KR20210001045A - A cosmetic composition having prevention of lipid peroxidation, improved damaged skin and soothing effect on redness of skin - Google Patents

Abstract

The present invention relates to a cosmetic composition excellent in preventing lipid oxidation, improving skin damaged by ultraviolet rays, and soothing the skin. In one embodiment, the cosmetic composition comprises: a Pinus pinaster bark extract; an acacia pollen extract; and a vegetable oil unsaponifiable material.

Description

A cosmetic composition that prevents lipid oxidation, improves damaged skin by UV rays, and has an excellent skin soothing effect {A COSMETIC COMPOSITION HAVING PREVENTION OF LIPID PEROXIDATION, IMPROVED DAMAGED SKIN AND SOOTHING EFFECT ON REDNESS OF SKIN}

The present invention relates to a cosmetic composition excellent in skin soothing effects such as preventing lipid oxidation, improving damaged skin due to ultraviolet rays, and reddening the skin.

The skin is the largest tissue of the body and plays an important role as an epithelial tissue protecting the body from the outside of various organs, muscles, bones, etc. in the body. In addition, the skin has functions such as regulating body temperature, sensory functions, and vitamin D synthesis.

The skin consists of several layers, and it is largely composed of the epidermis, the dermis, and the subcutaneous fat. Among them, the components of the stratum corneum of the epidermis, the outermost layer, are keratinocytes and intercellular lipids. Keratinocytes contain natural moisturizing factors, moisture, keratin, etc., and intercellular lipids that fill between these cells.

Intercellular lipids in the stratum corneum are composed of ceramide (50%), cholesterol (25%), and free fatty acids (15%). These lipid components allow the pH of the skin to be maintained as weakly acidic, inhibit the penetration of external contaminants into the body, and perform an effective barrier function to prevent moisture loss in the epidermis.

On the other hand, the generation of active oxygen in the living body is generated through various pathways, and is generated by 2 to 3% of breathed oxygen, ultraviolet rays, cigarette smoke, air pollution, and the like. The generated free radical reacts with the unsaturated fatty acid of the cell membrane to form a new radical, a peroxidation radical, and causes a chain reaction to become lipid peroxidation. Lipid peroxidation increases the permeability of the cell membrane by reducing the liquidity of the cell membrane.

On the other hand, profilaggrin in the granular layer of the epidermis becomes filaggrin when granular cells are converted into keratinocytes. Filaggrin's trans-urocanic acid absorbs ultraviolet rays to block UV rays, and various organic acids maintain the pH of the epidermis as acidic, antibacterial and moisturizing factors.

When the skin barrier collapses due to the deficiency of filaggrin and oxidation of the lipid layer, ultraviolet rays, external pollutants, viruses, cigarette smoke, etc. penetrate through the damaged skin barrier, causing inflammation of the skin. In addition, when inflammation of the skin occurs, itching, heat sensation, dryness, etc. occur, and the skin is damaged, resulting in red and burning redness.

The background technology related to the present invention is disclosed in Korean Patent Application Publication No. 2018-0027375 (published on March 14, 2018, title of the invention: a cosmetic composition for moisturizing skin containing a plant composition).

An object of the present invention is to provide a cosmetic composition having excellent antioxidant effect of skin lipids.

Another object of the present invention is to provide a cosmetic composition excellent in improving damaged skin and soothing skin (redness).

Another object of the present invention is to provide a cosmetic composition having excellent skin barrier improvement and moisturizing effect.

Another object of the present invention is to provide a cosmetic composition that has excellent feeling of use and formulation stability such as application properties, prevents skin irritation, and is harmless to the human body.

