KR20190058951A - Chinese medicine for gastric ulcer treatment - Google Patents
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Abstract
Description
본 발명은 위궤양 치료를 위한 중의약에 대한 것이다.The present invention relates to a herbal medicine for treating gastric ulcer.
궤양병 혹은 소화성 궤양은 흔한 소화성 질병 중 하나로서 식도, 위 또는 십이지장에서 발생할 수 있고 또한 위-공장 문합 근처에서 또는 위 점막을 함유하는 메켈게실에서 발생할 수 있다. 위궤양 및 십이지장 궤양은 아주 흔하며 따라서 일반적으로 소위 소화성 궤양이라 함은 위궤양 및 십이지장 궤양을 일컫는다. 위궤양 및 십이지장 궤양이 점막 상의 펩신 및 위산의 자가 소화에 의해 형성되기 때문에 소화성 궤양이라고 불린다. 하지만, 위산 및 펩신은 실제로는 궤양병을 형성하는 주요 원인 중 하나에 불과하며 다른 원인 또한 소화성 궤양을 형성할 수 있다. 위궤양 및 십이지장 궤양의 병인론 및 임상 증상은 아주 많이 유사하여 그들 사이의 구별이 때론 어렵다; 따라서 소화성 궤양으로 진단되거나 위 및 십이지장 궤양으로 진단되는 경향이 있다. 만약 궤양병이 위 또는 십이지장에서 발생한 것이 명확하다면, 소화성 궤양은 바로 위궤양 또는 십이지장 궤양으로 진단될 수 있다.Ulcerative or peptic ulcer is one of the common digestive diseases that can occur in the esophagus, stomach or duodenum and can also occur in the Meckel's diverticulum near the stomach-factory anastomosis or in the gastric mucosa. Stomach ulcers and duodenal ulcers are very common, and so commonly referred to as so-called peptic ulcer refers to gastric ulcer and duodenal ulcer. Stomach ulcers and duodenal ulcers are called peptic ulcers because they are formed by self-digestion of pepsin and gastric acid on the mucosal surface. However, gastric acid and pepsin are actually only one of the major causes of ulceration, and other causes can also form peptic ulcers. The pathology and clinical manifestations of gastric and duodenal ulcers are very similar and distinction between them is sometimes difficult; Therefore, there is a tendency to diagnose peptic ulcers or to diagnose gastric and duodenal ulcers. If it is clear that the ulcer disease has occurred in the stomach or duodenum, a peptic ulcer can be diagnosed as a gastric ulcer or a duodenal ulcer.
질환의 주 증상은 위통이다. 상복부에서 흔히 나타나고 또한 좌복부에서 혹은 흉골 및 검상연골 뒤에서 나타난다. 종종 남모를 심한 괴로움, 둔통, 팽창통 및 작열통을 동반한다. 위궤양 통증은 종종 식후 1시간 이내에 나타나고, 1-2시간 후에 점차 누그러진다. 이 같은 한 번 이상의 리듬은 다음 식사까지 다시 나타나지 않는다. 환자들 중 일부는 증상이 없거나 출혈, 천공 및 다른 합병증이 제1 증상으로 나타난다. The main symptom of the disease is stomach pain. It is common in the upper abdomen and also in the left abdomen or behind the sternum and the gonadal cartilage. Often a mother is accompanied by severe bitterness, dullness, swelling and burning pain. Ulcer pain often appears within one hour after meals and gradually loosens after 1-2 hours. More than one such rhythm does not appear again until the next meal. Some of the patients have no symptoms or bleeding, perforation and other complications are the first symptoms.
따라서, 식후 복통을 완화할 수 있고 위궤양을 치료할 수 있는 중의약의 개발이 필요하다.Therefore, it is necessary to develop a herbal medicine that can alleviate postprandial abdominal pain and treat gastric ulcer.
본 발명의 목적은 위궤양 치료를 위한 중의약을 제공하는 것이다. It is an object of the present invention to provide a medicinal herb for the treatment of gastric ulcer.
식후에 위통을 완화하는데 효과가 있고 오랫동안 약으로서 사용된, 위궤양 치료를 위한 중의약은 무씨(Radish Seed) 및 법반하(Rhizoma Pinellinae Praeparata)을 주 성분으로 하고 전통 약 효과와 현대 약학 연구 성과를 조합한다.The medicinal herbs for gastric ulcer treatment, which have been effective for relieving post-prandial stomach pain and used for a long time, combine Radish Seed and Rhizoma Pinellinae Praeparata as main ingredients and combine traditional medicine effects with modern pharmaceutical research results .
