KR20200059342A - Antibacterial Nonwoven Dressing - Google Patents

Abstract

The present invention relates to an antibacterial non-woven fabric dressing which comprises: a first cover member including a plurality of pores and brought into contact with a wound; an antibacterial membrane laminated on the first cover member, including a plurality of pores, and formed by the accumulation of nanofibers containing water-soluble polymers dissolving in exudate secreted from the wound, synthetic polymers, and antibacterial substances released by means of dissolution of the water-soluble polymers; and a second cover member laminated on the antibacterial membrane, including a plurality of pores, and exposed to the air. The antibacterial membrane includes: a support member; a first membrane member disposed close to the wound, and formed on one surface of the support member by the accumulation of nanofibers containing water-soluble polymers, synthetic polymers, and antibacterial substances; and a second membrane member preventing the exudate secreted from the wound from passing through while enabling only the external air to pass through, and formed on the other surface of the support member by the accumulation of nanofibers containing synthetic polymers. The first membrane member is formed in a multi-layered structure and each layer is formed by the accumulation of nanofibers containing water-soluble polymers, synthetic polymers, and antibacterial substances. The amount of the water-soluble polymers increases as the layer is getting closer to the wound.

Description

Antibacterial Nonwoven Dressing

The present invention relates to an antimicrobial non-woven dressing, and more particularly, by slowly releasing the antibacterial substance using a water-soluble polymer dissolved in exudate, reducing the amount of the antibacterial substance contacting the wound to relieve pain while anti-bacterial properties on the wound side It relates to a wound antibacterial non-woven dressing that can maximize.

In general, when a wound is generated, after wound disinfection is performed, the dressing for wound healing is sufficiently covered with a medical tape according to the amount of exudate generated in the wound, and then fixed with medical tape.

Wound treatment dressing protects the wound, absorbs exudate, promotes hemostasis, and supports the wound. It covers the wound surface, which is a skin defect due to burns, wounds, bedsores and trauma, and speeds healing. Improves.

Recently, research on dressing to provide an optimal healing environment has been continuously conducted, and there is a need for development of a dressing capable of imparting various functions.

In Korean Patent Publication No. 2010-0021108, a nanofiber member containing silver nanoparticles; an exudate absorbing member stacked on top of the nanofiber member; And a cover member formed of a semi-transmissive film and stacked over the exudate absorbing member, wherein the nanofiber member containing silver nanoparticles is electrospun a spinning solution containing a fiber-forming polymer and a silver (Ag) metal salt. Thus, an antibacterial dressing laminate is disclosed, characterized in that it consists of nanofibers made in a web form having a fiber diameter of less than 1 μm, so that a dressing having antibacterial activity can be realized, but silver nanoparticles are bound and fixed to nanofibers of the nanofiber member. There is a disadvantage that the nanoparticle-containing nanofiber member exhibits an antibacterial effect only at the stacked position of the laminate, and the antibacterial properties on the wound surface are insignificant.

The present invention has been devised in view of the above points, and its purpose is to include a water-soluble polymer that can be dissolved in exudate secreted from the wound and an antimicrobial material that is slowly released by dissolving the water-soluble polymer in the nanofibers of the membrane, to the wound. It is to provide an antimicrobial nonwoven dressing that can maximize the antimicrobial properties on the wound surface while reducing pain by reducing the amount of antibacterial material to be contacted.

Another object of the present invention is to provide an antibacterial nonwoven dressing capable of adsorbing ionic foreign substances, bacteria, and viruses of heavy metals that penetrate outside the dressing.

