KR102268976B1 - Antibacterial Nonwoven Dressing - Google Patents

Abstract

The present invention relates to an antibacterial nonwoven dressing consisting of an absorbent layer in which a resin is bonded to an activated carbon fiber and a portion of the space between the activated carbon fibers, and metal nanoparticles are bonded to the inside and surface of the resin.

Description

Antibacterial Nonwoven Dressing

The present invention relates to an antibacterial nonwoven dressing, and more particularly, to an absorbent layer characterized by a resin containing metal nanoparticles in a portion of the space between activated carbon fibers, and an antibacterial nonwoven dressing in which nanolayers are laminated on both sides.

In the past, antibacterial drugs were applied directly to wounds on the body. Recently, depending on the type of wound, medical wound dressings such as medical tapes, patches, gelatin film bandages and dressings are used to cover the wound. As a result, the wound is blocked and protected from inappropriate contact with the external environment, thereby preventing infection and reducing pain.

In general, dressings for wound treatment reduce the loss of protein by encapsulating the wound area, reduce the evaporation of heat and loss of moisture from the wound surface, ventilate the skin wound, and prevent contamination of the wound from the external environment. plays an important role. In addition, when plasma is rapidly lost due to bleeding, it also serves to minimize bleeding or loss of plasma.

However, the conventional dressing did not have its own antibacterial ability other than the method of killing bacteria by sterilizing with a high-pressure sterilizer.

Therefore, there is a problem in that the dressing is not completely sterilized at the wound site, when bacteria or contaminants penetrate from the outside, or when the dressing itself is contaminated with bacteria, there is a problem of becoming defenseless against bacterial infection.

Therefore, in order to prevent bacterial contamination of the dressing itself, the manufacturer sterilizes it through an autoclave (gamma sterilization, EO gas sterilization, high temperature/high pressure) and distributes it to various medical institutions. It is very likely that this will happen. Existing wound healing dressings are composed of woven or non-woven fabrics, and the diameter of the fibers used is composed of several tens to hundreds of micrometers, and thus fundamental improvement is required because they are exposed to secondary infections caused by viruses or external contaminants. .

As a method to solve the above-mentioned problems, it is also possible to include silver nanoparticles prepared by injecting silver nanopowder or silver nanoliquid into various dressing materials, and adding silver threads at regular intervals of the inclination in manufacturing the dressing. there was.

In addition to silver, precious metals such as gold, palladium, platinum, copper and zinc are known to effectively kill bacteria in cladding. The use of such noble metals in cladding is also known in numerous references. For example, Robert Edward Burrell et al. (US 6,692,773 B2) discloses the use of noble metals such as silver, gold, palladium or platinum in the form of nanocrystals having a grain size of 100 nm or less, or alloys or compounds thereof. To provide a coating material having an anti-proliferative effect by coating. Widemire (US 5,782, 788) discloses the immobilization of a layer of silver foil on a gauze pad to inhibit the growth of bacteria, viruses and fungi. Fabo (US 5,340,363) discloses a coating material comprising an outer absorbent layer and an inner porous hydrophobic layer woven with elastic yarn and encapsulated by a soft silicone or polyurethane gel, said gel being a carrier for an antimicrobial agent (e.g. zinc). , as a pain-relieving substance and as a substance stimulating wound healing.

A dressing material for a wound that is in direct contact with the wound containing the antibacterial metal and promotes wound healing while protecting the wound is generally divided into a film-type dressing and a foam-type dressing.

While film-based dressings promote wound healing by keeping the wound moist, it can build up too much exudate around the wound and irritate the surrounding skin. In addition, in order to improve moisture permeability, it is necessary to additionally form pores physically/chemically.

On the other hand, in the case of a foam dressing, while excellent in absorbency and moisture permeability, it is difficult to attach to the skin because of its thick thickness and has no elasticity even if it is attached.

Therefore, there is a need to develop a new dressing with improved elasticity and moisture permeability in which activated carbon fibers are used as absorbent materials, silver nanoparticles are impregnated, and thermoplastic polyurethane nanolayers are laminated on the upper and lower surfaces of the activated carbon fibers.

