KR20200037486A - Cosmetic composition for external application for skin comprising Palmarosa oil and aroma composition as an active ingredient - Google Patents

Abstract

The present invention provides a cosmetic composition for external application for skin comprising: palmarosa oil; and an aroma composition comprising phenylacetaldehyde, benzaldehyde, camphor and phenylethyl alcohol. The cosmetic composition provides a function of effectively reducing cortisol levels in the skin.

Description

Cosmetic composition for external application for skin comprising palmarosa oil and aroma composition as an active ingredient}

The present invention relates to a cosmetic composition for external application for skin comprising palmarosa oil and an aroma composition as an active ingredient, which can effectively reduce the level of skin cortisol.

Cortisol is a glucocorticoid hormone that is produced in the adrenal cortex. Cortisol is a defense mechanism against stress that promotes cardiopulmonary activity and raises blood sugar to increase body responsiveness, but when stress conditions become chronic, blood sugar and blood pressure rise and the immune system weakens, causing substances that cause aging and disease. (Biogerontology. 2010 11 (4): 495-9).

In addition to the adrenal cortex, the main secretory organ of cortisol, the colon and lung also have the function of generating or activating cortisol, and the skin also has neuroendocrine action characteristics, thereby preventing cortisol from external irritants such as ultraviolet rays and fine dust. Self-generation has been reported (Exp Dermatol. 2014 23 (1): 15-17). Cortisol inhibits the proliferation of skin cells, delays wound healing, promotes keratinization of the skin epidermis, and is also involved in the induction of psoriasis, reduces collagen content, and promotes skin aging, affecting the physiological functions of various skins. It has been reported (J Dermatol Sci. 2016 84 (1) 11-16).

Recently, as cortisol levels have increased due to internal and external stress factors, and cortisol has been found to play various and major roles in skin physiological activity, interest in substances that regulate and improve skin condition by targeting cortisol It is increasing.

However, a substance or composition that can be effectively applied to the skin cortisol level by applying it as an external skin preparation has not been reported. Therefore, research on substances capable of effectively controlling skin cortisol levels is required.

Republic of Korea Patent Publication No. 10-2010-0011170

The present invention has been devised to solve the above problems of the prior art,

An object of the present invention is to provide a cosmetic composition for external application for skin, which can effectively reduce the level of cortisol.

In addition, by reducing the level of skin cortisol, improving skin erythema, improving skin barrier function, improving skin elasticity, reducing skin keratin, improving skin density, improving skin texture, etc. The purpose.

The present invention

Palmarosa oil; And

It provides a cosmetic composition for external application for skin containing; aroma composition comprising phenylacetaldehyde, benzaldehyde, camphor and phenylethyl alcohol.

In one embodiment of the present invention, the palmarosa oil and aroma composition may be included in a weight ratio of 1:99 to 99: 1.

In one embodiment of the present invention, the aroma composition may further include at least one component selected from the group consisting of benzyl alcohol, hexanol, and linalool.

In one embodiment of the present invention, the aroma composition may be chrysanthemum aroma.

In one embodiment of the present invention, the cosmetic composition for external application for skin provides an effect of reducing skin cortisol levels.

In one embodiment of the present invention, the cosmetic composition for external application for skin is skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, It can be prepared in any one formulation selected from the group consisting of nutrient essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, rust powder and eye shadow.

The cosmetic composition for external application for skin of the present invention provides an effect of effectively reducing the level of skin cortisol.

In addition, the cosmetic composition for external application for skin of the present invention provides excellent effects on improving erythema, improving skin barrier function, improving skin elasticity, reducing skin keratin, improving skin density, and improving skin texture by reducing the level of skin cortisol.

The present invention palmarosa oil; And phenylacetaldehyde, benzaldehyde, camphor and phenylethyl alcohol, and an aroma composition.

In the cosmetic composition for external application for skin of the present invention, the palmarosa oil and the aroma composition may be included in a weight ratio of 1:99 to 99: 1, and more preferably 1:99 to 70:30 wt%.

In the cosmetic composition for external application for skin of the present invention, the aroma composition may further include at least one component selected from the group consisting of benzyl alcohol, hexanol, and linalool.

In the cosmetic composition for external application for skin of the present invention, the aroma composition may be chrysanthemum aroma, and chrysanthemum aroma may be more preferably used among the chrysanthemums.

In the cosmetic composition for external application for skin of the present invention, the aroma composition comprises 5 to 55% by weight of phenylacetaldehyde, 3 to 45% by weight of benzaldehyde, 1 to 30% by weight of camphor, and 1 to 25% by weight of phenylethyl alcohol based on the total weight of the composition. It can contain.

