KR101999666B1

KR101999666B1 - Removable tooth-attached patch by brushing

Info

Publication number: KR101999666B1
Application number: KR1020150127721A
Authority: KR
Inventors: 안재현; 김종훈; 오광호; 이인호
Original assignee: 주식회사 엘지생활건강
Priority date: 2015-09-09
Filing date: 2015-09-09
Publication date: 2019-07-12
Also published as: KR20170030312A

Abstract

The present invention relates to a patch for dental attachment, which comprises a drug layer for delivering a drug to a tooth and a support layer which is located on the opposite side of the tooth adhesion surface of the drug layer and which simultaneously contains a water soluble polymer and a water insoluble polymer. The patch of the present invention can be easily removed only by brushing without removing the support layer separately.

Description

Removable tooth-attached patch by brushing < RTI ID = 0.0 >

The present invention relates to a tooth attachable patch which can be removed by brushing, and more particularly, to a tooth attaching patch which can be easily removed only by brushing without removing a support layer supporting the drug layer.

Background Art [0002] Procedures such as whitening of teeth have been mainly performed in dentistry in the past, but dental procedures are cumbersome and costly and expensive, so that a product that can be easily used recently has been developed.

Tooth whitening products include toothpaste, mouthrinse, chewing gum, oral trays, gels for oral application, oral patches, etc. However, patch type products are most frequently used in consideration of convenience of use .

The patch for dental attachment generally includes a drug layer containing a drug for the purpose of use such as a tooth whitening drug, a drug for preventing or ameliorating sickness, and a support layer for allowing the drug component to be selectively transferred to the teeth .

Patent No. 10-0458337 proposes that the support layer be made water-insoluble such that the drug component contained in the patch can be selectively transferred to the teeth only. However, patches containing such a water-insoluble support layer are troublesome to remove the remaining support layer after use of the product. On the other hand, when the toothbrush is removed without removing the toothbrush, the undegraded film chunk is entangled with the toothbrush, which makes it difficult to remove the toothbrush from the toothbrush. Although the product was developed to dissolve in the oral cavity after the patch was attached, the drug component was not selectively transferred to the teeth and mixed with the saliva, resulting in the problem that the intended drug efficacy was not expressed.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems, and provides a tooth attaching patch which can be easily removed from the tooth surface only by brushing, and the undegraded film lump is not clogged between the toothbrushes.

The present invention provides a simple patch for attaching a tooth, which does not generate any waste after use and can be removed simply by brushing.

In order to solve the above-mentioned problems, the present invention provides a tooth patch patch, comprising: a support layer of a patch for attaching a tooth, which is capable of selectively moving a drug of a drug layer selectively to a tooth surface in a patch for attaching a tooth or a peripheral portion of a tooth, Soluble polymer and a water-insoluble polymer at the same time, it can be easily decomposed and removed only by the same pressure as the brushing after use, and the present invention has been completed.

Most patch delivery drug delivery systems, particularly dental patches, have a backing layer to allow delivery of the drug specifically to the target site. It is possible to maintain the shape even when attached to the teeth using the polymer which is not dissolved in the above water or saliva. In addition, when the active ingredient is dissolved in the tooth and transferred to the tooth, it can be released only in the direction of the tooth. That is, it has been common that the drug is selectively delivered to the direction of the teeth and is made to be water-impermeable or water-insoluble so as to prevent the drug from being diluted with saliva or water.

This water-impermeable or water-soluble support layer had to be removed from the tooth surface after use of the patch.

The inventors of the present invention intend to search for a method of delivering a drug to the surface of a tooth only with a toothbrush without removing the support layer and to achieve a perfect finish after removing the support layer after use, and then cleaning the tooth surface to remove the residue remaining on the tooth surface. As a result, the present invention has been completed.

That is, in the industry, the drug support layer that has been manufactured and used only in the water insolubility has been manufactured in a form that can be dissolved by the saliva.

Specifically, the inventors of the present invention provide a patch for attaching a tooth or a peripheral portion of a tooth, which comprises a drug layer for delivering a drug to a tooth and a support layer which is located on the opposite side of the tooth adhesion surface of the drug layer and which simultaneously contains a water soluble polymer and a water- do.