One object of the present invention is to provide a dressing having excellent skin adhesion and elasticity.

Another object of the present invention is to provide a dressing having excellent absorbency and moisture permeability, and excellent deodorization and antibacterial properties.

In order to solve the above problems, the present invention provides an antibacterial nonwoven dressing composed of an absorbent layer in which a resin is bonded to an activated carbon fiber and a part of the space between the activated carbon fibers, and metal nanoparticles are bonded to the inside and surface of the resin. .

In addition, the present invention provides an antibacterial nonwoven dressing, characterized in that a nanolayer composed of nanofibers is laminated on one or both surfaces of the absorbent layer.

In addition, the resin of the present invention is polyurethane (Polyurethane (PU)), polyvinyl chloride (Poly (vinyl chloride) (PVC), acrylonitrile butadiene styrene copolymer (ABS)), polyoxymethylene (poly Oxy Methylene (POM)), polypropylene (PP), polyethylene (PE), polyphenylene oxide (PPO), polybutylene terephthalate (PBT)) , Polyethylene terephthalate (PET), Phenol, Fluorine, Epoxy, Unsaturated Polyester (UP), Polymethlymethacrylate (PMMA), Polyether ether Ketones (Polyetherether ketone (PEEK)), polyphenylene sulfide (PPS), polyamide (PA), polycarbonate (PC)), protein (Protein), poly (aspartic acid) ( Poly(Aspartic Acid)), Poly(L-Lactic Acid), Poly(Glycolic Acid), PLGA, Cellulose, Collagen, Gelatin, Chitin Chitin), provides an antibacterial nonwoven dressing characterized by any one of chitosan.

In addition, the metal nanoparticles of the present invention provide an antibacterial nonwoven dressing, characterized in that the nano-sized gold, silver, palladium, platinum, copper, zinc, or alloys or compounds thereof.

In addition, the present invention provides an antibacterial nonwoven dressing, characterized in that an organic antibacterial agent composed of at least one of alcohol-based, aldehyde-based, phenol-based, amide-based, imidazole-based, azole-based, and halogen-based organic antibacterial agents is added to the absorbent layer. to provide.

In addition, the nanolayer of the present invention is composed of one or more nanofibers, and nanofibers using melt electrospinning are laminated, and provides an antibacterial nonwoven dressing, characterized in that the elongation is 500% to 1,000%.

In addition, the nanofiber of the present invention is any one of a general polymer resin, a biocompatible polymer resin, or a natural polymer resin,

The general polymer resin is polyurethane (Polyurethane (PU)), poly(vinyl chloride) (PVC), acrylonitrile butadiene styrene copolymer (ABS), polyoxymethylene (poly Oxy) Methylene(POM)), polypropylene(PP), polyethylene(PE), polyphenylene oxide(PPO), polybutylene terephthalate(PBT), polyethylene terephthalate Phthalate (Polyethylene terephthalate (PET)), Phenol (Phenol), Fluorine, Epoxy, Unsaturated Polyester (UP), Polymethlymethacrylate (PMMA)), Polyetheretherketone (Polyetherether) ketone (PEEK)), polyphenylene sulfide (Polyphenylene sulfide (PPS)), polyamide (Polyamide (PA)), any one of polycarbonate (Polycarbonate (PC)),

The biocompatible polymer is any one of protein (Protein), poly (aspartic acid) (Poly (Aspartic Acid)), poly (L-Lactic Acid), polyglycolic acid (Poly (Glycolic Acid)), PLGA One, and the natural polymer provides an antibacterial nonwoven dressing characterized in that any one of cellulose (Cellulose), collagen (Collagen), gelatin (Gelatin), chitin (Chitin), chitosan (Chitosan).

In addition, the nanolayer of the present invention is composed of an ultrafine fiber aggregate, and between the ultrafine fibers, small pores having an average diameter of 0.1 μm or more and less than 10 μm and air pores having an average diameter of 10 μm or more and less than 50 μm Antibacterial characterized in that Non-woven dressings are provided.