In order to solve the above problems, the present invention has a plurality of pores are formed, the first cover member in contact with the wound; the exudate that is bonded to the first cover member, a plurality of pores are formed and secreted from the wound An antimicrobial membrane made by accumulating nanofibers containing a water-soluble polymer, a synthetic polymer, and an antimicrobial substance released by dissolving the water-soluble polymer; And a second cover member that is laminated to the antibacterial membrane, has a plurality of pores, and is exposed to the outside air. Including, The antibacterial membrane, Support member; A first membrane member formed by accumulating nanofibers containing water-soluble polymers, synthetic polymers, and antibacterial substances on one side of the support member; And a second membrane member that is made by accumulating nanofibers made of synthetic polymer on the other surface of the support member, and allows the exudate secreted from the wound not to pass, but to pass only outside air, and the first membrane member. Is formed of a multi-layered structure and each layer is made by accumulating nanofibers containing a water-soluble polymer, a synthetic polymer, and an antibacterial substance, and the layer closer to the wound increases the content of the water-soluble polymer to produce an antibacterial nonwoven fabric. It is about dressing.

In addition, the present invention provides an antibacterial non-woven dressing characterized in that the antibacterial material is one of silver nanomaterials, silver particles, and natural antibacterial materials.

In addition, the present invention provides an antibacterial nonwoven dressing, wherein the first and second cover members are one of a nonwoven fabric, a fabric, and a mesh.

In addition, the present invention provides an antibacterial nonwoven dressing, wherein the first and second cover members are one of a nonwoven fabric, a fabric, and a mesh.

In addition, the present invention provides an antibacterial nonwoven dressing characterized in that the support member is one of a nonwoven fabric, a fabric, and a mesh.

According to the present invention, the antimicrobial membrane made by accumulating nanofibers containing a water-soluble polymer and an antibacterial substance is implemented as a dressing for wound healing, whereby the water-soluble polymer is dissolved in exudate secreted from the wound, and the antibacterial substance is gradually released, It has the advantage of improving the antibacterial properties on the wound surface while reducing pain by reducing the amount of antimicrobial substances in contact with the wound.

According to the present invention, it is possible to prevent a large amount of antibacterial material from coming into contact with a wound by controlling the content of the water-soluble polymer of the laminated structure to control the rate at which the antibacterial material is released.

According to the present invention, a nanofiber web made by accumulating nanofibers containing dopamine with functional groups attached thereto, or a nanofiber web made by accumulating ion-exchanging nanofibers is included in the dressing, and ions of heavy metals penetrating outside the dressing It has the advantage of adsorbing foreign substances, bacteria and viruses.

According to the present invention, the membrane member having excellent breathability is included in the dressing to provide an optimal wetting environment, so that substances involved in healing, such as polynuclear leukocytes, macrophages, proteolytic enzymes, and cell growth factors contained in exudate are external By not being discharged or dried, it is possible to efficiently perform wound healing.

1 is a conceptual diagram of the present invention antibacterial dressing nonwoven fabric.
Figure 2 is a table showing the deodorant results of the present invention

Hereinafter, a preferred embodiment of the present invention will be described in detail. First, in describing the present invention, detailed descriptions of related known functions or configurations are omitted so as not to obscure the subject matter of the present invention.

As used herein, the terms 'about', 'substantially', etc. are used in the sense of or close to the numerical values when manufacturing and material tolerances unique to the stated meaning are presented, and to understand the present invention. To help, accurate or absolute figures are used to prevent unscrupulous use of unintentional infringers by the disclosure.

Referring to Figure 1, the antibacterial dressing 100 according to the present invention has a plurality of pores are formed, the first cover member 110 in contact with the wound; The first cover member (110) is laminated, a plurality of pores are formed, and the water-soluble polymer dissolved in the exudate secreted from the wound, synthetic polymer and released by dissolving the water-soluble polymer (release) to exhibit antibacterial properties

Antibacterial membrane 120 made by accumulating nanofibers containing an antibacterial substance to burn out; And a second cover member 130 that is laminated to the antimicrobial membrane 120, has a plurality of pores, and is exposed to the outside air.

