JP2007119408A - Cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic composition having excellent antibacterial/antifungal effects without being compounded with any preservative. <P>SOLUTION: The cosmetic composition contains (A) an extract obtained by removing an essential oil component from an extract obtained by extraction of clove (Myrtaceae, bud of the clove) with a lower alcohol and/or water, or an extract obtained by extraction of clove freed from an essential oil component beforehand with a lower alcohol and/or water, (B) an extract obtained by extraction of Artemisia capillaris Thunb (Asteraceae, ear of Artemisia capillaris Thunb) with a lower alcohol and/or water, (C) an 8-12C fatty acid monoglyceride and (D) a 1,2-alkanediol. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention provides a method for preventing spoilage and microbial contamination without adding a preservative to a cosmetic composition.

  In general, cosmetics may cause deterioration, discoloration, odor and the like due to microbial contamination like foods, and in this case, commercial value is lost. Infectious diseases can also be caused if contaminated microorganisms are pathogenic. Therefore, a preservative is blended for the purpose of preventing these microbial contaminations.

  Antiseptics include benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, paraoxybenzoic acid esters (parabens), resorcin, isopropylmethylphenol, benzalkonium chloride, hydrochloric acid Chlorhexidine, chlorhexidine gluconate, trichlorocarbanilide, Photosensitizer 201, phenoxyethanol, trichlorohydroxydiphenyl ether, and the like are used. Among them, parabens are widely used as typical preservatives. Parabens may be accompanied by irritation and allergic reactions during use to some sensitive users. In recent years, cosmetics that are gentler to the skin and high antibacterial properties have been demanded, and it is difficult to satisfy the current demands for cosmetics only by using parabens as an antiseptic means. It is possible to create cosmetics that do not contain preservatives, but in this case, it is necessary to make full use of means such as subcontainer containers and backless mechanisms to ensure antiseptic properties, such as economy and versatility. The tendency to be lacking was remarkable.

  As a result of diligent research, the inventors of the present invention as a result of the above-mentioned problems, as a result, clove (clove) extract from which essential oil components have been removed, ginseng (kawara mugi) extract, and fatty acids having 8 to 12 carbon atoms. It has been found that by using monoglyceride in combination, the antibacterial action is synergistically improved against a wide range of bacterial species, and in particular, the antibacterial action against mold is remarkably improved. And applied for a patent (see Patent Document 1).

  On the other hand, an antiseptic and bactericide composed of 1,2-alkanediol (see Patent Document 2) has been disclosed as a technique for reducing or not adding a preservative. However, when used alone for antiseptic purposes, a large amount of 1,2-alkanediol must be added to the cosmetic composition in order to obtain sufficient effectiveness. Had the problem of being attached.

  In addition, as a technique related to preserving using 1,2-alkanediol, a composition for external use (see Patent Document 3) in which 1,2-pentanediol and 2-phenoxyethanol are combined is used, or 1,2-alkanediol and paraben. The antiseptic disinfectant which becomes (refer patent document 4) is disclosed. However, these are intended to improve the effect of the preservative by using a preservative and a 1,2-alkanediol such as 1,2-pentanediol in an attempt to completely eliminate the preservative itself. It was not intended to enhance the antibacterial activity of 1,2-alkanediol.

In any antiseptic technology, it is essential to increase the amount of antibacterial ingredients in order to exert high antibacterial properties without adding preservatives to cosmetics, so in terms of hue and odor There was a problem.
JP 2002-370921 A Japanese Patent Laid-Open No. 11-322591 JP-A-10-53510 JP 11-310506 A

  The present invention has been made in view of the above-mentioned problems existing in the prior art, and an object thereof is to provide a cosmetic composition having excellent antibacterial and antifungal properties.

  As a result of diligent research to solve the above-mentioned problems, the present inventors have used a clove extract from which essential oil components have been removed, a ginseng extract, a monoglyceride of a fatty acid having 8 to 12 carbon atoms, and 1,2-alkanediol. As a result, the antibacterial action is synergistically improved for a wide variety of bacterial species, and the effect of preventing spoilage and microbial contamination is enhanced for cosmetics, and the present invention has been completed.

  That is, the present invention removes the essential oil component from the extract obtained by extracting (A) cloves (Apiaceae, cinnamon flower bud) with a lower alcohol and / or water, or removes the essential oil component in advance. An extract obtained by extracting the prepared clove with a lower alcohol and / or water. (B) An extract obtained by extraction of Inchinkou (Asteraceae, Sponge of Hydrangea) with lower alcohol and / or water. (C) Monoglycerides of fatty acids having 8 to 12 carbon atoms. (D) A cosmetic composition containing (A) to (D) of 1,2-alkanediol.

