KR20200098943A - Oral Cleansing And Oral Care omposition - Google Patents

Abstract

The present invention relates to an oral cleansing and oral care composition comprising 30-50% by weight of beta-sitosterol, 20-40% by weight of beta-phellandrene, 10-20% by weight of beta-caryophyllene, 10-20% by weight of myrcene, and 10-20% by weight of acacia extract, and toothpaste and gargle comprising the composition. The oral cleansing and oral care composition according to the present invention prevents and alleviates tooth and gum diseases, periodontitis and gingivitis, in advance by being included in an oral cleaning tool and a cleaning care product, removes bad breath with the unique fragrance of natural materials, and maintains a soft and fragrant texture.

Description

Oral Cleansing And Oral Care omposition

The present invention is intended to manufacture a functional oral care product by adding natural ingredients that are effective in preventing and improving gum disease to toothpaste and gargle solution, which are oral cleaning and cleaning tools, and in more detail, toothpaste or gargle In addition to the original functions of toothpaste and gargle, gum diseases such as periodontitis and gingivitis are prevented in advance by adding extracts such as corn cobs and pine cones, which are recognized to be effective in preventing and improving gum diseases such as periodontitis and gingivitis. It relates to an oral cleaning and oral care composition that adds a function of preventing and improving, and also removes bad breath by adding natural materials such as acacia and maintains a soft and fragrant texture.

In general, as society enters the advanced country, interest in oral products including toothpaste continues to increase. In order to meet these needs, many types of oral products such as toothpaste, mouthwash, and tooth whitening agent have been released, but the satisfaction of consumers is not very high due to each problem.

Among them, oral mouthwash products are easily available products like toothpaste, and consumers' demands are increasing for the purpose of removing bad breath and eradicating bacteria in the mouth.This is confirmed that the domestic oral mouthwash market continues to rise. Is expected to continue to increase.

Conventional oral mouthwash compositions consist of solvents, solubility aids, preservatives, pH adjusters, bases, flavoring agents, sweeteners, etc., and alcohol used in solvents, preservatives, sodium fluoride, and cetylpyridinium chloride, which are the main components in the pH adjuster, are used. Synthetic sweeteners are used, and the existing invention mainly uses oral mouthwash, which is used for the purpose of eradicating bacteria in the mouth, with sodium fluoride and cetylpyridinium chloride as main components, and users use this solution to eradicate bacteria and remove bad breath. I have purchased and used it.

However, there is a drug that is mainly composed of a single ingredient, corn unsaponified quantitative extract, as a gum medicine that is effective against periodontal disease, but the situation is not fundamentally preventing the occurrence of gingival inflammation.

Accordingly, the present invention has the function of preventing and improving gum diseases such as periodontitis and gingivitis in advance by adding corn cobs, pine cones and acacia, which are natural ingredients containing beta-sitosterol, which are effective for gum health, to eradicate bacteria in the mouth. Its purpose is to make oral mouthwash composition.

Here, beta-sitosterol is a plant sterol found in plants such as corn, soybeans, rice bran, etc., and has a chemical structure very similar to cholesterol. When absorbed into the body, it reduces cholesterol, increases anticancer activity, increases immunity, It is introduced as a substance that plays a variety of roles, such as anti-inflammatory properties, and is known to be useful for gum disease, periodontitis and gingivitis because it has the effect of mitigating inflammation.

The present invention is the original toothpaste and gargle by adding extracts and constituents thereof, such as corn cobs and pine cones, which are recognized to be effective in preventing and improving tooth and gum diseases such as periodontitis and gingivitis in the manufacturing process of toothpaste or gargle. In addition to the functions of, it provides an oral cleaning and oral care composition that prevents and improves gum diseases such as periodontitis and gingivitis in advance, and also removes bad breath by adding natural ingredients such as acacia and maintains a soft and fragrant texture. have.

As a result of researching the above subject, the present inventors have found that the above subject can be solved by providing an oral cleansing and oral care composition having a specific constituent and composition, and has come to complete the present invention.

