KR20180092563A - Blood Glucose Test Strip - Google Patents

Abstract

The present invention relates to a blood glucose test strip. More specifically, the blood glucose test strip exhibits excellent quality while being manufactured at low costs by removing a process of connecting a conductive layer on a lower portion of an upper substrate to a conductive layer on a lower substrate in order to form a conventional pad for an auxiliary electrode on the lower substrate during a manufacturing process of an electrochemical blood glucose test strip for self-measurement having a converse type electrode structure. Accordingly, an electrochemical blood glucose test strip having a converse type electrode structure, in which a lower substrate, an intermediate substrate, and an upper substrate are sequentially stacked, and a part of the intermediate substrate is removed to form a sample chamber, comprises: a pad for an operating electrode formed by removing a part of the upper substrate and the intermediate substrate to expose a conductive layer on an upper portion of the lower substrate; and a pad for an auxiliary electrode formed by removing a part of the lower substrate and the intermediate substrate to expose a conductive layer on a lower portion of the upper substrate.

Description

Blood Glucose Test Strip < RTI ID = 0.0 >

The present invention relates to a blood glucose test strip, and more particularly, to a blood glucose test strip for self-measurement self-measurement having a face-to-face electrode structure, in order to form a pad for a conventional auxiliary electrode on a lower substrate, The process of connecting to the conductive layer on the substrate is eliminated so that the blood glucose test strip is excellent in quality and low in cost.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a configuration diagram of an electrophysiological blood glucose meter and a blood glucose test strip for self-measurement according to the prior art; FIG. The blood glucose meter usually consists of a power button, a display, and a blood glucose test strip insert. A blood glucose test strip is formed with a sample injection port for supplying blood, and a sample chamber (not shown) for storing a predetermined amount of blood is formed inside the sample injection port.

An air outlet (not shown) is formed in the sample chamber so that blood can be smoothly supplied from the sample inlet to the sample chamber by capillary phenomenon. In the sample chamber, working electrodes (not shown) and auxiliary electrodes (not shown) are formed to measure blood glucose, and each of the electrodes is electrically connected to the pad for the working electrode and the pad for the auxiliary electrode, do.

When the blood glucose test strip is inserted into the blood glucose meter, an elastic connector (not shown) formed in the blood glucose meter is electrically contacted to each pad of the blood glucose test strip. Therefore, when the blood glucose test strip is inserted into the blood glucose meter and blood is supplied to the sample chamber, a current proportional to blood glucose flows between the working electrode and the auxiliary electrode, and this current flows through the working electrode pad and the auxiliary electrode pad It is transferred to the circuit part of the blood glucose meter and the blood glucose value is calculated, and then the measured blood glucose value is displayed on the display window.

FIG. 2 is a cross-sectional view of a conventional electrophysiological blood glucose test strip according to the related art. In general, the lower substrate, the intermediate substrate, and the upper substrate are laminated with an adhesive. A part of the intermediate substrate is removed to form a space between the upper substrate and the lower substrate to form a sample chamber.

In addition, a sample inlet (not shown) for supplying blood to the sample chamber and an air outlet (not shown) for discharging air from the sample chamber so that blood can be smoothly supplied to the sample chamber by the capillary phenomenon are formed. In the sample chamber, working electrode and auxiliary electrode coated with a sensing film responsive to blood glucose contained in blood are formed.

(A) is illustrated in U.S. Patent No. 5120420 and Korean Patent No. 0426638 as a cross-sectional electrode structure. The cross-sectional electrode structure is advantageous in that the manufacturing process is simple because the working electrode and the auxiliary electrode, the working electrode pad and the auxiliary electrode pad, and the conductive layer connecting the respective electrodes and the pad are formed on the lower substrate.

However, when the two electrodes are arranged in a plane in the sample chamber, the volume of the sample chamber becomes large, so that a large amount of blood is required for blood glucose measurement, or when the volume of the sample chamber is made small, There is a disadvantage. In addition, the electric field applied between the two electrodes is not uniform, so that the signal is inaccurate or the characteristics between the products are uneven.

