KR20190090390A - 스테로이드 투여 및 면역요법 - Google Patents

스테로이드 투여 및 면역요법 Download PDF

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KR20190090390A
KR20190090390A KR1020197018023A KR20197018023A KR20190090390A KR 20190090390 A KR20190090390 A KR 20190090390A KR 1020197018023 A KR1020197018023 A KR 1020197018023A KR 20197018023 A KR20197018023 A KR 20197018023A KR 20190090390 A KR20190090390 A KR 20190090390A
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steroid
cells
amount
administered
modified
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로렌스 제이.엔. 쿠퍼
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인트렉손 코포레이션
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KR1020197018023A 2016-11-30 2017-11-30 스테로이드 투여 및 면역요법 Ceased KR20190090390A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662428474P 2016-11-30 2016-11-30
US62/428,474 2016-11-30
PCT/US2017/064060 WO2018102606A1 (en) 2016-11-30 2017-11-30 Steroid administration and immunotherapy

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KR20190090390A true KR20190090390A (ko) 2019-08-01

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US (1) US20190351019A1 (enExample)
EP (1) EP3548047A4 (enExample)
JP (1) JP2019536786A (enExample)
KR (1) KR20190090390A (enExample)
CN (1) CN110234327A (enExample)
AU (1) AU2017368248A1 (enExample)
CA (1) CA3044261A1 (enExample)
WO (1) WO2018102606A1 (enExample)

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Publication number Priority date Publication date Assignee Title
ES2954311T3 (es) * 2017-04-01 2023-11-21 Avm Biotechnology Llc Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular
JP2021530217A (ja) * 2018-07-10 2021-11-11 プレシゲン，インコーポレイテッド Ｒｏｒ−１特異的キメラ抗原受容体およびその使用
WO2020076815A1 (en) * 2018-10-08 2020-04-16 New York University Steroid compounds as treg modulators and uses thereof
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
CN113616660A (zh) * 2020-05-07 2021-11-09 深圳埃格林医药有限公司 孕激素制剂及其用途
WO2022016150A1 (en) * 2020-07-17 2022-01-20 Ross Peter M Methods for the treatment of cytokine release syndromes
EP4247850A1 (en) 2020-11-20 2023-09-27 Simcere Innovation, Inc. Armed dual car-t compositions and methods for cancer immunotherapy
JP2022091709A (ja) * 2020-12-09 2022-06-21 株式会社ゲノム創薬研究所 サイトカインストーム治療・予防剤のスクリーニング方法及びサイトカインストーム治療・予防剤
US11969434B1 (en) 2022-08-29 2024-04-30 Lipocine Inc. Oral allopregnanolone compositions and methods of use
US12186327B2 (en) 2022-08-29 2025-01-07 Lipocine Inc. Oral allopregnanolone compositions and methods of use

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US20070208057A1 (en) * 2003-11-06 2007-09-06 Zeldis Jerome B Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases
US20130058921A1 (en) * 2009-10-30 2013-03-07 Frits VAN RHEE Use of autologous effector cells and antibodies for treatment of multiple myeloma
BR112015000657B1 (pt) * 2012-07-13 2023-12-05 The Trustees Of The University Of Pennsylvania Uso de uma célula geneticamente modificada para expressar um car
SG11201608393TA (en) * 2014-04-10 2016-11-29 Seattle Children S Hospital Dba Seattle Children S Res Inst Transgene genetic tags and methods of use
WO2016014565A2 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
CN108473957B (zh) * 2015-04-17 2024-07-16 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法

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