KR20190053180A - 시공간적 조절자들 - Google Patents
시공간적 조절자들 Download PDFInfo
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- KR20190053180A KR20190053180A KR1020197005579A KR20197005579A KR20190053180A KR 20190053180 A KR20190053180 A KR 20190053180A KR 1020197005579 A KR1020197005579 A KR 1020197005579A KR 20197005579 A KR20197005579 A KR 20197005579A KR 20190053180 A KR20190053180 A KR 20190053180A
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- South Korea
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- mirna
- engineered
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- cells
- gene construct
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
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- C12N15/62—DNA sequences coding for fusion proteins
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- C12N15/67—General methods for enhancing the expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/122—Hairpin
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
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- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
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- Plant Pathology (AREA)
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- Immunology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662366755P | 2016-07-26 | 2016-07-26 | |
| US62/366,755 | 2016-07-26 | ||
| PCT/US2017/043938 WO2018022749A1 (en) | 2016-07-26 | 2017-07-26 | Spatiotemporal regulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190053180A true KR20190053180A (ko) | 2019-05-17 |
Family
ID=59523304
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197005579A Ceased KR20190053180A (ko) | 2016-07-26 | 2017-07-26 | 시공간적 조절자들 |
| KR1020197005575A Withdrawn KR20190053179A (ko) | 2016-07-26 | 2017-07-26 | 유전자 지우개들 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197005575A Withdrawn KR20190053179A (ko) | 2016-07-26 | 2017-07-26 | 유전자 지우개들 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20190233844A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3491137A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2019521717A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20190053180A (cg-RX-API-DMAC7.html) |
| CN (2) | CN110073000A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2017302587A1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3031670A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2018022747A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| US11576872B2 (en) | 2017-05-08 | 2023-02-14 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| CN112367973A (zh) * | 2018-05-15 | 2021-02-12 | 旗舰先锋创新V股份有限公司 | 融合剂脂质体组合物和其用途 |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| CA3105953A1 (en) | 2018-07-09 | 2020-01-16 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| KR20210131991A (ko) | 2018-11-14 | 2021-11-03 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 구획-특이적 카고 전달을 위한 조성물 및 방법 |
| US12385054B2 (en) * | 2019-11-19 | 2025-08-12 | Protalix Ltd. | Removal of constructs from transformed cells |
| GB202006462D0 (en) * | 2020-05-04 | 2020-06-17 | Mote Res Limited | Modifying genomes with integrase |
| JP2024532963A (ja) | 2021-04-08 | 2024-09-11 | サナ バイオテクノロジー,インコーポレイテッド | Cd8特異的抗体コンストラクト及びその組成物 |
| KR20260044268A (ko) | 2023-06-26 | 2026-04-01 | 유니버시티 오브 하와이 | 진화한 인테그라제 및 이를 이용한 게놈 편집 방법 |
| CN120866333A (zh) * | 2024-04-30 | 2025-10-31 | 深圳市深研生物科技有限公司 | 利用膜蛋白进行细胞分选的方法 |
| CN118813656B (zh) * | 2024-06-19 | 2025-06-03 | 山东大学 | 一种大片段dna级联组装的方法、系统及应用 |
| GB2642222A (en) * | 2024-06-26 | 2026-01-07 | E V A Biosystems Ltd | A gene cassette and uses therefor |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19834430C2 (de) * | 1998-07-30 | 2000-05-31 | Harald Von Melchner | Selbstdeletierende Vektoren für die Krebstherapie |