Therefore, the present invention, by slowly dissolving the water-soluble polymer contained in the nanofibers of the antimicrobial membrane 120 in the exudate, the antimicrobial substances contained in the nanofibers are slowly released, thereby contacting a small amount of the antimicrobial substances to the wound, thereby reducing pain. While doing so, it is possible to maximize antibacterial properties on the inside and the wound surface of the antibacterial membrane 120.

That is, when the silver is coated on the dressing so that excessive silver is released from the silver-coated surface of the antibacterial dressing, the patient may feel a lot of pain due to contact with the excessive silver abnormality, whereas the antibacterial dressing of the present invention is a small amount. The antimicrobial material is released slowly and can help the patient feel the pain by contacting the wound.

The antimicrobial membrane is formed of a nanofibrous web with a number of pores made by accumulating nanofibers obtained by electrospinning a spinning solution of a mixture of water-soluble polymers, synthetic polymers and organic solvents.

The water-soluble polymer is one selected from polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), polyethylene oxide (PEO), carboxyl methyl cellulose (CMC), starch, polyacrylic acid (PAA), and hyaluronic acid. It may contain a mixture of two or more.

The antibacterial material is preferably one of natural antibacterial materials such as silver nanomaterials, silver particles, and chitosan. Here, the silver nanomaterial is a silver (Ag, silver) metal salt such as silver nitrate (AgNO3), silver sulfate (Ag2SO4), or silver chloride (AgCl).

In addition, the silver particles can be used by selecting silver particles having a smaller size than the diameter of the nano fibers so that they can be dispersed in the nano fibers.

The synthetic polymer is capable of electrospinning and is intended to maintain the structure of the antimicrobial membrane 120 even if the water-soluble polymer is dissolved in the exudate and the antimicrobial material is released. The synthetic polymer is not particularly limited as long as it is a resin that can be dissolved in an organic solvent for electrospinning and can form nanofibers by electrospinning. For example, polyvinylidene fluoride (PVdF), poly (vinylidenefluoride-co-safluoropropylene), perfuropolymer, polyvinylchloride, polyvinylidene chloride or copolymers thereof, polyethylene glycol di Polyethylene glycol derivatives including alkyl ethers and polyethylene glycol dialkyl esters, poly (oxymethylene-oligo-oxyethylene), polyoxides including polyethylene oxide and polypropylene oxide, polyvinyl acetate, poly (vinylpyrrolidone- Vinyl acetate), polystyrene and polystyrene acrylonitrile copolymers, polyacrylonitrile (PAN), polyacrylonitrile copolymers including polyacrylonitrile methyl methacrylate copolymer, polymethyl methacrylate, polymethyl methacrylate Acrylate copolymers or mixtures thereof.

In addition, synthetic polymers that can be used include polyamide, polyimide, polyamideimide, poly (meth-phenylene isophthalamide), polysulfone, polyether ketone, polyetherimide, polyethylene telephthalate, polytrimethylene telephthalate, Aromatic polyesters such as polyethylene naphthalate, polytetrafluoroethylene, polydiphenoxyphosphazene, polyphosphazenes such as poly {bis [2- (2-methoxyethoxy) phosphazene]}, polyurethanes and polys Polyurethane copolymers including ether urethane, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, and the like.

Solvents include DMAc (N, N-Dimethyl acetoamide), DMF (N, N-Dimethylformamide), NMP (N-methyl-2-pyrrolidinone), DMSO (dimethyl sulfoxide), THF (tetra-hydrofuran), (EC (ethylene carbonate ), DEC (diethyl carbonate), DMC (dimethyl carbonate), EMC (ethyl methyl carbonate), PC (propylene carbonate), water, acetic acid,

Formic acid, chloroform (Chloroform) dichloromethane (dichloromethane), acetone (acetone) and any one selected from the group consisting of isopropyl alcohol (isopropylalchol) can be used.

The first and second cover members 110 and 130 may be used as one of nonwoven fabrics, fabrics, and meshes.

