KR20200083407A - Gel composition having improved adhesive property for tooth patch - Google Patents

Abstract

Provided is a gel composition for attaching a dental patch, wherein the gel composition contains water and ethanol as solvents for forming a gel, and is gelled using a polymer soluble in both water and ethanol. In addition, the present invention provides a kit for teeth whitening comprising a tooth surface adhesive gel composition and a tooth whitening patch. The gel composition of the present invention can improve the adhesion of a patch for attaching teeth, and can increase the whitening efficiency of the tooth whitening patch.

Description

Gel composition having improved adhesive property for tooth patch

The present invention relates to a gel composition for adhesion of a tooth in the form of a gel for attaching a tooth patch to a tooth surface, wherein the adhesion of the tooth patch is improved, and more specifically, the tooth whitening while allowing the patch to be well attached to the tooth. It relates to a composition for bonding a tooth surface in the form of a gel that can enhance the effect.

Recently, as interest in beauty increases, interest in teeth whitening is also increasing, and thus, whitening agents containing a whitening component have been developed. A representative formulation among these whitening agents is a whitening patch that can be attached to teeth.

In some cases, the tooth whitening patch is composed of a single layer containing both the tooth whitening component and other active ingredients. In general, along with the drug (whitening component) delivery layer containing the tooth whitening component, the whitening component is effectively delivered to the tooth, or , Including an additional layer other than the drug (whitening component) delivery layer for a variety of reasons, such as promoting the effect of the whitening component, or preventing the stability of other components from being lowered when mixed with the whitening component Multi-layered patches have been studied.

This multi-layered whitening patch has the advantage of being able to achieve a desired effect through various designs, such as improving the stability of active ingredients such as whitening components, compared to a patch for whitening composed of only a drug delivery layer containing an active ingredient. . However, in the case of the tooth whitening patch having a multi-layer structure, there has been a case where a problem that the whitening effect decreases with time has often occurred.

In order to solve this problem, a method of attaching a whitening patch after applying a separate gel agent to the tooth surface before applying the whitening patch was provided to increase the effect of the whitening patch.

However, it is common for such a gel agent to dissolve or disperse a desired efficacious substance after forming a basic viscosity with water and a polymer, and also contains a high content of alcohol instead of water for quick drying.

However, the gels of the above two compositions are not difficult to use alone, but when used together with the patch, when water is used as the main solvent, the patch slips and does not provide proper seating, making it difficult to deliver the drug to the desired site, and mainly using alcohol. When used as a solvent, it dried too quickly and dried together with the saliva of the teeth, causing a problem that it is difficult to deliver the appropriate drug because the patch is not attached to the teeth.

Therefore, the present invention is to provide a gel agent capable of enhancing the usability, ease of use and effect of the whitening patch by allowing the whitening patch for tooth attachment to be well adhered to the tooth surface.

That is, the present invention is intended to provide a composition of the most effective gel agent that can be dried at an appropriate rate when applied to a tooth.

In addition, it is intended to provide a gel agent that can obtain a tooth whitening effect more quickly and effectively.

In addition, the problem to be solved by the present invention is to use a tooth whitening kit comprising the gel as a composition, while having excellent adhesion to teeth, it is easy to attach a dental patch to a tooth, and the dental patch is a patch for whitening. In this case, it is to provide a kit for whitening teeth having excellent whitening effect.

In order to solve the above problems, the present invention provides a gel composition for tooth surface adhesion for attaching a dental patch. Specifically, the gel composition for adhesion to the tooth surface is characterized in that the adhesion of the dental patch to the tooth surface is improved, using water and ethanol as a solvent, and gelling using a polymer dissolved in both water and ethanol. It provides a gel composition for tooth surface adhesion.

The inventors of the present invention have completed the present invention as a result of research on a method capable of effectively delivering a drug while a patch for attaching a tooth, especially a dry type patch for attaching a tooth well adheres to a tooth surface.

