KR20180104123A - 비알콜성 지방간염 (NASH)의 치료를 위한 sGC 자극제의 용도 - Google Patents
비알콜성 지방간염 (NASH)의 치료를 위한 sGC 자극제의 용도 Download PDFInfo
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- KR20180104123A KR20180104123A KR1020187024680A KR20187024680A KR20180104123A KR 20180104123 A KR20180104123 A KR 20180104123A KR 1020187024680 A KR1020187024680 A KR 1020187024680A KR 20187024680 A KR20187024680 A KR 20187024680A KR 20180104123 A KR20180104123 A KR 20180104123A
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- South Korea
- Prior art keywords
- alkyl
- ring
- membered heterocyclic
- phenyl
- membered heteroaryl
- Prior art date
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| US10844064B2 (en) * | 2014-09-17 | 2020-11-24 | Cyclerion Therapeutics, Inc. | sGC stimulators |
| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| US11357777B2 (en) | 2016-02-01 | 2022-06-14 | Cyclerion Therapeutics, Inc. | Use of sGC stimulators for the treatment of nonalcoholic steatohepatitis (NASH) |
| CN110831593A (zh) * | 2017-06-14 | 2020-02-21 | 特维娜有限公司 | 用于调节s1p1活性的化合物及其使用方法 |
| WO2019055859A1 (en) * | 2017-09-14 | 2019-03-21 | Ironwood Pharmaceuticals, Inc. | TREATMENT OF METABOLIC SYNDROME BY SGC STIMULATOR |
| US12220414B2 (en) * | 2018-07-11 | 2025-02-11 | Tisento Therapeutics Inc. | Use of sGC stimulators for the treatment of mitochondrial disorders |
| AU2019301887A1 (en) * | 2018-07-12 | 2021-01-07 | Boehringer Ingelheim International Gmbh | Alkoxy pyrazoles as soluble guanylate cyclase activators |
| WO2021073643A1 (zh) * | 2019-10-18 | 2021-04-22 | 正大天晴药业集团股份有限公司 | 用于治疗非酒精性脂肪性肝炎的药物 |
| MX2022005766A (es) | 2019-11-19 | 2022-08-08 | Trevena Inc | Compuestos y métodos para la preparación de compuestos moduladores de esfingosina 1-fosfato tipo 1 (s1p1). |
| CA3170507A1 (en) * | 2020-02-21 | 2021-08-26 | Universiteit Maastricht | Use of a soluble guanylate cyclase (sgc) stimulator or of a combination of a sgc stimulator and an sgc activator for conditions wherein the heme group of sgc is oxidized or wherein sgc is deficient in heme |
| CN118525022A (zh) * | 2022-01-27 | 2024-08-20 | 西藏海思科制药有限公司 | 一种氮杂并环衍生物及其在医药上的应用 |
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| WO2008124505A2 (en) * | 2007-04-05 | 2008-10-16 | Ironwood Pharmaceuticals,Inc. | Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders |
| CN102056907B (zh) | 2008-04-04 | 2014-12-31 | 武田药品工业株式会社 | 杂环衍生物及其用途 |
| US9260424B2 (en) * | 2009-10-26 | 2016-02-16 | Auspex Pharmaceuticals, Inc. | 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase |
| DE102010021637A1 (de) * | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| ES2549979T3 (es) | 2010-05-26 | 2015-11-03 | Adverio Pharma Gmbh | El uso de estimuladores de la sGC, activadores de la sGC, solos y en combinaciones con inhibidores de la PDE5 para el tratamiento de esclerosis sistémica (EcS) |
| US8569339B2 (en) | 2011-03-10 | 2013-10-29 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators |
| CN102164320B (zh) | 2011-04-11 | 2016-06-22 | 北京数字太和科技有限责任公司 | 一种改进的基于条件接收技术的终端 |
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| AU2015292833B2 (en) * | 2014-07-22 | 2019-11-28 | Boehringer Ingelheim International Gmbh | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
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- 2017-01-31 AU AU2017216429A patent/AU2017216429B2/en not_active Ceased
- 2017-01-31 CN CN201780013129.8A patent/CN108697678A/zh active Pending
- 2017-01-31 WO PCT/US2017/015749 patent/WO2017136309A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US11357777B2 (en) | 2022-06-14 |
| CN108697678A (zh) | 2018-10-23 |
| BR112018015718A2 (pt) | 2019-01-08 |
| AU2017216429A1 (en) | 2018-08-16 |
| IL260701A (enExample) | 2018-09-20 |
| CN116726178A (zh) | 2023-09-12 |
| JP2019507185A (ja) | 2019-03-14 |
| MX2018009173A (es) | 2018-11-19 |
| WO2017136309A1 (en) | 2017-08-10 |
| EP3411026A1 (en) | 2018-12-12 |
| MX386216B (es) | 2025-03-18 |
| US20210161893A1 (en) | 2021-06-03 |
| EP3411026B1 (en) | 2022-03-09 |
| CA3012001A1 (en) | 2017-08-10 |
| IL260701B (en) | 2022-09-01 |
| JP7098214B2 (ja) | 2022-07-11 |
| AU2017216429B2 (en) | 2022-10-06 |
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