AU2021106160A4 - Novel broad spectrum sanitizer composition - Google Patents
Novel broad spectrum sanitizer composition Download PDFInfo
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- AU2021106160A4 AU2021106160A4 AU2021106160A AU2021106160A AU2021106160A4 AU 2021106160 A4 AU2021106160 A4 AU 2021106160A4 AU 2021106160 A AU2021106160 A AU 2021106160A AU 2021106160 A AU2021106160 A AU 2021106160A AU 2021106160 A4 AU2021106160 A4 AU 2021106160A4
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- citric acid
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 42
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000341 volatile oil Substances 0.000 claims abstract description 8
- 230000003253 viricidal effect Effects 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000010634 clove oil Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 5
- 239000004909 Moisturizer Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims description 2
- 241000700605 Viruses Species 0.000 abstract description 20
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract description 15
- 239000004202 carbamide Substances 0.000 abstract description 8
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract description 4
- 238000012546 transfer Methods 0.000 abstract description 3
- 206010011409 Cross infection Diseases 0.000 abstract description 2
- 230000002458 infectious effect Effects 0.000 abstract description 2
- 230000009467 reduction Effects 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 description 19
- 238000000034 method Methods 0.000 description 6
- 150000007524 organic acids Chemical class 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 241000711573 Coronaviridae Species 0.000 description 2
- 208000032163 Emerging Communicable disease Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 239000008238 pharmaceutical water Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 239000012873 virucide Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- PLKYJWLKIDFVHM-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;urea Chemical compound NC(N)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O PLKYJWLKIDFVHM-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
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- 241001115402 Ebolavirus Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000013409 condiments Nutrition 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000009365 direct transmission Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229940034040 ethanol / isopropyl alcohol Drugs 0.000 description 1
- 239000001902 eugenia caryophyllata l. bud oil Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009920 food preservation Methods 0.000 description 1
- 235000013611 frozen food Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000009349 indirect transmission Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000014594 pastries Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
Abstract
The importance of hand hygiene in health care and community settings is undoubted, with
numerous studies demonstrating the association between proper hand hygiene and reductions in
both rates of nosocomial infections and rates of infectious illnesses in communities. Virus
transfer via human hands is a major route of infection inside and outside medical settings. The
present invention relates to novel broad spectrum sanitizer composition which comprises citric
acid, urea, iodine,combination of essential oils, and isopropyl alcohol. The instant invention has
virucidal activity.
1
Description
FIELD OF THE INVENTION The present invention relates to novel broad spectrum sanitizer composition and process of manufacture thereof. Specifically, the present invention relates to a novel sanitizer composition comprises of alcohol, citric acid, urea, iodine, clove oil, lavender oil, carbopol and pharmaceutical water which can act on the different types of bacteria, fungi and viruses including envelope and non-envelope virus, includes influenza virus, corona virus and ebola virus. The composition has synergistic effect against different bacteria and viruses. The present application also describes a method of preparation for the same.
BACKGROUND OF THE INVENTION The importance of hand hygiene in health care and community settings is undoubted, with numerous studies demonstrating the association between proper hand hygiene and reductions in both rates of nosocomial infections and rates of infectious illnesses in communities. Hand hygiene is also an infection control procedure that can be rapidly adopted by the public and healthcare workers in the case of emerging and re-emerging infectious diseases to limit the spread of viruses by breaking the transmission.
The present disclosure generally relates to antimicrobial hand sanitizers including alcohols that are effectivein killing microorganisms while providing a moisturizing benefit to the user's skin. More particularly, the alcohol-basedhand sanitizers include a high internal phase emulsion which allows moisturizers or skin protectants such as emollientsand/or silicones to be stably incorporated into the sanitizer.
Virus transfer via human hands is a major route of infection inside and outside medical settings. The efficiency of virus transfer from hands to hands (direct transmission) or via contaminated surfaces (indirect transmission) is closely connected with virus persistence. Viruses of the respiratory tract like the non-enveloped coronavirus can persist on surfaces for several days.
Serious infectious disease outbreaks and hospital-acquired infections are threats to human health. Effective vaccines and drug products are often not available, but antiseptic products for hand washing can help to control the spread of disease.Multiple hand hygiene agents are currently available including plain non-medicated soap, medicated hand washes with various active ingredients, and waterless or alcohol-based hand rubs. It is recognized that some antiseptics and alcohol-based hand rubs are characterized by resistant bacteria and efficacy gaps.
A cleaning composition for hand hygiene therefore would ideally possess broad antiviral spectrum covering non-enveloped in addition to enveloped viruses offering increased protection against persistent, unexpected, or unknown viruses.
Research has been carried out in this area which discloses the formulation possessing alcohol and organic acid. The prior artsare summarized as below.
For example, the patent literatures JP-A3168075 and JP-A6322171 individually disclose ethanol preparations for food preservation comprising ethanol, and an organic acid or a salt thereof, etc.