One aspect of the present invention relates to a cosmetic composition excellent in preventing lipid oxidation, improving damaged skin by ultraviolet rays, and soothing skin. In one embodiment, the cosmetic composition is French coast pine bark extract ( Pinus Pinaster Bark Extract); Acacia (Acacia) Pollen (Pollen) extract; And vegetable oil unsaponifiable; wherein the vegetable oil unsaponifiable is dolkong oil unsaponifiable ( glycine soja oil unsaponifiables), olive oil unsaponifiables olive oil unsaponifiables ( olea europaea oil unsaponifiables) and wheat germ oil unsaponifiables ( triticum vulgare germ unsaponifiables).

In one embodiment, with respect to the total weight of the cosmetic composition, it may include 0.01 to 5% by weight of French coast pine bark extract, 0.001 to 1% by weight of acacia pollen extract, and 0.01 to 10% by weight of unsaponifiable vegetable oil.

In one embodiment, the vegetable oil unsaponifiable product may include a dolkong oil unsaponifiable product, an olive oil unsaponifiable product, and a wheat germ oil unsaponifiable product in a weight ratio of 1:0.5-10:0.2-5.

In one embodiment, the cosmetic composition is a solution, suspension, emulsion, paste, essence, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, such as basic cosmetics, sun cosmetics, color cosmetics, etc. It may be an emulsion foundation, wax foundation or spray formulation.

In one embodiment, the cosmetic composition may be an Oil-in-Water (O/W), Water-in-Oil (W/O) or Water-in-Silicone (W/S) formulation.

The cosmetic composition according to the present invention has excellent anti-oxidation effect of skin lipids, improves damaged skin by ultraviolet rays and soothes skin (redness), improves skin barrier and has excellent moisturizing effect, and has excellent application feeling. It has excellent stability in over-formulation, prevents skin irritation, and can be harmless to the human body.

1 is a graph showing the skin lipid oxidation improvement test result of Example 1.
2 is a graph showing the test results for improving skin damage (erythema) by ultraviolet rays of Example 1. FIG.
3 is a graph showing the test results for improving skin damage (skin redness) caused by ultraviolet rays of Example 1. FIG.
4 is a photograph showing a test result of improving skin damage caused by ultraviolet rays of Example 1.

In describing the present invention, if it is determined that a detailed description of a related known technology or configuration may unnecessarily obscure the subject matter of the present invention, a detailed description thereof will be omitted.

In addition, terms to be described later are terms defined in consideration of functions in the present invention and may vary according to the intentions or customs of users and operators, and thus their definitions should be made based on the contents throughout the present specification describing the present invention.

Cosmetic composition excellent in preventing lipid oxidation, improving damaged skin by UV rays, and soothing skin

One aspect of the present invention relates to a cosmetic composition excellent in preventing lipid oxidation, improving damaged skin by ultraviolet rays, and soothing skin. In one embodiment, the cosmetic composition is French coast pine bark extract ( Pinus Pinaster Bark Extract); Acacia (Acacia) Pollen (Pollen) extract; And vegetable oil unsaponifiable; wherein the vegetable oil unsaponifiable is dolkong oil unsaponifiable ( glycine soja oil unsaponifiables), olive oil unsaponifiables olive oil unsaponifiables ( olea europaea oil unsaponifiables) and wheat germ oil unsaponifiables ( triticum vulgare germ unsaponifiables).

Hereinafter, the components of the cosmetic composition will be described in more detail.

France Coastal song Bark extract

The French coastal pine bark extract ( Pinus Pinaster Bark Extract) is an extract derived from the bark of a pine tree growing on the southwest coast of France. The French coast pine bark extract prevents skin lipid oxidation, and the French coast pine bark extract is a polyphenolic acid, including procyanidin, which is a powerful antioxidant in a form in which flavonoids in the form of polyphenols are concentrated. Catechin and epicatechin, and the like. In addition, it increases skin immunity to UV rays, and by selectively binding with collagen and elastin, which are major proteins in the skin, prevents degradation by enzymes, thereby contributing to the prevention of skin aging.