The dressing material of the present invention is impregnated with silver nanoparticles and a resin that helps the silver nanoparticles to adhere well to the activated carbon fibers, so that the activated carbon fibers with excellent absorbency have excellent antibacterial properties and durability. Therefore, it has excellent moisture permeability and breathability, allowing exudates from wounds to pass through, helping to absorb exudates in another dressing, and has excellent antibacterial durability, so it can be used without changing the dressing for several days.

In addition, the present invention can form a nano-layer by directly electrospinning a polyurethane having non-adhesive properties on the outermost layers of both surfaces of the dressing material in which the activated carbon fibers are impregnated with silver nanoparticles and resin.

In addition, the present invention can provide stability and comfort by serving as an elastic support when used on an injured site due to excellent elongation and elastic restoring force.

1 is an explanatory diagram for the configuration and function of the present invention.
2 and 3 are conceptual diagrams of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. First, in describing the present invention, detailed descriptions of related known functions or configurations are omitted so as not to obscure the gist of the present invention.

As used herein, the terms 'about', 'substantially' and the like are used in or close to the numerical value when manufacturing and material tolerances inherent in the stated meaning are presented, and provide an understanding of the present invention. To help, precise or absolute figures are used to prevent unfair use by unscrupulous infringers of the stated disclosure.

Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings. In describing the present invention, detailed descriptions of related known general-purpose functions or configurations will be omitted.

As used herein, the term “ultrafine fibers” refers to fibers having a diameter of about 0.1 to 10 μm.

“Fiber aggregate” refers to a nonwoven fabric made by arranging fibers in parallel or negative directions without going through a weaving process and mechanically treating the fibers to become entangled with each other.

1 is an explanatory diagram for the configuration and function of the present invention, and Figures 2 and 3 are conceptual diagrams for the present invention.

The present invention relates to an absorption layer in which a resin 30 is bonded to a part of the space between the activated carbon fibers 33 and the activated carbon fibers 33, and metal nanoparticles 31 are bonded to the inside and the surface of the resin 30 ( 10), and if necessary, a nanolayer 20 composed of nanofibers may be additionally laminated on one or both surfaces of the absorption layer.

The activated carbon fiber 33 is a high-performance adsorbent material with a large specific surface area, a fast adsorption rate and a large adsorption capacity, developed by developing micropores of less than 10 Å of carbon fiber. It is possible as a new water treatment agent that can replace activated carbon not only in the gas phase adsorption field but also in the advanced water purification field. In the dressing of the present invention, wound exudate can be quickly absorbed, and various odors from the wound can be removed together.

Since the activated carbon fiber 33 retains the properties of the fiber as it is, it is very convenient to process and handle in the form of woven fabric, non-woven fabric, paper, etc., and thus can be used in various fields, and in the present invention, it can be used as a non-woven fabric or a fiber assembly.

The present invention is a polyurethane resin (30) containing the activated carbon fiber (33) of the nano-sized metal nanoparticles (31) at least any one of gold, silver, palladium, platinum, copper, zinc, or alloys or compounds thereof. ) After impregnating with the solution, the activated carbon fiber to which the metal is attached is dried in a dryer for at least 24 hours.

In addition, as a solvent of the resin solution, a polar solvent such as dimethylacetamide (DMA), dimethyl solfoxide (DMSO), hexamethylphosphoric acid (HMPA), etc. may be mixed and used in addition to water.

Resins are water-soluble or water-soluble resins, and can be used as biocompatible polymer resins and natural polymer resins in addition to general polymer resins.

General polymer resins are polyurethane (Polyurethane (PU)), poly(vinyl chloride) (PVC), acrylonitrile butadiene styrene copolymer (ABS), polyoxymethylene (poly Oxy Methylene) (POM)), polypropylene (PP), polyethylene (PE), polyphenylene oxide (PPO), polybutylene terephthalate (PBT), polyethylene terephthalate (Polyethylene terephthalate (PET)), Phenol, Fluorine, Epoxy, Unsaturated Polyester (UP), Polymethlymethacrylate (PMMA), Polyetherether ketone (PEEK)), polyphenylene sulfide (PPS), polyamide (PA), polycarbonate (PC),

Biocompatible polymers include Protein, Poly(Aspartic Acid), Poly(L-Lactic Acid), Poly(Glycolic Acid), PLGA, etc. ,

Natural polymers include cellulose, collagen, gelatin, chitin, and chitosan.