The patent literatures JP-A115734 and JP-A2002253188 individually describe that microbicide comprising an alcohol such as ethanol and an organic acid can be used for hand wash and hand disinfection.
The patent literature JP-A2004107667 discloses a sanitizing hand cleanser that can be used without water, comprising about 60 to 90 % by weight of an organic alcohol, about 5 to 35% by weight of one or more silicone-based materials, about 5% by weightor less of one or more humectants, about 12% by weight or less of one or more additives for maintaining the skin pH, and one or more thickeners at such a concentration that the viscosity of the cleanser is within the range of 100 to 10,000 cp at about 25°C.
The patent literature JP-A7298862 discloses an alcohol preparation for reducing a population of microorganisms at low temperature, which is used for refrigerated or frozen foods, etc. and which comprises ethyl alcohol and phytic acid as essential ingredients.
The patent literature JP-B3761199 describes a method for disinfection, comprising contact with a 0.05 to 3% by weightaqueous solution of citric acid to inactivate a hepatitis virus B. In this method, lactic acid, malic acid and/or tartaric acidmay be further added to the above solution. The patent literature JP-A6314702 discloses a broad spectrum virucide comprising atleast 70% by weight of ethanol and/or propanol, and 0.5 to 5% by weight of a short chain organic acid. The virucide inquestion has a short chain organic acid especially with 2 to 6 carbon atoms and is effective against a wide range ofviruses, such as polioviruses, vaccinia viruses, SV40-viruses, and adenoviruses. The literature also describes that thisvirucide can be used for hand disinfection as an example of its application.
EP 2135507 which discloses the composition comprising lactic acid, citric acid, zine containing compound and ethanol/isopropyl alcohol. According to inventor, such composition has antiviral effect.
Hand cleaning is important for the prevention of virus transmission in the health care system and environment. The development of broad-spectrumsanitizer composition with activity against enveloped and non-enveloped viruses is limited due to a small number of permissible active ingredients able to inactivate viruses.
The present invention over the preparation which possess virucidal effect.
Accordingly, there remains a need for improved disinfecting compositions that are environmentally sustainable, completely botanical, or natural, biodegradable, non-toxic and capable of providing a broad disinfecting spectrum, and that utilize relatively low concentrations of a limited number of naturally occurring essential plant oils. There is also a need for improved essential oils-based compositions that disperse the essential oils well in a water carrier, that do not require wiping or rinsing off after being applied to inanimate surfaces, and that are stable, have a long shelf life and are affordable and aesthetically appealing to consumers.
Antimicrobial cleaners and hand sanitizers are now in widespread use in the United States, as well as other countries around the world. Many products are effective against bacteria. However, most have limited effectiveness against fungi and virus. Thus, there is a need for effective antimicrobial compositions that are non-toxic and effective against a range of pathogenic agents, including bacterial, viruses and fungi. The present invention provides such compositions.
OBJECT OF THE INVENTION An object of the present invention is to provide a composition that has a virucidal activity and an excellent fast-acting effect.
The main object of the present invention is to provide novel broad spectrum sanitizer composition.
Another object of the present invention is to provide novel broad spectrum sanitizer composition which comprises alcohol, citric acid, urea, iodine, essential oils,and pharmaceutical water.
Another object of the present invention is to provide novel broad spectrum sanitizer composition which comprises citric acid, urea, and iodine useful in the control of the virus spread.
DETAILED DESCRIPTION OF THE INVENTION The present invention relates to novel broad spectrum sanitizer composition which applicable to use for hands and skin, which has a virucidal activity.
The present inventors found that novel broad spectrum sanitizer composition comprising citric acid; urea, iodine, clove oil, lavender oil, carbopoland isopropyl alcohol as highly effective against virusesand excellent fast-acting effect. Moreover, the proposed composition provides moistening effect to skin.
While the invention has been described and illustrated with reference to certain embodiments thereof, those skilled in the art will appreciate that various adaptations, changes, modifications, substitutions, deletions, or additions of procedures and protocols may be made without departing from the spirit and scope of the invention. The present invention can be more readily understood by reading the following detailed description of the invention and study of the included examples. It must be noted that, as used in the specification and appended claims, the singular forms such as "a", "an", and "the" include plural referents unless the content clearly directs otherwise.
The novel broad spectrum sanitizer compositionof the present invention comprises (a) isopropanol, (b) clove oil, (c) citric acid, (d) clove oil, (e) lavender oil. Such novel broad spectrum sanitizer composition of the present invention is highly effective against viruses. Further, the composition of the present invention has an excellent virucidal activity,
The alcohol of the present invention, a microbicidal ingredient of the composition, is isopropyl alcohol. This composition is advantage over the ethanol-based composition which are not effective and known for misuse.
The antiviral surface composition of the present invention comprises specific organic acids, i.e.,citric acid, which produce a synergistic effect with isopropyl alcohol. Therefore, the composition has an enhanced fast-acting and persistent effect.