The drug layer may comprise a drug delivered to the teeth. The medicament can be preferably delivered to the surface of the teeth. Examples of the medicament include a tooth whitening component, a component for preventing or improving rhinorrhea, a component for preventing or improving periodontal disease such as periodontitis, gingivitis, can do.

The tooth whitening component includes peroxides, polyphosphates, enzymes, and chlorine bleaching agents. The peroxides may be selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, tetrasodium pyrophosphate peroxidate, and mixtures thereof. And can be selected from the group constituted. Phosphates and enzymes are effective in removing the main stain contained in the enamel adhesion layer. Examples of polyphosphates include tetrasodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP), sodium hexametaphosphate (SHMP), sodium tripolyphosphate (STP) One or two of sodium potassium tripolyphosphate (SKTP), tetrapotassium pyrophosphate (TKPP), and acidic sodium meta-polyphosphate and acidic sodium polyphosphate, which are ultraphosphates, More than species can be used. In general, polyphosphate is known to be effective in inhibiting tartar formation and tartar removal in toothpaste. In addition, they can be a good chelating agent for metals, which can effectively remove tooth stains generated by metals such as iron, calcium, and magnesium in the food or working environment in the stain of teeth, thereby contributing to improvement of whitening effect. When these polyphosphates are used in the preparation according to the present invention, it is possible to improve not only the whitening effect due to the removal of light extrinsic stain but also the contact time between the teeth and the condensed phosphate, . Chlorine-based whitening agents include sodium chlorite, sodium hypochlorite and the like. In addition, papain, vitamin E and sodium bicarbonate can also be used as a whitening agent.

In another embodiment, strontium chloride, calcium carbonate, sodium citrate, sodium fluoride, silica, hydroxyapatite, potassium nitrate, potassium phosphate and the like may be used as preventive or remedy for acylation or as a component for preventing cavities.

In another embodiment, the active ingredient may include a periodontal disease preventive component. Periodontal disease clinically refers to loss of teeth due to periodontitis, gingival inflammation and hemorrhage, formation of periodontal pockets, and destruction of alveolar bone. In order to prevent the occurrence of periodontal disease, the effective layer may be selected from the group consisting of bamboo salt, corn-deficient quantitative extract, polycrysulene, tetracycline, chlorhexidine gluconate, cetylpyridium chloride ), Sanguinarine and Triclosan, and the like, such as Cucurbitaceae, Centella asiatica, Chamomile, Latania, Myrrh, Manganese, Horse riding, Green tea, Licorice, Herbal extracts.

The drug layer is preferably a dry type in which the adhesive layer is hydrated by a small amount of water at a desired site where the whitening agent works, However, it can be used in a gel state that can be attached to teeth by its own viscosity. The polymer used herein should be hydrophilic or at least partially hydrophilic. Polymers such as polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer: Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, Poloxamer 407 (Pluronic, poly (ethylene oxide) -poly (ethylene oxide) -poly (ethylene oxide) triblock copolymer, polyethylene oxide, polyvinylpyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA) , Polyvinylpyrrolidone (PVP; K-15 to K-120), polyquaternium-11, Gafquat 755N, polyquaternium-39, Merquat plus 3330, Hydroxypropylmethylcellulose, hydroxypropylcellulose, gelatin, sodium alginate, or a mixture thereof may be used. As the solvent of these polymers, water, ethanol alone or a mixture thereof, and other organic solvents such as ethyl acetate, methylene chloride, isopropyl alcohol, acetonitrile alone or a mixture thereof may be used in a controlled manner .

The dental attachment should be flexible enough to be attached directly to the tooth and easily shaped according to the flexion of the tooth. Depending on the polymer, this plasticity may be poor, so a suitable plasticizer may be added. Suitable plasticizers are polypropylene glycol, glycerin, or polyethylene glycol which are generally used although they differ depending on the kind of polymer and the prescription, and both of them are usable.

A chelating agent such as EDTA or sodium citrate may be added to the drug layer for the purpose of improving the stability with time of the peroxide.

As used herein, the term "drug layer" refers to a layer containing a pharmaceutical active ingredient capable of achieving the purpose of a patch for tooth attachment. For example, a tooth whitening patch means a layer containing a tooth whitening component (preferably, hydrogen peroxide, sodium peroxide, etc.), and a silylation preventing patch means a layer containing potassium nitrate, potassium chloride, etc. do.

