KR20180106173A - Feed additive composition for relieving a summertime stress of milk-producing animals, feed comprising the composition and method for relieving a summertime stress of milk-producing animals using the composition - Google Patents

Abstract

The present invention relates to a feed additive composition, a feed and a method for using the same, and specifically, to a feed additive composition having an excellent effect of reducing stress of milk-producing animals in summertime, the feed comprising the composition and a method for reducing the summertime stress of the milk-producing animals using the feed. The feed additive composition contains resveratrol and vitamin E.

Description

Technical Field [0001] The present invention relates to a feed additive composition for reducing stress in a high-temperature environment of a milk animal, a feedstuff containing the feed additive composition and a method for relieving stress in a high temperature of a milk animal using the same, a summertime stress of milk-producing animals using the composition}

The present invention relates to a feed additive composition for reducing stress in a high temperature of an animal milk animal, a feed containing the feed additive composition, and a method for reducing stress in a high temperature of a milk animal using the same. Specifically, the present invention relates to a feed additive composition for enhancing the high temperature productivity of an animal milk animal including resveratrol and vitamin E.

Recent research has shown that resveratrol can inhibit the proliferation of cancer cells through the activation of genes promoting apoptosis in many cancer cells including breast cancer, prostate cancer, colorectal cancer, and lung cancer. It has been reported to extend the life span by 80%.

Vitamin E is a fat-soluble vitamin that acts to maintain cell membranes and neutralize free radicals with antioxidants. In other words, vitamin E acts as an antioxidant that prevents the progress of peroxidation of unsaturated fatty acids in the presence of unsaturated fatty acids in the cell membrane.

Vitamin C is a generic term for all compounds that exhibit the biological activity of ascorbic acid and, like vitamin E, has antioxidant properties. Most vitamin C exists as ascorbic acid in the animal body. Vitamin C is essential in some animals, including humans and primates, but many livestock, including ruminants, can synthesize ascorbic acid from glucose in the liver. However, because of the severe vitamin C deficiency symptoms when the synthetic route is compromised, they also take vitamin C intake.

Milk animals are weak in heat, and the high temperatures in the summer can cause loss of appetite, loss of milk production, and changes in quality of milk to the milk animals. When the temperature is above 27 ° C, animal feed reduces feed intake by 7-12% and reduces milk yield by 10-20% to reduce heat in the body. Recently, the production of white milk has decreased due to summer heat, and white milk has not been supplied to the market properly.

Especially, in summer, the summer weather is hot and humid, and the days when temperatures exceed 27 ° C are more than 30 days, so summer management is a very important issue for dairy farmers. Accordingly, dairy farmers are seeking to relieve the stresses of these high temperatures through facility management and nutrition management. First of all, the facility management includes installation of additional water supply facility to allow the hot food animals to eat more water, ventilation fan to cool the heat through cool wind, heat insulation in the house, shade installation have. Nutrition management is to increase the nutrient concentration by increasing the quality of feed and grain feed if the feed intake of the animal is decreased, to maintain the feed intake by mixing additives in the feed, to prevent the decrease of milk fat, And to increase the amount of pay.

Reduced milk production due to the high temperature stress of the milk animal directly leads to economic loss to the dairy farmer, but the above-mentioned facility management and nutrition management also incur additional costs to reduce the high temperature stress of the milk animal. Accordingly, there is a continuing need for a composition for reducing stress in a high temperature which is still efficient in terms of nutrition management.

Korean Patent Publication No. 10-2016-0132184 (published on November 17, 2016)

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a feed additive composition for reducing the stress of a high temperature of a milk-producing animal and thereby helping milk milk productivity of a milk-producing animal, and a feed containing the feed additive composition and a method for reducing stress in a high- will be.

In order to accomplish the above object, the present invention provides a feed additive composition for reducing the stress of a high temperature of an animal milk animal, and more particularly, to a feed additive composition for reducing the stress of a high temperature of an animal milk animal containing resveratrol and vitamin E as an active ingredient An additive composition is provided.

The inventors of the present invention have found that when feeding a feed additive including resveratrol and vitamin E to a milk animal and feeding it with a certain range of weight, resveratrol and vitamin E The synergistic effect of the milk milk production of the milk animal is excellent, and the present invention has been completed.

