KR20190016755A - Diet-food composition for inducing satiation comprising L-tryptophan and dietary fiber of chicory and method for preparing diet tablet using the same - Google Patents

Abstract

A food composition for diet according to the present invention comprises L-tryptophan and chicory dietary fibers as active ingredients, and has an excellent obesity improving effect by inducing synergistic effect with appetite control and feces-promoting effects through enhancement of psychological and physical satiety. Particularly, tablets manufactured with the composition are easy to be ingested and can be easily used for diet by improving the inconvenience of intake of L-tryptophan.

Description

TECHNICAL FIELD [0001] The present invention relates to a food composition for dieting having a function of promoting fullness, comprising L-tryptophan and chicory dietary fiber as an active ingredient, and a method for producing dietary tablets using the same. for preparing diet tablet using the same}

The present invention relates to a food composition for diet having a satiety-improving function comprising L-tryptophan and chicory dietary fiber as an active ingredient, and a method for preparing dietary tablets using the same.

Recently, the intake of calories has increased due to westernization and instantaneous dietary habits. However, obesity or various diseases have been increasing due to decrease in the amount of fibrin consumption and decrease of exercise, and obesity is caused by excessive accumulation of body fat It is known that it interferes with physiological function and causes various chronic diseases such as diabetes, cardiovascular disease, lipid metabolism abnormality, cancer, etc. Therefore, researches on methods for prevention, improvement and treatment of such obesity and adult diseases actively It is progressing.

Conventionally, there has been an attempt to improve obesity by using an obesity treatment agent such as sibutramine, phentermine, methamphetamine, etc. However, the above-mentioned obesity treatment agent has insomnia, nervous anxiety, headache, tachycardia, It has been known that there are serious side effects such as disorders, hypersensitivity, cholestatic disorder, and fat-soluble vitamin absorption inhibition. Various studies have been carried out to improve these problems. In recent years, understanding the mechanism of controlling food intake Research is also under way to induce weight loss by blocking calories entering the body and consuming body fat.

On the other hand, serotonin is a neurotransmitter known as a happy hormone in the body. It is related to appetite control. As the amount of serotonin in the body decreases, depression can be caused. As a result, the appetite is increased to induce excessive food intake L-tryptophan, which is a raw material of serotonin, is used as a food additive as an essential amino acid. In a study on the relationship between the concentration of L-tryptophan and the obesity, the intake of L- The results of the human body test have confirmed that there is an effect on the human body.

However, in the case of L-tryptophan, it is inconvenient to ingest due to the bitter taste characteristic of amino acids. In the case of products with strong taste for jelly, chewable tablets and beverages, it is necessary to develop a product capable of satisfying functionality and palatability. It is difficult to find a diet product containing tryptophan as a main functional raw material. Also, some of the products using this product are very low in content, and studies on a method of effectively improving obesity using the tryptophan are needed.

Korean Patent No. 10-1341475 (Publication date: December 13, 2013) Korean Patent Laid-Open No. 10-2013-0030049 (Publication date: March 23, 2013) Korean Patent Laid-Open No. 10-2017-0069464 (Publication date: Jun. 2017)

DISCLOSURE Technical Problem The present invention has been conceived to solve the problems of the prior art as described above, and it is an object of the present invention to provide a food composition for diets having excellent obesity improving effect by inducing synergy of promoting fullness and defecation promotion effect using tryptophan and chicory dietary fiber as main ingredients And a method for producing a tablet for diet using the same.

The present invention has been made in view of the above problems, and it is an object of the present invention to provide an apparatus and method for controlling the same.

In order to accomplish the above object, the present invention provides a food composition for diet comprising chicory dietary fiber and L-tryptophan.

In addition, the food composition for diet may further include crystalline cellulose, CMC-Ca salt, magnesium stearate, hydroxypropyl methylcellulose, glycerin fatty acid ester, and alcohol.

Also, the food composition for diet includes 35 to 45 wt% of chicory dietary fiber, 15 to 25 wt% of L-tryptophan, 35 to 40 wt% of crystalline cellulose, 1 to 5 wt% of carboxymethyl cellulose (CMC-Ca 0.1 to 2% by weight of magnesium stearate, 0.1 to 1% by weight of hydroxypropylmethylcellulose, 0.1 to 1% by weight of glycerin fatty acid ester and 0.1 to 1% by weight of a spirit.