The present invention includes 30 to 50% by weight of beta-sitosterol, 20 to 40% by weight of beta-phellandrene, 10 to 20% by weight of beta-calophylene, 10 to 20% by weight of myrcene, and 10 to 20% by weight of acacia extract It provides an oral cleaning and oral care composition.

In a preferred embodiment of the present invention, 30 to 50% by weight of an abrasive, 25 to 30% by weight of a wetting agent, 8 to 10% by weight of a foaming agent, 4 to 8% by weight of a binder, 3 to 4% by weight of a sweetener, 2 to 5% of a fluorine compound, It provides a toothpaste comprising 3 to 5% by weight of flavoring agent, 2 to 3% by weight of preservative, and 3 to 8% by weight of the oral cleaning and oral care composition according to claim 1.

In another preferred embodiment of the present invention, the abrasive is silicon dioxide or calcium carbonate, the wetting agent is sorbitol, glycerin, or propylene glycol, the blowing agent is sodium lauryl sulfate, the binder is carboxymethylcellulose, gum arabic, or carrageenan, and the sweetener Is saccharin, xylitol, or stevioside, the flavoring agent is spearmint oil or peppermint oil, and the preservative is butyl benzoate.

Another preferred embodiment of the present invention is 70 to 90% by weight of mineral water, 3 to 5% by weight of baking soda, 2 to 3% by weight of sodium chloride, 2 to 3% by weight of essential oil, peppermint or tea tree oil, and the above It provides a mouthwash and mouthwash liquid containing 3-8% by weight of the oral care composition.

The oral cleaning and oral care composition according to the present invention is a disease of teeth or gums by containing the oral cleaning and oral care composition. It has the effect of preventing and improving gum inflammation, periodontitis, and gingivitis in advance, removing bad breath with the unique scent of natural ingredients, and maintaining a soft and fragrant texture.

Hereinafter, a preferred embodiment according to the present invention will be described in detail. However, the following embodiments are provided so that the present invention may be sufficiently understood by those with ordinary knowledge in the technical field, and may be modified in various other forms, and the scope of the present invention is limited to the embodiments described below. It does not become.

The oral cleaning and oral care composition according to the present invention has the following ingredients and compositions:

Beta-sitosterol 30-50% by weight,

Betaphellandrene 20-40% by weight,

10 to 20% by weight of beta caryophyllene,

10-20% by weight of myrcene, and

10-20% by weight of acacia extract.

Beta-sitosterol used in the present invention has the following formula (C ₂₉ H ₅₀ O) and is known to have anti-ulcer, antibacterial, anti-inflammatory, antioxidant effects, etc., and recently, its safety and effectiveness are Recognized in Europe.

The beta-sitosterol is put into a hot-air drying device that maintains the corn at a temperature of 18-20°C and dried for 24 to 36 hours, and then only the corn cob is separated from the dried corn, then washed and sterilized, and the corn cob It is obtained by cutting into 4~5 pieces of suitable size and putting it in hot water at 20℃~30℃. The content is preferably 30 to 50% by weight based on the total weight of the composition.

In addition, beta-phellandrene used in the present invention has the following formula (C ₁₀ H ₁₆ ) and molecular weight of 136, has a specific aromatic scent, and has anti-inflammatory and antibacterial effects. The betaphellandrene is found to be contained in pine needles, especially pine cones, although essential oils of "Archagelica officinalis" of the parsley family or present in ginger oil.

The content of betaphellandrene used in the present invention is preferably 20 to 40% by weight based on the total weight of the composition.

Beta caryophyllene used in the present invention has the following formula, has an anti-inflammatory action, and is found to be contained in a large number of pine needles, especially pine cones.

The content of beta caryophyllene used in the present invention is preferably 10 to 20% by weight based on the total weight of the composition.

Myrcene used in the present invention is an olefinic natural organic hydrocarbon, has the following chemical structure, is extracted from plants such as cannabis and wild thyme, is an important component of essential oils, and is contained in a large number of pine needles, especially pine cones. Turned out.

The content of myrcene used in the present invention is preferably 10 to 20% by weight based on the total weight of the composition.