The gel composition of the present invention can improve the ability of the tooth attachment patch to adhere to the tooth surface. In addition, the gel composition may include a tooth whitening component active agent, and the tooth whitening component active agent may affect activation of the whitening component included in the tooth whitening patch to be attached after applying the gel composition.

The gel composition may use a polymer having tooth adhesiveness and soluble in both water and ethanol.

The polymer is carboxymethyl cellulose, carboxypropyl cellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and hydroxypropylethyl Any one cellulose selected from the group consisting of cellulose (hydroxypropylethylcellulose);

Any gum selected from the group consisting of xanthan gum, guar gum, carrageenan gum, arabic gum, and alginate gum; And

Polyvinylalcohol, poloxamer, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate copolymer (polyvinylpyrrolidone/vinylacetate copolymer), polyacrylic acid, carbopol ), polyalkylvinyl ether-maleic acid copolymer (PVM/MA copolymer) and any one or more selected from the group consisting of synthetic polymers made of polyox (polyox) can be used, preferably polyvinylpyrrolidone can be used. have.

The composition may include a tooth whitening component activator in order to have an effective activity when the whitening component included in the tooth attachment patch, in particular, the tooth attachment patch for tooth whitening is attached to the tooth surface.

The tooth whitening component active agent is included in the gel composition for tooth surface adhesion of the present invention, and a gel formulation can be used as a carrier to prevent the tooth whitening component active agent from flowing down when applied to the tooth surface in a state dissolved in water.

The tooth whitening component active agent may act to promote the activity of the tooth whitening component, prevents the whitening activity from being inhibited by the stabilizer used for stabilizing the whitening component during product distribution, and induces an excellent whitening effect Can be used to

The tooth whitening ingredient active agent may be used as a component for the activation of peroxide, which is generally used in the industry, and is not particularly limited. However, preferably, a divalent or trivalent metal catalyst, a pH adjusting agent, or a mixture thereof may be included.

The divalent or trivalent metal catalyst can promote decomposition of peroxide. The divalent or trivalent metal catalyst is preferably capable of releasing calcium, magnesium, manganese, copper, iron or potassium ions, more preferably magnesium chloride, magnesium gluconate, iron lactate, iron gluconate, iron chloride, Manganese sulfate, manganese gluconate, manganese chloride and manganese citrate can be used.

The pH adjusting agent may react with peroxide to generate a perhydroxy radical to enhance the tooth whitening effect, and such alkali pH adjusting agents include sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate and sodium pyrophosphate , Sodium citrate, one or more selected from the group consisting of EDTA-4Na may be used, but is not limited thereto. The alkali pH adjusting agent may be used in an appropriate amount such that the pH of the composition is 8-11.

When using a tooth whitening agent containing the tooth whitening components, the stabilizer acts as a barrier to the whitening component from showing activity, and the above-mentioned tooth whitening component activator is used to solve this.

The drying rate of the adhesive gel composition of the present invention varies depending on the type and ratio of the solvent used, and may affect the adhesion of the patch for tooth attachment.

Thus, the inventors of the present invention have confirmed through experiments that when using water and ethanol as a solvent at the same time, the patch for tooth attachment is stably attached and can effectively deliver the drug contained in the patch. In addition, the mixing ratio of the solvent in the composition for adhesion was confirmed so that the patch could stably adhere without flowing down from the tooth surface.

The composition may include 0.5 to 4 parts by weight of ethanol relative to 1 part by weight of water.

The content of water contained in the gel composition is 10 to 70% by weight based on the total weight of the composition, and ethanol may be included from 5 to 70% by weight based on the total weight of the composition.

If the water contained in the solvent exceeds the above content range, the patch may slip and not settle on the tooth surface, which may cause a problem that the drug is not properly delivered to a desired portion of the tooth surface. When the ethanol contained in the solvent exceeds the above content range, the gel composition of the present invention is dried too quickly and dried to saliva, which may cause a problem that a patch is not attached. Therefore, the inventors of the present invention have confirmed the solvent ratio of the gel composition to which the patch can be attached most effectively through experiments.