(B) is a face-to-face type electrode structure in which the working electrode and the auxiliary electrode are arranged facing each other, and is exemplified in Korean Patent No. 0554649 or U.S. Patent No. US20050000805. In the face-to-face electrode structure, Therefore, it is possible to form an electrode having a sufficient area even in a sample chamber having a small volume, so that a large signal can be obtained, and the electric field between the two electrodes is uniform.

However, since the auxiliary electrode is formed on the lower portion of the upper substrate, the auxiliary electrode is formed on the lower substrate. Therefore, the electrode connection portion must be formed in order to electrically connect the auxiliary electrode and the auxiliary substrate. Electrode, pad, and conductive layer are usually formed by silk screen printing, which is a low-cost process. However, since the process of forming the electrode connection portion requires a relatively expensive process, the face-to- There is a disadvantage in that the temperature is increased.

KR Patent No. 0426638 (Mar. 29, 2004) KR 0554649 (2006.02.16)

SUMMARY OF THE INVENTION The present invention has been proposed in order to solve the above problems of the prior art, and it is an object of the present invention to provide a method of manufacturing a semiconductor device, The pad for the auxiliary electrode is formed by exposing the conductive layer under the upper substrate by removing another part of the area of the lower substrate, The present invention has been made to solve the above problems, and it is an object of the present invention to provide a low-cost blood glucose test strip having excellent quality and low cost by eliminating the process of connecting the conductive layer under the upper substrate to the conductive layer on the lower substrate.

In order to accomplish the above object, a blood glucose test strip of the present invention comprises a lower electrode, an intermediate substrate, and an upper substrate sequentially stacked, and a portion of the intermediate substrate is removed to form a sample chamber, A pad for the working electrode formed by removing a part of the upper substrate and the intermediate substrate to expose the conductive layer on the upper substrate; And a pad for an auxiliary electrode formed by removing a portion of the lower substrate and the intermediate substrate to expose a conductive layer under the upper substrate; And a control unit.

The present invention also provides an electrophilic-type blood glucose test strip having a face-type electrode structure in which a lower substrate, an intermediate substrate and an upper substrate are sequentially laminated and a part of an intermediate substrate is removed to form a sample chamber, A plurality of electrode pads which are formed so as to be electrically isolated by exposing a conductive layer on an upper portion of the lower substrate by removing a portion of the electrode pad; And an electrode pad formed by removing a portion of the lower substrate and the intermediate substrate to expose a conductive layer under the upper substrate; And a control unit.

Here, a plurality of electrically conductive layers, which are electrically isolated from each other in an area where one upper substrate and an intermediate substrate are removed, or one area where a lower substrate and an intermediate substrate are removed, are exposed, And exposes one conductive layer electrically connected to the regions where the lower substrate and the intermediate substrate are removed.

A part of the region from which the upper substrate and the intermediate substrate are removed to the lower substrate and a part of the region from which the intermediate substrate is removed may have a hole shape, a hole shape opened to the front direction, a hole shape opened to the side direction, Is opened in the front and side directions.

Preferably, the upper substrate, the lower substrate, and the intermediate substrate are made of an organic polymer material, and the upper substrate and the lower substrate have a thickness of 0.1 to 0.5 mm and the intermediate substrate has a thickness of 0.05 to 0.2 mm.

The thus constructed blood glucose test strip of the present invention exhibits the following useful effects.

First, since a large area signal electrode can be formed in a sample chamber having a small volume with a face-to-face electrode structure, a large signal can be obtained, and the electric field between the two electrodes can be uniform, Excellent quality and low price.