In the present invention, the term 'milk-bearing animal' is used to refer to an animal capable of producing milk, such as a goat, a goat, a camel, a sheep, a cow, and the like, preferably a cow.

In the present invention, the term 'high temperature' is used to refer to the time when the body temperature of the animal is 35.5 ° C. to 38.8 ° C. or 75% or more, and the ambient temperature is 27 ° C. or more. For example, May to September, preferably June to August, may be the high temperature.

The term " hot period stress " to be reduced by the present invention means a symptom or symptom of stress caused by a high temperature, for example, an increase in minerals (Na, K, etc.) emitted by sweat or respiration, a decrease in immunity, , Loss of appetite, decrease in blood volume, decrease in milk production, change in oil quality, reproductive disorder, weight loss, and increase in somatic cell count. Preferably, the effect of the stress reduction of the high temperature according to the present invention is an increase in feed intake, an increase in the amount of milk production, and an improvement in oil quality.

Hereinafter, the present invention will be described in more detail.

The resveratrol is a compound represented by the following formula (1) with molecular formula C14H12O, molecular weight of 228.

[Chemical Formula 1]

The resveratrol is a substance belonging to the polyphenol family which is an antioxidant substance found in plants. It is found in many plants including audi, peanut and grape. The resveratrol contained in the present invention can be extracted from natural products or artificially synthesized and used , And the natural products may include grapes, audi, blueberries, mulberry, and the like.

The resveratrol contained in the present invention is 0.01 to 1% by weight, preferably 0.05 to 0.8% by weight, more preferably 0.1 to 0.5% by weight based on the total weight of the composition. When the content of resveratrol is less than 0.01% by weight, the effect of reducing the stress may be insignificant. When the content of resveratrol is more than 1% by weight, difficulties may arise in controlling the pH of the feed additive.

The vitamin E contained in the present invention is a compound of which the efficacy of antioxidation is known and is represented by the following formula (2).

(2)

The vitamin E contained in the present invention can be extracted from natural products or artificially synthesized and used. The natural products include vegetable oils (sunflower seeds, rape seeds, safflower seed oil, etc.); Animal fats (fish, crustaceans, etc.), and the like. It may also be used in the form of a complex containing vitamin E, but is not limited thereto.

The content of vitamin E contained in the present invention is 0.1 to 3% by weight, preferably 0.5 to 2% by weight based on the total weight of the composition. If the content of vitamin E is less than 0.1% by weight, the effect of the present invention may be insignificant. If the content of vitamin E is more than 3% by weight, difficulties may arise in the digestive ability of the animal animal ingesting the feed additive.

The weight ratio of lasveratrol and vitamin E contained in the present invention is 1: 1-20, preferably 1: 1-15, more preferably 1: 1-10, in terms of lasveratrol: vitamin E, Most preferably 1: 5. If the weight ratio is less than 1: 1 or more than 1:20, the intended effect of the present invention may not be obtained, which may lead to problems such as reduction of platelet aggregation, gastrointestinal disorder, muscle weakness and the like.

The composition of the present invention may further comprise at least one compound selected from the group of vitamin B, and may include at least one selected from the group including biotin, niacin, and choline.

The content of the at least one compound selected from the vitamin B group is 0.1 to 20% by weight, preferably 0.1 to 15% by weight, based on the total weight of the composition. If the content of the compound is less than 0.1% by weight or more than 20% by weight, problems associated with stomach uptake of the animal animal may occur after feeding of the feed additive.

The composition of the present invention may be an amino acid-based feed additive composition further comprising an amino acid. Examples of the amino acid include glycine, alanine, valine, leucine, isoleucine, threonine, serine, cysteine, cystine, methionine, aspartic acid, asparagine, glutamic acid, diiodothyrosine, lysine, arginine, histidine, phenylalanine, tyrosine, tryptophan, proline, Proline, and the like, preferably lysine and / or methionine, but is not limited thereto.

The content of the amino acid is 0.1 to 15% by weight, preferably 1 to 10% by weight, based on the total weight of the composition. If the content of the amino acid is less than 0.1% by weight or more than 15% by weight, problems in nutritional aspects of the feed additive may occur.

