KR20190029503A - Insect repellent composition, and insect repellent method - Google Patents

Abstract

(A) and at least one component selected from the group consisting of a component (B), a component (C) and a component (D), wherein the component (A) , The component (B) is an antioxidant component, the component (C) is a chelating agent, and the component (D) is at least one selected from the group consisting of polyvinylpyrrolidone and a vinyl acetate / vinylpyrrolidone copolymer Wherein the insect repellent composition is one kind of polymer compound.

Description

Insect repellent composition, and insect repellent method

The present invention relates to a pest repellent composition, and a pest control method.

The present application claims priority based on Japanese Patent Application No. 2016-140794 filed on July 15, 2016, the contents of which are incorporated herein by reference.

BACKGROUND ART [0002] Conventionally, a repellent for a pest such as a mosquito has been applied to the skin to avoid pests.

Patent Document 1 proposes an insect repellent composition comprising an antimicrobial compound and a repellent active ingredient. According to the invention described in Patent Document 1, the repelling effect of the avoidance active ingredient is enhanced by the antimicrobial compound.

Patent Document 1: JP-A-2016-102092

However, since the risk of infecting mosquito-borne infectious diseases is increasing in Korea, such as "dengue fever" occurring in 2014, the insect repellent composition is required to further improve the insect repellent effect. In the summer when the insect repellent composition is used, the repellent composition applied to the skin due to perspiration or the like tends to fall, and insect repellent effect and insect repellent persistent effect are not sufficient.

An object of the present invention is to provide a pest-resistant composition which is excellent in pest control effect and a pest control method using the same.

The present invention has the following aspects.

[1] A insect repellent composition comprising a component (A), at least one component selected from the group consisting of a component (B), a component (C), and a component (D)

Wherein the component (A) is a repellent effective component,

Wherein the component (B) is an antioxidant component,

Wherein the component (C) is a chelating agent,

Wherein the component (D) is at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer.

[2] The insect-repellent composition according to [1], wherein the component (A) is icaridine.

[3] The insect repellent composition according to [1] or [2], which comprises the component (B) and the component (C).

[4] The insect repellent composition according to [1] or [2], which comprises the component (B), the component (C), and the component (D).

[5] The composition according to any one of [1] to [4], wherein the component (E) comprises an antimicrobial compound.

[6] A pest-control method using the pest-resistant composition according to any one of [1] to [5].

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a pest-resistant composition which is excellent in pest-control, and a pest-control method using the same.

1 is a perspective view of a connection cage used in the embodiment;

«Pest repellent composition»

The insect repellent composition of the present invention comprises at least one component selected from the group consisting of (A) component, (B) component, (C) component and (D) component.

[0009]

≪ Component (A): avoidance active ingredient >

The component (A) is a component having a repelling effect of insect pests.

Examples of the component (A) include, but are not limited to, icaridine (1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate), di (N, 3-methylbenzamide), 3- (N-butyl-N-acetyl) aminopropionic acid ethyl ester (IR3535), p- menthan-3,8-diol, lemon eucalyptus oil and citronella . Among them, icaridine is preferable from the viewpoints of skin feeling and smell when applied to the skin.

The component (A) may be used singly or in combination of two or more.

The content of the component (A) is preferably from 1 to 80 mass%, more preferably from 5 to 30 mass%, based on the total mass of the insect repelling composition. Particularly in the case of icaridine, the content is preferably 1 to 30 mass%, more preferably 5 to 20 mass%, based on the total mass of the insect repellent composition. In the case of diatoms, the amount is preferably from 5 to 50 mass%, more preferably from 10 to 30 mass%, based on the total mass of the insect repellent composition. When the content of the component (A) is less than the upper limit, there is no sticky feeling and a feeling of use is good. If it is not less than the lower limit, the avoidance effect tends to be exerted.

≪ Component (B): Antioxidant component >

Component (B) is a component having an antioxidative action and enhances the avoidance effect.

Examples of the antioxidant component include sugars or sugar alcohols such as trehalose, xylitol, sorbitol, maltitol, xylose and mannitol; Vitamins and derivatives thereof such as vitamin A, vitamin E and vitamin C; Amino acids and peptides such as tyrosine, tryptophan, methionine, and histidine. Among these, trehalose, sorbitol and maltitol are preferable.