The antimicrobial membrane of the first embodiment applied to the antibacterial dressing of the present invention is a first membrane member made by accumulating nanofibers containing water-soluble polymers, synthetic polymers, and antibacterial substances on one side of the support member, and synthesized on the other surface of the support member. It can be constructed by laminating a second membrane member made by accumulating nanofibers made of a polymer.

The first and second membrane members are nanofiber webs formed by accumulating nanofibers obtained by electrospinning and having a large number of pores.

 The first membrane member is dissolved in a water-soluble polymer, a synthetic polymer, an antibacterial substance, and an organic solvent to prepare a spinning solution, and the spinning solution can be electrospinned to realize a nanofiber web made by accumulating nanofibers containing antibacterial substances. .

The second membrane member is dissolved in a synthetic polymer and an organic solvent to prepare a spinning solution, and the spinning solution can be electrospun to realize a nanofiber web made by accumulating nanofibers containing the synthetic polymer.

That is, the first membrane member may have excellent antibacterial properties by containing a water-soluble polymer dissolved in an exudate and an released antibacterial substance. Here, the first membrane member 121 is close to the wound.

In addition, the second membrane member is designed to have no effect on the exudate because it does not contain an antibacterial substance and a water-soluble polymer, and an extremely fine pore having excellent air permeability through which only the outside air can pass is formed without passing through the exudate.

Meanwhile, substances involved in healing, such as multinuclear leukocytes, macrophages, proteolytic enzymes, and cell growth factors contained in exudate, are discharged or dried outside in a dry environment, and thus cannot function.

Therefore, the second membrane member having excellent breathability is capable of efficiently performing wound healing by providing an optimal wetting diameter on the wound surface.

The support member can be used as one of non-woven fabric, fabric and mesh.

Referring to FIG. 3, the antimicrobial membrane of the second embodiment applied to the antibacterial dressing of the present invention comprises a first membrane member (a stack of water-soluble polymers, synthetic polymers, and nanofibers containing antimicrobial materials) and a first membrane member. It can be configured by laminating a second membrane member made of nanofibers made of synthetic polymer.

In the antimicrobial membrane of the second embodiment, the first membrane member is formed into a first nanofiber web by electrospinning, and then a second membrane member is formed by electrospinning on the first nanofiber web.

As described above, the antimicrobial membrane of the first embodiment applied to the antibacterial dressing of the present invention has a three-layer structure in which a support member is interposed between the first and second membrane members, and the strength of the antimicrobial membrane is increased and the handleability is increased by the support member. It has the advantage of being improved.

Accordingly, the antimicrobial membrane of the second embodiment has a two-layer structure in which the first and second membrane members are stacked, and a thin antibacterial membrane can be implemented.

4 to 7 are cross-sectional views illustrating variations of the membrane member applied to the antibacterial membranes of the first and second embodiments according to the present invention.

Referring to FIG. 4, the first membrane member of the antibacterial membranes of the first and second embodiments controls the content of the water-soluble polymer to control the rate at which the antibacterial substance is released, thereby preventing a large amount of the antibacterial substance from contacting the wound. have.

That is, in the first membrane member, nanofibers in which each layer contains a water-soluble polymer, a synthetic polymer, and an antibacterial substance are accumulated.

It is composed of at least two or more multi-layered structures, and the more water-soluble polymer content is, the closer to the wound.

Configuration.

For example, as shown in FIG. 4, when the first membrane member is configured in a two-layer stacked structure of the first and second layers), the first layer close to the wound has a higher water-soluble polymer content than the second layer.

In the present invention, a number of pores are formed in the first membrane member, and nanofibers made of nanofibers containing dopamine with functional groups adsorbing ionic foreign substances, bacteria, viruses, etc., penetrated from the outside of the antibacterial dressing are accumulated. A fibrous web, or a nanofiber web made by accumulating ion-exchanging nanofibers, can be further deposited. Here, it is preferable that one surface of the first membrane member is close to the wound, and a nanofiber web is laminated on the other surface of the first membrane member. Of course, the opposite can also exist.