The composition of the present invention may be a vitamin-based feed additive composition further comprising vitamin C. The vitamin C is a compound of the formula C ₆ H ₈ O ₆ , which may be named ascorbic acid. The vitamin C contained in the present invention can be natural vitamin C or synthetic vitamin C contained in the nutrients and the like.

The content of the vitamin C is 0.1 to 10% by weight, preferably 1 to 8% by weight based on the total weight of the composition. When the content of vitamin C is less than 0.1, the effect of the vitamin-based feed additive according to the present invention is insignificant, and if it exceeds 10% by weight, gastrointestinal disorder of a milk animal may be caused.

The composition of the present invention may be an amino acid-based feed additive composition containing an amino acid, a vitamin-based feed additive composition containing vitamin C, or a fused feed additive composition containing both an amino acid and vitamin C. Preferably, the composition is an amino acid-based feed additive composition or a vitamin-based feed additive composition, most preferably an amino acid-based feed additive composition.

The composition according to the present invention may further contain other feed additive ingredients which can be easily selected by those skilled in the art without departing from the purpose of the present invention. The components that may be further included in the composition according to the present invention may be varied depending on the purpose of use. For example, various minerals such as organic selenium, cobalt, vitamin C, protective fat, main anchovin, etc. disclosed in an embodiment of the present invention, But it is not limited thereto.

The milk of the animal milk to which the feed additive including the composition according to the present invention is applied may include the effect of increasing the milk production, the milk protein content, the milk fat content, the selenium content, But is not limited thereto.

The present invention provides a feed comprising the feed additive composition, wherein the content of the feed additive composition is 0.05 to 2% by weight based on the total weight of the feed.

In addition, the feed according to the present invention may further comprise other ingredients which can be readily selected by those skilled in the art. Ingredients that may be further included in the feed according to the present invention may vary depending on the purpose of use, and may include, for example, various vitamins, various amino acids, coloring agents, preservatives, hormones and the like, but are not limited thereto.

The present invention provides a method for reducing oil animal stress in a high temperature by feeding the feed additive composition or the feed to an animal. In addition, minerals blocks, soy sauce, salt and the like can be freely vegetarian together with the feed according to the present invention.

The present invention is able to reduce the stress of the high temperature of a milk animal through a feed additive composition comprising resveratrol and vitamin E. This can increase the feed intake of milk animals and increase milk production. This makes it possible to alleviate the phenomenon that the amount of milk supplied to the high temperature machine is reduced.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments of the invention and, together with the description of the invention, It should not be construed as limited.
FIG. 1 is an amino acid-based additive composition containing amino acids in the feed additive composition according to the present invention.
FIG. 2 is a vitamin-based additive composition containing vitamin C in the feed additive composition according to the present invention.
FIG. 3 is a view of a fusing system additive including amino acid and vitamin C in the feed additive composition according to the present invention.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

Table 1 shows the compositions and the weights thereof in one embodiment when preparing feed additives according to the present invention. However, the compositions and weights shown in the embodiments described herein are merely preferred embodiments, and are not intended to represent all of the technical ideas of the present invention, so that various equivalents And variations are possible.

<Test Example> Feed intake, milk yield and oil content according to feeding of feed additive

1. Preparation of Examples 1-3

Feed additives were prepared using the composition components and weights shown in Table 1 below.

Example 1 was made with an amino acid-based additive including resveratrol and vitamin E, Example 2 was made with a vitamin-based additive including resveratrol and vitamin E, Example 3 was made with a fusarium additive including resveratrol and vitamin E .