The component (B) may be used singly or in combination of two or more.

When the insect repellent composition of the present invention contains the component (B), the content of the component (B) is preferably from 0.1 to 10 mass%, more preferably from 0.5 to 5 mass%, based on the total mass of the insect- , And more preferably 1 to 3 mass%. When the content of the component (B) is less than the upper limit, there is no stickiness and the feel is good. If the lower limit is more than the lower limit, the effect of component (B) is easily obtained.

When the insect repellent composition of the present invention contains the component (B), the mass ratio (hereinafter also referred to as A / B ratio) represented by the component (A) / (B) is preferably 0.1 to 800, More preferably from 0.5 to 30, and still more preferably from 0.5 to 30. If the A / B ratio is within the above range, the avoiding effect tends to be exerted.

≪ Component (C): chelating agent >

The component (C) is a component having a kyrate action and enhances the avoidance effect.

As the component (C), ethylenediamine acetic acid type (type) chelating agent, organic acid type chelating agent and phosphoric acid type chelating agent are preferable. As the ethylenediamine acetic acid type klyate, ethylene diamine acetic acid derivatives or salts thereof may be mentioned. (EDTA), ethylenediamine diacetic acid (EDDA), diethylenetriaminepentaacetic acid (DTPA), N- (2-hydroxyethyl) ethylenediamine-3-acetic acid (HEDTA), etc. And may be used as pharmacologically or physiologically acceptable salts (for example, sodium salt, potassium salt, magnesium salt and calcium salt such as sodium ethylenediaminetetraacetate). Among them, ethylenediamine tetraacetic acid or a salt thereof is preferable, and specifically, disodium ethylenediaminetetraacetate, disodium ethylenediaminetetraacetate dihydrate (hereinafter also referred to as sodium edetate) and the like can be mentioned. Examples of the organic acid type chrysotheter include maleic acid, tartaric acid, citric acid, succinic acid, gluconic acid and the like, and they may be used as pharmacologically or physiologically acceptable salts. Phosphoric acid, sodium polyphosphate, metaphosphoric acid and the like can be mentioned as the phosphoric acid type chrysotheter, and they may be used as pharmacologically or physiologically acceptable salts. Among them, citric acid and sodium citrate are preferable.

The component (C) may be used singly or in combination of two or more kinds.

When the component (C) is a salt or hydrate (monohydrate or the like) of a counter ion (monosodium salt, trisodium salt, tripotassium salt, etc.), the mass fluctuation becomes large. Therefore, in this specification, the content is expressed as the content of "acid" which is not neutralized but converted to "anhydride" (hereinafter also referred to as "acid conversion (acid conversion)").

When the insect repellent composition of the present invention contains the component (C), the content of the component (C) is preferably "acid converted" to the total mass of the insect repellent composition in an amount of preferably 0.01 to 3 mass% % By mass is more preferable. When the content of the component (C) is lower than the upper limit, it is easy to inhibit precipitation of the component (C) or skin irritation. If it is more than the lower limit, it is easy to obtain the effect of component (C).

When the insect repellent composition of the present invention contains citric acid or sodium citrate, the content of citric acid or sodium citrate is preferably 0.01 to 3% by mass, more preferably 0.1 to 2% by mass based on the total mass of the insect- By mass, more preferably 0.2 to 1% by mass. When the content of citric acid or sodium citrate is lower than the upper limit, citric acid or sodium citrate can be prevented from being precipitated or skin irritation can be suppressed. If it is not less than the lower limit, the avoidance effect tends to be exerted.

When the insect repellent composition of the present invention contains EDTA or a salt thereof, the content of EDTA or its salt is preferably 0.03 to 0.5 mass%, more preferably 0.05 to 0.3 mass%, based on the total mass of the insect repellent composition, % Is more preferable. If EDTA or its salt is below the upper limit, EDTA or a salt thereof may precipitate or skin irritation may be suppressed. If it is more than the lower limit value, the avoidance effect is likely to be enhanced.