According to another embodiment of the present invention, the present invention (a) a solvent for forming a gel containing water and ethanol in the gel composition,

A gel composition for adhesion to a tooth for attaching a dental patch, characterized in that it is gelled using a polymer dissolved in both water and ethanol; And

(b) A kit for teeth whitening comprising a tooth whitening component and optionally a tooth whitening component stabilizer, and a patch for tooth whitening having one or more layered structures.

Peroxide may be used as a tooth whitening component that can be used in the patch for tooth attachment of the present invention, and hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate (peroxide) may be used as the peroxide. Sodium percarbonate, sodium perborate, tetrasodium pyrophosphate peroxidate, or mixtures thereof can be used. However, for the purpose of the present invention, it is preferable that the patch for tooth whitening of the present invention includes hydrogen peroxide as a whitening component.

The patch of the present invention may optionally further include a stabilizer to further increase the stability of the peroxide. That is, it is possible to further improve stability by using a metal-complex agent having excellent compatibility with peroxide. Stabilizers with good peroxide compatibility in the present invention are polysodium phosphate (tetrasodium pyrophosphate), sodium pyrophosphate (sodium acid pyrophosphate), sodium metaphosphate (sodium hexametaphosphate), sodium polyphosphate (sodium tripolyphosphate) , Sodium potassium tripolyphosphate, tetrapotassium pyrophosphate, acidic sodium meta-polyphosphate, acidic sodium polyphosphate or metal-chelating agent as ethylenediaminetetraacetate, Aminotrimethylene phosphate and salts thereof, hydroxyethylene diphosphonates and salts thereof, ethylenediaminetetramethylenephosphonate and salts thereof, diethylenetriaminepentamethylenephosphonate and salts thereof.

Polymers that can be used in the patch for tooth attachment of the present invention include polyalkylvinyl ether-maleic acid copolymers (PVM/MA copolymer; Gantrez AN 119, AN139, S97), polyvinyl alcohol, polyacrylic acid, poloxamer 407 (Poloxamer 407; Pluronic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, polyethylene oxide (Polyox), polyvinylpyrrolidone-vinyl acetate copolymer (PVP/VA copolymer; Luviskol VA, Plasdone S PVP/VA), polyvinylpyrrolidone (PVP;K-15~K120), polyquaternium-11 (Gapquat 755N), polyquaternium-39 (polyquaternium-39, Merquat plus 3330) , Carboxypolymethylene (Carbomer, Carbopol), gelatin, alginic acid (sodium alginate) alone or a mixture thereof can be used.

In order to rapidly release the active ingredients included in the patch comprising one or more layers of the present invention, it may further include a polymer that is hydrophilic and has good solubility in water. The polymer may be carboxymethyl cellulose, xanthan, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, fluran, or a mixture thereof.

In order to flexibly bend the patch of the present invention along the curved surface of the teeth, polypropylene glycol, glycerin or polyethylene glycol, castor oil, hydrogenated castor oil castor oil).

The patch for attaching a tooth of the present invention may be a patch for attaching a tooth of a multi-layer structure that further includes a new layer above or below the above-mentioned whitening component-containing layer, for example, such a new layer is a fragrance, a bleach activator, a gum disease improving agent, It may contain various ingredients such as fruit tree stabilizer.

According to further embodiments of the present invention, the patch of the present invention may further include a support layer for a role of preventing contact with other skin in the oral cavity.

For the purpose of the support layer, the support layer may be mainly composed of non-soluble materials such as polyethylene and ethyl cellulose, and may further include components such as plasticizer and oil.

The patch for tooth attachment according to the present invention may further include a release liner attached to the drug delivery layer to be removed prior to use.