In one embodiment, the French coastal pine bark extract may be included in an amount of 0.01 to 5% by weight based on the total weight of the cosmetic composition. When included in the above content, formulation stability, antioxidant effect, and antioxidant effect of skin lipids may be excellent. For example, it may be included 0.01 to 3% by weight.

Acacia pollen (flower pot) extract

The acacia pollen (pollen) extract is an extract derived from pollen of Acacia , and enhances skin barrier strengthening and moisturizing effect of the present invention. In addition, the acacia pollen (flower pot) extract contains a large amount of useful components such as proteins, vitamins and minerals.

In one embodiment, the acacia pollen (flower pot) extract may be obtained by applying an extraction method of a general method used in the field. For example, it can be obtained using one or more of ultrasonic extraction, hot water extraction, fermentation extraction, and solvent extraction. For example, the solvent extraction may be obtained by adding 10 to 1000 parts by weight of an extraction solvent to 100 parts by weight of acacia pollen and extracting at 40 to 90°C. The extraction solvent may be water, acetone, ethyl acetate, butyl acetate, diethyl ether, benzene, chloroform, hexane, and alcohols having 1 to 10 carbon atoms. These may be used alone or in combination of two or more. In one embodiment, the alcohols having 1 to 10 carbon atoms include lower monohydric alcohols such as methanol, ethanol, butanol, pentanol, and hexanol, 1,2-pentanediol, 1,5-pentanediol, hexanediol, heptanediol , Intermediate dihydric alcohols such as octanediol and decanediol, lower trihydric alcohols such as propylene glycol, 1,3-butylene glycol, and glycerin may be used. These may be used alone or in combination of two or more.

In one embodiment, the acacia pollen (flower pot) extract may be included in an amount of 0.001 to 1% by weight based on the total weight of the cosmetic composition. When included in the above range, formulation stability, skin barrier improvement, and moisturizing effect may be excellent. For example, it may be included in 0.001 to 0.5% by weight.

vegetable oil Unsaponifiable

The vegetable oil unsaponifiable product has excellent filaggrin activity, and is included to improve skin conditioning and skin barrier improvement effects. In one embodiment, the vegetable oil unsaponifiable is Dolkong oil unsaponifiable ( glycine soja oil unsaponifiables), olive oil unsaponifiables olive oil unsaponifiables ( olea europaea oil unsaponifiables) and wheat germ oil unsaponifiables ( triticum vulgare germ unsaponifiables).

In one embodiment, the dolkong oil unsaponifiable product is an unsaponified dolkong oil fraction component in the process of purifying and recovering the soybean oil fatty acid and imparts skin conditioning. In one embodiment, the dolkong oil unsaponifiable may be included in an amount of 0.01 to 4% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability may be excellent and the skin barrier improvement effect may be excellent. For example, it may be included in 0.01 to 2% by weight.

In one embodiment, the olive oil unsaponifiable product is an unsaponified olive oil fraction component in the process of purifying and recovering olive oil fatty acids, imparting conditioning to skin and hair, etc., and giving vitality by being involved in smoothing, and flexible skin And it can help with hair care. In one embodiment, the olive oil unsaponifiable may be included in an amount of 0.01 to 5% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability may be excellent and the skin barrier improvement effect may be excellent. For example, it may be included 0.01 to 4% by weight.

In one embodiment, the wheat germ oil unsaponifiable product is an unsaponifiable wheat germ oil fraction component that provides skin conditioning during the purification and recovery process of wheat germ oil fatty acids. In one embodiment, the wheat germ oil unsaponifiable may be included in an amount of 0.01 to 4% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability may be excellent and the skin barrier improvement effect may be excellent. For example, it may be included in 0.01 to 2% by weight.

In one embodiment, the vegetable oil unsaponifiable may be included in an amount of 0.01 to 10% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability of the present invention may be excellent and the skin barrier improvement effect may be excellent. For example, it may be included in 0.05 to 5% by weight.