이를 위해, 본 발명은 위궤양 치료를 위한 중의약을 제공하고, 상기 중의약은 무씨(Radish Seed) 20-40중량부, 법반하(Rhizoma Pinellinae Praeparata) 10-20중량부, 현호색(Rhizoma Corydalis) 6-8중량부, 지각(Fructus Aurantii) 8-12중량부, 귤피(Tangerine Peel) 4-8중량부, 참마(Yam) 4-6중량부, 천우슬(Cyathula officinalis) 1-3중량부 및 감초(liquorice) 1-3중량부를 포함한다.To this end, the present invention provides a medicinal herb for the treatment of gastric ulcers, wherein the herbal medicine comprises 20-40 parts by weight of Radish Seed, 10-20 parts by weight of Rhizoma Pinellinae Praeparata, 6-8 parts by weight of Rhizoma Corydalis 6-8 8 to 12 parts by weight of fructus aurantii, 4-8 parts by weight of Tangerine Peel, 4-6 parts by weight of Yam, 1-3 parts by weight of Cyathula officinalis and liquorice ) ≪ / RTI >
본 발명의 일 실시 예에 따르면, 위궤양을 치료하기 위한 중의약은 무씨 20중량부, 법반하 10중량부, 현호색 6, 지각 8중량부, 귤피 4중량부, 참마 4중량부, 천우슬 1중량부 및 감초 1중량부를 포함한다.According to one embodiment of the present invention, the Chinese medicine for treating gastric ulcer is composed of 20 parts by weight of sucrose, 10 parts by weight of actinic acid, 10 parts by weight of corn, 6 parts by weight of crust, 4 parts by weight of citrus fruit, 4 parts by weight of yam, And 1 part by weight of licorice.
본 발명의 일 실시 예에 따르면, 위궤양을 치료하기 위한 중의약은 무씨 30중량부, 법반하 15중량부, 현호색 7중량부, 지각 10중량부, 귤피 6중량부, 참마 5중량부, 천우슬 2중량부 및 감초 2중량부를 포함한다.According to one embodiment of the present invention, the herbal medicine for treating gastric ulcer comprises 30 parts by weight of sucrose, 15 parts by weight of the anti-obesity agent, 7 parts by weight of corn starch, 10 parts by weight of crust, 6 parts by weight of citrus fruit, 5 parts by weight of yam, And 2 parts by weight of licorice.
본 발명의 일 실시 예에 따르면, 위궤양을 치료하기 위한 중의약은 무씨 40중량부, 법반하 20중량부, 현호색 8, 지각 12중량부, 귤피 8중량부, 참마 6중량부, 천우슬 3중량부 및 감초 3중량부를 포함한다.According to one embodiment of the present invention, the Chinese medicine for treating gastric ulcer comprises 40 parts by weight of sucrose, 20 parts by weight of the anticancer, 8 parts by weight of corn, 8 parts by weight of crust, 8 parts by weight of citrus fruit, 6 parts by weight of yam, And 3 parts by weight of licorice.
본 발명의 일 실시 예에 따르면, 위궤양을 치료하기 위한 상기 중의약은 뱀 기름 3-8중량부를 더 포함한다.According to one embodiment of the present invention, the herbal medicine for treating gastric ulcer further comprises 3-8 parts by weight of snake oil.
전술한 본 발명에 따른 중의약 제조방법 및 용도는 다음과 같다:The above-described method for producing a Chinese medicine and its use according to the present invention are as follows:
각 중량부에 맞게 모든 성분들이 칭량되어 거즈 백에 포장된다;All ingredients are weighed and packed in a gauze bag for each weight part;
상기 칭량된 성분들을 담은 거즈 백이 10-20배 중량부의 순수에 첨가되고, 10분 동안 끓여진 후 30분 동안 달여졌고, 그 후 상온에서 냉각된다;The gauze bag containing the weighed ingredients was added to 10-20 parts by weight of pure water, boiled for 10 minutes and then dated for 30 minutes and then cooled at room temperature;
냉각된 액체를 여과하여 위궤양 치료용 중의약 상청액을 얻는다. The cooled liquid is filtered to obtain a suppository aqueous solution for gastric ulcer treatment.
사용시, 환자는 치료 코스(course)로서 위궤양 치료용 중의약을 70ml씩 1일 3회 섭취하고, 인접한 치료 코스의 간격은 1일이다. 연속적인 3회 치료 코스 후에 환자는 치료된다. 위궤양에 의한 식후 위통은, 치료 코스에서 정 시간에 의약을 섭취하면, 효과적으로 완화될 수 있다. In use, the patient consumes 70 ml of herbal medicine for gastric ulcer treatment three times a day as a course of treatment, and the interval between adjacent treatment courses is one day. After three consecutive courses of treatment, the patient is treated. Postprandial gastroenteritis caused by gastric ulcers can be effectively alleviated if the medicines are consumed on a regular basis in a course of treatment.
