는 것을 특징으로 하는 비듬 완화 두피 세정용 조성물.
The method of claim 1,
The dandruff relief component comprises at least one selected from zinc-pyrithione, pyrotone olamine, sulfur, climbazole, salicylic acid, etc. Composition for cleaning the scalp.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220170591A (en) 2021-06-23 2022-12-30 제동 루구안 테크 디벨롭먼트 리미티드 Traditional chinese medicine composition and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220170591A (en) 2021-06-23 2022-12-30 제동 루구안 테크 디벨롭먼트 리미티드 Traditional chinese medicine composition and preparation method thereof

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