  Furthermore, in the cosmetic composition, (A) and (B) are extracted with an ethyl alcohol aqueous solution having an ethyl alcohol concentration of 50% by weight or more and / or a methyl alcohol aqueous solution having a methyl alcohol concentration of 50% by weight or more. . Furthermore, (A) is obtained by removing components insoluble in water. Details will be described below.

  According to the present invention, a composition having excellent antibacterial and antifungal properties that can prevent the decay of cosmetics and can be applied in a wide range of fields can be obtained.

  The 1,2-alkanediol used in the present invention preferably has 5 to 10 carbon atoms, more preferably 1,2-hexanediol. The content of 1,2-hexanediol varies depending on the cosmetic used, but is 0.01 to 20% by weight, more preferably 0.1 to 5% by weight in the water-containing cosmetic. It is not economical to add more than the necessary amount. By using in this range, the effect of the present invention is remarkably exhibited.

  The monoglyceride of a fatty acid having 8 to 12 carbon atoms used in the present invention is a monoester of a fatty acid having 8 to 12 carbon atoms such as caprylic acid, pelargonic acid, capric acid, undecyl acid, undecylenic acid, lauric acid and glycerin. , One or more of these are used. Normally, these monoglycerides are produced by esterifying the above fatty acid and glycerin and separating the monoglyceride by molecular distillation or the like, but even those containing diglyceride or triglyceride can be used. Usually, these monoglycerides are produced by the above-mentioned chemical synthesis, but they are components that exist in nature, and the safety to the human body is superior to the above-mentioned chemical synthetic antibacterial agents. Since these monoglycerides have low solubility in water and precipitate or separate in aqueous cosmetics such as lotion, it is necessary to add a surfactant to the cosmetic composition to solubilize these monoglycerides. However, it is particularly preferable to use caprylic acid monoglyceride because solubilization becomes difficult because the longer the carbon chain length of the fatty acid constituting the monoglyceride, the more the surfactant is required.

  The fatty acid monoglyceride having 8 to 12 carbon atoms is blended in an amount of 0.01 to 2% by weight, preferably 0.05 to 1% by weight, based on the cosmetic composition.

The clove used in the present invention is called a clove as another name, and is a flower bud of Euphoria caryophyllata (scientific name: Eugenia caryophyllata ). In order to obtain the clove extract used in the present invention, it may contain leaves and stems in addition to florets, but it is desirable to use only florets.

  As an extraction solvent for obtaining a clove extract, one or more selected from lower alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol and water can be used, and the concentration of ethyl alcohol is 50% by weight. The above-mentioned ethyl alcohol aqueous solution and / or a methyl alcohol aqueous solution having a methyl alcohol concentration of 50% by weight or more are preferred, and an ethyl alcohol aqueous solution having an ethyl alcohol concentration of 70 to 90% by weight is particularly preferred. Antibacterial components are also extracted when using an ethyl alcohol aqueous solution or an aqueous methyl alcohol solution with an alcohol concentration of less than 50% by weight, but because many pigment components that are hardly involved in antibacterial properties are extracted, the color of the extract itself becomes darker, The appearance of the cosmetic to be added may be impaired, which is not preferable. In particular, it is particularly preferable to use an aqueous ethyl alcohol solution having an ethyl alcohol concentration of 70 to 90% by weight because there is little extraction of the pigment component.

  The amount of the extraction solvent is not particularly limited, but is equivalent to 20 times by weight, preferably equivalent to 5 times the weight of the clove. Extraction is preferably performed at room temperature or low temperature because the extraction of the pigment component can be suppressed. However, the extraction may be performed by heating in order to improve extraction efficiency or shorten the extraction time.

  The clove extract used in the present invention is required to remove essential oil components such as eugenol. Essential oil components such as eugenol have an antibacterial action, but are volatile and have a unique strong odor. Therefore, containing the essential oil component is not preferable because it impairs the scent of cosmetics to be added. Examples of methods for removing essential oil components such as eugenol include a method of removing by steam distillation before clove extraction, a method of removing water by adding water or blowing water vapor and azeotropically with water after extraction, etc. Any method may be used.

  The thus obtained clove extract from which the essential oil component has been removed may be used as it is, concentrated or used after being completely or properly concentrated and dissolved in a solvent. The solvent that dissolves after the concentration is not particularly limited, but is preferably one commonly used in cosmetics, such as water, ethyl alcohol, isopropyl alcohol, glycerin, propylene glycol, 1,3-butylene glycol. Etc. can be illustrated.