본 발명의 위궤양 치료용 중의약은 위궤양에 의한 식후 위통을 빠르게 완화할 수 있고, 위궤양 치료에 특히 효과적이다.The gastric ulcer therapeutic drug of the present invention can rapidly alleviate postprandial gastric emptying by gastric ulcer and is particularly effective in the treatment of gastric ulcer.
본 발명의 다른 특징 및 이점은 아래에서 더 상세히 설명될 것이다.Other features and advantages of the invention will be described in more detail below.
본 발명은 여려 적용 가능한 창의적인 개념을 제공하고 광범위하게 구현될 수 있다. 이하의 구체적인 여러 실시 예들은 본 발명의 예시적인 구현을 설명하는 것일 뿐 본 발명의 범위를 제한하는 것은 아니다.The present invention provides a creative concept that can be applied to a wide variety of applications. The following specific embodiments are illustrative of exemplary implementations of the invention and are not intended to limit the scope of the invention.
일반성을 잃지 않고, 본 발명은 위궤양 치료를 위한 중의약(Chinese medicine)을 제공하며, 이 중의약은, 무씨(Radish Seed) 20-40중량부, 법반하(Rhizoma Pinellinae Praeparata) 10-20중량부, 현호색(Rhizoma Corydalis) 6-8중량부, 지각(Fructus Aurantii) 8-12중량부, 귤피(Tangerine Peel) 4-8중량부, 참마(Yam) 4-6중량부, 천우슬(Cyathula officinalis) 1-3중량부 및 감초(liquorice) 1-3중량부를 포함한다.Without loss of generality, the present invention provides Chinese medicine for the treatment of gastric ulcers, which comprises 20-40 parts by weight of Radish Seed, 10-20 parts by weight of Rhizoma Pinellinae Praeparata, 6-8 parts by weight of Rhizoma Corydalis, 8-12 parts by weight of Fructus Aurantii, 4-8 parts by weight of Tangerine Peel, 4-6 parts by weight of Yam, 3 parts by weight and liquorice 1-3 parts by weight.
전술한 모든 성분은 가공된 상태로서 구입할 수 있고 또한 파우더를 얻기 위해 잘 알려진 방법 예를 들어 성분을 건조 및 분쇄함으로써 얻을 수 있다. 건조 방법은 가열건조(stoving) 또는 자연광건조(natual insolation)일 수 있고 자연광건조가 선호된다. 분쇄 방법은 전통 중의약 분야에서 중의약 재료를 분쇄하여 파우더로 만드는 일반적인 방법일 수 있다. 바람직하게, 원하는 분쇄 조건은 20-30메쉬(mesh), 더 바람직하게는 20메쉬의 평균 입자 직경을 갖는 성분을 얻는 것이다.All of the above-mentioned components can be obtained in a processed state and can also be obtained by drying and pulverizing the components well known in the art, for example, to obtain a powder. The drying method may be stoving or natual insolation and natural light drying is preferred. The pulverization method may be a general method of pulverizing a Chinese medicine material into a powder in the traditional Chinese medicine field. Preferably, the desired milling conditions are to obtain a component having an average particle diameter of 20-30 mesh, more preferably 20 mesh.
본 발명에서 제공하는 위궤양 치료용 중의약은 위궤양에 의한 식후 위통(stomachache)을 빠르게 완화할 수 있고, 위궤양 치료에 특히 효과를 나타낸다.The gastric herbal medicines provided by the present invention can rapidly alleviate stomachache caused by gastric ulcer, and are particularly effective in treating gastric ulcer.
본 발명이 제안하는 기술을 구현하기 위해서, 본 발명은 위궤양 치료를 위한 주으이약의 제조 방법 및 사용을 제공하며 다음과 같다:In order to implement the techniques proposed by the present invention, the present invention provides a method for the manufacture and use of a paclitaxel for the treatment of gastric ulcers, comprising:
각 중량부에 맞게 모든 성분들이 칭량되어 거즈 백(gauze bag)에 포장된다;All components are weighed and packed in a gauze bag for each weight part;
상기 칭량된 성분들을 담은 거즈 백이 10-20배 중량부의 순수(pure water)에 첨가되고, 10분 동안 끓여진 후 30분 동안 달여졌고, 그 후 상온에서 냉각된다;The gauze bag containing the weighed ingredients was added to 10-20 parts by weight of pure water, boiled for 10 minutes and then allowed to thaw for 30 minutes and then cooled at room temperature;
냉각된 액체를 여과하여 위궤양 치료용 중의약 상청액을 얻는다.The cooled liquid is filtered to obtain a suppository aqueous solution for gastric ulcer treatment.