When the insect repellent composition of the present invention contains the component (C), the component (C) is "acid-converted" and the mass ratio (hereinafter also referred to as A / C ratio) Is preferably from 0.1 to 8,000, more preferably from 1 to 1,000, further preferably from 5 to 200. If the A / C ratio is within the above range, the avoidance effect tends to be exerted.

When the insect repellent composition of the present invention contains the component (B) and the component (C), the component (C) is "acid converted" and the mass ratio of the component (B) / C ratio) is preferably 0.01 to 1000, more preferably 0.1 to 200, further preferably 1 to 50. If the B / C ratio is within the above range, the avoidance effect tends to be exerted.

<Component (D): at least one kind of polymer compound selected from the group consisting of polyvinyl pyrrolidone, and vinyl acetate / vinyl pyrrolidone copolymer>

Examples of the component (D) include at least one kind of polymer compound selected from the group consisting of polyvinyl pyrrolidone and a vinyl acetate / vinyl pyrrolidone copolymer. (D), the persistence of the avoidance effect can be improved.

As the polyvinyl pyrrolidone, those having a weight average molecular weight of 8,000 to 3,000,000 can be used. Particularly, a weight average molecular weight of 2,000,000 or less is preferable in view of solubility, feeling of use, and persistence of deodorizing effect. In addition, the weight average molecular weight is a value obtained by converting the K value defined by the United States Pharmacopoeia USP into the weight average molecular weight measured by the light scattering method.

Rubiscol K90 (weight average molecular weight: about 1,600,000) (available from BASF), PVPK-15 (commercially available from BASF), Rubiscol K17 (weight average molecular weight: about 9,000) (Weight average molecular weight: 8,000), PVPK-30 (weight average molecular weight: 60,000), PVPK-60 (weight average molecular weight: 400,000), PVPK- (Weight average molecular weight: about 45,000) and Rubiscol K90 (weight average molecular weight: about 1,600,000) from the standpoint of sustainability of the deodorizing effect.

The copolymerization molar ratio (VP / VA) of vinyl pyrrolidone and vinyl acetate in the vinyl acetate / vinyl pyrrolidone copolymer is preferably in the range of 7/3 to 3/7. Of these, those having a copolymerization molar ratio (VP / VA) of 7/3 or 6/4 are preferable from the viewpoints of solubility, feeling of use, and persistence of a deodorizing effect. PVP / VA E-535 (VP / VA molar ratio 5/5 (PV / VA molar ratio 6/4), PVP / VA E-735 ), PVP / VA E-335 (VP / VA molar ratio 3/7) (manufactured by ISP), Rubiscol VA37E (VP / VA molar ratio 3/7), Rubiscol VA55I (VP / VA molar ratio 5/5) PVP / VA S-630, PVP / VA (manufactured by BASF), and the like can be given as examples of the PVP / VA S-630, VP / VA molar ratio 6/4, and Rubiscol VA 73W E-735 is preferred.

The component (D) may be used singly or in combination of two or more kinds.

The weight average molecular weight of the vinyl acetate / vinyl pyrrolidone copolymer is preferably 200 to 80,000, more preferably 40,000 to 70,000. In addition, the weight average molecular weight is a value obtained by converting the K value defined by the United States Pharmacopoeia USP into the weight average molecular weight measured by the light scattering method.

When the insect repellent composition of the present invention contains the component (D), the content of the component (D) is preferably 0.1 to 3% by mass, more preferably 0.2 to 1% by mass based on the total mass of the insect- .

When the content of the component (D) is within the above range, persistence of the avoidance effect is high, and there is no sticky feeling and good feeling of use.

When the insect repellent composition of the present invention contains the component (D), the mass ratio (hereinafter also referred to as A / D ratio) represented by the component (A) / (D) is preferably 0.1 to 800, More preferably from 5 to 50, and even more preferably from 5 to 50. If the A / D ratio is within the above range, the avoiding effect tends to be exerted.

When the insect repellent composition of the present invention contains the component (B) and the component (D), the mass ratio (hereinafter also referred to as B / D ratio) represented by the component (B) More preferably from 1 to 100, and still more preferably from 1 to 30. If the B / D ratio is within the above range, the avoidance effect tends to be exerted.