Component (% by weight) Example 1 Example 2 Example 3 One Resveratrol 0.2 0.2 0.2 2 Vitamin E One One One 3 Organic selenium 0.003 0.003 0.003 4 cobalt 0.03 0.03 0.03 5 Niacin 3 3 3 6 Biotin 0.01 0.01 0.01 7 Choline 10 10 10 8 Lysine 6 - 6 9 Methionine 3 - 3 10 Vitamin C - 5 5 11 Protective fat 45 42 52.5 12 Main berth To 100 To 100 To 100

2. Feed additive benefits

After feeding the prepared feed additives to milking cows, the feed intake and the amount of milk production were investigated. As the test axis, milking of the farm in Gochang, Jeonbuk Province was participated. In the experimental group fed with the feed additive of Example 1, milking with an average milk production of 35.7 (± 2.6) kg / day for 255.0 days was participated. In the experimental group, the mean milk yield of 199.7 days was 36.6 (± 2.9) kg / day, and the feed group of Example 3 was 221.7 days of milk yield of 36.0 (± 2.0) kg / day. As a control group, milking with an average milk yield of 216.6 days (± 2.4) kg / day was participated. Each experimental group was fed four treatments with compound feed and 100g of the feed additive, and six treatments per treatment. In the control group, only compound feed was fed at six times daily. The composition of the fed diets was as shown in Table 2. During the test period, changes in temperature and humidity in the house of Jeonbuk Gochang farm were as shown in Table 3. The temperature and humidity changes were automatically collected every 30 minutes using a Mini data logger (model testo 174H).

division Jeonbuk Gochang In May June In July August September moisture(%)
Crude protein (%)
Crude fat (%)
Crude fiber (%)
Views min (%)
NDF (%)
ADF (%)
calcium(%)
sign(%) 38.63
10.73
5.47
12.37
4.32
24.17
13.89
0.51
0.32 38.31
10.35
4.86
11.95
4.47
22.72
13.36
0.54
0.32 39.73
10.05
4.51
12.63
4.58
22.77
13.45
0.66
0.27 34.02
12.59
5.44
13.84
4.90
25.10
14.34
0.81
0.32 29.36
12.28
5.30
15.42
5.85
27.53
16.23
0.87
0.29

division In May June In July August September Temperature
(° C) Best 29.9 35.0 34.9 35.0 31.1 lowest 10.5 15.3 19.2 16.2 14.1 Average 19.81 22.66 26.47 27.18 22.31 Humidity
(%) Best 99.9 99.9 99.9 99.9 99.9 lowest 27.5 45.0 56.5 45.0 48.5 Average 75.81 86.51 88.69 85.62 89.01

3. Feed intake comparison

During the test period, feed intakes and residuals were calculated by dividing the feed amount and the residual amount by the daily number of feeds. Feed dietary intakes were recorded in Table 4. In the control group, only the compound feed was fed, and Experimental Groups 1-3 were the treatments in which the feed additives of Example 1-3 were fed together.

division Jeonbuk Gochang Control Experiment 1 Experiment 2 Experiment 3 Feed amount (kg of raw material / two)
Feed amount (raw material / kg) 44.0
2.02 44.0
0.79 44.0
0.95 44.0
1.01 Feed intake (kg of raw material / two)
Feed intake (DM kg / both)
Additive (g / d) 41.98
27.13
- 43.21
27.92
100 43.05
27.82
100 42.99
27.78
120

4. Comparison of production volume

During the test period, milk yields by treatments and individuals were recorded by collecting milk yields during milking twice a day in the morning and afternoon, and the milk yields by treatments were shown in Table 5. In the control group, only the compound feed was fed, and Experimental Groups 1-3 were the treatments in which the feed additives of Example 1-3 were fed together.

division Jeonbuk Gochang Control Experiment 1 Experiment 2 Experiment 3 Average production (kg / two)
- Initiation
- End
36.0
34.2
35.7
36.4
36.3
35.0
36.0
34.2

5. Oil component analysis

In order to investigate the changes in milk quality during the test period, milk samples were collected once a month and analyzed for constituents. The results of the analysis are shown in Table 6. In the control group, only the compound feed was fed, and Experimental Groups 1-3 were the treatments in which the feed additives of Example 1-3 were fed together.