사용시에, 환자는 치료 코스(course)로서 위궤양 치료용 중의약을 70ml씩 1일 3회 섭취하고, 인접한 치료 코스의 간격은 1일이다. 연속적인 3회 치료 코스 후에 환자는 치료된다. 위궤양에 의한 식후 위통은, 치료 코스에서 정 시간에 의약을 섭취하면, 효과적으로 완화될 수 있다. In use, the patient consumes 70 ml of gastric juice for gastric ulcer treatment three times a day as a course of treatment, and the interval between adjacent treatment courses is one day. After three consecutive courses of treatment, the patient is treated. Postprandial gastroenteritis caused by gastric ulcers can be effectively alleviated if the medicines are consumed on a regular basis in a course of treatment.
본 발명이 실시 예들을 통해 아래에서 더 구체적으로 설명된다.BRIEF DESCRIPTION OF THE DRAWINGS The invention is explained in more detail below with reference to embodiments.
실시 예 1-5Examples 1-5
본 발명에 따른 위궤양 치료용 중의약에 대한 실시 예 1-5가 제공된다.Example 1-5 of a drug for treating gastric ulcer according to the present invention is provided.
실시 예 1-5의 중의약은 아래 표 1의 조합 방법에 따라 제조되었다.The herbal medicine of Example 1-5 was prepared according to the combination method shown in Table 1 below.
실시 예 1-3을 참조하여 본 발명에 따른 위궤양 치료용 중의약의 효과를 설명한다.The effects of the drug for treating gastric ulcer according to the present invention will be described with reference to Examples 1-3.
(1) 내재 원인(inherent cause)에 의해 유발된 위궤양에 대한 효과(1) Effect on the gastric ulcer induced by inherent cause
내재 원인에 의해 유발된 위궤양을 겪는 평균 연령 30-55세의 남녀 150명을 무작위로 다섯 그룹(각 그룹당 30명)으로 나눴다. 다섯 그룹의 사람이 본 발명에 따른 위궤양 치료용 중의약을 70ml씩 하루 세 번 3일을 치료 코스로 하여 섭취하였으며, 인접한 치료 코스 간격은 하루였다. 3회의 치료 코스를 연속으로 한 후 치료 전 대비 효과를 비교하였으며, 어떠한 증상도 없는 경우 O로 표시하였고, 증상이 분명히 완화된 경우 △로 표시하였고, 증상 호전이 거의 없는 경우 X로 표시하였으며 아래 표 2에 정리되어 있다.We randomly assigned 150 men and women with an average age of 30-55 years suffering from gastric ulcer induced by intrinsic causes to 30 groups (30 per group). Five groups of people consumed 70 ml of herbal medicines for treating gastric ulcer according to the present invention three times a day for three days as a treatment course, and the interval between adjacent treatment courses was one day. After three consecutive treatment courses, the efficacy was compared before treatment. When no symptoms were present, the patient was marked with O, when the symptoms were clearly alleviated, marked with △, when there was no symptom improvement, marked with X, 2.
(2) 생활 요인(living factor)에 의해 유발한 위궤양에 대한 효과(2) The effect of living factor on gastric ulcer
생활 원인에 의해 유발된 위궤양을 겪는 평균 연령 30-55세의 남녀 150명을 무작위로 다섯 그룹(각 그룹당 30명)으로 나눴다. 다섯 그룹의 사람이 본 발명에 따른 위궤양 치료용 중의약을 70ml씩 하루 세 번 3일을 치료 코스로 하여 섭취하였으며, 인접한 치료 코스 간격은 하루였다. 3회의 치료 코스를 연속으로 한 후 치료 전 대비 효과를 비교하였으며, 어떠한 증상도 없는 경우 O로 표시하였고, 증상이 분명히 완화된 경우 △로 표시하였고, 증상 호전이 거의 없는 경우 X로 표시하였으며 아래 표 3에 정리되어 있다.We randomly assigned 150 men and women with an average age of 30-55 years suffering from gastrointestinal (GI) -induced causes of life to five groups (30 per group). Five groups of people consumed 70 ml of herbal medicines for treating gastric ulcer according to the present invention three times a day for three days as a treatment course, and the interval between adjacent treatment courses was one day. After three consecutive treatment courses, the efficacy of the treatment was compared. When no symptoms were present, the patient was marked with O, when the symptoms were clearly relieved, marked with △, when there was no improvement, marked with X, 3.