The support layer used to protect the drug layer from physical and chemical contact such as saliva, oral contact, etc., or to maintain the shape of the product is generally preferably a water-insoluble polymer in order to serve as a support layer, Has been recognized in the industry. However, the inventors of the present invention have devised a method for easily removing the water-soluble polymer by simply brushing the water-soluble polymer without peeling off the water-soluble polymer.

As used herein, "support layer" means a layer that serves to prevent contact with other skin in the oral cavity other than the teeth.

In one embodiment of the present invention, the support layer may comprise a water-insoluble polymer generally used in oral films, such as cellulose acetate phthalate, shellac, polyvinylacetate, ethylcellulose, polymethylmethacrylate Methacryloylethyl betaine / methacrylate copolymer, methacrylic acid copolymer (Eudragit L 100, Eudragit L 12, 5, Eudragit), methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer: Eudragit L 30D-55, and aminoalkyl methacrylate copolymer (Eudragit E 100, Eudragit E 12,5, Eudragit RL 100, and Eudragit RL 30D). In addition, the supporting layer of the patch for adhering the tooth or tooth periphery of the present invention comprises a water-soluble polymer. As used herein, a water-soluble polymer means a polymer that can be dissolved in water, swelled, or dispersed in small particles. A hydrophilic polymer may also be used in the same sense as the water-soluble polymer of the present invention.

The water-soluble polymer may include a water-soluble polymer that can be used in a drug layer, and may be a polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer: Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, , Poloxamer 407 (Pluronic, poly (ethylene oxide) -poly (ethylene oxide) triblock copolymer), polyethylene oxide (Polyox), polyvinylpyrrolidone-vinyl acetate copolymer (PVP / VA copolymer, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP; K-15 to K-120), polyquaternium-11, Gafquat 755N, polyquaternium- polyquaternium-39, Merquat plus 3330, carbomer, Carbopol, hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, gelatin, sodium alginate, , Preferably hydroxypropyl methacrylate Cellulose, polyvinylpyrrolidone is available money or a mixture thereof.

The weight ratio of the water-soluble polymer and the water-insoluble polymer contained in the support layer may be 1: 4 to 4: 1, and preferably 1.5: 4 To 3.5: 4 by weight.

When the water-soluble polymer and the water-insoluble polymer are in the same weight ratio as above, the patch can be decomposed well while the structure of the patch is maintained stably while being removed after use.

The support layer can be used by adding various plasticizers for the same reasons as the drug layer. In addition to the above-mentioned plasticizers, propylene glycol, glycerin, and polyethylene glycol, more kinds of plasticizers can be used depending on the solvent used, and castor oil and hydrogenated castor oil can be used.

As the solvent, water, ethanol alone or a mixture thereof, and other organic solvents such as ethyl acetate, methylene chloride, isopropyl alcohol, acetonitrile alone or a mixture thereof may be used in a controlled manner.

In addition to the drug layer and the support layer, the patch for adhering the tooth or the teeth of the present invention may further include a layer between the drug layer and the support layer or each of the outskirts, depending on the purpose.

According to one embodiment of the present invention, the patch for attaching the tooth or the peripheral portion of the tooth of the present invention can be easily removed from the tooth by brushing alone without removing the support layer separately after use.

The patch according to an embodiment of the present invention was brushed for 3 minutes per minute at a load of 250 g and washed with distilled water. The washing solution was collected and examined with a mesh having a sieve size of 1 mm. The residue was dried to determine the total weight To less than 2% by weight. The tooth attaching patch of the present invention can be easily removed only by brushing after use.

A patch comprising the drug layer and the support layer of the present invention can be attached to teeth. In another embodiment, the patch may be attached to the teeth and tissues surrounding the teeth according to the purpose of use of the patch. As used herein, " tooth periphery or surrounding tissue " may include both the portion of the gum that is in contact with the tooth and the portion of the mouth that can be in contact with the toothbrush in the process of brushing, albeit somewhat distant from the tooth.

By "decomposition" it is meant that one large piece is divided or broken into smaller pieces. The disassembled pieces of the present invention may have a certain size, but may be divided into various sizes depending on external forces or pressures. Any word that has the meaning of being divided into several parts can be included in the scope of equivalence of the present invention.

As used herein, the term "patch" refers to an adherent formulation containing a specific ingredient, and the form or structure of the patch is not particularly limited.