In addition, the food composition for diet may be a tablet formulation, and the tablet preferably contains 100 to 150 mg of L-tryptophan and 200 to 300 mg of chicory dietary fiber.

(A) granulating a mixture comprising chicory dietary fiber, L-tryptophan, crystalline cellulose, CMC-Ca salt, silicon dioxide and alcohol to produce granules; (b) mixing and granulating the granules and the glidant to form an naked tablet; And (c) coating the surface of the tablet with a coating agent to prepare tablets.

In addition, the lubricant may include magnesium stearate, and the coating agent may include hydroxypropyl methylcellulose, glycerin fatty acid ester, and alcohol.

The food composition for diet according to the present invention contains L-tryptophan and chicory dietary fiber as an active ingredient to induce a synergistic effect of controlling appetite and promoting bowel movement through promotion of psychological and physical fullness, Particularly, the tablets prepared by the above composition are easy to ingest and improve the inconvenience of intake of L-tryptophan, and when they are consumed before or after the meal, they can provide sufficient fullness for a long time to reduce the intake of food, It is easy to use for applications.

The effects of the present invention are not limited to those mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the following description.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process drawing showing a method for producing a tablet for diet according to the present invention. FIG.

Further objects, features and advantages of the present invention will become more apparent from the following detailed description and the accompanying drawings.

Before describing the present invention in detail, it is to be understood that the present invention is capable of various modifications and various embodiments, and the examples described below and illustrated in the drawings are intended to limit the invention to specific embodiments It is to be understood that the invention includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

It is to be understood that when an element is referred to as being "connected" or "connected" to another element, it may be directly connected or connected to the other element, . On the other hand, when an element is referred to as being "directly connected" or "directly connected" to another element, it should be understood that there are no other elements in between.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, the terms "comprises" or "having" and the like refer to the presence of stated features, integers, steps, operations, elements, components, or combinations thereof, But do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or combinations thereof.

In the following description of the present invention with reference to the accompanying drawings, the same components are denoted by the same reference numerals regardless of the reference numerals, and redundant explanations thereof will be omitted. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description, well-known functions or constructions are not described in detail since they would obscure the invention in unnecessary detail.

Hereinafter, the present invention will be described in detail.

The present invention provides a food composition for diet comprising chicory dietary fiber and L-tryptophan.

The L-tryptophan exhibits a sedative effect, immune enhancement and anti-aging effect, which induces natural sleeping, reduces pain sensitivity, and improves tension, nervousness, depression headache, etc. It is also effective in controlling cholesterol, blood pressure, improving menopausal symptoms, Not only has an effect of improving the body weight of obesity, but also has an effect of reducing appetite, promoting a feeling of fullness, participating in energy metabolism, and reducing body weight of obesity, especially as a raw material of serotonin.

The chicory dietary fiber is a natural dietary fiber material that contains inulin and oligofructose called oligo fibers to help prevent overeating by promoting fullness. give. In addition, by increasing the amount of stool and stimulating the growth of beneficial bacteria in the intestines such as Bifidobacterium, it facilitates bowel movement and weight loss. Especially, inuline is a low caloric polysaccharide which helps blood glucose control by acting as a natural insulin, Satisfaction can be maintained by giving.

The chicory dietary fiber may be extracted from chicory leaves, stems, roots and the like. Preferably, the chicory dietary fiber may be extracted from chicory roots and used with natural inulin-soluble dietary fiber having a high content of inulin. Fiber can normalize the peristaltic movement of the intestines, improve the function of the large intestine, and release it in combination with bile acids and lipids in the small intestine, thus reducing the levels of serum cholesterol and triglyceride.

In addition, the food composition for diet according to the present invention can be prepared into foods by further mixing excipients, binders, disintegrants, lubricants, sweeteners, etc., which are acceptable as foods, and include crystalline cellulose, Representative examples include calcium carboxymethylcellulose (CMC-Ca salt), magnesium stearate, silicon dioxide (SiO ₂ ), lactose, corn starch, mannitol and magnesium aluminometasilicate have. Preferably, the food composition for diet according to the present invention may further comprise crystalline cellulose, CMC-Ca salt, magnesium stearate, hydroxypropyl methylcellulose, glycerin fatty acid ester and alcohol.

