KR100896793B1 - Anti-bacterial Shield of a Wound - Google Patents

Abstract

The present invention relates to a medical antibacterial wound protector, a silver cloth member 10 made of silver or a silver synthetic cloth member 40 prepared by mixing the silver and the fiber, and the silver cloth member 10 or silver synthetic fabric A nanofiber member 20 stacked on top of the member 40 and made of nanofibers, and a cover layer member 30 stacked on top of the nanofiber member 20 to cover the outer side of the nanofiber member 20. It is configured to include.

That is, the silver cloth member 10 including the silver and the silver synthetic cloth member 40 are in contact with the wound area by the sterilization effect by the silver, and the heat release effect through the heat transfer effect of the silver formed continuously to the outside of the wound treatment It is effective to prevent infection caused by bacteria.

In addition, the wet and dressing action of the nanofiber member 20 is to maintain a constant humidity suitable for wound healing during wet dressing, as well as to prevent bacteria from penetrating from the outside.

Therefore, it is a very useful invention to increase the therapeutic effect of the wound and to enable fast and stable wound healing.

Description

Anti-bacterial Shield of a Wound

1a to 1b is a perspective view showing an embodiment of the present invention

Figure 2 is a photograph showing a silver cloth member of the present invention

Figure 3 is a photograph showing a silver composite cloth member of the present invention

Figure 4 is a scanning electron micrograph of the nanofibers used in the present invention

5 is a scanning electron micrograph showing a nanofiber member and a cover layer member of the present invention;

* Description of the major symbols in the drawings *

10: silver cloth member 20: nano fiber member

30: cover layer member 40: silver synthetic cloth member

The present invention relates to medical antibacterial wound guards and more particularly to guards used as bandages or patches surrounding a wound.

Medical wound protectors are generally classified into a bandage that wraps and protects the wound and a patch type that is attached to the skin near the wound to cover and protect the wound.

Medical wound protectors, such as bandages or patches, cover the wound area to reduce protein loss, reduce heat evaporation and moisture loss from the wound surface, ventilate the wound on the skin, and prevent wound contamination from the external environment. Surgically important function.

In addition, if the plasma is rapidly lost due to bleeding is to minimize the bleeding or plasma loss.

Such bandages and patches are mainly used in dressings to protect and heal wounds.

The dressing is divided into a dry dressing that absorbs the wound's essence in a dry state and a wet dressing that contains a suitable moisture in a bandage or patch to heal the wound.

The wet dressing is capable of absorbing the essence from the wound to maintain the proper moisture to heal the wound, so that the healing speed is fast, the replacement cycle is long, and the bandage or patch does not adhere to the wound, thereby effectively healing.

The wet dressing is used by washing the bandage or the patch with clean water or physiological saline and the like to wet the protector.

By the way, the conventional medical wound protector did not have its own antibacterial ability other than the method of killing the bacteria by sterilization by autoclaving.

Conventional medical wound guards have a problem that can not prevent the bacterial infection of the wound by the bacteria of the wound site, the bacterial infection of the wound by invading bacteria from the outside, the bacterial infection of the wound by the bacteria of the bandage itself.

Therefore, in order to prevent bacterial contamination of the bandage itself, the manufacturer sterilizes through autoclave and distributes it to various medical institutions. If the distribution period is long, the bandage is very likely to be caused by the external environment.

In addition, in the case of using a conventional bandage, there was an inconvenience of frequently replacing the bandage in order to maintain the cleanliness of the wound.

Existing medical bandages are composed of woven or nonwoven fabrics, and the fibers used are composed of tens or hundreds of micrometers in diameter, which is exposed to secondary infections caused by viruses or external contaminants.

As a method for solving the above-mentioned problems, the development of a bandage for wound treatment has recently been applied by applying silver nanotechnology. Important advantages of this technology are to prevent the growth of bacteria and other bacteria, deodorization, temperature control, antistatic, conductor treatment effects (far-infrared radiation, blood circulation, skin regeneration speed), safety, etc. have.

As a method for solving the above-mentioned problems, a bandage containing silver nanoparticles prepared by adding silver nano powder or silver nano liquid to various bandage materials (Korean Patent Publication No. 10-2004-0082357) or In weaving bandages, a bandage (Korean Utility Model Registration No. 20-0297932), etc., which is woven with silver yarn by adding a silver yarn at a predetermined interval of inclination, has been proposed.