(3) 감염원에 의해 유발된 위궤양에 대한 효과(3) Effect on infected gastric ulcer
감염원에 의해 유발된 위궤양을 겪는 평균 연령 30-55세의 남녀 150명을 무작위로 다섯 그룹(각 그룹당 30명)으로 나눴다. 다섯 그룹의 사람이 본 발명에 따른 위궤양 치료용 중의약을 70ml씩 하루 세 번 3일을 치료 코스로 하여 섭취하였으며, 인접한 치료 코스 간격은 하루였다. 3회의 치료 코스를 연속으로 한 후 치료 전 대비 효과를 비교하였으며, 어떠한 증상도 없는 경우 O로 표시하였고, 증상이 분명히 완화된 경우 △로 표시하였고, 증상 호전이 거의 없는 경우 X로 표시하였으며 아래 표 4에 정리되어 있다.We randomly assigned 150 men and women with an average age of 30-55 with an infection-induced gastric ulcer (30 per group). Five groups of people consumed 70 ml of herbal medicines for treating gastric ulcer according to the present invention three times a day for three days as a treatment course, and the interval between adjacent treatment courses was one day. After three consecutive treatment courses, the efficacy was compared before treatment. When no symptoms were present, the patient was marked with O, when the symptoms were clearly alleviated, marked with △, when there was no symptom improvement, marked with X, 4.
위 실험 결과들로부터 본 발명에 따른 위궤양 치료용 중의약이 식후 위통 및 위궤양 치료에 특히 효과적임을 알 수 있다.From the above experimental results, it can be seen that the herbal medicines for treating gastric ulcer according to the present invention are particularly effective for post-prandial gastric and gastric ulcer treatments.
Claims (5)
무씨 20-40중량부, 법반하 10-20중량부, 현호색 6-8중량부, 지각 8-12중량부, 귤피 4-8중량부, 참마 4-6중량부, 천우슬 1-3중량부 및 감초 1-3중량부를 포하는 위궤양 치료용 중의약.A herbal medicine for treating gastric ulcer, wherein the herbal medicine is:
20 to 40 parts by weight of mulberry, 10 to 20 parts by weight of corn, 6-8 parts by weight of precious color, 8-12 parts by weight of crust, 4-8 parts by weight of citrus fruit, 4-6 parts by weight of yam, And 1-3 parts by weight of licorice.
상기 위궤양 치료용 중의약은:
무씨 20중량부, 법반하 10중량부, 현호색 6, 지각 8중량부, 귤피 4중량부, 참마 4중량부, 천우슬 1중량부 및 감초 1중량부를 포함하는 위궤양 치료용 중의약.The method according to claim 1,
Wherein the gastric ulcer treatment herbal medicine comprises:
20 parts by weight of sucrose, 10 parts by weight of the anticorrosion, 10 parts by weight of corn starch, 8 parts by weight of crust, 4 parts by weight of citrus fruit, 4 parts by weight of yams, 1 part by weight of cinnabar and 1 part by weight of licorice.
상기 위궤양 치료용 중의약은:
무씨 30중량부, 법반하 15중량부, 현호색 7중량부, 지각 10중량부, 귤피 6중량부, 참마 5중량부, 천우슬 2중량부 및 감초 2중량부를 포함하는 위궤양 치료용 중의약.The method according to claim 1,
Wherein the gastric ulcer treatment herbal medicine comprises:
30 parts by weight of sucrose, 15 parts by weight of anti-obesity, 7 parts by weight of erythrocyte, 10 parts by weight of crust, 6 parts by weight of citrus peel, 5 parts by weight of yam, 2 parts by weight of cinnabar and 2 parts by weight of licorice.
상기 위궤양 치료용 중의약은:
무씨 40중량부, 법반하 20중량부, 현호색 8, 지각 12중량부, 귤피 8중량부, 참마 6중량부, 천우슬 3중량부 및 감초 3중량부를 포함하는 위궤양 치료용 중의약.The method according to claim 1,
Wherein the gastric ulcer treatment herbal medicine comprises:
40 parts by weight of sucrose, 20 parts by weight of antiarrhythmia, 8 parts by weight of corn starch, 12 parts by weight of crust, 8 parts by weight of citrus fruit, 6 parts by weight of yam, 3 parts by weight of cinnabar and 3 parts by weight of licorice.
상기 위궤양 치료용 중의약은 뱀 기름 3-8중량부를 더 포함하는 위궤양 치료용 중의약.
The method according to any one of claims 1 to 4,
Wherein the gastric ulcer treatment herbal medicine further comprises 3-8 parts by weight of snake oil.
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