KR20190082192A - 암 치료를 위한 다수의 사이토카인 성분 함유 생물제제와 pd-1/pd-l1 저해제 및/또는 ctla-4 저해제의 사용 - Google Patents

암 치료를 위한 다수의 사이토카인 성분 함유 생물제제와 pd-1/pd-l1 저해제 및/또는 ctla-4 저해제의 사용 Download PDF

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KR20190082192A
KR20190082192A KR1020197007858A KR20197007858A KR20190082192A KR 20190082192 A KR20190082192 A KR 20190082192A KR 1020197007858 A KR1020197007858 A KR 1020197007858A KR 20197007858 A KR20197007858 A KR 20197007858A KR 20190082192 A KR20190082192 A KR 20190082192A
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biological agent
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derived biological
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존 더블유. 하덴
네일 엘. 베린스테인
제임스 이. 이건
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브루클린 이뮤노테라퓨틱스 엘엘씨
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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KR1020197007858A 2016-08-19 2017-08-18 암 치료를 위한 다수의 사이토카인 성분 함유 생물제제와 pd-1/pd-l1 저해제 및/또는 ctla-4 저해제의 사용 Ceased KR20190082192A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662377051P 2016-08-19 2016-08-19
US62/377,051 2016-08-19
PCT/US2017/047477 WO2018035395A1 (en) 2016-08-19 2017-08-18 Uses of pd-1/pd-l1 inhibitors and/or ctla-4 inhibitors with a biologic containing multiple cytokine components to treat cancer

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KR20190082192A true KR20190082192A (ko) 2019-07-09

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KR1020197007858A Ceased KR20190082192A (ko) 2016-08-19 2017-08-18 암 치료를 위한 다수의 사이토카인 성분 함유 생물제제와 pd-1/pd-l1 저해제 및/또는 ctla-4 저해제의 사용

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US (1) US20200330557A1 (enExample)
EP (1) EP3500290A4 (enExample)
JP (2) JP2019524887A (enExample)
KR (1) KR20190082192A (enExample)
CN (1) CN109890405A (enExample)
AU (1) AU2017312121A1 (enExample)
BR (1) BR112019003248A2 (enExample)
CA (1) CA3034266A1 (enExample)
EA (1) EA201990530A1 (enExample)
MX (1) MX2019002023A (enExample)
PH (1) PH12019550027A1 (enExample)
SG (1) SG11201901271VA (enExample)
WO (1) WO2018035395A1 (enExample)
ZA (1) ZA201901258B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021071127A1 (ko) * 2019-10-11 2021-04-15 경북대학교 산학협력단 엑소좀 pd-l1의 발현에 대한 억제제를 유효성분으로 포함하는 항암 효과 증진용 조성물

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201609131YA (en) 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Zinc-pga compositions and methods for treating cancer
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
AU2018273914A1 (en) 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance
EP3675905A4 (en) * 2017-08-30 2021-09-22 Sanford Burnham Prebys Medical Discovery Institute TP53 AS A BIOMARKER FOR RESPONSE TO IMMUNOTHERAPY
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
MX2020013883A (es) * 2018-06-22 2021-05-27 Xylonix Ip Holdings Pte Ltd Tratamientos oncológicos con agentes de zinc.
AU2020279240A1 (en) 2019-05-20 2021-12-23 Pandion Operations, Inc. MAdCAM targeted immunotolerance
CN110746493A (zh) * 2019-09-06 2020-02-04 中国药科大学 一种pd-l1拮抗剂多肽及其应用
HUE069670T2 (hu) * 2019-12-27 2025-04-28 Wuhan Vast Conduct Science Found Co Ltd Készítmény és módszer a sclerosis multiplex kezelésére
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CN113450877B (zh) * 2021-06-28 2022-04-08 深圳裕泰抗原科技有限公司 一种基于多重免疫组化技术的生物标志物分析方法及其应用
AU2023226512A1 (en) 2022-02-23 2024-08-29 Bright Peak Therapeutics Ag Immune antigen specific il-18 immunocytokines and uses thereof
WO2024215753A2 (en) * 2023-04-10 2024-10-17 Oregon Health & Science University Combination therapy for treatment of solid tumors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010248761B2 (en) * 2009-05-15 2016-02-11 Irx Therapeutics, Inc. Vaccine immunotherapy
ES2816625T3 (es) * 2010-09-24 2021-04-05 Niels Grabe Medios y métodos para la predicción de la respuesta a un tratamiento de un paciente con cáncer
PT3134123T (pt) * 2014-02-21 2021-03-22 Nektar Therapeutics India Pvt Ltd Agonistas seletivos de il-2rbeta em combinação com um anticorpo anti-ctla-4 ou um anticorpo anti-pd-1
KR20170066546A (ko) * 2014-10-03 2017-06-14 노파르티스 아게 조합 요법
SG11201702401RA (en) * 2014-10-14 2017-04-27 Novartis Ag Antibody molecules to pd-l1 and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021071127A1 (ko) * 2019-10-11 2021-04-15 경북대학교 산학협력단 엑소좀 pd-l1의 발현에 대한 억제제를 유효성분으로 포함하는 항암 효과 증진용 조성물

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EA201990530A1 (ru) 2019-07-31
EP3500290A1 (en) 2019-06-26
MX2019002023A (es) 2019-11-18
JP2019524887A (ja) 2019-09-05
BR112019003248A2 (pt) 2019-10-01
AU2017312121A1 (en) 2019-03-21
US20200330557A1 (en) 2020-10-22
EP3500290A4 (en) 2020-04-29
PH12019550027A1 (en) 2019-07-24
CN109890405A (zh) 2019-06-14
WO2018035395A1 (en) 2018-02-22
JP2023116576A (ja) 2023-08-22
CA3034266A1 (en) 2018-02-22
ZA201901258B (en) 2020-11-25
SG11201901271VA (en) 2019-03-28

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