AU2017368248A1 - Steroid administration and immunotherapy - Google Patents

Steroid administration and immunotherapy Download PDF

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Publication number
AU2017368248A1
AU2017368248A1 AU2017368248A AU2017368248A AU2017368248A1 AU 2017368248 A1 AU2017368248 A1 AU 2017368248A1 AU 2017368248 A AU2017368248 A AU 2017368248A AU 2017368248 A AU2017368248 A AU 2017368248A AU 2017368248 A1 AU2017368248 A1 AU 2017368248A1
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AU
Australia
Prior art keywords
steroid
cell
administered
modified
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2017368248A
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English (en)
Inventor
Laurence J.N. Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precigen Inc
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of AU2017368248A1 publication Critical patent/AU2017368248A1/en
Abandoned legal-status Critical Current

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
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AU2017368248A 2016-11-30 2017-11-30 Steroid administration and immunotherapy Abandoned AU2017368248A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662428474P 2016-11-30 2016-11-30
US62/428,474 2016-11-30
PCT/US2017/064060 WO2018102606A1 (en) 2016-11-30 2017-11-30 Steroid administration and immunotherapy

Publications (1)

Publication Number Publication Date
AU2017368248A1 true AU2017368248A1 (en) 2019-06-06

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AU2017368248A Abandoned AU2017368248A1 (en) 2016-11-30 2017-11-30 Steroid administration and immunotherapy

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US (1) US20190351019A1 (enExample)
EP (1) EP3548047A4 (enExample)
JP (1) JP2019536786A (enExample)
KR (1) KR20190090390A (enExample)
CN (1) CN110234327A (enExample)
AU (1) AU2017368248A1 (enExample)
CA (1) CA3044261A1 (enExample)
WO (1) WO2018102606A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2954311T3 (es) * 2017-04-01 2023-11-21 Avm Biotechnology Llc Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular
JP2021530217A (ja) * 2018-07-10 2021-11-11 プレシゲン，インコーポレイテッド Ｒｏｒ−１特異的キメラ抗原受容体およびその使用
WO2020076815A1 (en) * 2018-10-08 2020-04-16 New York University Steroid compounds as treg modulators and uses thereof
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
CN113616660A (zh) * 2020-05-07 2021-11-09 深圳埃格林医药有限公司 孕激素制剂及其用途
WO2022016150A1 (en) * 2020-07-17 2022-01-20 Ross Peter M Methods for the treatment of cytokine release syndromes
EP4247850A1 (en) 2020-11-20 2023-09-27 Simcere Innovation, Inc. Armed dual car-t compositions and methods for cancer immunotherapy
JP2022091709A (ja) * 2020-12-09 2022-06-21 株式会社ゲノム創薬研究所 サイトカインストーム治療・予防剤のスクリーニング方法及びサイトカインストーム治療・予防剤
US11969434B1 (en) 2022-08-29 2024-04-30 Lipocine Inc. Oral allopregnanolone compositions and methods of use
US12186327B2 (en) 2022-08-29 2025-01-07 Lipocine Inc. Oral allopregnanolone compositions and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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US20070208057A1 (en) * 2003-11-06 2007-09-06 Zeldis Jerome B Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases
US20130058921A1 (en) * 2009-10-30 2013-03-07 Frits VAN RHEE Use of autologous effector cells and antibodies for treatment of multiple myeloma
BR112015000657B1 (pt) * 2012-07-13 2023-12-05 The Trustees Of The University Of Pennsylvania Uso de uma célula geneticamente modificada para expressar um car
SG11201608393TA (en) * 2014-04-10 2016-11-29 Seattle Children S Hospital Dba Seattle Children S Res Inst Transgene genetic tags and methods of use
WO2016014565A2 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
CN108473957B (zh) * 2015-04-17 2024-07-16 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法

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