However, in the case of the bandage containing the conventional silver nanoparticles, a large amount of silver nanoparticles were used because they are prepared by mixing silver particles.

Since the bandages containing silver nanoparticles are manufactured by conventional solution and melt spinning, the diameter of the fiber is composed of several tens to hundreds of micrometers, which may cause secondary infection of bacteria, viruses, and other micro-contaminants. And, there was a problem that can not effectively deal with the odor or dust generated from the wound.

In addition, the bandage woven with a conventional silver has a problem that is virtually impossible to use in wet dressing because of the low wetting efficiency, it is possible to use only dry dressing in use, so the wound healing effect is low, the replacement cycle is frequent, the disadvantage of dry dressing Eggplant had been closed.

The purpose of the present invention is to maintain antibacterial and sterilization function for a long time, prevent the secondary infection of the wound medical antibacterial wound protector to increase the antibacterial and sterilization performance

Another object of the present invention is to provide a medical antimicrobial wound protector that can transmit the heat of the wound area through the gift of high thermal conductivity and dissipate, and can be used in the wet dressing to increase the healing effect of the wound by excellent wet function. .

An object of the present invention is a silver cloth member made of silver yarn, a nanofiber member made of nanofibers stacked on top of the silver cloth member, and laminated on top of the nanofiber members to cover the outside of the nanofiber members A cover layer member is achieved.

In addition, a silver synthetic cloth member manufactured by mixing silver yarn and fiber, a nanofiber member made of nanofibers and stacked on top of the silver synthetic cloth member, and stacked on top of the nanofiber member to cover the outer side of the nanofiber member. A cover layer member for covering is achieved.

That is, the silver cloth member or the silver composite cloth member, respectively, including the silver yarn has antibacterial and sterilization functions, and has a high thermal conductivity to quickly cool the heat of the wound to increase the therapeutic effect.

Figure 1a to Figure 1b is a perspective view showing an embodiment of the present invention, Figure 1a is a perspective view showing a bandage of one of the medical guard of the present invention, Figure 1b is a perspective view showing a patch of one of the medical guard of the present invention.

Figure 2 is a photograph showing a silver cloth member of the present invention shows a silver knitted fabric braided with a diameter of 50 ~ 70㎛ silver.

Figure 3 is a photograph showing the silver synthetic fabric member of the present invention (a) is a silver synthetic cloth member synthesized braided silver and PET yarn, (b) is a silver synthetic cloth member synthesized braided silver, PET yarn, cotton yarn Indicates.

Figure 4 is a scanning electron micrograph of the nanofibers used in the present invention.

5 is a scanning electron micrograph showing a nanofiber member and a cover layer member of the present invention.

Hereinafter, as shown in FIGS. 1A to 1B, the medical antimicrobial wound protector of the present invention is mainly manufactured and carried out with an antimicrobial bandage (1) or an antimicrobial patch (2). .

The medical antimicrobial wound protector of the present invention, that is, the silver cloth member 10 or the silver synthetic cloth member 40 of the antimicrobial bandage 1 and the antimicrobial patch 2 is a part in direct contact with the wound, sterilizing bacteria or viruses It is.

In particular, the antimicrobial patch 2 is provided with an adhesive 31 attached to the skin to the cover layer member 30 to be described later, the adhesive 31 is an antibacterial patch (2) by using a hydrogel or a harmless medical adhesive ) Is appropriately attached to the affected area, and preferably manufactured to block the invasion of an external pollution source.

Silver is known to control over 650 species of bacteria, viruses and fungi while being harmless to the human body.

Silver attaches to -SH group of protein cysteine composed of bacteria or virus, converts to sulfur compound, inhibits reproduction, or attaches to enzymes that work with oxygen, and acts as a catalyst to promote oxidation reaction. It has the same function as a semi-permanent antimicrobial agent that exerts antimicrobial activity by acting in a special form on the part involved in (digestion, respiration), and the detailed description thereof is omitted.

The silver cloth member 10 may be manufactured by knitting only the silver yarn as shown in Figure 2, and is made of a fabric woven by crossing the silver yarn with warp, end and filling yarn (weft) It can be.

In addition, the silver synthetic fabric member 40 is manufactured by mixing with natural fibers or synthetic fibers, etc. in order to control the elongation of the silver can be produced by mixing the silver and natural fibers or synthetic fibers in various ratios using a composite yarn covering device. will be.

The silver synthetic fabric member 40 is made of a knitted or mixed with a silver yarn and PET yarn as shown in Figure 3, or may be made of a fabric.

