KR102187824B1 - Gel composition for adhesiving teeth surface and kit comprising the same - Google Patents

Abstract

The present invention provides a composition used before applying a tooth whitening patch or composition containing peroxide, a composition for attaching a tooth surface in a gel formulation containing a metal ion catalyst and a phosphate, and a tooth whitening kit comprising the same. The present invention provides a composition capable of reducing oral irritation and tooth damage while having an improved tooth whitening effect, and a kit including the same.

Description

Gel composition for adhesiving teeth surface and kit comprising the same}

The present invention relates to a composition for attaching a gel to a tooth surface and a kit including the same, and more particularly, to a composition capable of reducing irritation and tooth damage while having an excellent tooth whitening effect, and a kit including the same.

Recently, as the public's interest in beauty has increased, the public's interest in teeth whitening is increasing. Options for whitening teeth include toothpaste, mouthrinse, chewing gum, indoor whitening, and tooth whitening solutions using trays purchased from most common stores or dentists. Tooth whitening solutions typically contain active ingredients that bleach teeth, such as hydrogen peroxide.

Hydrogen peroxide is an unstable substance, and its activity continues to decrease over time. Therefore, a typical tooth whitening product maintains its activity by using a hydrogen peroxide stabilizer in order to prevent the activity of hydrogen peroxide from falling during distribution.

When actually using a tooth whitening agent, there may be a problem in that hydrogen peroxide does not properly display activity due to such a stabilizer, and thus, rapid activity of hydrogen peroxide is induced by using a catalyst.

However, in addition to the positive aspect that the catalyst induces the activity of a tooth whitening agent, there is a problem of causing dental caries and an irritation sensation. In particular, a catalyst such as iron chloride is dissolved in water and has acidity, so tooth caries due to low pH This becomes even more problematic.

Therefore, research is being conducted on a method capable of reducing tooth damage and oral irritation while inducing the activity of the tooth whitening component.

Accordingly, an object of the present invention is to provide a tooth whitening pretreatment composition and a tooth whitening kit capable of solving the above problems and alleviating tooth damage and irritation caused by temporary decomposition of hydrogen peroxide.

In addition, it is intended to obtain an increased tooth whitening effect by preventing the phenomenon that the whitening effect is lowered due to stabilization of the tooth whitening component.

In addition, the present invention is to improve the symptoms of aching while alleviating the irritation that may be caused by the decomposition of hydrogen peroxide.

In order to solve the above problems, the present invention provides a composition of a tooth surface attachment gel formulation comprising a metal ion catalyst and a phosphate as a composition used before applying a tooth whitening patch or composition containing peroxide.

Peroxide, which is mainly used as a tooth whitening component, needs to be stabilized in the distribution state in order to increase the whitening effect, and immediately exhibit activity at the time of use.

Therefore, for the immediate activation of tooth whitening components such as hydrogen peroxide, a method has been proposed in which a catalyst is first applied to the teeth in the form of a gel for pretreatment of teeth whitening and then a whitening patch is used thereon. However, this method may cause irritation due to excessive catalytic action, and may also have a problem of causing dental caries.

The inventors of the present invention completed the present invention while researching a method for activating a tooth whitening component by a catalyst and alleviating tooth damage and irritation.

The composition for attaching a tooth surface of the present invention may be used before attaching a patch including a tooth whitening component to the tooth surface.

The tooth surface attachment composition includes a metal ion catalyst serving as a whitening component activator to activate the tooth whitening component.

The metal ion catalyst can act to promote the activity of teeth whitening ingredients, and prevents the tooth whitening activity from being inhibited by a stabilizer that can be used to stabilize the whitening ingredients during product distribution and induces excellent whitening effects. Can be used to

The tooth whitening component activator may include components for activating peroxides generally used in the industry, and is not particularly limited thereto. However, preferably, a divalent or trivalent metal catalyst may be included.