division Jeonbuk Gochang Control Experiment 1 Experiment 2 Experiment 3 butterfat(%)
- At the beginning (May)
- One month later (June)
- Two months later (July)
- Three months later (August)
- Four months later (September)
- Overall average
4.07
3.90
3.17
3.04
3.41
3.52
4.02
3.87
3.57
3.52
3.89
3.77
4.02
3.97
3.25
3.50
3.54
3.65
4.15
4.03
3.54
3.38
3.60
3.74 Milk protein
- At the beginning (May)
- One month later (June)
- Two months later (July)
- Three months later (August)
- Four months later (September)
- Overall average
3.34
3.25
3.22
3.40
3.35
3.31
3.31
3.28
3.29
3.36
3.44
3.34
3.29
3.32
3.32
3.30
3.31
3.31
3.33
3.30
3.38
3.39
3.30
3.34 Lactose
- At the beginning (May)
- One month later (June)
- Two months later (July)
- Three months later (August)
- Four months later (September)
- Overall average
4.78
4.72
4.87
4.94
4.83
4.83
4.80
4.75
4.73
4.84
4.77
4.78
4.80
4.77
4.92
4.94
4.95
4.88
4.83
4.83
4.96
4.91
4.89
4.88 Total solids
- At the beginning (May)
- One month later (June)
- Two months later (July)
- Three months later (August)
- Four months later (September)
- Overall average
12.90
12.76
11.99
12.09
12.75
12.50
12.85
12.61
12.20
12.26
12.82
12.55
12.82
12.77
12.09
12.13
12.52
12.47
13.01
12.86
12.51
11.81
12.51
12.54

7. Results

As can be seen in Table 4, daily feed intake was calculated as (feed feed - feed feed) and was expressed on raw and building basis. The feed intake of control group was 27.13kg / 2, and the feed intake of experimental group 1-3 was 27.78 ~ 27.82kg / t, and there was no significant difference between treatments.

As can be seen in Table 5, the mean milk yield of the control group increased by 0.7 kg / d (2.8%) in Experiment 1 in contrast to a decrease of 1.8 kg / d, ie, about 5%, during the test period. In experiment groups 2 and 3, the decrease was 1.9% and 5%, respectively. As a result, it was confirmed that when the amino acid-based feed additive of Example 1 was fed, a significant increase was observed in the average amount of milk production, and when the vitamin-based feed additive of Example 2 was fed, the decrease in the amount of reduced oil was confirmed.

As shown in Table 6, the lowest value was 3.52% in the control group and 3.34% in the experimental group 1 using the amino acid additive. In the case of milk proteins, the highest value was 3.34% in Experiments 2 and 3 using amino acid and fused system additives. The lowest value was 3.31% in the control and vitamin additives.

Taken together, the fact that the average milk yield and milk quality of the hot milk are decreased, the milk feed containing the feed additive according to the present invention, preferably the amino acid feed additive according to the present invention, does not significantly increase the feed intake, But also improvement of oil quality was observed. It was confirmed that the addition of the vitamins and fuels feed additives according to the present invention not only reduced or maintained the rate of reduction of the average milk yield, but also improved the quality of milk.

Claims (14)

The present invention relates to a feed additive composition for relieving stress in a high-temperature environment of an animal animal containing resveratrol and vitamin E as an active ingredient. The feed additive composition according to claim 1, wherein the content of resveratrol is 0.01 to 1% by weight based on the total weight of the composition. The feed additive composition of claim 1, wherein the content of vitamin E is 0.1 to 3% by weight based on the total weight of the composition. The feed additive composition according to claim 1, further comprising at least one compound selected from the vitamin B group. The feed additive composition according to claim 1, further comprising at least one compound selected from the group consisting of biotin, niacin, and choline. 5. The feed additive composition according to claim 4, wherein the content of at least one compound selected from the vitamin B group is 0.1 to 20% by weight based on the total weight of the composition. The feed additive composition according to claim 1, further comprising an amino acid. The feed additive composition of claim 7, wherein the amino acid content is 0.1 to 15% by weight based on the total weight of the composition. The feed additive composition according to claim 1, which further comprises vitamin C. The feed additive composition of claim 9, wherein the content of vitamin C is 0.1 to 10% by weight based on the total weight of the composition. The feed additive composition according to claim 1, wherein the high temperature stress is at least one of a feed intake reduction, a milk yield decrease, and a milk quality decrease. 11. A feed additive composition according to any one of claims 1 to 11 for the production of stress-relieving feeds for animal feeders. The feed according to claim 12, wherein the content of the feed additive composition is 0.05 to 2% by weight based on the total weight of the feed. A method for reducing the stress of a pyrogenic animal by feeding the feed according to claim 13.

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