When the insect repellent composition of the present invention contains the component (C) and the component (D), the component (C) is "converted to an acid" so that the mass ratio represented by the component (C) / / D ratio) is preferably from 0.001 to 50, more preferably from 0.005 to 30, and further preferably from 0.1 to 10. If the C / D ratio is within the above range, the avoidance effect tends to be exerted.

<Other Ingredients>

(Hereinafter also referred to as component (F)), a solvent, a humectant, a thickener (hereinafter also referred to as a component (D)), , A coloring agent, a pH adjusting agent, a flavoring agent, an ultraviolet absorbing agent, and an ultraviolet scattering agent.

Examples of the component (E) include various compounds such as a phenolic antimicrobial component, a quaternary ammonium salt-based antimicrobial component, an acetylenic antibacterial component, and an organic-owned sulfur-based antibacterial component. Examples of the phenolic antimicrobial component include isopropylmethylphenol (3-methyl-4-isopropenol), ortho-phenylphenol and the like. Examples of the quaternary ammonium salt-based antibacterial component include benzalkonium chloride and benzethonium chloride. Examples of the biguanide antimicrobial component include chlorohexidine hydrochloride and polyhexamethylenebiguanide hydrochloride. Examples of the organic-owned sulfur-based antibacterial component include 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 2-mercaptobenzothiazole, Octyl-4-isothiazolin-3-one, 1,2-benzoisothiazolin-3-one and the like. Examples of the other component (E) include triclosan acid, dichloric acid, 2-bromo-2-nitropropane-1,3-diol, dichlorocarbanilide, pylotronamine and tongue extract.

Of these, a phenolic antimicrobial component and a quaternary ammonium salt-based antimicrobial component are preferable, and isopropylmethylphenol and benzalkonium chloride are more preferable.

The antimicrobial compound may be used alone, or two or more of them may be used in combination. It is preferable to use a combination of a phenolic antimicrobial component and a quaternary ammonium salt antimicrobial component, and a combination of isopropylmethylphenol and benzalkonium chloride .

When the insect repellent composition of the present invention contains the component (E), the content of the component (E) is preferably from 0.001 to 1% by mass, more preferably from 0.01 to 0.5% by mass, based on the total mass of the insect- . If the content of the component (E) is within the above range, the avoidance effect tends to be exerted.

When the insect repellent composition of the present invention contains the component (B) and the component (E), the mass ratio (hereinafter also referred to as B / E ratio) represented by the component (B) / component (E) , More preferably from 1 to 500, further preferably from 5 to 200. If the B / E ratio is within the above range, the avoidance effect is likely to be exerted.

When the insect repellent composition of the present invention contains the component (C) and the component (E), the component (C) is "converted to an acid" so that the mass ratio of the component (C) / E ratio) is preferably from 0.005 to 300, more preferably from 0.1 to 100. If the C / E ratio is within the above range, the avoidance effect tends to be exerted.

When the insect repellent composition of the present invention contains the component (D) and the component (E), the mass ratio (hereinafter also referred to as D / E ratio) represented by the component (D) , More preferably 0.5 to 10. If the D / E ratio is within the above range, the avoidance effect tends to be exerted.

As the component (F), anionic surfactants, nonionic surfactants, and amphoteric surfactants can be used. Examples of the anionic surfactant include fatty acid soap, alkylbenzenesulfonate, linear alkylbenzenesulfonate, alkylsulfate, alpha olefinsulfonate, alkylphosphate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl ether carboxy Acid salts, polyoxyethylene alkylphenyl ether sulfate, polyoxyethylene alkyl ether phosphate, alkylsulfo succinic acid salt, and polyoxyethylene alkylsulfo succinic acid salt. Examples of the nonionic surfactant include polyoxyalkylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene higher fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil Free, coconut fatty acid diethanolamide, fatty acid alkanolamide, amine oxide and the like. Examples of the amphoteric surfactant include alkylcarbobetaine, alkylamide carbobetaine, alkylsulfobetaine, alkylhydroxysulfobetaine, alkylamide sulfobetaine, alkylamide hydroxysulfobetaine and the like.

