KR20190051956A - 단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 - Google Patents
단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 Download PDFInfo
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- KR20190051956A KR20190051956A KR1020197005928A KR20197005928A KR20190051956A KR 20190051956 A KR20190051956 A KR 20190051956A KR 1020197005928 A KR1020197005928 A KR 1020197005928A KR 20197005928 A KR20197005928 A KR 20197005928A KR 20190051956 A KR20190051956 A KR 20190051956A
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020237006942A KR102637610B1 (ko) | 2016-08-23 | 2017-08-22 | 단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662378614P | 2016-08-23 | 2016-08-23 | |
| US62/378,614 | 2016-08-23 | ||
| PCT/US2017/048040 WO2018039247A1 (en) | 2016-08-23 | 2017-08-22 | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237006942A Division KR102637610B1 (ko) | 2016-08-23 | 2017-08-22 | 단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190051956A true KR20190051956A (ko) | 2019-05-15 |
Family
ID=61245300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197005928A Ceased KR20190051956A (ko) | 2016-08-23 | 2017-08-22 | 단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 |
| KR1020237006942A Active KR102637610B1 (ko) | 2016-08-23 | 2017-08-22 | 단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237006942A Active KR102637610B1 (ko) | 2016-08-23 | 2017-08-22 | 단백질용해 절단가능한 키메라 폴리펩타이드 및 이의 사용 방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11401332B2 (enExample) |
| EP (1) | EP3504245A4 (enExample) |
| JP (2) | JP7500195B2 (enExample) |
| KR (2) | KR20190051956A (enExample) |
| CN (1) | CN109843929B (enExample) |
| AU (1) | AU2017316649A1 (enExample) |
| CA (1) | CA3034093A1 (enExample) |
| SG (2) | SG10201913583QA (enExample) |
| WO (1) | WO2018039247A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013540757A (ja) | 2010-09-24 | 2013-11-07 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル |
| WO2016134371A2 (en) | 2015-02-20 | 2016-08-25 | Ohio State Innovation Foundation | Bivalent antibody directed against nkg2d and tumor associated antigens |
| HK1250918A1 (zh) | 2015-04-06 | 2019-01-18 | Cytoimmune Therapeutics, Inc. | 用於胶质母细胞瘤的egfr导向的car疗法 |
| PL3512537T3 (pl) * | 2016-09-15 | 2024-02-26 | Elicera Therapeutics Ab | Immunoterapia limfocytami t |
| US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| US11807662B2 (en) * | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
| US11325957B2 (en) * | 2017-06-19 | 2022-05-10 | Cell Design Labs, Inc. | Methods and compositions for reducing the immunogenicity of chimeric notch receptors |
| CN112118850A (zh) * | 2018-03-16 | 2020-12-22 | 赛通免疫治疗公司 | 双特异性抗体car细胞免疫疗法 |
| GB201804291D0 (en) * | 2018-03-16 | 2018-05-02 | Evox Therapeutics Ltd | Cell-mediated exosome delivery |
| EP3773478A1 (en) | 2018-04-04 | 2021-02-17 | Alivio Therapeutics, Inc. | Self-assembled gels for controlled delivery of biologics and methods of making thereof |
| WO2019195586A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| AU2019249221A1 (en) | 2018-04-06 | 2020-10-22 | The Regents Of The University Of California | Methods of treating glioblastomas |
| AU2019247830A1 (en) * | 2018-04-06 | 2020-10-22 | The Regents Of The University Of California | Trans-antigen targeting in heterogeneous cancers and methods of use thereof |
| KR20210008840A (ko) * | 2018-04-10 | 2021-01-25 | 스티흐팅 산퀸 불드포르지닝 | 키메라 노치 수용체 |
| EP3847650A1 (en) | 2018-09-06 | 2021-07-14 | The Broad Institute, Inc. | Nucleic acid assemblies for use in targeted delivery |
| AU2019392687A1 (en) * | 2018-12-06 | 2021-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Regulatable cell surface receptors and related compositions and methods |
| WO2020140973A1 (en) * | 2019-01-03 | 2020-07-09 | Nanjing Legend Biotech Co., Ltd. | Modified immune cells expressing flagellin polypeptide |
| US20240173352A1 (en) * | 2019-08-09 | 2024-05-30 | A2 Biotherapeutics, Inc. | Cell-surface receptors responsive to loss of heterozygosity |
| CN114729025A (zh) * | 2019-09-24 | 2022-07-08 | 加利福尼亚大学董事会 | 用于配体依赖性转录调控的新型受体 |
| RS66476B1 (sr) * | 2019-09-24 | 2025-03-31 | Univ California | Notch receptori sa zglobnim domenom |
| EP4034254A4 (en) * | 2019-09-24 | 2023-11-01 | The Regents of the University of California | HETEROLOGOUS TRANSMEMBRANE DOMAIN RECEPTORS |
| WO2021061791A1 (en) * | 2019-09-24 | 2021-04-01 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| CN110716044B (zh) * | 2019-10-23 | 2023-04-18 | 郑州大学 | 一种用于食管鳞癌早期筛查和诊断的血清蛋白标志物、试剂盒及检测方法 |