In addition, the acacia extract used in the present invention has excellent ability to inhibit tyrosinase enzyme activity and inhibit melanin production in B16 murine melanoma cells, as well as excellent radical scavenging ability and lipid peroxidation inhibitory ability.

Acacia extract is dried and ground after washing acacia leaves with clean water, and one or more solvents selected from the group consisting of distilled water, ethanol, methanol, propanol, butanol, acetone, ethyl acetate, and 1,3-butylene glycol are used as extraction solvents. After adding to 10 times the weight, the active ingredient is extracted by stirring at 300 to 500 rpm in a magnetic stirrer for 24 hours at room temperature. Again, the extract was centrifuged at 4,000 to 7,000 rpm for 10 minutes to take only the supernatant and then filtered using a 0.4 to 10 μm filter to obtain an extract filtrate.

The content of the acacia extract used in the present invention is preferably 10 to 20% by weight based on the total weight of the composition.

The present invention also provides a toothpaste comprising the oral cleaning and oral care composition according to the present invention in an abrasive, a wetting agent, a foaming agent, a binder, a sweetener, a flavoring agent and a preservative.

More specifically, the present invention provides 30 to 50% by weight of silicon dioxide or calcium carbonate as an abrasive, 25 to 30% by weight of sorbitol, glycerin, or propylene glycol as a wetting agent, 8 to 10% by weight of sodium lauryl sulfate as a blowing agent, and a binder 4-8% by weight of carboxymethylcellulose, gum arabic, or carrageenan as a sweetener, 3-4% by weight of saccharin, xylitol, or stevioside as a sweetener, 2-5% by weight of a fluorine compound, 3 to 5% by weight of spearmint oil or peppermint oil as a flavoring agent It provides a toothpaste comprising 5% by weight, and 2 to 3% by weight of butyl benzoate as a preservative, and 3 to 8% by weight of the oral cleaning and oral care composition according to the present invention.

Silicon dioxide or calcium carbonate is used as the abrasive, and the amount is preferably 30 to 50% by weight based on 100% by weight of the oral cleaning and oral care composition.

As the humectant, sorbitol, glycerin, or propylene glycol is used, and the amount is preferably 25 to 30% by weight based on 100% by weight of the oral cleaning and oral care composition.

Sodium lauryl sulfate is used as the foaming agent, and the amount is preferably 8 to 10% by weight based on 100% by weight of the oral cleaning and oral care composition.

As the binder, carboxymethyl cellulose, gum arabic, or carrageenan is used, and the amount is preferably 4 to 8% by weight based on 100% by weight of the oral cleaning and oral care composition.

As the sweetener, saccharin, xylitol, or stevioside is preferable, and the amount thereof is preferably 3 to 4% by weight based on a total of 100% by weight of the oral rinse and oral care composition.

In the toothpaste of the present invention, it is preferable that 2 to 5% of a fluorine compound is used based on 100% by weight of the oral cleaning and oral care composition.

As the flavoring agent, spearmint oil or peppermint oil is used, and the amount is preferably 3 to 5% by weight based on a total of 100% by weight of the oral washing and oral care composition.

As the preservative, butyl benzoate is used, and the amount is preferably 2 to 3% by weight based on the total 100% by weight of the oral cleaning and oral care composition.

And it is preferable that the oral cleaning and oral care composition according to the present invention contain 3 to 8% by weight.

The present invention also provides a gargle liquid comprising bottled water, baking soda, sodium chloride, essential oil, peppermint or tea tree oil, and the mouthwash and oral care composition according to the present invention as another embodiment.

More specifically, the oral cleansing and oral care composition of the present invention is 70 to 90% by weight of mineral water, 3 to 5% by weight of baking soda, 2 to 3% by weight of sodium chloride, essential oil, peppermint based on the total 100% by weight of the composition. Or it provides a gargle solution comprising 2 to 3% by weight of tea tree oil, and 3 to 8% by weight of the oral cleaning and oral care composition according to the present invention.

Tea tree oil used in the present invention is obtained by extracting a fragrance active ingredient from leaves and twigs of tea tree, cooling with cooling water, and condensing. The tea tree oil is known to effectively act on bacteria, viruses, and fungi, and to increase immunity.