In addition, the silver composite cloth member 40 is made of a knitted fabric or fabric by mixing the silver yarn and cotton yarn, PET yarn, in addition to the silver yarn and the user can be manufactured by mixing a variety of synthetic yarn and cotton yarn, or The ratio can also be produced by various adjustments according to the user's purpose and use.

The silver cloth member 10 and the silver composite cloth member 40 is a woven or braided woven fabric, the desorption phenomenon of the silver particles in the knitted fabric does not occur as well as the heat generated by the heat of the silver having a predetermined length is generated in the wound site It will quickly release heat to the outside.

The gift is to release the heat of the wound area to the outside quickly, to prevent the bacterial propagation and deterioration of the treatment effect due to the heat of the wound area, and to further increase the therapeutic effect.

It is preferable to include a therapeutic drug such as collagen, disinfectant, ointment, etc. in the silver cloth member 10 or the silver synthetic cloth member 40.

The silver cloth member 10 or the silver synthetic cloth member 40 is a contact portion directly contacting the wound site, and when a variety of therapeutic drugs are included to assist the healing of the wound, the therapeutic drug is absorbed into the wound, thereby treating the healing force of the wound. To increase.

The method for including the therapeutic drug in the silver cloth member 10 or the silver synthetic cloth member 40 is a therapeutic drug in the gift itself in the process of manufacturing the gift of the silver cloth member 10 or the silver synthetic cloth member 40. It may be prepared by including, may be prepared by impregnating the prepared silver cloth member 10 or silver synthetic cloth member 40 into the solution containing the therapeutic drug, the prepared silver cloth member 10 or the silver synthetic fabric There are various methods such as spraying the therapeutic drug on the member 40 or coating the surface.

In addition, the therapeutic drug is mixed with the spinning solution used to prepare the nanofibers of the nanofiber member 20 to be described later, and included in the nanofiber member 20, the present invention is gradually worn after the present invention is worn on the wound site It may be to be delivered to the wound site through the member 10 or the silver synthetic fabric member 40, the moisture absorbed by the manufactured nanofiber member 20, the present invention is gradually worn after the wound cloth member 10 Or through the synthetic synthetic fabric member 40 may be to be delivered to the wound.

On the other hand, the nanofiber member 20 made of nanofiber is laminated and fixed on the upper portion of the silver cloth member 10 or the silver synthetic cloth member 40.

The nanofiber member 20 is manufactured by an electrospinning method such as flash spinning, electrostatic spinning, and melt blown spinning. The nanofibers are not shown, but are sprayed by discharging the spinning solution together with compressed air, but the electrode is applied. It is manufactured with a nanofiber manufacturing apparatus including an electrospinning nozzle, a collector for collecting the spinning fibers radiated from the electrospinning spray nozzle, and a voltage applying means for applying a high voltage between the electrospinning nozzle and the collector will be.

Since the nanofiber member 20 is collected and manufactured in a web state on the collector by the nanofiber manufacturing apparatus, the electrospinning method using the nanofiber manufacturing apparatus is a well-known configuration, and thus the detailed description thereof will be omitted.

Since the nanofiber member 20 is manufactured with a fiber diameter of less than 1 μm, as shown in FIG. 4, the specific surface area is large and the passage of viruses, bacteria, and microfouling sources is blocked. It is excellent in the wetting power that can absorb and maintain it can be effectively used in wet dressing.

In addition, the nanofiber member 20 is preferably manufactured using a spinning solution made of a biocompatible polymer or a hygroscopic polymer.

The biocompatible polymer defines a polymer which does not cause side effects when it comes into contact with the skin. Such biocompatible polymers have recently been used in various ways in the manufacture of artificial organs and in the manufacture of medical devices. Note that any polymer material that is not available can be used.

The hygroscopic polymer is a polymer having high hygroscopicity, and may be any one of a natural polymer such as cellulose or a synthetic polymer having high hygroscopicity.

The nanofiber member 20 is made of a biocompatible polymer to prevent the occurrence of side effects due to long-term contact with the skin during use.

In addition, since the nanofiber member 20 is made of a hygroscopic polymer having high hygroscopicity, the nanofiber member absorbs the dust generated from the wound and preserves it for a long time, and when used as a wet dressing, it absorbs moisture and can be kept constant for a long time, thereby increasing the therapeutic effect. It is.