Patch for tooth attachment according to the present invention, for example, can be prepared by the method disclosed in U.S. Patent Nos. 6,682,721, 6,689,344, 6,780,401, 6,946,142, etc. It is not limited to.

The gel composition for adhesion of the present invention can stably attach a patch for tooth attachment to a tooth surface. The adhesive strength of the tooth whitening patch can be measured using a universal test machine (UTM), and the adhesive force is in the range of 55 gf/cm 2 to 400 gf/cm 2, preferably 60 gf/cm 2 to 350 gf/cm 2 , More preferably 63 gf/cm 2 to 330 gf/cm 2.

If the adhesion between the adhesive gel of the present invention applied to the surface of the tooth and the patch for tooth attachment is less than 55 gf/cm 2, the patch may not be properly attached to the tooth surface, and thus there may be a problem that delivery of an active ingredient is difficult, and 400 gf If it exceeds /cm 2, it may be difficult to remove the patch from the tooth surface, which may cause a problem that a residue may remain on the tooth surface.

The present invention improves the adhesion of the patch for tooth attachment, and provides a composition for adhesion of a gel formulation with improved usability.

The composition for adhesion of the gel formulation may further include a tooth whitening component activator to further improve the whitening effect of the tooth whitening patch.

The kit for teeth whitening of the present invention has the advantage of improving the adhesion of the patch for tooth attachment and increasing the convenience of use, thereby effectively delivering the active ingredient to a desired site.

Hereinafter, examples and the like will be described in detail to help understanding of the present invention. However, the embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be interpreted as being limited to the following examples. The embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

<Production of whitening patch>

A first agent (gel agent) and a second agent (patch agent) having the following composition were prepared.

The first agent of Examples 1 to 6 of the present invention was dissolved in iron chloride, silica, and sodium saccharin in purified water and an alcohol mixed solution, and then PVP and glycerin were added and stirred for 20 minutes. Sodium saccharin was added and vacuum degassed for 10 minutes.

The first agent of Comparative Example 1 was prepared using only purified water as a solvent instead of a mixture of purified water and alcohol, and the first agent of Comparative Example 2 was prepared using only ethanol as a solvent.

The second agent was prepared as in Example 2 of U.S. Patent No. 6,682,721.

The content of Table 1 is shown in weight percent.

division Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Gel Iron chloride 0.5% Iron chloride 0.5% Iron chloride 0.5% Iron chloride 0.5% Iron chloride 0.5% Iron chloride 0.5% Iron chloride 0.5% Iron chloride 0.5% Glycerin 5% Glycerin 5% Glycerin 5% glycerin
5% glycerin
5% glycerin
5% glycerin
5% glycerin
5% Silica 9% Silica 9% Silica
9% Silica
9% Silica
9% Silica
9% Silica
9% Silica
9% Sodium saccharin 1% Sodium saccharin 1% Sodium saccharin 1% Sodium saccharin 1% Sodium saccharin 1% Sodium saccharin 1% Sodium saccharin 1% Sodium saccharin 1% PVP 10% PVP 10% PVP
10% PVP
10% PVP
10% PVP
10% PVP
10% PVP
10% Purified water to 100% Ethanol to 100% ethanol
10% ethanol
20% ethanol
30% ethanol
40% ethanol
50% ethanol
60% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Patch Hydrogen peroxide 3% Hydrogen peroxide 3% Hydrogen peroxide 3% Hydrogen peroxide 3% Hydrogen peroxide 3% Hydrogen peroxide 3% Hydrogen peroxide 3% Hydrogen peroxide 3% PVP 10% PVP 10% PVP 10% PVP 10% PVP 10% PVP 10% PVP 10% PVP 10% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% SAPP 0.5% SAPP 0.5% SAPP 0.5% SAPP 0.5% SAPP 0.5% SAPP 0.5% SAPP 0.5% SAPP 0.5% Pullulan 5% Pullulan 5% Pullulan 5% Pullulan 5% Pullulan 5% Pullulan 5% Pullulan 5% Pullulan 5% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100%

<Measurement of adhesion of the kit for whitening teeth of the present invention>

After preparing the artificial dental specimen and adding water in advance, the surface is wiped off to form a wet state, and after about 1 minute of applying the gel of the same composition as Comparative Examples 1 to 2 and Example 1, the patch is attached. After applying the force for a period of time with a constant force, the force required to detach the patch was measured using a universal tester.

