KR101983824B1 - Tooth patch comprising anti-transfer layer - Google Patents

Abstract

The present invention relates to a multi-layered patch for attaching teeth to a tooth, wherein the patch according to the present invention is a patch for preventing tooth whitening component contained in one layer from being transferred to another layer not containing a tooth whitening component Prevention layer is included. The patch for dental attachment according to the present invention can solve the problem that the whitening effect of the product is lowered as a result of the teeth whitening component being diffused and consequently lowered in concentration.

Description

Tooth patch comprising anti-transfer layer < RTI ID = 0.0 >

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a patch for attaching to a tooth, and more particularly to a patch for attaching a tooth which can stably maintain the effect of the patch (particularly the whitening effect) during storage.

In recent years, as interest in beauty has increased, interest in tooth whitening has also been increasing. As a result, whitening agents containing whitening ingredients are being developed. A representative formulation of these whitening agents is a whitening patch that can attach to the teeth.

Various studies have been carried out to transmit an effective ingredient to a tooth using a whitening patch. For example, in combination with a drug (whitening component) delivery layer containing a tooth whitening component, the whitening component can be effectively delivered to the teeth, the promotion of the effect of the whitening component can be promoted, or the stability of other components A patch of a multi-layer structure including an additional layer other than the above-mentioned drug (whitening component) transfer layer has been studied for various reasons such as prevention of deterioration.

Such a multi-layered whitening patch has an advantage in that it can achieve a desired effect through various designs such as improving the stability of an active ingredient such as a whitening ingredient as compared with a whitening patch comprising only a drug delivery layer containing an active ingredient . For example, there is an advantage that a new layer can be added above and below the layer which does not contain peroxide so as not to react with the peroxide, the fragrance, the bleaching activator,

However, in the case of such a multi-layer tooth whitening patch, there is a problem that the whitening effect deteriorates over time.

On the other hand, in the whitening patch, the drug layer needs to have an appropriate thickness. If the thickness of the drug layer is thin, the whitening efficiency may be lowered because the contact area between the patch layer and the interdental spaces and the curved face of the teeth becomes smaller in a whitening patch deformed into a gel shape. On the other hand, if the thickness of the drug layer is large, the amount of the fruit juice is increased, and the time for the fruit juice to reach the mucous membrane in the oral cavity increases, so that the stimulation is increased and the time required for releasing the drug is increased The whitening effect can not be obtained efficiently.

Thus, there has been a need for a tooth whitening patch that can prevent dilution of whitening ingredients caused by diffusion of whitening patches during distribution or use while having a constant thickness.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a tooth whitening patch capable of stably maintaining a tooth whitening effect of a tooth whitening patch during storage.

That is, the present invention is to provide a tooth whitening patch capable of stably preserving and using a tooth whitening component while maintaining a constant thickness while preventing dilution of the whitening component.

In order to solve the above problems, the present invention provides a multi-layered tooth attaching patch comprising at least one layer, wherein the active ingredient contained in one layer (in particular, hydrogen peroxide) And a transfer preventing layer for preventing transfer of the patch.

The present inventors have found that in a tooth whitening patch having a multilayered structure, the whitening component is transferred to another layer during storage of the product, particularly when the whitening component is hydrogen peroxide, these components are transferred to the other layer, And a water-insoluble transition preventing layer capable of preventing the whitening component (in particular, hydrogen peroxide) contained in the patch from being transferred to the other layer, It is possible to keep the whitening effect of the product for a long time by holding it in between the other layers.

That is, in the present invention, whitening of a tooth is extremely effective in whitening the fruit with intensive contact with the tooth within a short period of time. In the present invention, deformation (deformation) of an appropriate patch is made to fit the curved surface of the tooth, Can be applied to the teeth intensively.

One layer constituting the dental patch of the present invention is a drug delivery layer containing an active ingredient, and the drug delivery layer may include a drug that is transferred to the surface of the teeth or between the teeth and the teeth. Generally, a tooth whitening agent can be used, and a peroxide can be used as a tooth whitening agent. In particular, for the purpose of the present invention, hydrogen peroxide is used as a tooth whitening agent. For example, the drug delivery layer may include a peroxide (preferably hydrogen peroxide), an adhesive polymer, etc., and may further include a surfactant, a stabilizer, a flavoring agent, a colorant, a pH adjuster, and the like.