The aroma composition may further include 0.1 to 15% by weight of benzyl alcohol, 0.1 to 15% by weight of hexanol, and 0.1 to 15% by weight of linalool relative to the total weight of the composition.

In particular, the aroma composition is 30 to 40% by weight of phenylacetaldehyde, 20 to 30% by weight of benzaldehyde, 5 to 15% by weight of camphor, 4 to 12% by weight of phenylethyl alcohol, 1 to 10% by weight of benzyl alcohol, 1 to hexanol 10% by weight, and linalool 0.1 to 5% by weight. When the aroma composition is composed of the above-described components and compositions, it may exhibit a more excellent effect in reducing cortisol level of the skin.

The cosmetic composition for external application for skin of the present invention may include palmarosa oil and aroma composition in an amount of 0.001 to 30% by weight based on the total weight of the composition as an active ingredient. When the content of palmarosa oil and aroma composition is included in an amount of 0.001% by weight or less, it is difficult to expect a decrease in cortisol level, and when it exceeds 30% by weight, side effects may be greater compared to an increase in effect, which is undesirable.

In addition, the cosmetic composition for external application for skin may include various ingredients known in the field according to the formulation of cosmetics in addition to the palmarosa oil and aroma composition.

The cosmetic composition for external application for skin of the present invention can effectively reduce the level of skin cortisol. The reduction in cortisol level is accompanied by effects such as improving erythema, improving skin barrier function, improving skin elasticity, reducing skin keratin, improving skin density, and improving skin texture.

Cosmetics prepared with the cosmetic composition for external application for skin of the present invention may be prepared in the form of general emulsifying formulations and solubilizing formulations. Cosmetics in emulsified formulations include nutrient makeup, cream, essence, etc., and cosmetics in solubilized formulations include softened makeup.

In addition, the cosmetic composition for external application for skin of the present invention is palmarosa oil as an active ingredient; And phenylacetaldehyde, benzaldehyde, camphor and phenylethyl alcohol. In addition, by containing a dermatologically acceptable medium or base, it can be prepared in the form of an adjuvant for topical or systemic application commonly used in the field of dermatology.

Suitable cosmetic formulations include, for example, solutions, gels, solid or dough anhydrous products, emulsions obtained by dispersing an oil phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes), nonionic Vesicle dispersants, creams, skins, lotions, powders, ointments, sprays or conceal sticks. In addition, it may be prepared in the form of a foam or aerosol composition further containing a compressed propellant.

In addition, the cosmetic composition for external application for skin of the present invention is palmarosa oil as an active ingredient; And phenylacetaldehyde, benzaldehyde, camphor and phenylethyl alcohol. In addition, fatty substances, organic solvents, solubilizers, thickeners and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers Cosmetics or dermatology, such as metal ion blockers and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients commonly used in cosmetics It may contain adjuvants commonly used in the art. In addition, the above ingredients may be introduced in an amount generally used in the field of skin science.

The cosmetic composition for external application for skin of the present invention may be made of cosmetics and cleansing agents such as convergent makeup, softening makeup, nutrient makeup, various creams, essences, packs, foundations, cleansing agents, soaps, treatments, and cosmetics. .

The cosmetic composition for external application for skin of the present invention specifically includes skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack , Soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, rust powder, eye shadow, etc.

Hereinafter, the present invention will be described in more detail through examples. However, the following examples are intended to illustrate the present invention more specifically, but the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Example 1: Preparation of a composite composition of a composition of palmarosa oil and aroma

A fresh grass of Palmarosa (Palmarosa) is extracted using steam distillation to prepare palmarosa oil, and after preparing an aroma composition (composition of Table 1 below), the palmarosa oil and aroma composition are mixed in a weight ratio of 1: 9. A composite composition was prepared.

The extraction by the steam distillation method, the fresh grass of Palmarosa (Palmarosa) is put into a distiller, and the steam is blown to heat to vaporize the essential oil with the heat of the steam, and then volatilize on top of the distiller to cool the vapor and steam of the collected essential oil. After liquefaction through the tube, it was performed by separating the essential oil floating insoluble in water.

ingredient content(%) Phenylacetaldehyde 35.2 Benzaldehyde 25.6 Camper 10.8 Phenyl ethyl alcohol 8.9 Benzyl alcohol 5.1 Hexanol 4.5 Linalool 3 Other 6.9 Total 100

Comparative Example 1: Clariy Sage essential oil extraction

The clary sage essential oil was prepared by extracting the upper part and leaves of the clary sage using steam distillation.

