KR20190065296A - 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 - Google Patents

아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 Download PDF

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Publication number
KR20190065296A
KR20190065296A KR1020197010786A KR20197010786A KR20190065296A KR 20190065296 A KR20190065296 A KR 20190065296A KR 1020197010786 A KR1020197010786 A KR 1020197010786A KR 20197010786 A KR20197010786 A KR 20197010786A KR 20190065296 A KR20190065296 A KR 20190065296A
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KR
South Korea
Prior art keywords
formulation
acetaminophen
sulfoalkyl ether
ether cyclodextrin
formulation according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020197010786A
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English (en)
Korean (ko)
Inventor
제임스 디 피프킨
제럴드 엘 모셔
로저 라쥬스키
Original Assignee
사이덱스 파마슈티칼스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사이덱스 파마슈티칼스, 인크. filed Critical 사이덱스 파마슈티칼스, 인크.
Priority to KR1020237043884A priority Critical patent/KR20240005122A/ko
Publication of KR20190065296A publication Critical patent/KR20190065296A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
KR1020197010786A 2016-09-16 2017-09-15 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 Ceased KR20190065296A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237043884A KR20240005122A (ko) 2016-09-16 2017-09-15 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662395794P 2016-09-16 2016-09-16
US62/395,794 2016-09-16
PCT/US2017/051919 WO2018053358A1 (en) 2016-09-16 2017-09-15 Formulations containing acetaminophen and sulfoalkyl ether cyclodextrin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237043884A Division KR20240005122A (ko) 2016-09-16 2017-09-15 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형

Publications (1)

Publication Number Publication Date
KR20190065296A true KR20190065296A (ko) 2019-06-11

Family

ID=61619250

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237043884A Pending KR20240005122A (ko) 2016-09-16 2017-09-15 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형
KR1020197010786A Ceased KR20190065296A (ko) 2016-09-16 2017-09-15 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020237043884A Pending KR20240005122A (ko) 2016-09-16 2017-09-15 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형

Country Status (9)

Country Link
US (1) US20190255000A1 (OSRAM)
EP (1) EP3512511A4 (OSRAM)
JP (3) JP7181185B2 (OSRAM)
KR (2) KR20240005122A (OSRAM)
CN (2) CN116869983A (OSRAM)
AU (3) AU2017326519B2 (OSRAM)
CA (1) CA3036989A1 (OSRAM)
MX (2) MX2019002976A (OSRAM)
WO (1) WO2018053358A1 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250339364A1 (en) * 2022-05-20 2025-11-06 Daicel Corporation Liquid pharmaceutical composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US7034013B2 (en) 2001-03-20 2006-04-25 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin
EP2307056B1 (en) * 2008-01-17 2021-12-15 Pharmis Biofarmacêutica, LDA Stabilized aqueous formulation containing paracetamol
HUE027032T2 (en) * 2009-07-23 2016-08-29 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S A Stable, immediate injectable paracetamol preparation
SG10201507554RA (en) * 2010-09-13 2015-10-29 Bev Rx Inc Aqueous drug delivery system comprising off - flavor masking agent
WO2013130666A1 (en) * 2012-02-28 2013-09-06 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
CN102871994B (zh) * 2012-09-29 2015-07-29 中国科学院大连化学物理研究所 氟比洛芬对乙酰氨基酚酯环糊精包合物及其制备方法
BR102014005885B1 (pt) * 2014-03-13 2021-04-13 Biotec Biológica Indústria Farmacêutica Ltda E.P.P Formulação farmacêutica líquida injetável estável de paracetamol em bolsa plástica pronta para uso
KR20190005823A (ko) * 2016-02-04 2019-01-16 잡 리써치 앤드 디벨롭먼트, 엘엘씨 제어된-방출 및 혼층 사이클로덱스트린 내포 복합체 비히클

Also Published As

Publication number Publication date
WO2018053358A1 (en) 2018-03-22
MX2019002976A (es) 2019-07-10
AU2017326519B2 (en) 2023-03-16
EP3512511A4 (en) 2020-05-20
JP7181185B2 (ja) 2022-11-30
AU2017326519A1 (en) 2019-04-11
CN110167543A (zh) 2019-08-23
CA3036989A1 (en) 2018-03-22
CN116869983A (zh) 2023-10-13
JP2024051102A (ja) 2024-04-10
US20190255000A1 (en) 2019-08-22
KR20240005122A (ko) 2024-01-11
AU2023203660A1 (en) 2023-07-06
JP2022140780A (ja) 2022-09-27
EP3512511A1 (en) 2019-07-24
RU2019107764A (ru) 2020-10-16
JP2019532927A (ja) 2019-11-14
MX2023003761A (es) 2023-04-26
RU2019107764A3 (OSRAM) 2021-01-15
AU2025204233A1 (en) 2025-06-26

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