  The clove extract from which these essential oil components have been removed, the concentrate obtained by concentrating the extract, or the extract dissolved in the solvent after the concentration may be added to the cosmetic composition as it is. Since an insoluble component is precipitated or separated, it is preferable to use it after removing a component insoluble in water. The removal of the water-insoluble component can be carried out by filtration after adding water to the extract or concentrate to dissolve the water-soluble component. The step of removing the water-insoluble component may be before or after the step of removing the essential oil component. If the water-insoluble component is removed after removing the essential oil component, it should be concentrated as it is to make a concentrate, or after concentration, dissolved in the above-mentioned solvent to make an extract and then used in the cosmetic composition. Can do. When removing the essential oil component after removing the water-insoluble component, after removing the essential oil component, as it is, after concentrating to make a concentrate, or after concentrating and dissolving in the above-mentioned solvent to make an extract, It can be used in cosmetic compositions.

  Thus, the obtained clove extract is mix | blended 0.001 to 5 weight% in conversion of solid content with respect to cosmetics composition, Preferably 0.002 to 2 weight% is mix | blended.

The Inchinkou used in the present invention is a flower ear of the asteraceae (Scientific name: Artemisia capillaries Thumb. ) And is used as a herbal medicine. In order to obtain the Ginseng extract used in the present invention, it may contain leaves, stems and the like in addition to the flower ears, but it is desirable to use only the flower ears.

  As the extraction solvent for obtaining the ginseng extract, one or more selected from lower alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol and water can be used, but the concentration of ethyl alcohol is 50% by weight. The aqueous ethyl alcohol solution and / or the aqueous methyl alcohol solution having a methyl alcohol concentration of 50% by weight or more are preferred, and the aqueous ethyl alcohol solution having an ethyl alcohol concentration of 60 to 80% by weight is particularly preferred. Use of an aqueous ethyl alcohol solution or aqueous methyl alcohol solution with an alcohol concentration of less than 50% by weight is not preferred because the amount of antibacterial components extracted is reduced and the amount of pigment components extracted is increased. In particular, use of an ethyl alcohol aqueous solution having an ethyl alcohol concentration of 60 to 80% by weight is preferable because the extraction efficiency of the active ingredient is high.

  The amount of the extraction solvent is not particularly limited, but it is 3 to 20 times, preferably 5 to 10 times the weight ratio of the ginseng. Extraction is preferably performed at room temperature or low temperature because the extraction of the pigment component can be suppressed. However, the extraction may be performed by heating in order to improve extraction efficiency or shorten the extraction time.

  In addition, prior to the extraction of Inchinkou with the above-mentioned lower alcohol aqueous solution or the like, if the Inchinkou is extracted with water alone, antibacterial components are hardly extracted, and pigment components and Inchinkou-specific odor components are extracted. It is more preferable that an extract of mint with less odorous components and the like can be obtained without reducing the extraction amount of the antibacterial components by extracting and removing the pigment component and the odorous component and then extracting with the above-mentioned lower alcohol aqueous solution.

  The obtained ginseng extract may be used as it is, concentrated or used after being completely or moderately concentrated and then dissolved in a solvent. The solvent that dissolves after the concentration is not particularly limited, but is preferably one commonly used in cosmetics, such as water, ethyl alcohol, isopropyl alcohol, glycerin, propylene glycol, 1,3-butylene glycol. Etc. can be illustrated.

  The ginseng extract thus obtained is blended in the cosmetic composition in an amount of 0.001 to 5% by weight, preferably 0.002 to 2% by weight in terms of solid content.

  The cosmetic composition of the present invention includes, in addition to the above-described components, oils, powders (pigments, pigments, resins), fluorine compounds, resins, and surfactants that are commonly used in cosmetics, depending on the product form. The purpose of the present invention is to use components such as a thickener, a fragrance, an ultraviolet absorber (organic and inorganic), a moisturizer, a physiologically active ingredient, a salt, a solvent, an antioxidant, a neutralizer, a pH adjuster and an enzyme. It can be suitably used within the range that can be achieved.

  Examples of the dosage form of the cosmetic composition of the present invention include lotion, bilayer, water-in-oil emulsion, oil-in-water emulsion, gel, mousse, oily, solid, sheet, shampoo, liquid detergent, etc. The conventionally well-known dosage form can be used.

  The cosmetic composition of the present invention includes benzoic acid and salts thereof, salicylic acid and salts thereof, dehydroacetic acid and salts thereof, sorbic acid and salts thereof, benzalkonium chloride, benzethonium chloride, alkyltrimethylammonium chloride, and the like. By not containing amphoteric surfactants such as quaternary ammoniums, alkylaminoethyl glycine hydrochloride, sodium stearylhydroxyethyl betaine chloride, and preservatives such as photosensitizers, cosmetics without preservatives can be obtained.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to these. In addition, the unit of the numerical value in a following example is weight% unless there is particular notice.