Essential oils are also widely used in the food industry. For example, clove oil or clove bud oil is used as a compounded oil for the flavoring of pastry, in special sauces and as a condiment. The dried product is used directly in compounded infusions for liqueurs and bitters.
Furthermore, clove oil preparations are commonly accepted in the Ayurvedic system, as a safe and accepted medicine.
Antibacterial activity of clove oil has been reported againstV. cholarae, Gartner'sBacillusand SwineErysipelasbacteria andBrucella andMycobacterium, Trichophyton, AchorionandEpidermophyton.Activityof clove oil volatile fractions is reported by S. Agnihotri and A. D. B. Vaidya againstE. coli, S. aureus, Bacillus subtilis, S. typhi, P. aeruginosa, S. Flexner andP. vulgaris.
Frequent use of disinfectants with high alcohol concentration easily causes skin roughness on hands, which results in less frequent handwashing. In this respect, the novel broad spectrum sanitizer composition of the present invention does not produce such a problem since it possessesmoistening effect. The composition of the present invention may comprise any known moisturizer that is usually added. Examples of such a known moisturizer include, for example, propylene glycol, glycerol and any other of acceptable agent which retains moisture.
These compositions kill or inactivate a broader range of pathogens (e.g., bacteria, viruses, fungi) than do conventional antimicrobial compositions. For example, the compositions described herein are more effective against acid-labile viruses such as adenovirus types 2, 5 and 8. In one embodiment, there is provided an antimicrobial composition comprising:
• (a) An alcohol component that is miscible with water and constitutes about 50% to 90% of the composition; • (b) Water, which constitutes about 10% to 50% of the composition; • (c) An acid component sufficient to maintain the pH below about 5, which constitutes about 0.1-10%, or about 0.1-5%, of the composition; • (d) Essential oils; and • (d) A multivalent cation which constitutes about 0.01% to 5% of the composition. All percentages are by weight, with reference to the weight of the pure component or metal, not including any water (for the non-water components), solvent, or counter-ion (in the case of metals). Each of these components is described in more detail below.
Preparation method The novel broad spectrum sanitizer composition of the present invention can be obtained by mixing all the ingredients, if needed heat-dissolving an ingredient that is in a solid state at ordinary temperature, and usually adjusting the pH of the mixture.
Composition Citric acid Urea
Iodine Isopropyl alcohol Propylene glycol Purified water
Some illustrative non-limiting examples of the present invention are described below. The examples should not be considered as limiting the scope of this invention in any way, as these examples and other equivalents thereof will become apparent to those versed in the art, in the light of the present disclosure, and the claims.
Example 1: Citric acid ............... 0.1-10 % w/v Isopropyl alcohol.....40-90% v/v Propylene glycol ........ 0.2-3% Purified water ............... qs Example 2: Citric acid ...... 0.1-5% w/v Isopropyl alcohol.....40-90% v/v Urea ............. 14% w/w Iodine ....... 0.1-1% w/w/ Propylene glycol ..... 0.2-3% Purified water ............... qs Example 3: Citric acid ............... 0.1-10 % w/v Urea.......................i to 5% w/w/ Iodine......................2-5% w/w/ Essential oils (e, g. clove oil, lavender oil or a mixture thereof)....q.s. Isopropyl alcohol.....40-90% v/v Propylene glycol ..... 0.2-3% Purified water ................... q.s.
This novel broad spectrum sanitizer composition possessingisopropyl alcohol, citric acid and urea shown to have virucidal activity. In another embodiment, the present invention uses the nanotechnology for modifying each component of the formulation for better results.
Claims (3)
1. A novel broad spectrum sanitizer composition which applicable to use for hands and skin, which has a virucidal activity said composition comprising isopropanol, clove oil, citric acid, clove oil, and lavender oil.
2. The composition as claimed in claim 1 further comprises any known moisturizer that is usually added like as propylene glycol, glycerol and any other of acceptable agent which retains moisture.
3. The composition as claimed in claim 1 comprising:
(a) An alcohol component that is miscible with water and constitutes about 50% to 90% of the composition;
(b) Water, which constitutes about 10% to 50% of the composition;
(c) An acid component sufficient to maintain the pH below about 5, which constitutes about 0.1-10%, or about 0.1-5%, of the composition;
(d) Essential oils; and
(e) A multivalent cation which constitutes about 0.01% to 5% of the composition.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021106160A AU2021106160A4 (en) | 2021-08-20 | 2021-08-20 | Novel broad spectrum sanitizer composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021106160A AU2021106160A4 (en) | 2021-08-20 | 2021-08-20 | Novel broad spectrum sanitizer composition |
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|---|---|
| AU2021106160A4 true AU2021106160A4 (en) | 2021-12-02 |
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| Country | Link |
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| AU (1) | AU2021106160A4 (en) |
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- 2021-08-20 AU AU2021106160A patent/AU2021106160A4/en not_active Ceased
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