Further, the patch for dental attachment according to the present invention can be manufactured according to the method described in Korean Patent No. 10-0816250, US Patent No. 6,689,344, No. 6,682,721, No. 6,780,401, and the like.

The tooth attaching patch of the present invention is a tooth attaching patch in a convenient use form that does not need to remove the support layer while selectively releasing the drug to the tooth surface.

The patch of the present invention can be disassembled and removed with only light brushing.

The patch of the present invention may contain various drugs depending on the purpose.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments of the invention and, together with the description of the invention, It should not be construed as limited.
Fig. 1 shows the results of a questionnaire survey on the ease of removal of a patch (example) having a support layer containing starch of the present invention and a patch having a water-insoluble support layer (comparative example). As can be seen in FIG. 1, the users using the patch of the embodiment obtained higher scores.
2 is a view exemplarily showing a patch 1 for a tooth attachment of the present invention. As shown exemplarily in Figure 2 (a), may be a patch comprising a drug layer 10 and a support layer 20 and may be a patch between the drug layer 10 and the support layer 20, as shown in Figure 2 (b) Another layer 30 may be separately provided according to purposes.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to facilitate a specific understanding of the present invention. Unless specifically stated otherwise, the percentages recited herein are understood to mean% by weight.

A teeth whitening patch of the comparative example having the composition shown in the following Table 1 and a tooth whitening patch of the example having the composition shown in the following Table 2 were prepared. Was prepared according to the method for preparing the backing layer and drug reservoir layer of Preparation Example 1 of Korean Patent No. 10-0816250.

Comparative Example 1 Comparative Example 2 Effective layer Hydrogen peroxide 2.9%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Hydrogen peroxide 2.9%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Support layer Ethyl Cellulose 15.0%
Castor oil 10.0%
Ethanol etc to 100% Povidone 15.0%
Glycerin 3.0%
Pullulan 1.0%
Water etc. to 100%

Example 1 Example 2 Example 3 Example 4 Effective layer Hydrogen peroxide 2.9%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Hydrogen peroxide 2.9%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Hydrogen peroxide 2.9%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Hydrogen peroxide 2.9%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Support layer Ethyl Cellulose
12.0%
Hydroxypropylmethyl cellulose 3.0%
Castor oil 15.0%
SPAN80 5.0%
Ethanol etc to 100% Ethyl Cellulose
3.0%
Hydroxypropylmethyl cellulose 12.0%
Castor oil 5.0%
SPAN80 15.0%
Ethanol etc to 100% Ethyl Cellulose 12.0%
Povidone 3.0%

Castor oil 15.0%
SPAN80 5.0%
Ethanol etc to 100% Ethyl Cellulose 3.0%
Povidone 12.0%

Castor oil 5.0%
SPAN80 15.0%
Ethanol etc to 100%

Example 5 Example 6 Effective layer Potassium phosphate monobasic 2.0%
Potassium secondary phosphate 3.0%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Bamboo salt 3.0%
Corn sterilized quantitative extract 0.5%
Povidone 19.0%
Glycerin 3.0%
Pullulan 1.0%
SPAN80 5.0%
Water etc. to 100% Support layer Ethyl Cellulose 6.0%
Hydroxypropylmethyl cellulose 8.0%
Castor oil 15.0%
SPAN80 5.0%
Ethanol etc to 100% Ethyl Cellulose 7.0%
Hydroxypropylmethyl cellulose 8.0%
Castor oil 5.0%
SPAN80 15.0%
Ethanol etc to 100%

Except for Comparative Example 2, which dissolves during use, The comparative example 1 and the examples 1 to 6, which require a post-use removal process, were subjected to a questionnaire on ease of removal. The 30 respondents were allowed to attach the patches of Comparative Example 1 and Examples 1 to 6 for 15 minutes according to the groups, and then Comparative Example 1 or Examples 1 to 6 were removed by brushing. Each group then responded to a questionnaire on the ease of removal after changing the product.

- Based on survey responses -

5: Removal is very convenient and the toothbrush is not clogged.

4: Removal is convenient, but there is a little residue on the toothbrush.

3: Removal is inconvenient and the toothbrush remains uncomfortable.

2: Removal is inconvenient and there is a lot of residue in the toothbrush.

1: Removal is very inconvenient and there is a lot of residue on the toothbrush.