In one embodiment, the dolkong oil unsaponifiable product, olive oil unsaponifiable product and wheat germ oil unsaponifiable product may be included in a weight ratio of 1:0.5-10:0.2-5. When included in the weight ratio, the synergistic effect between the constituents of the vegetable oil unsaponifiable is excellent, so that the formulation stability is excellent, and the skin barrier improvement effect may be excellent. For example, it may be included in a weight ratio of 1:0.5-5:0.5-2. For another example, it may be included in a weight ratio of 1:1-3:1-3.

In one embodiment, the French coastal pine bark extract and vegetable oil unsaponifiable may be included in a weight ratio of 1:1 to 20. When included in the weight ratio, the synergistic effect between the constituents of the unsaponifiable vegetable oil is excellent, so that the formulation stability is excellent, and the skin protective film formation effect, the moisturizing effect, and the skin barrier improvement effect may be simultaneously excellent. For example, it may be included in a weight ratio of 1:1 to 15. For another example, it may be included in a weight ratio of 1:1 to 10. For another example, it may be included in a weight ratio of 1:6 to 10.

The cosmetic composition of the present invention may be prepared in a formulation conventionally prepared in the art. In one embodiment, the cosmetic composition includes solutions, suspensions, emulsions, essences, pastes, gels, creams, lotions, body creams, body lotions, powders, soaps, surfactants such as basic cosmetics, sun cosmetics, and color cosmetics. It may be a cleansing, cleansing water, oil, powder foundation, emulsion foundation, wax foundation, or spray formulation.

In one embodiment, the cosmetic composition of the present invention is Oil-in-Water (O/W), Water-in-Oil (W/O), Water-in-Silicone (W/S), Oil-in-Water-in -Oil (O/W/O) or Water-in-Oil-in-Water (W/O/W) formulation.

When the formulation of the present invention is a paste, cream, or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide may be used as carrier components. have.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane/ Propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol as a carrier component, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracant, and the like may be used.

When the formulation of the present invention is a surfactant containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether Sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester may be used.

For example, the cosmetic composition of the present invention is polysorbate 60, sorbitansquioleate, stearic acid, cetyl alcohol, squalane, glycerin, butylene glycol, arginine, carbomer, tocopheryl acetate, propanediol, 1, It may further contain at least one of 2-hexanediol and purified water.

In addition, the cosmetic composition may include surfactants, moisturizers, plant oils, ester oils, sunscreens, antioxidants, pH adjusters, pigments, flavors, preservatives, thickeners, emulsifiers, solubilizers, plant extracts, and the like.

The cosmetic composition according to the present invention can prevent skin irritation, have excellent formulation stability, are harmless to the human body, prevent lipid oxidation, improve damaged skin, and have excellent skin (redness) soothing effects.

Hereinafter, the configuration and operation of the present invention will be described in more detail through preferred embodiments of the present invention. However, the following examples are for aiding understanding of the present invention, and the scope of the present invention is not limited to the following examples. Contents not described herein can be sufficiently technically inferred by those skilled in the art, and thus description thereof will be omitted.

Example 1-4 and Comparative example 1~4

By applying the ingredients and contents shown in Tables 1 and 2 below, a cream-formed cosmetic composition was prepared by a conventional method. Specifically, the acacia ( Acacia ) pollen (flower pot) extract of Table 1 and Table 2 was prepared by adding 100 parts by weight of acacia pollen to 1000 parts by weight of ethanol, heating at 60 to 80°C, and then concentrating and freeze-drying the filtered filtrate. will be. In addition, vegetable oil unsaponifiable (A) is an unsaponifiable product ( glycine soja oil unsaponifiables), olive oil unsaponifiables olive oil unsaponifiables ( olea europaea oil unsaponifiables) and wheat germ oil unsaponifiables ( triticum vulgare germ unsaponifiables) in a weight ratio of 1:1~3:1~3, and vegetable oil unsaponifiable (B) contains dolphin oil unsaponifiable and olive oil unsaponifiable in a weight ratio of 1:1~3. Included was used.

