JP2019536786A - ステロイドの投与および免疫療法 - Google Patents
ステロイドの投与および免疫療法 Download PDFInfo
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- JP2019536786A JP2019536786A JP2019528885A JP2019528885A JP2019536786A JP 2019536786 A JP2019536786 A JP 2019536786A JP 2019528885 A JP2019528885 A JP 2019528885A JP 2019528885 A JP2019528885 A JP 2019528885A JP 2019536786 A JP2019536786 A JP 2019536786A
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- Prior art keywords
- cells
- steroid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
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- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Biophysics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662428474P | 2016-11-30 | 2016-11-30 | |
| US62/428,474 | 2016-11-30 | ||
| PCT/US2017/064060 WO2018102606A1 (en) | 2016-11-30 | 2017-11-30 | Steroid administration and immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019536786A true JP2019536786A (ja) | 2019-12-19 |
| JP2019536786A5 JP2019536786A5 (enExample) | 2021-01-14 |
Family
ID=62241962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528885A Pending JP2019536786A (ja) | 2016-11-30 | 2017-11-30 | ステロイドの投与および免疫療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190351019A1 (enExample) |
| EP (1) | EP3548047A4 (enExample) |
| JP (1) | JP2019536786A (enExample) |
| KR (1) | KR20190090390A (enExample) |
| CN (1) | CN110234327A (enExample) |
| AU (1) | AU2017368248A1 (enExample) |
| CA (1) | CA3044261A1 (enExample) |
| WO (1) | WO2018102606A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022091709A (ja) * | 2020-12-09 | 2022-06-21 | 株式会社ゲノム創薬研究所 | サイトカインストーム治療・予防剤のスクリーニング方法及びサイトカインストーム治療・予防剤 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2954311T3 (es) * | 2017-04-01 | 2023-11-21 | Avm Biotechnology Llc | Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular |
| JP2021530217A (ja) * | 2018-07-10 | 2021-11-11 | プレシゲン,インコーポレイテッド | Ror−1特異的キメラ抗原受容体およびその使用 |
| WO2020076815A1 (en) * | 2018-10-08 | 2020-04-16 | New York University | Steroid compounds as treg modulators and uses thereof |
| SE544015C2 (en) * | 2019-06-18 | 2021-11-02 | Tx Medic Ab | Allogenic car-t cell therapy |
| CN113616660A (zh) * | 2020-05-07 | 2021-11-09 | 深圳埃格林医药有限公司 | 孕激素制剂及其用途 |
| WO2022016150A1 (en) * | 2020-07-17 | 2022-01-20 | Ross Peter M | Methods for the treatment of cytokine release syndromes |
| EP4247850A1 (en) | 2020-11-20 | 2023-09-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
| US11969434B1 (en) | 2022-08-29 | 2024-04-30 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
| US12186327B2 (en) | 2022-08-29 | 2025-01-07 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015157386A1 (en) * | 2014-04-10 | 2015-10-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Production of engineered t-cells by sleeping beauty transposon coupled with methotrexate selection |
| WO2016168595A1 (en) * | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070208057A1 (en) * | 2003-11-06 | 2007-09-06 | Zeldis Jerome B | Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases |
| US20130058921A1 (en) * | 2009-10-30 | 2013-03-07 | Frits VAN RHEE | Use of autologous effector cells and antibodies for treatment of multiple myeloma |
| BR112015000657B1 (pt) * | 2012-07-13 | 2023-12-05 | The Trustees Of The University Of Pennsylvania | Uso de uma célula geneticamente modificada para expressar um car |
| WO2016014565A2 (en) * | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
-
2017
- 2017-11-30 WO PCT/US2017/064060 patent/WO2018102606A1/en not_active Ceased
- 2017-11-30 CN CN201780085063.3A patent/CN110234327A/zh active Pending
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015157386A1 (en) * | 2014-04-10 | 2015-10-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Production of engineered t-cells by sleeping beauty transposon coupled with methotrexate selection |
| WO2015157384A1 (en) * | 2014-04-10 | 2015-10-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Defined composition gene modified t-cell products |
| WO2016168595A1 (en) * | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
Non-Patent Citations (2)
| Title |
|---|
| MOLECULAR THERAPY ONCOLYTICS, 2016.4, vol. 3, JPN6021045696, pages 16011, ISSN: 0004817837 * |
| 医薬品インタビューフォーム 合成副腎皮質ホルモン剤 日本薬局方 プレドニゾロン錠 プレドニン錠5MG, 2, vol. 改訂第12版, JPN6021045698, ISSN: 0004644995 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022091709A (ja) * | 2020-12-09 | 2022-06-21 | 株式会社ゲノム創薬研究所 | サイトカインストーム治療・予防剤のスクリーニング方法及びサイトカインストーム治療・予防剤 |
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| EP3548047A4 (en) | 2020-07-01 |
| KR20190090390A (ko) | 2019-08-01 |
| EP3548047A1 (en) | 2019-10-09 |
| CA3044261A1 (en) | 2018-06-07 |
| WO2018102606A1 (en) | 2018-06-07 |
| AU2017368248A1 (en) | 2019-06-06 |
| US20190351019A1 (en) | 2019-11-21 |
| CN110234327A (zh) | 2019-09-13 |
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