Second, the electrodes can be easily added by exposing a plurality of electrically conductive layers which are separated from the upper / lower substrate and the intermediate substrate, and the electrically conductive layer can be conveniently formed by dividing the space.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram of an electrophysiological blood glucose meter and a blood glucose test strip for self-measurement according to the prior art; FIG.
2 is a cross-sectional view of a conventional electrophysiological blood glucose test strip according to the prior art;
FIG. 3 is a cross-sectional view showing an electrophilic-type blood glucose test strip of a face-to-face electrode structure according to the present invention;
FIG. 4 is an exploded perspective view showing an electrophilic type blood glucose test strip of a face type electrode structure according to the present invention; FIG.
FIG. 5 is a plan view showing various pad types of a blood glucose test strip according to the present invention; FIG.
FIG. 6 is a plan view showing various pad types of a blood glucose test strip according to another embodiment of the present invention; FIG.
7 is a cross-sectional view illustrating a pad shape of a blood glucose test strip according to an embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In describing the present embodiment, the same names are used for the same components, and further description thereof will be omitted.

FIG. 3 is a cross-sectional view showing an electrophilic-type blood glucose test strip according to the present invention, and FIG. 4 is an exploded perspective view showing an electrophilic-type blood glucose test strip according to the present invention.

3, the blood glucose test strip of the present invention basically comprises a lower substrate 10, an intermediate substrate 20, and an upper substrate 30 which are sequentially stacked and a part of the intermediate substrate 20 is removed And a sample chamber (40) is formed on the surface of the test strip.

The present invention includes a pad 100 for a working electrode and a pad 300 for an auxiliary electrode (reference electrode). The pad 300 removes a part of the upper substrate 30 and the intermediate substrate 20, The conductive layer on the upper substrate 30 is exposed to form the pad 100 for the working electrode and another portion of the lower substrate 10 and the intermediate substrate 20 is removed at another position, The conductive layer of the auxiliary electrode 300 is exposed to form the pad 300 for the auxiliary electrode.

At this time, although the pads 100 and 300 face each other in the up and down direction, electrical connection between the blood glucose test strip and the circuit part of the blood glucose meter can be realized by positioning the connector direction in the glucose meter in the upside down.

4, the lower substrate 10, the intermediate substrate 20, and the upper substrate 30 are laminated and adhered to each other, and a part of the intermediate substrate 20 Are removed and the upper and lower substrates 30 and 10 are covered with the upper substrate 30 and the lower substrate 10 to form a sample chamber 40.

A portion opened to one side forms a sample injection port 50. The air outlet 60 is realized by forming a small hole in the upper substrate 30 at the position of the sample chamber. In the sample chamber 40, the working electrode 11 formed on the lower substrate 10 and coated with a sensing film (not shown) and the auxiliary electrode 31 formed on the lower portion of the upper substrate 30 are opposed to each other Thereby forming a face-to-face electrode structure.

On the other hand, the conductive layer 13 on the upper part of the upper substrate 30 is removed through the intermediate substrate hole 22 from which a part of the intermediate substrate 20 is removed at the same position as the upper substrate hole 32 from which the part of the upper substrate 30 is removed. A part of the intermediate substrate 20 is removed at the same position as the lower substrate hole 12 from which the part of the lower substrate 10 is removed at another position, The conductive layer 33 under the upper substrate is exposed through the intermediate substrate hole 22 to form the pad 300 for the auxiliary electrode (for the reference electrode).

It is preferable that the intermediate substrate hole 22 is the same size or smaller than the upper substrate hole 32 or the lower substrate hole 12.

An organic polymer material having an insulator property capable of easily processing the shape of each substrate by a pressing process is proposed for the material of the lower substrate 10, the intermediate substrate 20, and the upper substrate 30. For example, , Polyvinyl chloride, polycarbonate, and polyethylene terephthalate may be used.

Preferably, the thickness of the upper substrate 30 and the lower substrate 10 is 0.1-0.5 mm, and the thickness of the intermediate substrate 220 is 0.05-0.2 mm.

Here, if the upper and lower substrates 30 and 10 are too thin, the blood glucose test strip is flexible and easy to bend when inserted into the blood glucose meter. If the upper and lower substrates 30 and 10 are too thick, Lt; / RTI >

If the intermediate substrate 20 is thin, the capillary phenomenon occurs well. However, if the intermediate substrate 20 is too thin, the thickness error due to the adhesive increases when the upper substrate 30 and the lower substrate 10 adhere to each other, It is preferable that the thickness is 0.05 to 0.2 mm.