| US7189506B1 (en) * | 1999-03-03 | 2007-03-13 | Genelabs Technologies, Inc. | DNA binding compound-mediated molecular switch system |
| US20060265771A1 (en) * | 2005-05-17 | 2006-11-23 | Lewis David L | Monitoring microrna expression and function |
| DK2002003T3 (en) * | 2005-05-27 | 2016-03-21 | Ospedale San Raffaele Srl | Gene vector comprising miRNA |
| WO2006128245A1 (en) * | 2005-06-03 | 2006-12-07 | Southern Adelaide Health Service-Flinders Medical Centre | Targeting cells with altered microrna expression |
| US20070054872A1 (en) * | 2005-08-24 | 2007-03-08 | Mirus Bio Corporation | Regulatable or conditional expression systems |
| US20080031816A1 (en) * | 2006-08-03 | 2008-02-07 | Charles Keller | Methods and compositions for identifying biomarkers |
| US20090286242A1 (en) * | 2007-12-10 | 2009-11-19 | Cold Spring Harbor Laboratory | MicroRNA Expression Profiling and Uses Thereof |
| US20110098346A1 (en) * | 2008-05-19 | 2011-04-28 | Agency For Science, Technology And Research | Nucleic acid molecule and method of targeting gene expression to gliomas |
| US20100229254A1 (en) * | 2009-03-04 | 2010-09-09 | Kmita Marie | Method for targeted cell ablation |
| CA2833912C (en) * | 2010-04-23 | 2021-09-21 | University Of Massachusetts | Aav-based treatment of cholesterol-related disorders |
| WO2012056440A1 (en) * | 2010-10-28 | 2012-05-03 | Nanodoc Ltd. | COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA |
| CN102719556A (zh) * | 2011-03-29 | 2012-10-10 | 北京五加和分子医学研究所有限公司 | 基于AAV载体的高通量miRNA活性检测方法及其应用 |
| WO2012131048A1 (en) * | 2011-03-31 | 2012-10-04 | Royal College Of Surgeons In Ireland | Treatment and prognosis of solid tumour cancers |
| CN102358901A (zh) * | 2011-11-11 | 2012-02-22 | 天津托普泰克生物科技有限公司 | Has-miR-520e的抗肿瘤用途 |
| EP2684962A1 (en) * | 2012-07-10 | 2014-01-15 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Vector for the selective silencing of a gene in astrocytes |
| JP6419082B2 (ja) * | 2012-12-13 | 2018-11-07 | マサチューセッツ インスティテュート オブ テクノロジー | リコンビナーゼに基づく論理/メモリシステム |
| US10227589B2 (en) * | 2013-01-28 | 2019-03-12 | Council Of Scientific And Industrial Research | Method for inhibiting tumor growth through RNA-interference using liposomally associated CDC20 siRNA |
| FR3004463A1 (fr) * | 2013-04-11 | 2014-10-17 | Genethon | Systeme d'expression pour une therapie genique selective |
| WO2016065001A1 (en) * | 2014-10-21 | 2016-04-28 | University Of Massachusetts | Recombinant aav variants and uses thereof |
| JP2016088884A (ja) * | 2014-11-04 | 2016-05-23 | 国立大学法人岐阜大学 | 腫瘍治療用組成物 |
| EP3310915A4 (en) | 2015-06-19 | 2019-04-10 | Massachusetts Institute of Technology | TUMOR IMMUNOTHERAPY |
| US11174495B2 (en) * | 2015-12-04 | 2021-11-16 | Board Of Regents, The University Of Texas System | Reporter system for detecting and targeting activated cells |
-
2017
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- 2017-07-26 US US16/319,791 patent/US20190233844A1/en not_active Abandoned
- 2017-07-26 CN CN201780058989.3A patent/CN110088285A/zh active Pending
- 2017-07-26 KR KR1020197005579A patent/KR20190053180A/ko not_active Ceased
- 2017-07-26 KR KR1020197005575A patent/KR20190053179A/ko not_active Withdrawn
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| WO2018022747A1 (en) | 2018-02-01 |
| US20190233844A1 (en) | 2019-08-01 |
| WO2018022749A1 (en) | 2018-02-01 |
| CA3031670A1 (en) | 2018-02-01 |
| AU2017302587A1 (en) | 2019-02-07 |
| JP2019527563A (ja) | 2019-10-03 |
| EP3491137A1 (en) | 2019-06-05 |
| US20190169634A1 (en) | 2019-06-06 |
| CN110073000A (zh) | 2019-07-30 |
| KR20190053179A (ko) | 2019-05-17 |
| AU2017302589A1 (en) | 2019-02-28 |
| EP3491138A1 (en) | 2019-06-05 |
| CA3031673A1 (en) | 2018-02-01 |
| CN110088285A (zh) | 2019-08-02 |
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