Specifically, the crystalline cellulose may serve as a disintegrant which swells and expands in the gastrointestinal tract to induce a satiety feeling, and promotes the process for the absorption of the active ingredient into the body. The crystalline cellulose may improve the fluidity of the mixture during the production of food, It can play a role of promoting the mixing of the chicory dietary fiber and producing a homogeneous mixture.

The calcium carboxymethyl cellulose may serve as a disintegrating tablet for promoting the absorption of the active ingredient into the body, the silicon dioxide serving as an adsorbent, the magnesium stearate serving as a lubricant, To prevent mold adhesion of the tablets generated by compression, and to reduce the friction while the tablets are discharged from the tablet machine, thereby imparting gloss to the tablets.

Hydroxypropyl-methylcellulose may be included as a controlled-release additive for controlling the drug release from the preparation, while providing safety of the formulation and minimizing the burden of necking.

The glycerin fatty acid esters can prevent the lack of moisture due to overdrying, and can be used as a coating agent for alcohol.

The food composition for diets according to the present invention can be used as a food, which can be used as a food, such as sweeteners such as oligosaccharide, honey, syrup, chocolate and the like, other seasoning materials such as salt and the like, siblings, binders, disintegrators, lubricants, mating agents, A coloring agent or a mixture thereof may be mixed with a food additive and formulated into a dry powder, a granule, a capsule, a tablet, a pill, a drink, an emulsion, a diet bar, a chocolate, a caramel, a cereal, Functional food, general food, and the like.

Preferably, the food composition for diet is preferably prepared in a tablet formulation, and when prepared in such a tablet formulation, the discomfort of ingestion due to the bitter taste peculiar to L-tryptophan can be solved.

In addition, when the food composition for diet is prepared by tableting using a tablet machine, the tablets have a total weight of 600 to 750 mg, 100 to 150 mg of L-tryptophan and 200 to 300 mg of chicory dietary fiber And can be taken twice a day, so that it can be introduced into the body at an optimum supply amount of L-tryptophan and chicory dietary fiber required for a day, and it is possible to induce an excellent obesity improvement effect through the fullness-enhancing effect.

For example, the food composition for diet according to the present invention comprises 35 to 45% by weight of chicory dietary fiber, 15 to 25% by weight of L-tryptophan, 35 to 40% by weight of crystalline cellulose, 1 to 5% by weight of carboxymethylcellulose 1 to 5% by weight of silicon dioxide, 0.1 to 2% by weight of magnesium stearate, 0.1 to 1% by weight of hydroxypropyl methylcellulose, 0.1 to 1% by weight of glycerol fatty acid ester and 0.1 to 1% Can be utilized to prepare dietary tablets, including% w / w alcohol.

Preferably, the chicory dietary fiber comprises 37 to 40 wt%, 18 to 20 wt% of L-tryptophan, 35 to 37 wt% of crystalline cellulose, 2 to 4 wt% of carboxymethyl cellulose (CMC-Ca salt) To about 2% by weight of silicon dioxide, from 0.5 to 1.5% by weight of magnesium stearate, from 0.3 to 0.8% by weight of hydroxypropyl methylcellulose, from 0.3 to 0.8% by weight of glycerin fatty acid esters and from 0.3 to 0.8% can do.

Further, the food composition for diet according to the present invention may further comprise a vitamin B group such as vitamin B1, vitamin B2, vitamin B6, and vitamin B12, and may further comprise a function that can be caused by prolonged intake or overdose of L-tryptophan And preferably, in the case of tablets having a total weight of 600 to 750 mg, 50 to 200 mg of vitamin B2 (riboflavin) may be mixed instead of crystalline cellulose.

The food composition for diet according to the present invention as described above contains L-tryptophan and chicory dietary fiber as an active ingredient to induce a synergistic effect of controlling appetite and promoting bowel movement by enhancing psychological and physical filling feeling, In particular, the tablets made from the above composition are easy to ingest and can be easily used for dieting by improving the inconvenience of intake of L-tryptophan.

On the other hand, the present invention provides a method for producing granules comprising the steps of: (a) granulating a mixture containing chicory dietary fiber, L-tryptophan, crystalline cellulose, CMC-Ca salt, silicon dioxide and alcohol to prepare granules; (b) mixing and granulating the granules and the glidant to form an naked tablet; And (c) coating the surface of the tablet with a coating agent to prepare tablets.