The peroxides that can be used in the patch of the present invention include hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, Tetrasodium pyrophosphate peroxidate or a mixture thereof may be used. However, for the purpose of the present invention, the tooth whitening patch of the present invention preferably contains hydrogen peroxide as a whitening component.

The patch of the present invention may further include a stabilizer optionally in order to further enhance the stability of the peroxide. That is, the metal-complex agent having excellent compatibility with the peroxide can be used to further improve the stability. In the present invention, stabilizers having good compatibility with peroxide include tetrasodium pyrophosphate, sodium acid pyrophosphate, sodium hexametaphosphate, and sodium tripolyphosphate as condensed polyphosphates, Sodium potassium tripolyphosphate, tetrapotassium pyrophosphate, acidic sodium meta-polyphosphate, acidic sodium polyphosphate or metal chelating agents include ethylene diamine tetraacetate, Aminotrimethylene phosphate and salts thereof, aminotrimethylene phosphate and salts thereof, hydroxyethylenediaphosphonate and salts thereof, ethylenediamine tetramethylene phosphonate and salts thereof, diethylenetriaminepentamethylenephosphonate and salts thereof.

As a polymer having a tooth sticking property, it has to have a property of being hydrated by water, so it should be a hydrophilic polymer or at least a hydrophilic polymer. Examples of commonly used polymers include polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer: Gantrez AN 119, AN139, S97), polyvinyl alcohol, polyacrylic acid, Poloxamer 407 (Pluronic, poly (ethylene oxide) triblock copolymer, polyethylene oxide, polyvinylpyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), poly (PVP; K-15 to K120), polyquaternium-11, Gafquat 755N, polyquaternium-39, Merquat plus 3330, Carbomer, Carbopol ), Gelatin, sodium alginate alone or a mixture thereof may be used. As the solvent of these polymers, water, ethanol alone or a mixture thereof, and other organic solvents such as ethyl acetate, methylene chloride, isopropyl alcohol, acetonitrile alone or a mixture thereof may be used in a controlled manner .

The drug delivery layer of the present invention may further include a polymer which is further hydrophilic and soluble in water to rapidly release the active ingredients contained in the drug delivery layer of the present invention. The polymer may be selected from the group consisting of carboxymethyl cellulose, xanthan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, pluran, and mixtures thereof.

In order to flexibly bend the patches of the present invention along the curved surface of the teeth, it is possible to use polypropylene glycol, glycerin or polyethylene glycol, castor oil, hydrogenated castor oil castor oil) may be added.

The patch for dental attachment of the present invention is a multilayered patch for dental attachment that further comprises a new layer above or below the above-described whitening component-containing layer. For example, the new layer may contain a perfume, a bleaching activator, And the like.

The present invention is intended to solve the problems that may occur in a patch for attaching a tooth forming a multilayer structure as described above.

As used herein, the term " transition " refers to the phenomenon in which an active ingredient is transferred from one layer to another. That is, the drug (whitening component) delivery layer is made of a water-soluble polymer in order to effectively deliver the drug. In this case, the whitening component or the like may be transferred from the drug delivery layer to another layer.

In order to solve the above problems, the whitening patch of the present invention further comprises a transition preventing layer comprising a water-insoluble polymer. More preferably, the whitening patch of the present invention further comprises a transition preventing layer comprising a water-insoluble polymer and a plasticizer.

The transition preventing layer is made of a water-insoluble polymer to prevent the peroxide from transferring to another layer.

The water-insoluble polymer may be selected from the group consisting of polyvinyl acetate, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer), methacrylic acid copolymer, polyester, polyurethane, polyethylene, May be used, and ethylcellulose is most preferred for the purposes of the present invention.