The divalent or trivalent metal catalyst may accelerate the decomposition of peroxide. The divalent or trivalent metal catalyst may preferably release calcium, magnesium, manganese, copper, iron or potassium ions, more preferably magnesium chloride, magnesium gluconate, iron lactate, iron gluconate, iron chloride, Manganese sulfate, manganese gluconate, manganese chloride, and manganese citrate may be used, and most preferably, iron chloride is most preferable in terms of enhancing the teeth whitening effect and achieving the object of the present invention.

The components that release metal ions used as catalysts dissolve in water to show acidity, and among them, iron chloride dissolves in water and shows strong acidity.Therefore, there is a problem that causes tooth caries more strongly due to low pH. there was.

Accordingly, the inventors of the present invention intend to provide a pretreatment composition for tooth whitening that can prevent the oral pH from being lowered by the catalyst and reduce tooth damage.

The pretreatment composition for tooth whitening of the present invention further includes a phosphate.

As the phosphate, in particular, tripotassium phosphate capable of releasing potassium ions (K ₃ PO ₄ ), dipotassium hydrogen phosphate (K ₂ HPO ₄ ), potassium dihydrogen phosphate (KH ₂ PO ₄ ), or a mixture thereof may be used. , Preferably, tripotassium phosphate may be used.

The phosphate, especially potassium phosphate capable of releasing potassium ions, prevents the pH of the oral cavity from lowering due to the metal catalyst, thereby preventing tooth damage, corrosion, and demineralization. In addition, since the stabilization of tooth whitening components such as hydrogen peroxide is prevented and decomposition is promoted, an improved whitening effect can be expected.

The phosphate may be used 3 to 20 times, preferably 5 to 15 times, more preferably 5.5 to 13 times, based on the weight of the tooth whitening component activator.

When used in the above ratio, the composition may be alkaline, and is most preferred to achieve the object of the present invention.

In order to achieve the object of the present invention, the composition of the phosphate-containing gel formulation for tooth surface attachment preferably has an alkalinity of pH 8 to 11.

In addition, the potassium component released from the phosphate fills the dentinal tubules, which can also be expected to relieve ache.

The pretreatment composition for tooth surface attachment may preferably have a gel formulation in order to prevent dripping when applied to teeth and to increase adhesion to teeth.

The gel formulation includes a viscous liquid formulation, and is used in a broad sense including a state in which fluidity is lost compared to the liquid formulation.

In order to have a gel formulation, the pretreatment composition may further include a water-soluble polymer and a solvent, and may further include components such as an abrasive and an emulsifier.

Polymers that can be used to play a role of tooth adhesion are polyalkyl vinyl ether-maleic acid copolymer (PVM/MA copolymer, Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, Poloxamer (poly( ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer), polyethylene oxide (Polyox), polyvinyl pyrrolidone-vinyl acetate copolymer (PVP/VA copolymer; Luviskol VA, Plasdone S PVP/VA) ), polyvinyl pyrrolidone (PVP, K15 ~ K-120), Polyquaterium-11 (Gafquat 755N), Polyquaterium-39 (Merquat plus 3330), carboxypolymethylene (Carbopol), hydroxy propyl methyl cellulose, hydroxy ethyl Cellulose, Hydroxypropyl Cellulose, Gelatin, Sodium Alginate, or mixtures thereof. As these solvents, mainly water, ethanol alone or a mixture thereof, and other organic solvents such as ethyl acetate, methylene chloride, isopropyl alcohol, acetonitrile alone or a mixture thereof may be used in a controlled ratio.

The abrasive is selected from precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, anhydrous calcium monohydrogen phosphate, hydrous alumina, light calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate, aluminum silicate, or mixtures thereof. You can use either.

According to another embodiment of the present invention, in a kit for whitening teeth, (a) a composition for attaching a tooth surface in a gel formulation containing a metal ion catalyst and a phosphate; And (b) in contact with the tooth surface attachment composition, and provides a kit for teeth whitening comprising a tooth whitening patch containing peroxide.