Preferably, the conductive layers 13 and 33 formed on the upper part of the lower substrate and the lower part of the upper substrate may be made of a metal or a carbon material such as gold, silver or copper. In the present invention, Was printed by silk screen printing to form a carbon conductive layer.

5 is a plan view showing various pad shapes of a blood glucose test strip according to the present invention.

In the figure, a solid line indicates a region where the upper substrate and the intermediate substrate are removed. The conductive layer on the lower substrate is exposed to form the pad 100 for the working electrode, and the dotted line shows a region where the lower substrate and the intermediate substrate are removed The conductive layer under the upper substrate is exposed to form the pad 300 for the auxiliary electrode.

(A) is a plan view of the structure illustrated in FIG. 4, in which the upper substrate and the intermediate substrate are removed in the form of a square hole to form the pad 100 for the working electrode, and the lower substrate and the intermediate substrate are removed in the shape of a square hole Electrode pads 300 are formed.

(B) is a view showing a state in which the hole shape illustrated in (a) is opened in the front direction of the blood glucose test strip to form the working electrode pad 100 and the auxiliary electrode pad 300, The length of the pads 100 and 300 can be made longer.

(C) shows a hole shape illustrated in (A) opened in the lateral direction of the blood glucose test strip to form a working electrode pad 100 and an auxiliary electrode pad 300, The width of the pads 100 and 300 can be increased.

(D) is a cross-sectional view of the blood glucose test strip in which the hole shape illustrated in (a) is opened in the front direction and the lateral direction of the blood glucose test strip to form the working electrode pad 100 and the auxiliary electrode pad 300, It is possible to increase the length and width of the pads 100 and 300 while making the length and width equal to those of (a).

On the other hand, as exemplified in Korean Pat. Nos. 0426638 and 0554649 mentioned above, sometimes, in addition to the working electrode and the auxiliary electrode, at least one additional electrode (for example, a fluidity sensing electrode for measuring the fluidity of the sample, etc.) ) May be further formed. In this case, it is necessary to form pads for three or more electrically independent electrodes, and FIG. 6 shows a top view of the blood glucose test strip in which three electrically independent electrode pads are formed.

In the figure, the solid line indicates that the electrode pad is formed by exposing the conductive layer above the lower substrate as an area from which the upper substrate and the intermediate substrate are removed, and the dotted line indicates the area where the lower substrate and the intermediate substrate are removed, And the electrode pad is formed by exposing the underlying conductive layer.

(A), two substrates are formed on both sides in the width direction of the blood glucose test strip by removing the upper substrate and the intermediate substrate in the form of a square hole, and the lower substrate and the intermediate substrate are removed in the form of a square hole, And the pad is formed.

(B) is a view showing a pad formed by opening the hole shape shown in (a) in the front direction of the blood glucose test strip. The length of the test strip is the same as that of (a) .

(C) shows a case where the pads are formed by opening the hole patterns on both sides in the width direction of the blood glucose test strip shown in (A) in the lateral direction of the blood glucose test strip, The advantage is that the width can be made wider.

(D) is a cross-sectional view of the blood glucose test strip shown in Fig. 1 (a), in which the hole patterns on both sides in the width direction of the blood glucose test strip are opened in the front direction and the lateral direction of the blood glucose test strip, The pad has the advantage that the length and width of the test strip can be made wider while the length and width of the test strip are the same.

7 is a cross-sectional view of a pad portion of a blood glucose test strip according to an embodiment of the present invention. As shown in (a), the upper substrate 30 and the intermediate substrate 20 are removed, (Two or more) electrically independent electrode pads formed at the same time by exposing a plurality of electrically independent plural (two or more) conductive layers 13 formed on the upper portion.