The step (a) is a step of granulating a mixture containing chicory dietary fiber, L-tryptophan, crystalline cellulose, CMC-Ca salt, silicon dioxide and alcohol to prepare granules.

In this step, the mixture can be prepared by mixing L-tryptophan, crystalline cellulose, calcium carboxymethyl cellulose and silicon dioxide after mixing the chicory dietary fiber with the alcohol such as ethanol and stirring for a sufficient time to disperse uniformly, The thus-prepared mixture is introduced into a granulating machine such as a flow type granulator, spray granulator, etc., and the mixture is molded and dried to produce granules. The granules can be manufactured by shaping the granules so as to have an average diameter of 1 to 5 mm .

In this step, the vitamin B group may be further added to the mixture when the mixture is prepared.

The step (b) is a step of mixing and granulating the granules and a lubricant to prepare an naked tablet. The granules and the lubricant mixture thus prepared are mixed in a ventilator, a pelletizer, etc., And the mixture can be pressed to form a kneaded product. Magnesium stearate may be used as such a lubricant.

Also, in this step, it is preferable to manufacture the nunner so that the average weight of the manufactured nuns is 600 to 750 mg.

The step (c) is a step of preparing a tablet by coating a coating agent on the surface of the tablet, wherein hydroxypropyl methylcellulose and glycerin fatty acid ester are mixed using a solvent such as ethanol as a solvent to prepare a coating solution The coating solution thus prepared is coated on the surface of the tablet, and hydroxypropyl methylcellulose and glycerin fatty acid ester are cross-linked and dried to prepare tablets in the form of a coating agent coated on the surface of the tablet. Such a coating step can be configured to be repeated several times as required.

In this step, the tablets prepared by coating the coating agent as described above may be further packed by using various conventional packing methods. The packaged tablets may be commercialized and marketed have.

According to the manufacturing method of the present invention as described above, a mixture containing L-tryptophan and chicory dietary fiber is granulated, a lubricant is mixed by mixing the lubricant, and a coating layer is formed on the flange to prepare tablets Accordingly, it is possible to minimize the burden of necking and to control the release of the tablet, thereby making it possible to produce a tablet for diet that can be easily used for a diet.

The embodiments and the accompanying drawings described in the present specification are merely illustrative of some of the technical ideas included in the present invention. Therefore, it is to be understood that the embodiments disclosed herein are not for purposes of limiting the technical idea of the present invention, but rather are not intended to limit the scope of the technical idea of the present invention. It will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Hereinafter, the present invention will be described in more detail with reference to examples.

The embodiments presented are only a concrete example of the present invention and are not intended to limit the scope of the present invention.

<Examples>

Tablets for diet having compositions and mixing ratios as shown in Table 1 below were prepared.

To this end, a mixture of homogeneously mixed crystalline cellulose, CMC calcium, and silicon dioxide as a refining auxiliary material is used as a main raw material of chicory dietary fiber and L-tryptophan as a tablet, and the mixture is molded into a granule molding machine Respectively. Magnesium stearate was added as a lubricant to the prepared granules, followed by mixing to prepare a mixture. The mixture thus prepared was put into a tablet machine to prepare a tablet.

Next, a coating solution was prepared by mixing hydroxypropylmethylcellulose (HPMC), glycerin fatty acid ester, and alcohol, spray-coating the prepared coating solution on the nail, drying the tablet coated with the coating solution, .

&Lt; Comparative Example 1 &

Tablets were prepared in the same manner as in Example except that glucomannan was used instead of Chicory dietary fiber at the same mixing ratio and dosage.

&Lt; Comparative Example 2 &

Purification was carried out in the same manner as in Example except that L-carnitine was used instead of L-tryptophan in the same mixing ratio and dose.

&Lt; Comparative Example 3 &

Tablets were prepared in the same manner as in Example except that 375 mg of chicory dietary fiber was added without adding L-tryptophan.

&Lt; Comparative Example 4 &

Purification was carried out in the same manner as in Example except that 375 mg of glucomannan was added without adding L-tryptophan.