Hereinafter, the present invention will be described in more detail with reference to examples. However, this description does not limit the present invention.

For reference, young pine cones contain a component called Tefpen, and when absorbed into the body, they increase the body's activity and help blood circulation, so it is good for preventing hypertension, arteriosclerosis, numbness in the hands and feet, constipation, skin care, and periodontal disease. It has been proven through various clinical trials that it is good for gum diseases such as toothache, and it is preferable to use young fresh blue pine cones collected in May to June as the pine cones used in the common embodiments of the present invention mentioned below, but limited to this. You don't have to do it.

On the other hand, the pine cone constituting the present invention contains components such as beta-phellandrene, beta-caryophyllene, and myrcene, and the beta-phellandrene is a secretory tree, which is a coniferous evergreen tree living in a clean forest. In particular, beta-phellandrene is a volatile component found in pine needles. It is widely distributed in essential oils (Angelica, Eucalyptus, Lavandula, Mentha, Pinus species) and is a fragrance component. Among them, Phellandrene is the name of a pair of organic compounds with similar molecular structure and similar chemical properties, and alpha-Phellandrene and beta-phellandrene are cyclic. It is a monoterpene and is a double bond isomer.

The beta-caryophyllene (β-caryophyllene), among many essential oils, especially clove oil (Syzygium aromaticum) (clove tree) stems and flowers derived from the oil, Cannabis sativa, rosemary, essential oils, and other constituents. It is found as a mixture with ring-opening isomers.

The myrcene is a type of isoprenoid derived from phytoncide, and has increased glucose absorption in muscle cells treated with myrcene at a concentration of 10 μM, and plays a role in increasing phosphorylation of AMPK, a major protein that regulates homeostasis in vivo. Do it.

(Manufacture of oral cleaning and oral care composition)

Example 1

Beta-sitosterol may be extracted from corn cob, or commercially available, but in the present invention, 500 g of commercially available beta-sitosterol was used.

To the beta-sitosterol 500 g, commercially available beta-phellandrene 200 g, beta caryophyllene 100 g and myrcene 100 g were added to the beta-sitosterol.

Separately, 1 kg of acacia leaves were washed with clean water, dried in a cool place, crushed finely, added to 10 liters of a 1:1 mixture of distilled water and ethanol, and stirred with a magnetic stirrer at 500 rpm for 24 hours at room temperature. After concentrating at 60° C. for 8 hours, the concentrate was centrifuged at 7,000 rpm for 10 minutes to take only the supernatant and filtered through a 10 μm filter to obtain 100 g of acacia extract. 100 g of the acacia extract was added to the mixture to obtain 1,000 g of a mouthwash and oral care composition according to the present invention.

Example 2

To 500 g of commercially purchased beta-sitosterol, 200 g of betaphellandrene, 100 g of beta caryophyllene, and 100 g of myrcene were added.

Separately, 1 kg of acacia leaves were washed with clean water, dried in a cool place, crushed finely, added to 10 liters of a 1:1 mixture of distilled water and ethanol, and stirred with a magnetic stirrer at 400 rpm for 24 hours at room temperature, After concentrating at 70° C. for 7 hours, the concentrate was centrifuged at 5,000 rpm for 10 minutes to take only the supernatant and filtered through a 10 μm filter to obtain 100 g of acacia extract. 100 g of the acacia extract was added to the mixture to obtain 1,000 g of an oral cleaning and oral care composition according to the present invention.

(Manufacture of toothpaste)

Example 3

50 g of calcium carbonate as an abrasive, 25 g of sorbitol as a wetting agent, 8 g of sodium lauryl sulfate as a blowing agent, 4 g of carboxymethylcellulose as a caking agent, 3 g of xylitol as a sweetener, 2 g of fluorine, 3 g of spearmint oil as a flavoring agent, 2 g of butyl benzoate as a preservative, and the above 100g of toothpaste was prepared by mixing 3g of the oral cleaning and oral care composition prepared in Example 1.