As shown in FIG. 1, in Comparative Example 1, the majority of the researchers evaluated that the toothbrush was left with a lot of residue and the removal was very inconvenient. However, the investigators using the embodiments of the present invention rated that the majority of them were easy to remove through brushing and very little residue was left.

The tooth patch of the present invention was conveniently removed upon brushing after use and was found to be clean without clumping and clinging on the toothbrush.

Two sets of Comparative Example 1 and Examples 1 to 6 were prepared. Each set was shaken in distilled water for 30 minutes to leave only the support layer. Then, the weight was measured and the other set was attached to a slide glass. After holding for 30 minutes in the environment, a brushing machine was used for 3 minutes at a speed of 90 g / min. The slide glass, brushing chamber and toothbrush were then removed and washed with distilled water to collect the wash solution. The thus collected washing solution was filtered with a mesh having a sieve size of 1 mm, and the residue was dried and weighed to determine the ratio of the residue to the total weight of the supporting layer.

Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Residual rate (% by weight) 98.6 1.6 0.8 1.9 0.6 0.5 0.4

As shown in Table 4, it was confirmed that the patch of the comparative example had a ratio of the residue of 98% or more and was hardly decomposed by brushing. However, in the case of the patch having the support layer in which the water-soluble polymer of the present invention was mixed, it was confirmed that the residual ratio was less than 2%, and most of the patches were broken down by brushing.

1: Patch
10: drug layer
20: Support layer

Claims

A drug layer that delivers the drug to the teeth; And
Soluble polymer and a water-insoluble polymer at the opposite side of the tooth adhesion surface of the drug layer,
Wherein the tooth is removed by brushing.

The water-soluble polymer according to claim 1, wherein the water-soluble polymer is selected from the group consisting of a polyalkyl vinyl ether-maleic acid copolymer, polyvinyl alcohol, polyacrylic acid, Poloxamer 407, polyethylene oxide, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinylpyrrolidone, Polyvinylpyrrolidone, polyquaternium-11, polyquaternium-39, carboxypolymethylene, hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, gelatin, and alginic acid. A tooth or a tooth patch attached to the periphery of the tooth.

The patch of claim 2, wherein the water-soluble polymer is hydroxypropylmethylcellulose, polyvinylpyrrolidone, or a mixture thereof.

The toothbrush of claim 1, wherein the weight ratio of the water-soluble polymer and the water-insoluble polymer contained in the support layer is 1: 4 to 4: 1, Or patches for perimeter attachment.

The method according to claim 1, wherein the drug layer comprises at least one selected from the group consisting of a tooth whitening component, a component for preventing or improving rhinorrhea, a component for preventing dental caries, and a component for preventing periodontal disease Patch for tooth or tooth perimeter attachment.

[6] The tooth whitening composition of claim 5, wherein the tooth whitening component is at least one peroxide selected from the group consisting of hydrogen peroxide, peroxide, calcium peroxide, sodium percarbonate, sodium perborate, sodium pyrophosphate peroxide and mixtures thereof;
At least one polyphosphate selected from the group consisting of sodium pyrophosphate, sodium pyrophosphate, sodium metaphosphate, sodium polyphosphate, potassium sodium pyrophosphate, potassium pyrophosphate, ultrametaphosphate being ultraphosphate, and acid polyphosphate; Or a mixture thereof. &Lt; RTI ID = 0.0 > 14. < / RTI >

6. The method according to claim 5, wherein the component for preventing or improving cavitation or cavities is at least one selected from the group consisting of strontium chloride, calcium carbonate, sodium citrate, sodium fluoride, silica, hydroxyapatite, potassium nitrate, A tooth or a tooth patch attached to the periphery of the tooth.

[Claim 6] The method of claim 5, wherein the periodontal disease prevention component is at least one selected from the group consisting of bamboo salt, corn-deficient quantitative extract, polycrysullerene, tetracycline, chlorohexidine gluconate, cetylpyridinium chloride, Wherein the at least one patch is at least one selected from the group consisting of Telia asia trica, chamomile, latania, myrrh, alabaster, horseradish, green tea, licorice, gold, porpoise, and gold and silver.

The brush of claim 1, wherein the patch is brushed for 3 minutes at a rate of 90 reciprocations per minute at a load of 250 g, and the dry weight of the residue filtered on a 1 mm mesh is less than 2% by weight based on the total weight of the pre- A tooth or a perineal patch for attachment.