Test example 1: skin irritation evaluation

In the case of using the cosmetic compositions of Examples 1 to 4 and Comparative Examples 1 to 4, a skin patch test was performed in order to investigate the skin irritation test. The blood test was selected as a person with no skin disease at the test site between 20 and 59 years old, and a total of 22 subjects were conducted in 8 groups. After wiping the upper arm, which is the patch area, with 70% ethanol and drying it, 0.1 g of the cosmetic composition of Examples and Comparative Examples was added each to apply a patch for 24 hours, and after removing the patch, the skin reaction was examined within 1 hour, and the next day ( 48 hours after the start of the patch) was examined again. The skin half was judged according to the following test criteria. The results of the skin patch test are shown in Table 3 below.

* Skin reaction test criteria

-No reaction ± Weak positive reaction (erythema) + Positive reaction (erythema) ++ Strong positive reaction (erythema, edema) +++ Severe positive reaction (erythema, edema, blisters)

Referring to the results of Table 3, in the case of the cosmetic composition of Examples 1 to 4 of the present invention, it was found that there was little skin irritation compared to Comparative Examples 1 to 4.

Test example 2: Formulation stability evaluation

In order to measure the stability against the degree of separation and discoloration for the cosmetics of Examples 1 to 4 and Comparative Examples 1 to 4, refrigerators and sunlight conditions maintained at a constant temperature of 4°C at 45°C and 25°C The Example and Comparative Example compositions were put in a sample container and stored for 4 weeks, and then the degree of separation and discoloration was compared and measured, and the results are shown in Table 4 below. At this time, the degree of separation and discoloration of the product was evaluated by classifying it into the following 6 grades.

* Separation and discoloration evaluation criteria

0: No change 1: Very little separation (discoloration) 2: Little separation (discoloration) 3: Slightly separation (discoloration) 4: Very severe separation (discoloration) 5: Extremely separation (discoloration)

Referring to the results of Table 4, it was found that Examples 1 to 4 of the present invention had less separation and discoloration compared to Comparative Examples 1 to 4 that deviated from the configuration of the present invention, and thus formulation stability was excellent.

Test example 3: prevent skin lipid oxidation

Lipid oxidation prevention was measured for the cosmetic compositions of Examples 1 to 4 and Comparative Examples 1 to 4. Specifically, it was conducted with 22 female clinical groups aged 20 to 59. The skin conditions of 22 subjects participating in the above evaluation were dry skin 9, normal dry skin 2, normal skin 9, oily skin 2, skin diseases, itchiness, itching, erythema, cosmetic side effects, drug side effects, light sensitivity. And there were no subjects corresponding to the experience of atopic disease.

The entire thin section of the test subject was divided into three areas and divided into a circle with a diameter of 4.5 cm. In the case of the negative control, no application was applied to proceed without exposure to cigarette smoke, and in the case of the positive control, no application was applied and exposed to cigarette smoke. In the case of Examples 1 to 4 and Comparative Examples 1 to 4, each 4 µl/cm ² It was applied at a dose and absorbed for 30 minutes, and after exposure to cigarette smoke for 15 minutes, it was waited for 1 hour. After extracting lipids from the skin surface for MDA measurement of three areas, MDA values were measured and shown in Table 5 and FIG. 1 below. The lipid oxidation prevention measurement is a test that uses the phenomenon of oxidation when lipids in the stratum corneum of the skin are exposed to contaminants, and the amount of change in malondialdehyde (MDA) generated when tobacco smoke, which is a contaminant, is exposed to the whole thin part is observed. I did.