Pre-load: 1gf

Pre-load speed: 2mm/s

Test speed: 5mm/s

division Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Need 50gf/㎠ 15gf/㎠ 65gf/㎠ 120gf/㎠ 280gf/㎠ 305gf/㎠ 310gf/㎠ 270gf/㎠

As shown in Table 2, compared to Comparative Example 1 using only purified water as a solvent and Comparative Example 2 using only ethanol as a solvent, Examples 1 to 6 were found to require more force when removing the attached patch. .

These results are believed to support the prediction that patch attachment will be easier when using a mixed solvent of water and ethanol.

In particular, different results were obtained depending on the mixing ratio of ethanol and water, and in the case of Example 5 in which the ratio of ethanol: purified water was about 2:1, it was shown that the most force was required to remove the patch.

Claims (8)

A gel composition applied to teeth,
The gel composition contains water and ethanol as a solvent for forming a gel in the composition,
Gelled using a polymer that is soluble in both water and ethanol,
A gel composition applied to a tooth comprising a tooth whitening component active agent selected from the group consisting of a divalent or trivalent metal catalyst, a pH adjusting agent, and mixtures thereof. The method of claim 1, wherein the polymer is soluble in both water and ethanol is carboxymethyl cellulose (carboxymethyl cellulose), carboxypropyl cellulose (carboxypropyl cellulose), hydroxyethylcellulose (hydroxyethylcellulose), hydroxypropylcellulose (hydroxypropylcellulose), hydroxy Any one cellulose selected from the group consisting of hydroxypropylmethylcellulose, and hydroxypropylethylcellulose;
Any gum selected from the group consisting of xanthan gum, guar gum, carrageenan gum, arabic gum, and alginate gum; And
Polyvinylalcohol, poloxamer, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate copolymer (polyvinylpyrrolidone/vinylacetate copolymer), polyacrylic acid, carbopol ), polyalkyl vinyl ether-maleic acid copolymer (PVM/MA copolymer) and a gel composition applied to a tooth, characterized in that at least one selected from the group consisting of polyox (polyox) synthetic polymer. 3. The gel composition of claim 2, wherein the polymer is polyvinylpyrrolidone. The gel composition of claim 1, wherein the content of water in the gel composition is 10 to 70% by weight based on the total weight of the composition, and the content of ethanol is 5 to 70% by weight based on the total weight of the composition. The method of claim 1, wherein the divalent or trivalent metal catalyst is any one selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, iron gluconate, iron chloride, manganese sulfate, manganese gluconate, manganese chloride and manganese citrate. Gel composition applied to the teeth characterized in that the above. The tooth of claim 1, wherein the pH adjusting agent is at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate and EDTA-4Na. Gel composition applied to. (a) water and ethanol in the gel composition as a solvent for forming a gel,
Gelled using a polymer that is soluble in both water and ethanol,
A gel composition applied to teeth, comprising a tooth whitening component active agent selected from the group consisting of a divalent or trivalent metal catalyst, a pH adjusting agent, and mixtures thereof; And
(b) a tooth whitening component and optionally a tooth whitening component stabilizer, comprising a patch for tooth whitening having one or more layered structures
Kit for whitening teeth. The method of claim 7, wherein in using the kit,
The gel composition applied to the tooth is applied to the tooth surface, and then the patch for whitening the tooth is attached,
Kit characterized in that the adhesive strength of the gel composition applied to the tooth and the whitening patch is 55 gf/cm 2 to 400 gf/cm 2.