KR20200034824A - Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 - Google Patents

Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Download PDF

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Publication number
KR20200034824A
KR20200034824A KR1020207008228A KR20207008228A KR20200034824A KR 20200034824 A KR20200034824 A KR 20200034824A KR 1020207008228 A KR1020207008228 A KR 1020207008228A KR 20207008228 A KR20207008228 A KR 20207008228A KR 20200034824 A KR20200034824 A KR 20200034824A
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mmol
compound
nmr
pharmaceutical composition
ral
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Korean (ko)
Inventor
댄 테오도레스쿠
마이클 벰페
데이비드 로스
챠오 얀
필립 레이건
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
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Publication of KR20200034824A publication Critical patent/KR20200034824A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207008228A 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Ceased KR20200034824A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022946P 2014-07-10 2014-07-10
US62/022,946 2014-07-10
PCT/US2015/040021 WO2016007905A1 (en) 2014-07-10 2015-07-10 Anti-cancer compounds target ral gtpases and methods of using the same

Related Parent Applications (1)

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KR1020197005669A Division KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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KR20200034824A true KR20200034824A (ko) 2020-03-31

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KR1020207008228A Ceased KR20200034824A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020197005669A Expired - Fee Related KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020177002960A Ceased KR20170018084A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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KR1020177002960A Ceased KR20170018084A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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US (4) US10202397B2 (enExample)
EP (2) EP3686202A1 (enExample)
JP (2) JP6672255B2 (enExample)
KR (3) KR20200034824A (enExample)
CN (1) CN106604731B (enExample)
AU (2) AU2015287567A1 (enExample)
CA (1) CA2954560C (enExample)
IL (1) IL249959A0 (enExample)
WO (1) WO2016007905A1 (enExample)

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JP6672255B2 (ja) * 2014-07-10 2020-03-25 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト Ｒａｌ ＧＴＰアーゼを標的とする抗癌化合物及びそれを使用する方法
US10646475B2 (en) 2015-03-10 2020-05-12 The Trustees Of Princeton University SHMT inhibitors
US10077273B2 (en) 2016-09-14 2018-09-18 The Trustees Of Princeton University SHMT inhibitors
CN109305972B (zh) * 2018-09-27 2021-07-09 广州医科大学 一种二氢吡喃并吡唑类化合物及其制备方法和应用
EP3766544A1 (en) * 2019-07-18 2021-01-20 Centre Hospitalier Regional Universitaire de Lille Novel pyrazolone derivatives as pd-1/pd-l1 interaction inhibitors
BR112023009420A2 (pt) * 2020-11-18 2023-10-03 Univ Texas Tech System Terapias para o câncer usando moléculas pequenas que se ligam e inibem proteínas de interação ral
CN114765064A (zh) * 2021-01-14 2022-07-19 南京天顶星医药科技有限公司 一种靶向RalA-GDP蛋白的药物的虚拟筛选方法
US20240240342A1 (en) 2021-05-10 2024-07-18 Novalum Sa Cathode current collector bar of an aluminium production cell
CN114632147B (zh) * 2021-11-09 2024-04-30 南京大学 人类受试者心肌病的治疗

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Publication number Publication date
US20170204112A1 (en) 2017-07-20
JP2020105195A (ja) 2020-07-09
KR20170018084A (ko) 2017-02-15
JP2017520588A (ja) 2017-07-27
US10202397B2 (en) 2019-02-12
EP3166609B1 (en) 2020-03-11
IL249959A0 (en) 2017-03-30
CA2954560C (en) 2021-12-28
US10676480B2 (en) 2020-06-09
US20200255442A1 (en) 2020-08-13
JP7102012B2 (ja) 2022-07-19
EP3166609A4 (en) 2017-12-27
EP3686202A1 (en) 2020-07-29
US20190135824A1 (en) 2019-05-09
KR102093848B1 (ko) 2020-03-30
KR20190022929A (ko) 2019-03-06
USRE48557E1 (en) 2021-05-18
CN106604731A (zh) 2017-04-26
AU2020277293B2 (en) 2021-10-21
AU2015287567A1 (en) 2017-02-16
AU2020277293A1 (en) 2021-01-07
CN106604731B (zh) 2021-05-18
EP3166609A1 (en) 2017-05-17
US11472812B2 (en) 2022-10-18
CA2954560A1 (en) 2016-01-14
WO2016007905A1 (en) 2016-01-14
JP6672255B2 (ja) 2020-03-25

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