Example 2: Flexible cosmetic formulation Preparation of cosmetic composition for external application for skin

As a cosmetic composition for external application for skin, a softened cosmetic composition was prepared according to the composition of Table 2 below.

Ingredients Content (% by weight) Example 1 Composite composition of prepared Palmarosa oil and aroma composition 0.01 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Polyoxyethylene cured castor oil 1.0 ethanol 10.0 Triethanolamine 0.1 Preservatives, pigments, flavors a very small amount Purified water Balance

Example 3: Preparation of cosmetic composition for external application for skin in lotion formulation

As a cosmetic composition for external application for skin, a lotion formulation was prepared according to the composition in Table 3 below.

Ingredients Content (% by weight) Example 1 Composite composition of prepared Palmarosa oil and aroma composition 0.01 Wax 1.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Floating paraffin 10.0 Sorbitan stearate 1.0 Lipophilic glycerin monostearate 0.5 Stearic acid 1.5 Glyceryl stearate / page-400 stearate 1.0 Propylene glycol 3.0 Carboxy polymer 0.1 Triethanolamine 0.2 Preservatives, pigments, flavors a very small amount Purified water Balance

Example 4: Preparation of a cosmetic composition for external application for skin in a serum formulation

Serum formulation was prepared according to the composition of Table 4 as a cosmetic composition for external application for skin.

Ingredients Content (% by weight) Example 1 Composite composition of prepared Palmarosa oil and aroma composition 0.01 Xanthan gum 0.02 Butylene glycol 10.0 Soybean Phospholipid 10.0 Hydroxyethyl cellulose 0.1 Sodium hyaluronate 5.0 Preservatives, pigments, flavors a very small amount Purified water Balance

Test Example 1: Clari Sage essential oil; And evaluation of skin cortisol level reduction efficacy of the composition of the composition of palmarosa oil and aroma

The cortisol reduction effect of the composite composition of Clariy Sage Essential Oil prepared in Comparative Example 1 and Palmarosa Oil and Aroma Composition prepared in Example 1 was evaluated through clinical trials.

As a sample, an essence containing 0.01% of a composite composition of clary sage essential oil and palmarosa oil and aroma composition was used, and the degree of improvement was measured before and after use.

Thirty-five 35 to 60-year-old female subjects were allowed to use the sample essence once a day for 4 weeks (evening), and the effect of lowering skin cortisol levels was measured before and after 4 weeks of use. Specifically, the subject's skin keratin was collected using a tape dedicated to collecting the stratum corneum (D-Squame discs, CuDerm, USA), and cortisol levels were measured using a MILLIPLEX Human Skin Magnetic Bead Panel (Millipore Corp., USA). It is shown in Table 5 below.

Comparative Example 1 Example 1 0 weeks 100% 100% 4 weeks 96% 75%

According to the experimental results shown in Table 5, when using the essence sample containing the clary sage essential oil of Comparative Example 1, it was confirmed that the skin cortisol level was not significantly changed.

On the other hand, when using the essence sample containing the composite composition of palmarosa oil and aroma composition of Example 1, it was confirmed that the skin cortisol level was significantly lowered.

These results seem to show that the effect on the skin cortisol level is different when applied to the skin, even if it is already known to lower the level of cortisol in the blood through the aroma and nerve neurological control properties.

In addition, when using the complex composition of palmarosa oil and aroma composition of Example 1 to the skin, it can be evaluated as showing that the skin cortisol level can be effectively reduced to affect the skin.

Test Example # 2: Compound composition of palmarosa oil and aroma composition Clinical skin efficacy evaluation

2-1: Erythema improvement effect

In order to evaluate the effect of protecting the skin damage of the composite composition of palmarosa oil and aroma composition of Example 1, the subject's back was damaged by ultraviolet irradiation, and then the composite composition of palmarosa oil and aroma composition prepared in Example 1 was 0.01. It was confirmed that the erythema generated by using an essence sample containing% was improved.

Specifically, after the essence sample was used, after 24 hours elapsed, the degree of improvement of erythema was measured using Visia-CR (Canfield Imaging Systems, USA), and the images captured were imaged with "Image-proⓡ" plus and "I-Measure". Analysis, and the results are shown in Table 6 below.

Erythema reduction rate (%) Uncoated -10.60 apply -42.70

* Significant difference between groups <0.05

From the results of Table 6, when applying the composite composition of palmarosa oil and aroma composition of Example 1 to the skin where erythema occurred, it can be seen that the erythema decreases very quickly.