The transition prevention layer may be formed of polypropylene glycol, glycerin or polyethylene glycol, castor oil, or the like in order to flexibly bend the patch along the curved surface of the tooth, ), Hydrogenated castor oil, and the like can be added.

The transition preventing layer may have a thickness of 10 to 70 占 퐉, preferably 15 to 50 占 퐉, more preferably 20 to 40 占 퐉. The components contained in the patch can be effectively transferred to the gap between the teeth and the teeth while preventing the transition of the peroxide at the above thickness.

According to further embodiments of the present invention, the patch of the present invention serves to support the drug delivery layer and the second layer, wherein the drug delivery layer or the second layer is in contact with other skin in the oral cavity other than the teeth The support layer may further include a support layer.

The support layer may be composed mainly of a non-decomposable material such as polyethylene or ethyl cellulose for the purpose of the support layer, and may further include components such as plasticizer and oil.

The patch for dental attachment according to the present invention may further comprise a release liner attached to the drug delivery layer to be removed before use.

The patch for dental attachment according to the present invention can be produced by, for example, the methods disclosed in U.S. Patent Nos. 6,682,721, 6,689,344, 6,780,401, 6,946,142, etc., .

The present invention can prevent the active ingredients contained in one layer (in particular, the peroxide, more preferably the hydrogen peroxide solution) from being transferred to the other layer in the patch for tooth attachment in a multi-layer structure.

Particularly, the thickness of the tooth whitening patch is kept constant, and the whitening component is uniformly transmitted to the surface of the tooth, thereby reducing the time taken for the fruit to reach the oral mucosa, thereby alleviating the irritation.

The present invention can keep the effect of whitening component (in particular, hydrogen peroxide solution), which is an effective component, the same as that immediately after preparation even if it retains its effects for a long time while retaining the advantages of the patch for attachment to a multilayer structure.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments of the invention and, together with the description of the invention, It should not be construed as limited.
Figure 1 shows a typical patch for tooth attachment made of a multi-layer structure.
FIG. 2 is a schematic view showing a state where a transition prevention layer is attached to one surface of a drug delivery layer according to an embodiment of the present invention. FIG.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

<Preparation of whitening patch>

Was prepared as in Example 2 of U.S. Patent No. 6,682,721 so as to have the following composition and thickness.

1. Preparation of Comparative Example

Each of the liquids having the composition shown in the following Table 1 was prepared, and then one layer was dried and then applied / dried so as to have a thickness of 100 탆. Then, two layers were applied / dried in the same manner so as to have a total thickness of 200 탆, .

2. Preparation of Example

Each of the liquids having the composition shown in Table 1 below was prepared, and one layer was dried and then applied / dried so as to have a thickness of 100 탆. Then, 3 layers of 30 탆 and 2 layers of 70 탆 were successively applied / dried, Mu m, and was laminated with a PE film (support layer).

The contents of the following Table 1 are expressed in% by weight.

Comparative Example Example First floor The drug substance (hydrogen peroxide solution) 5% The drug substance (hydrogen peroxide solution) 5% The water-soluble polymer (PVP) 13% The water-soluble polymer (PVP) 13% glycerin 5% glycerin 5% Polyphosphate (SAPP) 0.5% Polyphosphate (SAPP) 0.5% Phosphoric acid 0.1% Phosphoric acid 0.1% Pullulan 5% Pullulan 5% water to 100% water to 100% 3rd Floor - EC 22% Castor Oil 8% ethanol to 100% Second floor The water-soluble polymer (PVP) 13% The water-soluble polymer (PVP) 13% Polyphosphate (SAPP) 0.5% Polyphosphate (SAPP) 0.5% glycerin 10% glycerin 10% Pullulan 5% Pullulan 5% water to 100% water to 100%

<Peroxide content of whitening patch versus total hydrogen peroxide content>

The release solution was taken every 5 minutes in the whitening patches prepared according to Examples and Comparative Examples, and the concentration of hydrogen peroxide was measured.

1) Measurement of hydrogen peroxide released immediately after production

Immediately after the whitening patches of the comparative examples and the examples having the composition shown in Table 1 were prepared, the content of hydrogen peroxide released into water was measured every 5 minutes while dissolving in water.