| US12195723B2 (en) | 2019-11-08 | 2025-01-14 | The Broad Institute, Inc. | Engineered antigen presenting cells and uses thereof |
| CN110970090B (zh) * | 2019-11-18 | 2021-06-29 | 华中科技大学 | 一种用于判断待处理多肽与阳性数据集肽段相似度的方法 |
| CN115087466A (zh) * | 2019-12-12 | 2022-09-20 | 森迪生物科学公司 | 用于细胞的调控装甲的方法和组合物 |
| CN115151644B (zh) * | 2019-12-27 | 2024-06-21 | 国立大学法人神户大学 | 癌基因治疗药 |
| US20230226213A1 (en) * | 2020-06-18 | 2023-07-20 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating cells and cellular membranes |
| EP4100028A4 (en) | 2020-08-20 | 2023-07-26 | A2 Biotherapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF MESOTHELIN-POSITIVE CARCINOMAS |
| MX2023002017A (es) | 2020-08-20 | 2023-04-28 | A2 Biotherapeutics Inc | Composiciones y métodos para tratar cánceres positivos para ceacam. |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN116635064A (zh) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | 具有适应性受体特异性的嵌合抗原受体系统 |
| WO2022183056A1 (en) * | 2021-02-26 | 2022-09-01 | Salk Institute For Biological Studies | Modulating regulatory t cell function in autoimmune disease and cancer |
| JP2024512573A (ja) * | 2021-03-23 | 2024-03-19 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | カスタム抗原誘導性転写制御のための合成膜間タンパク質分解受容体 |
| US20250288672A1 (en) * | 2021-03-24 | 2025-09-18 | Raymond Liu | Humanized synthetic notch receptors with augmented transactivation domains and uses thereof |
| CN113307859B (zh) * | 2021-03-24 | 2022-03-01 | 深圳市新靶向生物科技有限公司 | 一种与乳腺癌驱动基因突变相关的抗原肽组合及其应用 |
| PE20241173A1 (es) | 2021-10-14 | 2024-05-28 | Arsenal Biosciences Inc | Celulas inmunitarias que tienen arnhc coexpresados y sistemas de compuerta logica |
| CN114107253B (zh) * | 2021-12-17 | 2024-03-15 | 复旦大学附属华山医院 | 一种利用工程细胞进行基因编辑的系统及方法 |
| CN114736308B (zh) * | 2022-03-15 | 2022-12-27 | 四川宜美康科技有限公司 | 球虫抗原肽/il5的融合蛋白基因工程菌的制备及用途 |
| CN117510615B (zh) * | 2023-01-31 | 2025-01-07 | 上海恩凯细胞技术有限公司 | SynNotch受体及其用途 |
| WO2025076422A1 (en) * | 2023-10-05 | 2025-04-10 | The Regents Of The University Of California | Regulated expression of card11-pik3r3 fusion protein |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| GB0112818D0 (en) | 2001-05-25 | 2001-07-18 | Lorantis Ltd | Conjugate |
| GB0220658D0 (en) | 2002-09-05 | 2002-10-16 | Lorantis Ltd | Immunotherapy |
| HUE028379T2 (en) | 2006-09-29 | 2016-12-28 | Oncomed Pharm Inc | Preparations and procedures for the diagnosis and treatment of cancer |
| US8426140B2 (en) | 2007-09-28 | 2013-04-23 | Royal College Of Surgeons In Ireland | Method of assessing colorectal cancer status in an individual |
| NZ590127A (en) | 2008-07-08 | 2012-11-30 | Oncomed Pharm Inc | Notch1 receptor binding agents and methods of use thereof |
| CA2796464C (en) | 2010-04-16 | 2021-08-03 | Immune Disease Institute, Inc. | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
| KR102198058B1 (ko) | 2012-10-02 | 2021-01-06 | 메모리얼 슬로안 케터링 캔서 센터 | 면역치료용 조성물 및 방법 |
| US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| SG11201603228TA (en) | 2013-10-31 | 2016-05-30 | Hutchinson Fred Cancer Res | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| US9730935B2 (en) | 2013-12-13 | 2017-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting a non-canonical notch signaling pathway for cancer treatment |
| CN106456748A (zh) | 2014-01-08 | 2017-02-22 | 小利兰·斯坦福大学托管委员会 | 小细胞肺癌的靶向疗法 |
| MX369513B (es) | 2014-02-14 | 2019-11-11 | Univ Texas | Receptores de antígenos quiméricos y métodos de realización. |
| US10196608B2 (en) | 2014-02-21 | 2019-02-05 | Cellectis | Method for in situ inhibition of regulatory T cells |
| US20160152725A1 (en) * | 2014-02-25 | 2016-06-02 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide |
| WO2016019300A1 (en) * | 2014-07-31 | 2016-02-04 | Novartis Ag | Subset-optimized chimeric antigen receptor-containing t-cells |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| RU2017113134A (ru) * | 2014-09-19 | 2018-10-19 | Регенерон Фармасьютикалз, Инк. | Химерные антигенные рецепторы |
| JP6959597B2 (ja) | 2014-12-09 | 2021-11-02 | 北海道公立大学法人 札幌医科大学 | 腫瘍抗原ペプチド |
| WO2016138034A1 (en) * | 2015-02-24 | 2016-09-01 | The Regents Of The University Of California | Binding-triggered transcriptional switches and methods of use thereof |
| WO2017193059A1 (en) | 2016-05-06 | 2017-11-09 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
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