Nonionic surfactants are preferable from the viewpoints of irritation to the skin and improvement in stability that can be placed at low temperatures, and polyoxyethylene hardened castor oil is more preferable. The oxyethylene group of the nonionic surfactant is preferably 10 to 100 moles in average on the average in terms of stability at low temperatures.

The component (F) may be used singly or in combination of two or more.

When the insect repellent composition of the present invention contains the component (F), the content of the component (F) is preferably from 0.1 to 10 mass%, more preferably from 0.1 to 5 mass%, based on the total mass of the insect- . When the content of the component (F) is within the above range, stickiness caused by the component (F) is suppressed and the stability at low temperature is improved.

Examples of the solvent include alcohol solvents such as ethanol, hydrocarbon solvents such as n-paraffin and isoparaffin, glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol and diethylene glycol monobutyl ether, and glycol ethers , A ketone-based solvent, an ester-based solvent, water (water), and the like.

The solvent may be used singly, or two or more kinds of solvents may be used in combination.

Ethanol is preferred from the standpoints of irritation to the skin, odor, feeling of use (easy to dry) and avoidance effect.

When the insect repellent composition of the present invention contains ethanol, the content of ethanol is preferably 0 to 90 mass%, more preferably 30 to 50 mass%, with respect to the total mass of the insect repellent composition, And is more preferable in terms of irritation. If the content of ethanol is within the above range, the avoidance effect tends to be exerted.

Appropriate water can be incorporated into the insect repellent composition of the present invention.

The thickener (excluding the component (D)) is not particularly limited as long as it is used in cosmetics, quasi-drugs, and pharmaceuticals, and includes natural water-soluble polymers, semi-synthetic water-soluble polymers, synthetic water-soluble polymers, And the like. Examples of natural water-soluble polymers include water-soluble polymers such as gum arabic, tragacanth, galactan, guar gum, xanthan gum, carob rubber, locust bean gum, karaya gum, carrageenan, pectin, agar, Starch and the like; microbial polymers such as dextran, dextrin, succinoglucan and pullulan; and animal polymers such as collagen, casein, albumin and gelatin. Examples of the semi-synthetic water-soluble polymer include starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, Cellulose polymers such as propylcellulose, carboxymethylcellulose sodium (CMC), crystal (crystalline) cellulose and cellulose cellulose; and alginic acid-based polymers such as sodium alginate and propylene glycol ester alginate. Examples of the synthetic water-soluble polymer include vinyl-based polymers such as polyvinyl alcohol, polyvinyl methyl ether and carboxyvinyl polymer (carbomer), polyoxyethylene-based polymers such as polyethylene glycol (molecular weights 1,500, 4,000 and 6,000) Polyoxyethylene polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate and polyethyl acrylate, polyethyleneimine, and cationic polymers. As the inorganic water-soluble polymer, for example, bentonite, silicic acid AlMg, laponite, hectorite, silicic anhydride and the like can be given.

The thickening agent may be used singly or in combination of two or more kinds.

Examples of the fragrance include fragrance oils such as peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cacao oil, kurobu oil, time oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, The present invention relates to a method for preparing a medicament for use in the preparation of a medicament for the prevention and treatment of cancer, which comprises administering an effective amount of a compound selected from the group consisting of lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, Natural fragrance ingredients such as absorro rose and orange flower; A perfume component processed by processing these natural perfume ingredients; Perfume ingredients such as menthol, carboen, anethole, cineol, methyl salicylate, cinnamic aldehyde, ogenol, 2-diol, pinene, octylaldehyde, citral, poulgene, carvir acetate, anisaldehyde, .

The perfume may be used singly or in combination of two or more kinds.

In the insect repellent composition of the present invention, the total content of the component (A) and the at least one component selected from the group consisting of the component (B), the component (C) and the component (D) is 100% .

The pH of the insect repellent composition of the present invention at 25 캜 is preferably from 3 to 9, and more preferably from 5 to 8, from the standpoint of avoiding an effect and reducing irritation to the skin. The pH can be measured by a conventional method using a pH meter (HM-30G, manufactured by Toa Denshi Kogyo Co., Ltd.).