The results of the experiment below are the ratio of the content released relative to the initial hydrogen peroxide content.

Time (minutes) 5 10 15 20 25 30 Comparative Example (%) 8 32 49 57 73 79 Example (%) 9 32 48 59 72 80

2) Measurement of hydrogen peroxide released after one month

One month after each preparation of the whitening patches of the comparative examples and the examples having the composition shown in Table 1, the content of hydrogen peroxide released into water in 5 minutes was measured while dissolving in water.

The results of the experiment below are the ratio of the content released relative to the initial hydrogen peroxide content.

Time (minutes) 5 10 15 20 25 30 Comparative Example (%) 5 12 20 32 43 50 Example (%) 9 32 48 59 72 80

According to the results shown in Table 2, it can be seen that there is no clear difference in the amount of hydrogen peroxide released from the whitening patch prepared according to the comparative example and the example immediately after the production. However, as shown in Table 3, it can be seen that the patches of Examples emit a large amount of hydrogen peroxide more rapidly than the Comparative Example after one month has elapsed from the production. It was thought that the amount of hydrogen peroxide lost due to stabilization of the drug delivery layer containing hydrogen peroxide by the added transition inhibiting layer was small.

<Measurement of change in tooth brightness value>

The whitening patch prepared in the above Comparative Examples and Examples was attached to an artificially colored HAP disk immediately after preparation and removed after a certain period of time (30 minutes), and the change amount of the brightness value was measured and shown in Table 4.

In addition, the whitening patches prepared in the above-mentioned Comparative Examples and Examples were attached to a HAP disc artificially colored after 1 month, and then removed after a predetermined time (30 minutes), and the change amount of the brightness value was measured and shown in Table 5.

1) Measurement of change of brightness value after attaching immediately after manufacturing

Comparative Example Example The amount of change in brightness (? L) 20.35 20.89

2) Measurement of change of brightness value after attaching 1 month after manufacture

Comparative Example Example The amount of change in brightness (? L) 13.57 21.39

As shown in Table 4, there was no significant difference in the change of tooth brightness value after the application immediately after manufacture. However, as shown in Table 5, when the patches were attached to the colored test pieces one month after the production, it was found that the brightness variation of the comparative example was not large compared to the examples.

The above results are considered to be due to the higher concentration of peroxide delivered to the colored teeth, and it is considered that the peroxide is stabilized by the transition prevention layer included in the embodiment.

10: drug delivery layer
20: non-drug layer
30: Support layer
40: peeling layer
50: Transition preventing layer

Claims (11)

A layer comprising a tooth whitening component;
A layer not containing a tooth whitening component; And
A transition preventive layer is provided between the layer containing the tooth whitening component and the layer not containing the tooth whitening component,
Wherein the transition preventing layer comprises a water-insoluble polymer,
The water-insoluble polymer may be at least one selected from the group consisting of polyvinyl acetate, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer), methacrylic acid copolymer, polyester, polyurethane, polyethylene, Of the tooth surface of the tooth. The patch of claim 1, wherein the tooth whitening component is a peroxide. The method according to claim 2, wherein the peroxide is at least one selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, sodium peroxide pyrophosphate tetrasodium pyrophosphate peroxidate, or a mixture thereof. delete The tooth attaching patch of claim 1, wherein the transition preventing layer comprises a water-insoluble polymer and a plasticizer. delete The tooth attaching patch according to claim 1, wherein the water-insoluble polymer is ethyl cellulose. 6. The tooth attaching patch of claim 5, wherein the plasticizer is castor oil, hydrogenated castor oil, or a mixture thereof. The tooth attachment patch according to claim 8, wherein the plasticizer is castor oil. The tooth attaching patch according to claim 1, wherein the transition preventing layer has a thickness of 10 to 70 占 퐉. The tooth whitening component according to any one of claims 1 to 3 and 5, wherein the patch further comprises a release liner removed before use, the release layer being attached to the layer comprising the tooth whitening component Wherein the patch is a tooth.

Images