Figure 1 is a control group exposed to cigarette smoke with application of Example 1 cosmetic composition and exposure to cigarette smoke, non-coating and exposure to cigarette smoke with no application of the embodiment, and non-coating and exposure to cigarette smoke without the regular Example. This is a graph comparing the degree of lipid oxidation of the control group. Referring to the results of Table 5 and FIG. 1, the application groups to which the cosmetic compositions of Examples 1 to 4 were applied, compared to Comparative Examples 1 to 4 and cigarette smoke exposed with no application, had the effect of preventing lipid oxidation on the skin. It was found to be excellent.

Experimental example 4: Improvement of damaged skin and skin ( Red flag ) Soothing effect

For the cosmetic compositions of Examples and Comparative Examples, the improvement of damaged skin due to ultraviolet rays was typically measured in Example 1.

Specifically, an experiment was conducted on 20 female clinical groups. After using Example 1 for 2 weeks on the entire skin, before UV irradiation, after UV irradiation, and after 1 day, 7 days, and 14 days after use of Example 1, erythema index (EI) and skin redness (a value) ) Was measured and photographed.

2 is a graph showing the test result of improving skin damage (erythema) by ultraviolet rays of Example 1, and FIG. 3 is a graph showing the test result of improving skin damage (skin redness) by ultraviolet rays of Example 1, and FIG. 4 is It is a photograph showing the test result of improving skin damage by ultraviolet rays of Example 1.

Referring to the results of Tables 6 and 7 and FIGS. 2 to 4, when Example 1 of the present invention is applied, damage skin improvement and skin (redness) due to reduction of the amount of erythema after 14 days compared to the unused area It was found that the calming effect of was excellent.

Test example 5: Improvement of damaged skin and skin ( Red flag ) To evaluate the effectiveness of

The cosmetic composition of Examples 1 to 4 and Comparative Examples 1 to 4 was applied once a day and used for 14 days for a total of 9 groups of 20 female clinical groups, and then damaged skin by UV rays was improved. And the results of the questionnaire values in the questionnaire survey conducted on the soothing effect of damaged skin (redness) and feeling of use (applyability) are shown in Table 8 below (5: very satisfied, 4: satisfied, 3: moderate, 2: unsatisfactory, 1: very dissatisfied).

Referring to the results of Table 8, Examples 1 to 4 of the present invention, with respect to Comparative Examples 1 to 4, improved damaged skin by ultraviolet rays and soothing effects of damaged skin (redness), and an effect of improving skin moisture. It was excellent, and it was found that the feeling of use such as spreadability was excellent.

Simple modifications or changes of the present invention can be easily implemented by those of ordinary skill in the art, and all such modifications or changes can be considered to be included in the scope of the present invention.

Claims (5)

French coastal pine bark extract ( Pinus Pinaster Bark Extract); Acacia (Acacia) Pollen (Pollen) extract; And vegetable oil unsaponifiable; contains,
The vegetable oil unsaponifiable is Dolkong oil unsaponifiable ( glycine soja oil unsaponifiables), olive oil unsaponifiables olive oil unsaponifiables ( olea europaea oil unsaponifiables) and wheat germ oil unsaponifiables ( triticum vulgare germ unsaponifiables), characterized in that it comprises a cosmetic composition.
The cosmetic according to claim 1, comprising 0.01 to 5% by weight of French coast pine bark extract, 0.001 to 1% by weight of acacia pollen extract, and 0.01 to 10% by weight of unsaponifiable vegetable oil based on the total weight of the cosmetic composition. Composition.
The cosmetic composition according to claim 1, wherein the vegetable oil unsaponifiable product comprises a dolkong oil unsaponifiable product, an olive oil unsaponifiable product and a wheat germ oil unsaponifiable product in a weight ratio of 1:0.5-10:0.2-5.
The method of claim 1, wherein the cosmetic composition is a solution, suspension, emulsion, paste, essence, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray. Cosmetic composition, characterized in that the formulation.
The cosmetic composition according to claim 1, wherein the cosmetic composition is in an Oil-in-Water (O/W), Water-in-Oil (W/O) or Water-in-Silicone (W/S) formulation. .

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