The insect repelling composition of the present invention comprises at least one component selected from the group consisting of a component (A), a component (B), a component (C), and a component (D) (B) is at least one member selected from the group consisting of trehalose, sorbitol and maltitol, and the component (C) is at least one member selected from the group consisting of citric acid and sodium citrate , And the component (D) is at least one member selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer.

The insect repelling composition of the present invention comprises at least one component selected from the group consisting of a component (A), a component (B), a component (C), and a component (D) (B) is at least one member selected from the group consisting of trehalose, sorbitol and maltitol, and the component (C) is at least one member selected from the group consisting of citric acid and sodium citrate (D) is at least one member selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer, and the total mass of the insect repellent composition is , The content of the component (A) is 1 to 80 mass%, the content of the component (B) is 0.1 to 10 mass%, the content of the component (C) %, And the content of the component (D) is 0.1 to 3% by mass It is preferred.

The insect repelling composition of the present invention comprises at least one component selected from the group consisting of a component (A), a component (B), a component (C), and a component (D) (B) is trehalose, (C) is at least one member selected from the group consisting of citric acid and sodium citrate, (D) is at least one member selected from the group consisting of citric acid and sodium citrate, Component is preferably a vinyl acetate / vinyl pyrrolidone copolymer. The insect repelling composition of the present invention comprises at least one component selected from the group consisting of a component (A), a component (B), a component (C), and a component (D) (B) is trehalose, (C) is at least one member selected from the group consisting of citric acid and sodium citrate, (D) is at least one member selected from the group consisting of citric acid and sodium citrate, Wherein the content of the component (A) is from 1 to 80 mass%, the content of the component (B) is from 0.1 to 10 mass%, and the content of the component (B) is from 0.1 to 10 mass%, based on the total mass of the insect- , The content of the component (C) is 0.01 to 3 mass% and the content of the component (D) is 0.1 to 3 mass% in terms of "acid conversion".

The insect repellent composition of the present invention comprises at least one component selected from the group consisting of the component (A), the component (B), the component (C), and the component (D) and the component (E) Wherein the component (A) is at least one member selected from the group consisting of icaridine and diethyl ester, the component (B) is trehalose, the component (C) is at least one member selected from the group consisting of citric acid and sodium citrate , The component (D) is a vinyl acetate-vinylpyrrolidone copolymer, and the component (E) is at least one member selected from the group consisting of benzalkonium chloride and isopropylmethylphenol. The insect repellent composition of the present invention comprises at least one component selected from the group consisting of the component (A), the component (B), the component (C), and the component (D) and the component (E) Wherein the component (A) is at least one member selected from the group consisting of icaridine and diethyl ester, the component (B) is trehalose, the component (C) is at least one member selected from the group consisting of citric acid and sodium citrate Wherein the component (D) is a vinyl acetate / vinyl pyrrolidone copolymer, the component (E) is at least one member selected from the group consisting of benzalkonium chloride and isopropylmethylphenol, the total of the pest- Wherein the content of the component (A) is 1 to 80 mass%, the content of the component (B) is 0.1 to 10 mass%, the content of the component (C) 3% by mass, the content of the component (D) is from 0.1% by mass to 3% by mass, The content is preferably 0.001 to 1% by mass.

&Lt; Method for preparing pest-resistant composition &

The method of preparing the insect repellent composition of the present invention includes a method of mixing at least one component selected from the group consisting of the component (A), the component (B), the component (C), and the component (D). Further, a method of dissolving at least one component selected from the group consisting of the component (A), the component (B), the component (C), and the component (D) .

«How to avoid pests»

The insect repellent composition of the present invention can be used as a form such as a milky lotion, a cream, a gel, and a spray (liquid agent). For example, the content of the insect repelling composition of the present invention in an emulsion, a cream or a gel is preferably 1 to 100 mass% with respect to the total mass of the emulsion, cream or gel. The content of the insect repelling composition of the present invention in the liquid agent is preferably 1 to 100% by mass with respect to the total mass of the liquid agent.