The biocompatible polymer or the hygroscopic polymer uses any one of known polymer materials, and thus the description of the known polymer materials will be omitted.

As shown in FIG. 5, the cover layer member 30 covering the outer side of the nanofiber member 20 is stacked on the upper portion of the nanofiber member 20, and the cover layer member 30 is formed of a conventional fabric. It is a cover material manufactured by nonwoven fabric, synthetic resin, etc.

The cover layer member 30 is preferably made of a material composed of natural fibers or synthetic fibers provided with an elongation to block the influx of large particles and to protect the nanofibers and the silver layer from external stimuli.

The silver cloth member 10 or the silver composite cloth member 40, the nanofiber member 20, the cover layer member 30 may be attached and fixed with an adhesive, respectively, thermal bonding, ultrasonic bonding, laminating techniques It can be manufactured by laminating by a lamination or the like, and any other thing which is laminated and bonded to each layer is included in the configuration of the present invention.

On the other hand, the above-described embodiments of the present invention will be described in detail as follows, and the present invention is not limited to the following embodiments, and various modifications can be made without departing from the spirit of the present invention. It is included in the.

Example 1

Using a silver yarn having a diameter of 50 to 70 μm in a test knitting machine, a silver knitted fabric illustrated in FIG. 2, that is, a silver cloth member 10 is manufactured.

In addition, in the test knitting machine, a 50-70 μm diameter silver yarn and PET yarn (PET; polyethylene terephthalate) are mixed 1: 1, or a 50-70 μm diameter silver yarn, PET (polyethylene terephthalate), cotton yarn 1 1: 1 is mixed to prepare the silver synthetic knitted fabric shown in FIGS. 3A and 3B, that is, the silver synthetic fabric member 40.

The nanofiber member 20 is formed by laminating nanofibers manufactured by using an electrospinning method on the upper portion of the silver knitted fabric member 10 or the silver synthetic fabric member 40 manufactured as described above in FIG. 2. The antimicrobial bandage 1 of FIG. 1 is manufactured by combining the woven fabric of cotton yarn on the upper portion of the nanofiber member 20, that is, the cover layer member 30 in a thermal adhesive manner.

At this time, the nanofiber of the nanofiber member 20 is mixed with polylactic acid (PLA), dimethylformamide (N-DMF; N-dimethylformamide), dichloromethan (DCM; dichloromethan), N-DMF and DCM Was prepared using a spinning solution in which PLA was added in an amount of 20: 50% by weight in a solvent mixed at 50:50 vol.%.

The spinning liquid is supplied to the electrospinning nozzles for electrospinning and is electrospun, applying a voltage of 50 kV to the electrospinning nozzles and the collector, and the distance between the electrospinning nozzles and the collector to 30 cm Electrospinning is carried out while being discharged in the amount of 0.1 ~ 1cc / gdml to each injection hole of the electrospinning injection nozzle in the maintained state, the nanofibers produced by such electrospinning is formed with a diameter of 1㎛, average 250nm It is prepared to have a diameter of.

The antimicrobial bandage (1) prepared as described above was cut to a size of 1 cm 2 and cultured Staphylococcus aureus (Staphylococcus aureus ATCC 12600) known as a causative agent of causing Escherichia coli and purulent disease is as follows. Density is measured by dilution to 1 × 10 ⁻⁶ CFU / ml.

                     Strain   Strain density  Strain after 10 minutes  Staphylococcus aureus ATCC 12600 1 × 10 ^-6 CFU / mL   0 CFU / mL               Escherichia coli 1 × 10 ^-6 CFU / mL   0 CFU / mL

As shown in Table 1, Staphylococcus aureus and Escherichia coli cultured in the present invention antimicrobial bandage was completely extinguished after 10 minutes, it was confirmed that the antimicrobial bandage (1) prepared by the present invention has an antibacterial effect of 99.9% It can be.

Example 2

Weaving a silver yarn and a cotton yarn having a diameter of 50 to 70 μm to produce a silver synthetic cloth member 40 having a thickness of 100 μm, and laminating nanofibers manufactured by using an electrospinning method on the silver synthetic cloth member 40. To form the nanofiber member 20, and the woven fabric, that is, the cover layer member 30, which is woven by cotton yarn on the upper part of the nanofiber member 20 in a heat-adhesive manner, the antimicrobial bandage 1 and the antimicrobial patch ( 2) to produce a thickness of the nanofiber member 20 to 50㎛, the thickness of the cover layer member 30 to 300㎛ by the antimicrobial bandage 1 and the antimicrobial patch having a thickness of 450㎛ (2) is manufactured.