As the type of metal in the metal nanoparticles 31, silver, gold, silver, palladium, platinum, copper, zinc, or alloys or compounds thereof are possible, all of which are known to effectively kill bacteria in the covering material, and in particular, silver metal is the most antibacterial. effective in

In particular, silver (Ag) can be used as a metal powder, and can also be used as a silver metal salt. As the silver metal salt, silver nitrate, silver sulfate, silver chloride, or the like may be used.

In addition, alcohol-based, aldehyde-based, phenol-based, amide-based, imidazole-based, azole-based, and halogen-based organic antibacterial agents may be mixed with the resin of the absorption layer.

Next, according to the present invention, a nanolayer 20 composed of nanofibers may be laminated on one or both surfaces of the absorbent layer 10 to be used.

According to the present invention, the absorbent layer 10 is impregnated with a solution of the resin 30 containing the metal nanoparticles 31 and then dried, and a portion of the space between the activated carbon fiber fibers inside and on the surface of the absorbent layer 10 is formed with metal nanoparticles ( 31) together with the resin 30 flows in and hardens. It has a structure in which the metal nanoparticles 31 are bonded to the inner and outer surfaces of the cured resin. Accordingly, a part of the inner space of the absorption layer 10 is an empty space and has pores through which air can pass.

In addition, it is preferable that the composition is similar at the lamination interface of the absorber layer 10 and the nanolayer 20, and as a result, there is no need for an additional adhesive or adhesive film, so that the pores of the absorber layer 10 and the nanolayer 20 composed of nanofibers Since the pores do not use a separate adhesive or adhesive film, the continuity of the pores is maintained, which is advantageous for absorbency and breathability.

The nanolayer 20 composed of the nanofibers is laminated with nanofibers through melt electrospinning, and it is characterized in that the elongation rate is 500% to 1,000%.

It is preferable to laminate the nanofibers of the nanolayer 20 by electrospinning with a resin similar to the type of the resin 30 of the absorption layer 10, and the similar type is the resin 30 used in the absorption layer 10. ), nanofibers can also be obtained from general polymer resins, biocompatible polymer resins, and natural polymer resins, and it is preferable to use the same type of resin, and more preferably, it is reasonable to use the same resin.

Melt electrospinning is a technology for producing micro-diameter fibers by spinning a melted fiber raw material in a charged state. The melt electrospinning method does not use a solvent and only uses a polymer melt to produce fibers, so there is no harmful effect due to residual solvent, and in particular, it is useful for using the prepared web as a dressing material for wound treatment.

In this melt electrospinning method, between two electrodes having opposite polarities, one pole of the electrode is located in the spinning nozzle part and the other pole in the collector, the charged polymer melt is discharged into the air through the spinning nozzle part, and then charged in the air. It is a method of manufacturing microfibers by stretching a filament and branching another filament. That is, the charged discharge filament is microscopic while undergoing severe fluctuations due to electrical influences such as mutual repulsion in the electric field formed between the nozzle and the collector.

In this case, the diameter of the ultrafine fibers constituting the ultrafine fiber nonwoven fabric can be adjusted by appropriately adjusting the conditions during electrospinning.

The nanolayer 20 according to an embodiment of the present invention preferably has an average diameter of the microfibers of 0.1 to 10 μm, a weight per unit area of 1.0 g/m 2 to 10 g/m 2, and a thickness of 10 μm to 100 μm. it is preferable

In addition, the nanolayer 20 according to an embodiment of the present invention exhibits excellent moisture permeability characteristics as measured by BS EN 13726-1:2002 for more than 5000 g/m 2 24 hours.

