KR20190040030A - 암 치료용 티오히단토인 안드로겐 수용체 길항제 - Google Patents

암 치료용 티오히단토인 안드로겐 수용체 길항제 Download PDF

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Publication number
KR20190040030A
KR20190040030A KR1020197007833A KR20197007833A KR20190040030A KR 20190040030 A KR20190040030 A KR 20190040030A KR 1020197007833 A KR1020197007833 A KR 1020197007833A KR 20197007833 A KR20197007833 A KR 20197007833A KR 20190040030 A KR20190040030 A KR 20190040030A
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KR
South Korea
Prior art keywords
oxo
thioxo
cpd
methyl
diazaspiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020197007833A
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English (en)
Korean (ko)
Inventor
질스 씨. 빅난
Original Assignee
얀센 파마슈티카 엔.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 얀센 파마슈티카 엔.브이. filed Critical 얀센 파마슈티카 엔.브이.
Publication of KR20190040030A publication Critical patent/KR20190040030A/ko
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197007833A 2016-08-22 2017-08-22 암 치료용 티오히단토인 안드로겐 수용체 길항제 Ceased KR20190040030A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662377932P 2016-08-22 2016-08-22
US62/377,932 2016-08-22
PCT/IB2017/055063 WO2018037342A1 (en) 2016-08-22 2017-08-22 Thiohydantoin androgen receptor antagonists for the treatment of cancer

Publications (1)

Publication Number Publication Date
KR20190040030A true KR20190040030A (ko) 2019-04-16

Family

ID=60009664

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197007833A Ceased KR20190040030A (ko) 2016-08-22 2017-08-22 암 치료용 티오히단토인 안드로겐 수용체 길항제

Country Status (12)

Country Link
US (1) US20190209539A1 (https=)
EP (1) EP3500259A1 (https=)
JP (1) JP2019528290A (https=)
KR (1) KR20190040030A (https=)
CN (1) CN109640986A (https=)
AU (1) AU2017316756A1 (https=)
BR (1) BR112019003406A2 (https=)
CA (1) CA3034449A1 (https=)
MA (1) MA45992A (https=)
MX (1) MX2019002097A (https=)
RU (1) RU2019108092A (https=)
WO (1) WO2018037342A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3666772A4 (en) * 2017-08-07 2021-01-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
BR112021015122A2 (pt) 2019-02-01 2021-09-28 Chia Tai Tianqing Pharmaceutical Group Co., Ltd Cristal de composto de diariltio-hidantoína
CN115403624B (zh) * 2022-09-30 2024-08-27 上海应用技术大学 一种二芳基硫代乙内酰脲化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103202A2 (en) 2010-02-16 2011-08-25 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
AU2013334102B2 (en) * 2012-10-26 2018-08-16 Memorial Sloan-Kettering Cancer Center Modulators of resistant androgen receptor

Also Published As

Publication number Publication date
RU2019108092A (ru) 2020-09-22
CN109640986A (zh) 2019-04-16
RU2019108092A3 (https=) 2020-11-30
AU2017316756A1 (en) 2019-02-21
EP3500259A1 (en) 2019-06-26
JP2019528290A (ja) 2019-10-10
CA3034449A1 (en) 2018-03-01
WO2018037342A1 (en) 2018-03-01
BR112019003406A2 (pt) 2019-05-21
US20190209539A1 (en) 2019-07-11
MX2019002097A (es) 2019-05-15
MA45992A (fr) 2019-06-26

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