Example 4

50 g of silicon dioxide as an abrasive, 25 g of glycerin as a wetting agent, 8 g of sodium lauryl sulfate as a blowing agent, 4 g of gum arabic as a caking agent, 3 g of stevioside as a sweetener, 2 g of stevioside as a sweetener, 3 g of peppermint oil as a flavoring agent, 2 g of butyl benzoate as a preservative, and the above implementation. 100g of toothpaste was prepared by mixing 3g of the oral cleaning and oral care composition prepared in Example 2.

(Manufacture of goggle liquid)

Example 5

90 g of mineral water, 3 g of baking soda, 2 g of sodium chloride, 2 g of essential oil, and 3 g of the mouthwash and oral care composition obtained in Example 1 were mixed to prepare 100 g of gargle solution.

Example 6

85 g of mineral water, 5 g of baking soda, 3 g of sodium chloride, 3 g of essential oil, and 4 g of the mouthwash and oral care composition obtained in Example 2 were mixed to prepare 100 g of gargle solution.

(Test example)

To confirm the antibacterial activity of the mouthwash and mouth care compositions obtained in Examples 1 and 2 of the present invention, and the mouthwash and mouth care compositions of the present invention containing the mouthwash liquid (for control) Antimicrobial activity experiments were conducted.

Experiment 1 (antibacterial activity)

Samples were prepared by dissolving the gargle solutions obtained in Examples 5 and 6 of the present invention in a DMSO solvent at a concentration of 10% in two test tubes. Separately, the mouthwash and oral care composition of the present invention was prepared in a certain ratio to prepare a mouthwash liquid containing no control was used.

45 ml of the medium was added to each of the three prepared test tubes, and 5 ml of each sample was added to each of the prepared samples at a concentration of 2%, followed by sequentially diluting by 2 times.

To this dilution, 100 µl of the oral pathogenic strain Actinobacillus actinomycetemcomitans was added to a test tube to be 2×10 ⁵ CFU/ml, and after incubating at 37° C. for 16 hours or more, turbidity was not shown. The minimum inhibitory concentration was measured. The results are shown in Table 1 below.

Minimum inhibitory concentration (㎍/㎖) Example 5 Example 6 For contrast Actinobacillus
Actinomy Setum Comitans 200 400 8,000

As can be seen from the table above, the mouthwash and oral care composition containing the mouthwash liquid (Examples 5 and 6) according to the present invention has an oral pathogenic strain 20 to 40 times higher than that of the control without it. It was confirmed that the antimicrobial effect of the oral cleaning and oral care composition of the present invention was very excellent as it was proliferated.

In the above, a preferred embodiment of the present invention has been described in detail, but the present invention is not limited to the above embodiment, and various modifications by those of ordinary skill in the art within the scope of the technical idea of the present invention This is possible.

Claims (4)

Oral cleansing and oral care composition comprising the following ingredients:
Beta-sitosterol 30-50% by weight,
Betaphellandrene 20-40% by weight,
10 to 20% by weight of beta caryophyllene,
10-20% by weight of myrcene, and
10-20% by weight of acacia extract. 30 to 50% by weight of abrasive, 25 to 30% by weight of wetting agent, 8 to 10% by weight of foaming agent, 4 to 8% by weight of binder, 3 to 4% by weight of sweetener, 2 to 5% of fluorine compounds, 3 to 5% by weight of flavoring agent , A toothpaste comprising 2 to 3% by weight of preservation, and 3 to 8% by weight of the oral cleaning and oral care composition according to claim 1. The method of claim 2, wherein the abrasive is silicon dioxide or calcium carbonate, the wetting agent is sorbitol, glycerin, or propylene glycol, the blowing agent is sodium lauryl sulfate, the binder is carboxymethylcellulose, gum arabic, or carrageenan, and the sweetener is saccharin. , Xylitol, or stevioside, the flavoring agent is spearmint oil or peppermint oil, and the preservative is butyl benzoate. Bottled water 70 to 90% by weight, baking soda 3 to 5% by weight, sodium chloride 2 to 3% by weight, essential oil, peppermint or tea tree oil 2 to 3% by weight, and oral cleansing and oral care composition 3 to according to claim 1 Gargle liquid containing 8% by weight.