The nanofiber of the nanofiber member 20 is a polylactic acid (polylativacid, PLA), dimethylformamide (N-DMF; N-dimethylformamide), dichloromethane (DCM; dichloromethan) mixed, N-DMF and DCM 50 It was prepared using a spinning solution in which PLA was added in an amount of 50 wt% and 20 wt% PLA.

The nanofibers made of the spinning solution are supplied to the electrospinning nozzle for electrospinning during electrospinning, and are electrospun, the electrospinning spray nozzles, the voltage applied on the collector, the distance between the spinner spray nozzles and the collector and It is prepared by dividing the injection amount discharged to each injection hole of the electrospinning injection nozzle to have an average diameter of 800nm, 600nm, 400nm, 200nm.

In addition, the nanofiber member 20 manufactured as described above is thermally bonded to a woven fabric, ie, the cover layer member 30, which is woven with cotton yarn, which can be confirmed by the scanning electron micrograph of FIG. The fiber member 20 is made of nanofibers having an average diameter of 200 nm to have a thickness of 50 μm, and the cover layer member 30 is made of a cotton yarn having an average diameter of 20 μm to have a thickness of 300 μm. .

The results of measuring the filtration performance of the nanofiber member 20 are as follows. In the case of antimicrobial bandages, it is difficult to measure, so it is clear that the nanofiber member 20 applied to the antimicrobial bandage was separately measured.

In addition, the filtration performance of the nanofiber member 20 is measured by dividing by the average diameter of the nanofiber, but filter evaluation is commonly used filter test equipment (TSI 3160 Fractional) using 0.3-μm di-octyl-phthalate (DOP) particles The porosity was measured using Mercury porosimetry (AutoPore IV9500).

 Average diameter of nanofibers (nm) Average thickness of nanofiber member (㎛)  Collection efficiency (%) Air resistance (mmH ₂ O)  Porosity (%)      800       50     97.451          7 64      600       50     98.667 13 55      400       50     99.925 25 42      200       50     99.999 37 35

As shown in Table 2, the nanofiber member 20 of the present invention has a difference depending on the average diameter of the nanofibers, but has a high collection efficiency and a low porosity to prevent penetration of external viruses, bacteria, and fine particles. And it can confirm the result that the function as a separator is apparent.

In addition, the nanofiber member 40 of the present invention is preferably made of nanofibers having an average diameter of less than 300㎛.

The nanofibers of the nanofiber member 40 of the present invention are manufactured to have an average diameter of 250 μm or 250 μm or less by electrospinning, and the nanofiber member 40 made of the nanofibers has a collection efficiency of 99.9% or more. Since the porosity is 40% or less, it is possible to completely prevent the penetration of viruses or bacteria, fine particles from the outside.

According to the configuration of the present invention described above, the bactericidal effect by the gift and the heat release effect has the effect of preventing infection due to external bacteria during wound treatment.

In addition, the wetting action and the filter action of the nanofiber member maintains a constant humidity suitable for wound healing during wet dressing, as well as prevents the penetration of viruses, bacteria and fine particles from the outside.

Therefore, it is a very useful invention to increase the therapeutic effect of the wound and to enable fast and stable wound healing.

Claims (6)

A silver cloth member made of silver; A nanofiber member made of nanofibers and stacked on top of the silver cloth cloth member; Medical antimicrobial wound protector comprising a cover layer member laminated on top of the nanofiber member to cover the outer side of the nanofiber member. The method according to claim 1, The nanofiber member is a medical antimicrobial wound protector, characterized in that it is manufactured using a spinning solution containing a biocompatible polymer or hygroscopic polymer. The method according to claim 1, Medical antimicrobial wound protector, characterized in that the silver cloth member contains a therapeutic drug. A silver synthetic cloth member manufactured by mixing the silver yarn and the fiber; A nanofiber member made of nanofibers and stacked on top of the silver synthetic fabric member; Medical antimicrobial wound protector comprising a cover layer member laminated on top of the nanofiber member to cover the outer side of the nanofiber member. The method according to claim 4, The nanofiber member is a medical antimicrobial wound protector, characterized in that it is manufactured using a spinning solution containing a biocompatible polymer or hygroscopic polymer. The method according to claim 4, Medical antimicrobial wound protector, characterized in that the silver synthetic fabric member contains a therapeutic drug.

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