KR20200118233A - 조효소 q10을 이용한 고형 종양의 치료 - Google Patents

조효소 q10을 이용한 고형 종양의 치료 Download PDF

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Publication number
KR20200118233A
KR20200118233A KR1020207028370A KR20207028370A KR20200118233A KR 20200118233 A KR20200118233 A KR 20200118233A KR 1020207028370 A KR1020207028370 A KR 1020207028370A KR 20207028370 A KR20207028370 A KR 20207028370A KR 20200118233 A KR20200118233 A KR 20200118233A
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South Korea
Prior art keywords
cancer
coq10
dose
administered
subject
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Ceased
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KR1020207028370A
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English (en)
Korean (ko)
Inventor
니븐 라진 나레인
존 패트릭 맥쿡
폴 와이. 송
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버그 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020207028370A 2012-06-01 2013-05-31 조효소 q10을 이용한 고형 종양의 치료 Ceased KR20200118233A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654245P 2012-06-01 2012-06-01
US61/654,245 2012-06-01
PCT/US2013/043785 WO2013181639A1 (en) 2012-06-01 2013-05-31 Treatment of solid tumors using coenzyme q10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147037100A Division KR102163948B1 (ko) 2012-06-01 2013-05-31 조효소 q10을 이용한 고형 종양의 치료

Publications (1)

Publication Number Publication Date
KR20200118233A true KR20200118233A (ko) 2020-10-14

Family

ID=49673946

Family Applications (2)

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KR1020207028370A Ceased KR20200118233A (ko) 2012-06-01 2013-05-31 조효소 q10을 이용한 고형 종양의 치료
KR1020147037100A Active KR102163948B1 (ko) 2012-06-01 2013-05-31 조효소 q10을 이용한 고형 종양의 치료

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KR1020147037100A Active KR102163948B1 (ko) 2012-06-01 2013-05-31 조효소 q10을 이용한 고형 종양의 치료

Country Status (16)

Country Link
US (3) US20140017317A1 (cg-RX-API-DMAC7.html)
EP (1) EP2854528B8 (cg-RX-API-DMAC7.html)
JP (3) JP6352905B2 (cg-RX-API-DMAC7.html)
KR (2) KR20200118233A (cg-RX-API-DMAC7.html)
CN (1) CN104507308A (cg-RX-API-DMAC7.html)
AU (2) AU2013267166A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014029954A2 (cg-RX-API-DMAC7.html)
CA (2) CA3090268A1 (cg-RX-API-DMAC7.html)
EA (1) EA032345B1 (cg-RX-API-DMAC7.html)
ES (1) ES2761449T3 (cg-RX-API-DMAC7.html)
IL (1) IL236008B (cg-RX-API-DMAC7.html)
IN (1) IN2014DN10734A (cg-RX-API-DMAC7.html)
MX (2) MX369768B (cg-RX-API-DMAC7.html)
NZ (1) NZ702369A (cg-RX-API-DMAC7.html)
SG (1) SG11201407880QA (cg-RX-API-DMAC7.html)
WO (1) WO2013181639A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102481269B (zh) 2009-05-11 2015-10-07 博格有限责任公司 包含辅酶q10的药物组合物及其制备方法
JP6092844B2 (ja) 2011-04-04 2017-03-08 バーグ エルエルシー 中枢神経系腫瘍の治療方法
US20140017317A1 (en) * 2012-06-01 2014-01-16 Niven Rajin Narain Methods of treatment of solid tumors using coenzyme q10
BR112015025424A2 (pt) * 2013-04-08 2017-07-18 Berg Llc tratamento de câncer usando terapias de combinação de coenzima q10
MX381399B (es) 2013-09-04 2025-03-12 Berg Llc Formulaciones de coenzima q10 y métodos de uso.
US9996463B2 (en) * 2015-11-10 2018-06-12 International Business Machines Corporation Selection and placement of volumes in a storage system using stripes
WO2017087576A1 (en) * 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
US20170255565A1 (en) * 2016-03-02 2017-09-07 Intel Corporation Method and apparatus for providing a contiguously addressable memory region by remapping an address space
WO2018005412A1 (en) * 2016-06-28 2018-01-04 Tien Yang Der Chemoprotective/chemoactive nanodroplets and methods of use thereof
CA3063916A1 (en) * 2017-05-17 2018-11-22 Berg Llc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
CA3239264A1 (en) * 2021-12-01 2023-06-08 Gambro Lundia Ab New dialysis fluid
WO2025087731A1 (en) * 2023-10-24 2025-05-01 Gambro Lundia Ab Compositions comprising insulin and ketones bodies to treat cancer