<Production Example 1>
200 g of an ethyl alcohol aqueous solution having an ethyl alcohol concentration of 80% by weight was added to 100 g of dried clove (butterfly florets), extracted by immersion for 16 hours at room temperature, and filtered under reduced pressure to obtain an extract. 400g of purified water was added to this, and the operation of concentrating the filtrate obtained by filtering the precipitate under reduced pressure was performed twice to remove the water-insoluble component and azeotropically remove the essential oil component together with water. did. 1,3-butylene glycol was added to this concentrate and dissolved to make a total amount of 100 g to obtain a clove extract from which essential oil components were removed. The clove extract had a solid content of 6.0%.

<Production Example 2>
500 g of an ethyl alcohol aqueous solution having an ethyl alcohol concentration of 70% by weight was added to 100 g of dried Inchinkou (Hanamugigi Kaho) and extracted by immersion for 16 hours at room temperature, and filtered under reduced pressure to obtain an extract. To this, 160 g of 1,3-butylene glycol was added, and then the mixture was concentrated under reduced pressure until the total amount became 200 g, to obtain an Inchinkou extract. The solid content of this ginseng extract was 4.5%.

<Antimicrobial test method> Test strains A to E below were used.
A: Staphylococcus aureus ATCC 6538
B: E. coli ( Escherichia coli ATCC 8739)
C: Pseudomonas aeruginosa ( Pseudomonas aeruginosa ATCC 9027)
D: Candida yeast ( Candida albicans ATCC 10231)
E: Black Koji mold ( Aspergillus niger ATCC 16404)
10 g of bacteria (AC) and 10 5 of fungi (D to E) are inoculated per 1 g of each cosmetic sample, with bacteria at 37 ° C. and fungi at 25 ° C. After culturing, the number of viable bacteria was measured immediately after inoculation on the 7th, 14th, 21st and 28th days, and evaluated according to the following criteria.
Evaluation criteria for bacteria (A to C):
A: All inoculated bacteria die within 7 days.
○: Inoculated bacteria are reduced to 0.1% or less of the initial number of bacteria within 7 days, and then the previous level is maintained or decreased to less than that.
(Triangle | delta): The inoculated bacteria reduce to 0.1% or less of the number of initial germs within 14 days, and then maintain the previous level or decrease to the level below that.
X: The above criteria of Δ are not satisfied.
Evaluation criteria for fungi (DE): The inoculated fungus decreases to 0.01% or less of the initial number of bacteria in 14 days, and then maintains the previous level or decreases to less than that.
○: The inoculated fungus decreases to 0.1% or less of the initial number of bacteria in 14 days, and then maintains the previous level or decreases to less than that.
(Triangle | delta): Inoculated fungus reduces to 10% or less of the number of first germs in 14 days, and maintains a level before it or decreases to less than it after that.
X: The above criteria of Δ are not satisfied.

<Examples 1-3, Comparative Examples 1-2>
Table 1 shows the results of preparing shampoos of Examples 1 to 3 and Comparative Examples 1 and 2 described in Table 1 and examining antibacterial properties. The blending amounts in the table are expressed in terms of solid content.

<Examples 4-5, Comparative Examples 3-4>
Table 2 shows the results of preparing the emollient creams of Examples 4 to 5 and Comparative Examples 3 to 4 shown in Table 2 and examining the antibacterial properties.

<Examples 6-7, Comparative Examples 5-7>
Table 3 shows the results of preparing the moisture lotions of Examples 6 to 7 and Comparative Examples 5 to 7 described in Table 3 and examining the antibacterial properties.

  As apparent from Tables 1 to 3 above, sufficient antibacterial activity was observed against both bacteria and fungi in the examples of the present invention. In Comparative Examples 1 to 7, it was confirmed that the antibacterial property against mold was weak.

INDUSTRIAL APPLICABILITY The present invention can prevent the decay of cosmetics without blending antiseptics, makes it possible to develop a cosmetic composition with excellent antibacterial and antifungal properties, and can be applied in a wide range of fields.

Claims (3)

The following (A) to (D):
(A) An extract obtained by removing essential oil components from an extract obtained by extracting clove (Apiaceae, Cistaceae flower buds) with lower alcohol and / or water, or a clove from which essential oil components have been previously removed is extracted with lower alcohol and / or water. Extract. (B) An extract obtained by extraction of Inchinkou (Asteraceae, Sponge of Hydrangea) with lower alcohol and / or water. (C) Monoglycerides of fatty acids having 8 to 12 carbon atoms. (D) A cosmetic composition characterized by imparting excellent antibacterial and antifungal properties by containing 1,2-alkanediol.   The cosmetic composition according to claim 1, wherein (A) and (B) are extracted with an ethyl alcohol aqueous solution having an ethyl alcohol concentration of 50% by weight or more and / or a methyl alcohol aqueous solution having a methyl alcohol concentration of 50% by weight or more. . The cosmetic composition according to claim 1 or 2, wherein (A) is obtained by removing water-insoluble components.