According to another embodiment of the present invention, the kit may further include a means for applying the composition for attaching the tooth surface of the gel formulation to the tooth surface, and preferably may have a shape such as a brush or a sponge.

The tooth whitening patch may be manufactured in the form of a patch that can be attached to the tooth surface, and the tooth attachment patch according to the present invention, for example, US Patent Nos. 6,682,721, 6,689,344, 6,780,401, 6,946,142 Although it may be manufactured by the method disclosed in the above, the present invention is not limited to the components and manufacturing method of such a patch.

The whitening ingredients are hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, tetrasodium pyrophosphate peroxidate, It may contain one or more selected from sodium bicarbonate and chlorine-based bleach, preferably from hydrogen peroxide, urea peroxide, calcium peroxide, and sodium pyrophosphate peroxidate. It may be one or more selected, and more preferably hydrogen peroxide or urea peroxide.

The tooth whitening component may include 0.01% to 50% by weight, preferably 0.1% to 30% by weight, and most preferably 0.5% to 20% by weight based on the total weight of the patch.

The tooth whitening component may be mixed with a stabilizer.

The stabilizers include sodium pyrophosphate, acidic sodium pyrophosphate, sodium metaphosphate, sodium polyphosphate, sodium pyrophosphate, potassium pyrophosphate, ultra metaphosphate, acidic sodium polyphosphate, ethylenediaminetetraacetate, aminotrimethylene phosphate, and its Salts, hydroxyethylenediphosphonate and salts thereof, ethylenediaminetetramethylenephosphonate and salts thereof, diethylenetriaminepentamethylenephosphonate and salts thereof, alkyl aryl sulfonates, alkyl sulfonate salts, alkyl carboxylates Salt, alkyl diphenyl oxide disulfonate, Span 20 (Sorbitan Monolaurate), Span 40 (Sorbitan Monopalmitate), Span 60 (Sorbitan Mono stearate), Span 80 (Sorbitan Monooleate) , Span 85 (Sorbitan Trioleate), Tween (POE sorbitan fatty acid ester) system, and at least one selected from the group consisting of a mixture thereof.

The patch is a polypropylene glycol, glycerin or polyethylene glycol, castor oil, hydrogenated castor oil in order to flexibly bend along the curved surface of the tooth. ) And other plasticizers may be added.

The gel composition for attaching teeth of the present invention can further improve the whitening effect of a patch including a tooth whitening component.

The present invention provides a tooth whitening gel composition and a tooth whitening kit capable of minimizing tooth damage and irritation while activating a tooth whitening component to enhance a tooth whitening effect.

In particular, the present invention can improve the symptoms of aching while alleviating the irritation that may be caused by the decomposition of hydrogen peroxide.

1 is a graph showing changes in brightness compared to the initial period of tooth specimens.

Hereinafter, in order to describe the present invention in more detail, it will be described with reference to the following examples. However, the embodiments according to the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided by way of example to aid in a specific understanding of the present invention.

<Examples and Comparative Examples>

A kit for whitening teeth according to the present invention was prepared in the composition ratio as shown in Table 1 below, and the unit is shown in% by weight.

The gel (gel) agent of the present invention was prepared according to the following procedure.

After dissolving iron chloride in purified water, ethanol and silica were added to confirm that the silica was completely dispersed, and povidone was added and stirred for 20 minutes.

In the case of the comparative example, it was prepared in the same manner as in the example except for the added components.