In FIG. 5, a nanofiber web made by accumulating nanofibers containing dopamine is stacked on a first membrane member, and as shown in FIG. 6, a nanofiber web 152 made by accumulating ion-exchange nanofibers is a first membrane member Stacked on.

The nanofiber web 151 made by accumulating nanofibers containing dopamine is a nanofiber web made by electrospinning a spinning solution containing a dopamine monomer or a polymer, a solvent, and a polymer material. Dopamine (DOPAMINE; 3,4-dihydroxyphenylalamine) ) Has a structure in which -NH2 and -OH are bonded to a benzene ring.

Functional groups attached to dopamine contained in nanofibers can be formed by post-treatment processes such as UV irradiation, plasma treatment, acid treatment and base treatment after forming nanofiber webs containing dopamine monomers or polymers. Nanofibrous webs containing dopamine are in a state where functional groups are attached to the nanofibers.

In addition, the nanofiber web 152 made by accumulating ion-exchanging nanofibers is a nanofiber web made by accumulating ion-exchanging nanofibers by electrospinning an ion-exchange solution. It can be defined as a solution synthesized by a synthetic process such as polymerization.

 Here, the ion exchange functional group is a cation exchange functional group selected from sulfonic acid groups, phosphoric acid groups, phosphonic groups, phosphinic groups, carboxylic acid groups, asonic groups, selinonic groups, iminodiacetic acid groups and phosphate ester groups; Or an anion exchange functional group selected from quaternary ammonium groups, tertiary amino groups, primary amino groups, imine groups, tertiary sulfonium groups, phosphonium groups, pyridyl groups, carbazolyl groups and imidazolyl groups.

 It is connected to the spinning nozzle 40, and is spaced apart from the spinning nozzle 40 at a constant speed.

A grounded collector 50 in the form of a moving conveyor is arranged, and the spinning nozzle 40 is connected to a high voltage generator.

The present invention described above is not limited by the above-described embodiments and the accompanying drawings, and various substitutions, modifications and changes are possible within the scope of the present invention without departing from the technical spirit of the present invention. It will be obvious to those who have the knowledge of

Claims (5)

A plurality of pores are formed, the first cover member in contact with the wound;
Nanofibers containing water-soluble polymers, synthetic polymers and antimicrobial substances released by dissolving the water-soluble polymers, which are laminated to the first cover member, have a large number of pores and are soluble in the exudate secreted from the wound Antibacterial membrane made by accumulation; And a second cover member that is laminated to the antibacterial membrane, has a plurality of pores, and is exposed to the outside air. Including,
The antibacterial membrane includes a support member; A first membrane member formed by accumulating nanofibers containing water-soluble polymers, synthetic polymers, and antibacterial substances on one surface of the support member; And a second membrane member that is made by accumulating nanofibers made of synthetic polymer on the other surface of the support member, so that exudate secreted from the wound does not pass, but only through external air.
The first membrane member is formed of a multi-layered structure, and each layer is made by accumulating nanofibers containing a water-soluble polymer, a synthetic polymer, and an antimicrobial material. The layer closer to the wound increases the content of the water-soluble polymer. Features antibacterial non-woven dressing.
According to claim 1,
The antibacterial material is an antibacterial nonwoven dressing, characterized in that one of silver nanomaterials, silver particles, and natural antibacterial materials.
According to claim 1,
The antibacterial material is an antibacterial nonwoven dressing, characterized in that one of silver nanomaterials, silver particles, and natural antibacterial materials.
According to claim 1,
The first and second cover members are non-woven fabric, fabric and mesh (Mesh), characterized in that the antibacterial non-woven dressing.
According to claim 1,
The support member is a non-woven fabric, antibacterial non-woven dressing, characterized in that one of a fabric and a mesh (Mesh).

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