&Lt; Experimental Example 1 >

A total of 35 subjects consisting of 30 males and 20 females over 20 years of age were analyzed for their satiety levels. The mean body weight of male subjects was 74.8 kg, the average weight of female subjects was 53.7 kg, and subjects were restricting food intake after sleeping, so that the satiety before eating was calculated as 0 and the satiety degree was analyzed. The tablets prepared by the methods of Comparative Examples 1 to 4 were taken in the place of breakfast with water and the fullness felt at intervals of 1 hour after ingestion was recorded in a questionnaire divided into 0 ± 20 and the average value was calculated to give a satisfactory degree of fullness And the results are shown in Table 2 below.

As shown in Table 2, it was confirmed that the fullness of the group ingesting the tablets of the Example was the highest, and the satiety feeling reached its peak at 1 hour after ingestion, and the satiety was continuously decreased with time .

In addition, it has been confirmed that the tablets of the Examples simultaneously containing L-tryptophan and chicory dietary fiber have the highest ability to impart satiety, and in the case of tablets containing glucomannan instead of chicory dietary fiber, But the inulin content was low, so it was predicted that the satiety inducing effect was somewhat lowered compared with the examples. Through these facts, it can be concluded that the tablets according to the examples have a psychological and physical satisfaction with L-tryptophan and chicory dietary fiber It was judged that appetite control was possible for a long time by inducing synergy effect through promotion.

<Experimental Example 2> Analysis of weight loss effect

In order to analyze the weight loss effects of tablets prepared by the method according to Examples and Comparative Examples 1 to 4, a method of analyzing weight gain using a rat induced by obesity was used.

First, 30 weeks old Sparague-Dawley male rats (mean weight 210 ± 10 g) were fed with high fat diet for 4 weeks to induce obesity. Thirty rats in which obesity was induced were divided into 6 groups of 5 rats and each 0.1 g of each of the tablets of Examples and Comparative Examples 1 to 4 was fed 5 minutes before the diet and 4.9 g by the high fat diet. . The results are shown in Table 3 below (one group is a control group fed with high fat diet).

As shown in Table 3, while the weight gain of the control group was confirmed to be 131%, the rats administered the tablets prepared by the method according to the examples and comparative examples 1 to 4, And it was confirmed that the recipients fed the prepared tablets did not take all of the high fat diet.

In particular, it was confirmed that the dietary intake was the lowest in the group fed the tablets according to the examples, and it was confirmed that the body weight gain rate was significantly reduced to -47.9% by feeding the tablets according to the examples for 4 weeks And it was confirmed that the dietary intake of cetyltreate for 4 weeks was the lowest, and the obesity improvement effect was greatly improved by the synergy effect of L-tryptophan and chicory dietary fiber, and the obesity improvement effect was the most excellent I was able to confirm the fact.

As a result, it can be confirmed that the food composition for diet according to the present invention has the effect of improving the obesity as well as the satiety feeling for a long time, so that it can be easily used for dieting.

Claims (8)

Chicory dietary fiber and L-tryptophan. The method according to claim 1,
Wherein the composition further comprises crystalline cellulose, calcium carboxymethyl cellulose (CMC-Ca salt), magnesium stearate, hydroxypropylmethyl cellulose, glycerin fatty acid ester and alcohol. 3. The method of claim 2,
35 to 40% by weight of crystalline cellulose, 1 to 5% by weight of carboxymethyl cellulose (CMC-Ca salt), 1 to 5% by weight of lactose, 35 to 45% by weight of chicory fiber, 15 to 25% By weight of silicon dioxide, 0.1 to 2% by weight of magnesium stearate, 0.1 to 1% by weight of hydroxypropyl methylcellulose, 0.1 to 1% by weight of glycerin fatty acid ester and 0.1 to 1% &Lt; / RTI &gt; The method of claim 3,
Wherein the food composition for diet has a tablet formulation. 5. The method of claim 4,
Wherein the tablet comprises 100 to 150 mg of L-tryptophan and 200 to 300 mg of chicory dietary fiber. (a) granulating a mixture comprising chicory dietary fiber, L-tryptophan, crystalline cellulose, CMC-Ca salt, silicon dioxide and alcohol to produce granules;
(b) mixing and granulating the granules and the glidant to form an naked tablet; And
(c) coating the surface of the tablet with a coating agent to prepare a tablet. The method according to claim 6,
Wherein the lubricant comprises magnesium stearate. The method according to claim 6,
Wherein the coating agent comprises hydroxypropylmethylcellulose, a glycerin fatty acid ester, and a meal.

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