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US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
WO2005048925A2 (en) * 2003-11-14 2005-06-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating a neoplastic disease in a subject using inorganic selenium-containing compounds
HRP20130459T1 (en) 2004-01-22 2013-06-30 University Of Miami Topical co-enzyme q10 formulations and methods of use
WO2008069276A1 (ja) * 2006-12-06 2008-06-12 Kaneka Corporation 癌治療剤および発癌抑制剤
US8454945B2 (en) 2007-03-22 2013-06-04 Berg Pharma Llc Topical formulations having enhanced bioavailability
WO2009064738A2 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
EP2229186A2 (en) 2007-12-04 2010-09-22 Alnylam Pharmaceuticals Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
US8247435B2 (en) * 2009-02-19 2012-08-21 Thornthwaite Jerry T Formulations for treating human and animal diseases
CN102481269B (zh) 2009-05-11 2015-10-07 博格有限责任公司 包含辅酶q10的药物组合物及其制备方法
GB0913193D0 (en) 2009-07-29 2009-09-02 Johnson Matthey Plc Deoxygenation process
BR112012022916B1 (pt) * 2010-03-12 2021-11-09 Berg Llc Formulações intravenosas de coenzima q10 (coq10), bem como método de preparação e uso da mesma
US20140239525A1 (en) 2011-06-17 2014-08-28 Board Of Regents, University Of Texas System Inhalable pharmaceutical compositions
US20140017317A1 (en) * 2012-06-01 2014-01-16 Niven Rajin Narain Methods of treatment of solid tumors using coenzyme q10

Also Published As

Publication number Publication date
IL236008B (en) 2018-08-30
KR102163948B1 (ko) 2020-10-12
MX369768B (es) 2019-11-21
CA3090268A1 (en) 2013-12-05
HK1208995A1 (en) 2016-03-24
JP6352905B2 (ja) 2018-07-04
JP2018168164A (ja) 2018-11-01
SG11201407880QA (en) 2014-12-30
US20140017317A1 (en) 2014-01-16
IL236008A0 (en) 2015-02-01
EP2854528A1 (en) 2015-04-08
MX2019013776A (es) 2020-01-30
AU2017202567A1 (en) 2017-05-11
EP2854528B8 (en) 2019-10-23
KR20150022932A (ko) 2015-03-04
EP2854528B1 (en) 2019-09-18
MX2014014492A (es) 2015-05-12
NZ702369A (en) 2016-12-23
AU2017202567B2 (en) 2019-06-13
CA2875150C (en) 2020-10-27
EA201492187A1 (ru) 2015-05-29
EP2854528A4 (en) 2016-03-09
ES2761449T3 (es) 2020-05-19
US20170216223A1 (en) 2017-08-03
CA2875150A1 (en) 2013-12-05
US20220096399A1 (en) 2022-03-31
JP7225167B2 (ja) 2023-02-20
AU2013267166A1 (en) 2014-12-18
EA032345B1 (ru) 2019-05-31
JP2015518056A (ja) 2015-06-25
WO2013181639A8 (en) 2014-12-31
WO2013181639A1 (en) 2013-12-05
IN2014DN10734A (cg-RX-API-DMAC7.html) 2015-09-04
JP2020183440A (ja) 2020-11-12
CN104507308A (zh) 2015-04-08
BR112014029954A2 (pt) 2017-06-27

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