The insect repelling composition of the present invention exerts a repelling effect on pests, for example, by being applied to the skin. The method for using the insect repellent composition of the present invention includes a step of adhering an effective amount of the insect repellent composition of the present invention to the skin or clothing of a subject who needs to avoid insect pests. Here, the effective amount is preferably 0.1 to 10 mg / cm 2, more preferably 0.5 to 5 mg / cm 2. Subjects requiring insect pest avoidance include humans and animals. Examples of the method for attaching are coating and spraying.

Examples of the insect pests to be avoided by the insect repellent composition of the present invention include mosquitoes, lupus, fleas, mites, bedbugs (bedbugs), mites, and mites. Among them, mosquitoes are preferable.

Example

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

The raw materials used in this embodiment are as shown below

In Table 1, the term "foreign standard" of grades is an abbreviation of the quasi-drugs raw material specification. "One Country" is an abbreviation of Japanese pharmacopoeia.

[Table 1]

[Preparation of pest-resistant composition]

According to the composition (expressed in mass%) shown in Table 2, each component was mixed to adjust the insect repellent composition of each example.

With respect to the obtained pest-resistant composition, the avoidance effect was evaluated in the following procedure.

[Evaluation of avoidance effect]

As shown in Fig. 1, two acrylic cans each having a size of 50 cm x 50 cm x 50 cm were connected to each other through a partition plate 4 to prepare a connection cage 10. 50 females (female) 5 mosquitoes (female) 5 were placed in the right cage 2 of the connection cage 10. Approximately 2 g of each avoiding composition was applied to the range of one arm (arm) to the fingertip of a professional panelist and dried. (Arm) is inserted into the barrel 3 of stocking agent, and the opening of the partitioning plate 4 is opened (Fig. 1) , The number of entries of the mosquitoes entering the left cage 1 in 5 minutes was measured (immediately after sweating). The escaping composition was applied to the arm (3) for 2 hours and 4 hours after application and then sweated, and the number of entries of the mosquito was measured. This was the number of entries at the time of application (application).

Evaluation of a carriage branch was carried out with an arm (arm) to which no escaping composition was applied, and the number of entries of the mosquito was measured. We regarded this as the number of moodle poses.

The avoidance rate was calculated from the obtained number of entries at the time of coating and the number of entries of the undisplaced city by the following formula, and the avoidance effect was evaluated by the following evaluation criteria.

Avoidance rate (%) = {1- (number of entries at the time of coating - number of corrected entries) / (number of undisplaced entries - number of corrected entries)} x 100

The number of correction entries is the number of entries of the mosquito under the condition that the arm (arm) is not inserted. After correction, when the number of entries became negative, it was evaluated as 0.

(Evaluation standard)

◎: Avoidance rate is over 90% ~ 100%.

○: Avoidance rate is 70% or more to less than 90%.

DELTA: Avoidance rate is 50% or more to less than 70%.

X: Avoidance rate is less than 50%.

[Table 2]

Table 3 shows the prescription examples of the insect repellent composition of the present invention other than Examples 1 to 8.

[Table 3]

In Examples 1 to 8 to which the present invention was applied, a high avoidance effect was obtained. On the other hand, Comparative Examples 1, 2 and 3, which do not include all the components (B) to (D), are inferior in the avoidance effect.

From the above results, it was found that the insect repellent effect of the present invention can provide a high insect repellent effect.

[Industrial Availability]

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a pest-resistant composition which is excellent in pest-control, and a pest-control method using the same.

10: Connection cage
1: Left cage
2: Right cage
3: Tong
4: partition plate
5: Rhododendron mosquito

Claims (6)

(A), at least one component selected from the group consisting of a component (B), a component (C), and a component (D)
Wherein the component (A) is a repellent effective component,
Wherein the component (B) is an antioxidant component,
Wherein the component (C) is a chelating agent,
Wherein the component (D) is at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone, and vinyl acetate / vinyl pyrrolidone copolymer. The method according to claim 1,
Wherein the component (A) is icaridine. 3. The method according to claim 1 or 2,
The component (B), and the component (C). 3. The method according to claim 1 or 2,
Wherein the insect repellent composition comprises the component (B), the component (C), and the component (D). 5. The method according to any one of claims 1 to 4,
Also, component (E): an antimicrobial compound. A pest control method, comprising using the pest-resistant composition according to any one of claims 1 to 5.

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