Among the resins used in the present invention, thermoplastic polyurethane can be prepared using a known polyurethane reaction technique. For example, by reacting an excess mole of organic diisocyanate with polyalkylene ether glycol in an amide-based polar solvent to prepare an intermediate polymer having an isocyanate group at the terminal, the intermediate polymer is then dissolved in an amide-based polar solvent and combined with a chain extender A polyurethane polymer can be obtained by reacting a terminator. Thermoplastic polyurethane is thermoplastic due to its large molecular structure of linear structure, and unlike general polyurethane, a chain addition reaction is required to produce thermoplastic polyurethane.

In addition, in order to obtain the linear structure of the thermoplastic polyurethane, MDI having two functional groups is used as a linear polyester polyol made of adipic acid, glycol and butanediol or polytetrahydrofuran. ) and react. The elastomeric properties of the thermoplastic polyurethane are affected by the phase separation that occurs during the polymer chain addition reaction. That is, phase separation occurs from the reaction product of MDI and polyol and MDI and butanediol.

In the production of the hydrophilic polyurethane prepolymer, it is preferably prepared by synthesizing the polyether polyol in a molar ratio of 0.15 to 0.95 to 1 to 3 moles of isocyanate.

As isocyanate, isophorone diisocyanate, 2,4-toluene diisocyanate and its isomers, diphenylmethane diisocyanate, hexamethylene diisocyanate, lysine diisocyanate, trimethylhexamethylene diisocyanate, bis(2-isocyanate ether)-fumarate , 3,3'-dimethyl-4,4'-diphenylmethane diisocyanate, 1,6-hexane diisocyanate, 4,4'-biphenylene diisocyanate, 3,3'-dimethylphenylene diisocyanate, p-phenyl Rendiisocyanate, m-phenylene diisocyanate, 1,5-naphthalene diisocyanate, 1,4-xylene diisocyanate, 1,3-xylene diisocyanate, etc. can be used, Preferably diphenylmethane diisocyanate, 2,4 -Toluene diisocyanate and its isomers, p-phenylene diisocyanate, isophorone diisocyanate, and hexamethylene diisocyanate are better to be used.

Polyether polyols are ethylene oxide/propylene oxide random copolymers having three or more hydroxyl groups in the molecule, molecular weight of 3,000 to 6,000, and ethylene oxide content of 50 to 80%, and two or more hydroxyl groups in the molecule and molecular weight of 1,000 to 4,000. An ethylene oxide/propylene oxide random copolymer having a molecular weight of 3,000 to 6,000 and an ethylene oxide content of 50% to 80%. It is better to use it alone. However, in order to control the physical properties, a mixture of other isocyanate compounds and polyols not mentioned above may be used.

When the thermoplastic polyurethane chip is prepared, the polyurethane chip is spun on the collector by electrospinning under a voltage applied between the spinneret and the collector to form an ultrafine fiber web. At this time, the speed of the collector was spun at a slow speed of 0.5 m/min to 1 m/min to obtain a fibrous web having small pores having an average diameter of 0.1 μm or more and less than 10 μm, and then the speed of the collector was changed from 5 m/min to 10 m. It is possible to obtain a fibrous web having air pores having an average diameter of 10 μm or more and less than 50 μm by spinning at a high speed of /min.

In embodiments of the present invention, the fibrous web including small pores and large pores in a predetermined ratio may be adjusted by adjusting the speed and spinning time of the collector as necessary.

It is also possible to repeat the steps of obtaining a fibrous web having small pores and obtaining a fibrous web having large pores twice or more. These thermoplastic ultrafine polyurethane ultrafine fibers are electrospun and simultaneously fused into a three-dimensional network to form the porous nanolayer 20 . Therefore, it is possible to manufacture the nanolayer 20 of a predetermined thickness even without a substrate.

Hereinafter, the present invention will be described in more detail by way of examples. These examples are intended to illustrate preferred embodiments of the present invention, and the protection scope of the present invention is not limited by these examples.

Example One

After drying 15 g of activated carbon fiber (ACF) with a size of 0.1 mm × 20 mm × 40 mm in an oven at 105° C. for more than 24 hours, it is impregnated in a polyurethane resin solution with silver nanoparticles. For uniform impregnation, the ACF impregnated with silver nano is pushed by using a coating bar. After that, the ACF is placed in an oven at 150° C. and dried for at least 24 hours.