In addition, the patch for attachment for whitening teeth used hydrogen peroxide as a whitening component as follows, and was prepared as in Example 2 of US Patent No. 6,682,721.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 The first agent (gel agent) effective substance - - Iron chloride 0.5% 0.5% iron chloride Tripotassium Phosphate 4.0% The first agent (gel agent)
Additive material Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Silica 10% Silica 10% Silica 10% Silica 10% Povidone 10% Povidone 10% Povidone 10% Povidone 10% Ethanol 10% Ethanol 10% Ethanol 10% Ethanol 10% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Second agent (patch) effective substance - Hydrogen peroxide
3.0% Hydrogen peroxide
3.0% Hydrogen peroxide
3.0%

Test example 1. Change in brightness

1) Experiment method

Comparative Examples 2, 3 and Example 1 were each attached to an artificially colored HAP disk, removed after 1 hour, and the amount of change in brightness compared to the initial was measured and expressed as ?L.

2) Experiment result

Compared to Comparative Example 2 using a gel containing no effective substance, an increased whitening effect can be seen in Comparative Example 3 using a gel containing iron chloride, compared to Example 1 using a gel containing iron chloride and tripotassium phosphate. It was able to confirm a more improved whitening effect than Example 3. That is, it was confirmed through an experiment that when tripotassium phosphate was used together with iron chloride, a more excellent tooth whitening effect was obtained, and these results are shown in FIG. 1.

Test example 2. teeth Caries Experiment on prevention

1) Experiment method

After measuring the initial hardness of the lozenge specimen by using the Vickers hardness, Comparative Examples 1 to 2 and Examples 1 to 2 were treated for 1 hour on each specimen, and then the hardness was measured again to calculate the degree of change in hardness.

2) Experiment result

division Hardness change Comparative Example 1 18.38 ±4.79 Comparative Example 2 49.83 ±5.64 Comparative Example 3 187.81 ±5.72 Example 1 62.15 ±4.94

As shown in Table 2, when iron chloride was used alone, the amount of change in hardness was greatest. It is believed that this is because the gel agent containing iron chloride has a greater effect on tooth wear compared to other Comparative Examples and Examples.

On the other hand, it was found that Example 1, which included both iron chloride and tripotassium phosphate, significantly reduced the amount of change in hardness to 1/3 level. This is thought to be because tripotassium phosphate contained in the gel prevents the oral pH from lowering due to metal catalysts such as iron chloride, thereby preventing damage or corrosion of teeth.

Claims (10)

A composition used before applying a tooth whitening patch or composition containing peroxide,
It is a composition for attaching a tooth surface of a gel formulation containing a metal ion catalyst and a phosphate,
The phosphate is tripotassium phosphate (K ₃ PO ₄ ), dipotassium hydrogen phosphate (K ₂ HPO ₄ ), potassium dihydrogen phosphate (KH ₂ PO ₄ ), or a mixture thereof. The composition of claim 1, wherein the metal ion catalyst releases divalent or trivalent metal ions in an aqueous solution state. The method of claim 1, wherein the metal ion catalyst is at least one selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, iron gluconate, iron chloride, manganese sulfate, manganese gluconate, manganese chloride and manganese citrate. Composition. delete The composition of claim 1, wherein the metal ion catalyst is iron chloride, and the phosphate salt is tripotassium phosphate. The composition of claim 1, wherein the composition is a gel formulation having a pH of 8-10. In the kit for whitening teeth,
(a) a composition for attaching a tooth surface in a gel formulation comprising a metal ion catalyst and a phosphate; And
(b) a kit for tooth whitening comprising a tooth whitening patch in contact with the tooth surface attachment composition and containing peroxide,
The phosphate is tripotassium phosphate (K ₃ PO ₄ ), dipotassium hydrogen phosphate (K ₂ HPO ₄ ), potassium dihydrogen phosphate (KH ₂ PO ₄ ), or a mixture thereof. The kit according to claim 7, wherein the kit further comprises means for applying the tooth surface attachment composition to the tooth surface. The kit according to claim 7, wherein the metal ion catalyst is iron chloride, and the phosphate is tripotassium phosphate. The method of claim 7, wherein the peroxide is hydrogen peroxide, urea carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, and sodium peroxide pyrophosphate. Kit, characterized in that at least one selected from the group consisting of (tetrasodium pyrophosphate peroxidate).

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