2-2: Evaluation of skin barrier function and effect on angular mass control

In order to evaluate the effect on the skin barrier function and angular mass control of the composite composition of palmarosa oil and aroma composition of Example 1, after 24 hours of using the essence sample, a transdermal moisture loss was measured using a vapometer and angular mass analysis After performing, the results are shown in Table 7 below.

Improvement rate (%) Significant difference Percutaneous moisture loss -23 <0.001 Angular mass -28.3 <0.001

It can be seen from the results of Table 7 that the composite composition of palmarosa oil and aroma composition of Example 1 provides a very good effect on improving skin barrier function and controlling each mass.

2-3: Evaluation of skin elasticity, dermal density and effect on skin texture

In order to measure the clinical skin effect after 4 weeks of use of the essence sample of the complex composition of palmarosa oil and aroma composition of Example 1, the essence sample was given to 35 35-60 year old female subjects weekly 1 once a day ( Evening) 탄력 After using the entire face, before using the product, 주 4 weeks after use, the skin elasticity, dermal density and skin texture were measured.

<Skin turbidity measurement>

The elasticity measurement was performed before and after the use of the essence sample using the Cutometer CM580, and the measurement was performed 3 times, and the average value was used as the elasticity evaluation data and is shown in Table 8 below.

Improvement rate (%) Significant difference R2 6.3 0.009 R5 7.1 0.001 R7 3.7 0.04

From the results of Table 5, it can be seen that the composite composition of the palmarosa oil of Example 1 and the aroma composition provides a very good effect for improving skin elasticity.

<Measurement of skin density>

For skin density measurement, skin density was analyzed through an image measuring the same area of the face before and after using the essence sample using Skin Scanner High Resolution Ultrasound (taberna promedicum, Germany), and the results are shown in Table 9 below.

Improvement rate (%) Significant difference Skin density 12.6 <0.001

From the results of Table 9, it can be seen that the composite composition of the palmarosa oil of Example 1 and the aroma composition provides a very excellent effect for improving skin density.

<Measurement of skin texture>

For skin texture measurement, the same area was taken before and after using the essence sample using a 3D skin imaging device (Primos Premium), and the skin texture parameter of the stored image, Ra (average roughness), was analyzed and the results were analyzed. It is shown in Table 10 below.

Before use (μm) After use (μm) Improvement rate (%) Significant difference Skin texture (Ra) 14.302 13.49 5.68 <0.001

From the results of Table 10, it can be seen that the composite composition of the palmarosa oil of Example 1 and the aroma composition provides a very good effect for improving skin texture.

Claims (10)

Palmarosa oil; And
Aroma composition comprising phenylacetaldehyde, benzaldehyde, camphor and phenylethyl alcohol; cosmetic composition for external application for skin. According to claim 1,
The palmarosa oil and aroma composition is a cosmetic composition for external application for skin, characterized in that it is included in a weight ratio of 1:99 to 99: 1. According to claim 1,
The aroma composition is a cosmetic composition for external application for skin further comprising at least one component selected from the group consisting of benzyl alcohol, hexanol, and linalool. According to claim 1,
The aroma composition is a cosmetic composition for external application for skin, characterized in that the chrysanthemum aroma. According to claim 1,
The aroma composition is a cosmetic composition for external application for skin, comprising 5 to 55% by weight of phenylacetaldehyde, 3 to 45% by weight of benzaldehyde, 1 to 30% by weight of camphor, and 1 to 25% by weight of phenylethyl alcohol based on the total weight of the composition. Composition. The method of claim 5,
The aroma composition is a composition for external application for skin characterized in that it further comprises 0.1 to 15% by weight of benzyl alcohol, 0.1 to 15% by weight of hexanol, and 0.1 to 15% by weight of linalool relative to the total weight of the composition. According to claim 1,
The cosmetic composition for external application for skin comprises as an active ingredient palmarosa oil and aroma composition in total 0.001 to 30% by weight based on the total weight of the composition. According to claim 1,
The composition for external application for skin is a cosmetic composition for external application for skin, wherein the level of cortisol is reduced. According to claim 1,
The cosmetic composition for external application for skin is characterized in that it provides one or more effects selected from improvement of erythema, improvement of skin barrier function, improvement of skin elasticity, reduction of skin keratin, improvement of skin density and improvement of skin texture. According to claim 1,
The cosmetic composition for external application for skin is skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, soap, shampoo , Cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, rust powder, and eye shadow cosmetic composition for external application, characterized in that it is prepared in any one formulation selected from the group consisting of eye shadow.