Example 2

Electrospinning is performed directly on the upper and lower surfaces of the absorption layer of Example 1, and the basis weight is adjusted to 1 g/m ² . The electrospinning method is as follows.

Using a thermoplastic polyurethane with an MI (melt index) of 60g/10min at 224℃, managed with a moisture content of less than 100ppm, in a single screw extruder with 40mm and L/D=25, each end is divided into Z1, Z2, and Z3. When doing this, set the temperature of Z1 to 210 to 230°C, the temperature of Z2 to 180 to 190°C, and the temperature of Z3 to 210 to 230°C, and set the temperature of the final spinning beam to 200°C and the gear pump speed to 5 Electrospinning was performed while controlling the speed to ~30 rpm. During electrospinning, the voltage of the spinneret was applied at 50 kv, and the voltage of the collector was applied at -30 to -50 kv. At this time, the process of obtaining a fibrous web having large pores was repeated three times by adjusting the speed of the collector to 0.8 m/min to collect the fiber web having micropores, and then increasing the speed of the collector to 7 m/min and spinning it. The tip to collector distance (TCD) was in the range of 20 to 50 cm, and 0.1 to 0.2 g of polymer per hole was discharged to form the nanolayer 20 . The ultrafine nanolayer 20 obtained by electrospinning was calendered at 100° C. to prepare an antibacterial nonwoven dressing.

comparative example One

Exsalt SD7 Wound Dressing from Exciton Technologies

comparative example 2

CalgonCarbon zorflex wound dressing

comparative example 3

Acticoat dressing by Smith & nephew

comparative example 4

Kocarbon Ag silver carbon wound dressing from Bio-medical Carbon Technology

<Evaluation of physical properties>

1. Evaluation of tensile properties

Tensile strain and tensile stress were measured using a universal testing machine (hereinafter referred to as UTM). The cross head speed was calculated as the final elongation until the specimen broke at 100 mm/min, and the stress at that time was defined as the tensile stress and compared. The dimensions of the specimen were prepared based on the No. 1 test piece of the KS M3054 plastic film and sheet tensile test method specification.

2. Water vapor permeability evaluation

Examples and Comparative Examples were evaluated for moisture permeability in accordance with BS EN 13726-1:2002 with an inner diameter of 35.7±0.1mm and a cross-sectional area of 10cm ^{2 in size, as shown in Table 1 below.}

3. Deodorization evaluation

Examples and Comparative Examples are 10 cm x 10 cm in size, and ammonia gas (NH3) and a sample are put together in a tedlar bag for 2 hours according to the environmental label certification standard (EL608), and the residual amount of ammonia gas (NH3) is checked with a detection tube to evaluate as a percentage

4. Antimicrobial evaluation

According to ASTM E2149-10, 10 ± 01 g of the samples of Example 1 and Comparative Examples 1 to 4 were prepared, and then a sterile 250 ml shaking flask was prepared for each sample, and 50 ± 05 ml of a running dilution of the bacterial inoculum was added to each flask. . After placing each of the samples of Example 1 and Comparative Examples 1 to 4 in each flask, each flask was placed on a wrist-action shaker, shaken at maximum speed for 60±5 minutes, diluted, and dispensed on a plate medium 24 Time, after culturing in an incubator at 35±2° C., the number of colonies in the cultured fedri dish was checked under a microscope. The antibacterial properties calculated by the following formula were calculated.

Antibacterial activity (%) = (B-A)/B × 100

A: Number of bacteria after contact time between sample and bacterial dilution

B: the number of bacteria in the control group not treated with the sample

* Negative control is 100%, positive control is 5.4%

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Tensile strain (%) 7.5432 7.73059 6.9248 6.9328 8.3769 7.2321 Tensile stress (kgf/cm2) 49.6824 50.2321 55.2311 49.3321 60.3474 49.2684 Moisture permeability (g/m2 24 hours) (%) 4638.2 4768.3 5380.2 5432 6328 4833 Deodorization (%) 99.9 99.9 22 60 20 40 Antibacterial (%) 99.9 99.9 99.9 99.9 99.9 98.2

In the above, the preferred embodiments of the present invention have been described in detail as an example, but these descriptions merely describe and disclose exemplary embodiments of the present invention. Those skilled in the art will readily recognize that various changes, modifications and variations are possible from the foregoing description and accompanying drawings without departing from the scope and spirit of the present invention, and such modifications and variations should be construed as falling within the scope of the claims of the present invention. .

10: absorption layer 20: nano layer
30: resin 31: metal nanoparticles
33: activated carbon fiber

Claims (8)

A resin is bonded to a part of the space between the activated carbon fiber and the activated carbon fiber,
an absorption layer in which metal nanoparticles are bonded to the inside and surface of the resin; and
It is composed of a nanolayer laminated with nanofibers by direct melt electrospinning on one or both sides of the absorption layer,
Antibacterial nonwoven dressing, characterized in that the elongation of the nanofiber is 500% to 1,000%
delete According to claim 1,
The resin is polyurethane (Polyurethane (PU)), polyvinyl chloride (Poly (vinyl chloride) (PVC), acrylonitrile butadiene styrene copolymer (ABS)), polyoxymethylene (poly Oxy Methylene ( POM)), polypropylene (PP), polyethylene (PE), polyphenylene oxide (PPO), polybutylene terephthalate (PBT), polyethylene terephthalate ( Polyethylene terephthalate (PET)), Phenol, Fluorine, Epoxy, Unsaturated Polyester (UP), Polymethlymethacrylate (PMMA), Polyetherether ketone ( PEEK)), polyphenylene sulfide (PPS), polyamide (PA)), polycarbonate (PC) , protein (Protein), poly (aspartic acid) (Poly (Aspartic Acid) ), Poly(L-Lactic Acid), Poly(Glycolic Acid), PLGA, Cellulose, Collagen, Gelatin, Chitin, Chitosan ( Chitosan) antibacterial non-woven dressing characterized by any one of.
According to claim 1,
The metal nanoparticles are antibacterial nonwoven dressing, characterized in that the nano-sized gold, silver, palladium, platinum, copper, zinc or alloys or compounds thereof.
According to claim 1,
An antibacterial nonwoven dressing, characterized in that the absorbent layer further contains an organic antimicrobial agent composed of at least one of alcohol-based, aldehyde-based, phenol-based, amide-based, imidazole-based, azole-based, and halogen-based organic antibacterial agents.
delete According to claim 1,
The nanofiber is any one of a general polymer resin, a biocompatible polymer resin, or a natural polymer resin,
The general polymer resin is polyurethane (Polyurethane (PU)), polyvinyl chloride (PVC), acrylonitrile butadiene styrene copolymer (ABS), polyoxymethylene (poly Oxy) Methylene (POM)), polypropylene (PP), polyethylene (Polyethylene (PE)), polyphenylene oxide (PPO), polybutylene terephthalate (PBT), polyethylene terephthalate Phthalate (Polyethylene terephthalate (PET)), Phenol (Phenol), Fluorine, Epoxy, Unsaturated Polyester (UP), Polymethyl methacrylate (PMMA), Polyetheretherketone (Polyetherether) ketone (PEEK)), polyphenylene sulfide (Polyphenylene sulfide (PPS)), polyamide (Polyamide (PA)), any one of polycarbonate (Polycarbonate (PC)),
The biocompatible polymer is any one of protein (Protein), poly (aspartic acid) (Poly (Aspartic Acid)), poly lactic acid (Poly (L-Lactic Acid)), polyglycolic acid (Poly (Glycolic Acid)), PLGA is one,
The natural polymer is an antibacterial nonwoven dressing, characterized in that any one of cellulose (Cellulose), collagen (Collagen), gelatin (Gelatin), chitin (Chitin), chitosan (Chitosan).
According to claim 1,
The nanolayer is composed of an ultrafine fiber aggregate,
An antibacterial nonwoven dressing, characterized in that it consists of small pores having an average diameter of 0.1 μm or more and less than 10 μm and large pores having an average diameter of 10 μm or more and less than 50 μm between the ultrafine fibers.

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