A plurality of (two or more) upper and lower substrates 30 and 20 are removed to expose one conductive layer 13 on the lower substrate 10 as shown in (b) Multiple (two or more) electrode pads connected may also be formed. The plurality of pads electrically connected to each other short-circuit the plurality of connectors in the blood glucose meter when inserting the blood glucose test strip into the blood glucose meter, thereby enabling the blood glucose meter to recognize the insertion of the blood glucose test strip.

In FIGS. 5 and 6, the regions where the upper substrate and the intermediate substrate are removed, and the regions where the lower substrate and the intermediate substrate are removed are illustrated as rectangles, but they may be formed in other shapes, for example, circular or elliptical.

5 and 6, a region where the upper substrate and the intermediate substrate are removed, a region where the lower substrate and the intermediate substrate are removed is referred to as a hole type, a hole type is opened toward the front side of the test strip, Of the blood glucose test strip in the side direction of the blood glucose test strip, and the shape of the hole can be freely combined with the front side direction of the blood glucose test strip and the side opening direction.

Although the pads are arranged in the width direction of the blood glucose test strips in FIGS. 5 and 6, it is also possible to freely dispose the positions of the pads on the plane of the blood glucose test strip, such as placing them in the longitudinal direction of the blood glucose test strip, Do not.

5 and 6 illustrate two pads and three pads. However, even when four or more pads are formed, they do not depart from the scope of the present invention. For convenience, in the present invention, the working electrode is disposed on the lower substrate and the auxiliary electrode is disposed on the lower portion of the upper substrate. Conversely, when the working electrode is disposed on the upper substrate and the auxiliary electrode is disposed on the lower portion of the lower substrate, Do not.

It will be apparent to those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit or scope of the invention as defined in the appended claims. It is self-evident to those who have.

Therefore, the above-described embodiments are to be considered as illustrative rather than restrictive, and the present invention is not limited to the above description, but may be modified within the scope of the appended claims and equivalents thereof.

10 ... lower substrate 11 ... working electrode
12: Lower substrate hole 13: Conductive layer
20 ... intermediate substrate 22 ... intermediate substrate hole
30: upper substrate 31: auxiliary electrode
32 ... upper substrate hole 33 ... conductive layer
40 ... sample chamber 50 ... sample inlet
60 ... air outlet 100 ... working electrode pad
300 ... Pad for auxiliary electrode

Claims (5)

An electrophilic blood glucose test strip having a face-type electrode structure in which a lower substrate, an intermediate substrate and an upper substrate are sequentially laminated and a sample chamber is formed by removing a part of an intermediate substrate,
A pad for the working electrode formed by removing a part of the upper substrate and the intermediate substrate to expose the conductive layer on the lower substrate; And
A pad for an auxiliary electrode formed by removing a portion of the lower substrate and the intermediate substrate to expose a conductive layer under the upper substrate; Wherein the test strip comprises a plurality of test strips. An electrophilic blood glucose test strip having a face-type electrode structure in which a lower substrate, an intermediate substrate and an upper substrate are sequentially laminated and a sample chamber is formed by removing a part of an intermediate substrate,
A plurality of electrode pads which are formed to be electrically isolated by exposing a conductive layer on an upper portion of the lower substrate by removing a portion of the upper substrate and the intermediate substrate; And
An electrode pad formed by removing a portion of the lower substrate and the intermediate substrate to expose a conductive layer under the upper substrate; Wherein the test strip comprises a plurality of test strips. 3. The method according to claim 1 or 2,
It is possible to expose a plurality of electrically conductive layers which are electrically isolated in a region where one upper substrate and an intermediate substrate are removed or in a region where one lower substrate and an intermediate substrate are removed or a region where several upper and intermediate substrates are removed, And exposing one conductive layer electrically connected to a region where the substrate and the intermediate substrate are removed. The method according to claim 1 or 2,
A part of the region from which the upper substrate and the intermediate substrate are removed and a part of the region from which the intermediate substrate is removed may be in the form of a hole, a shape in which a hole is opened in a front direction, a shape in which a hole is opened in a lateral direction, Wherein the test strip is formed in a shape selected from the group consisting of an open type and a side open type. 3. The method according to claim 1 or 2,
Wherein the upper substrate, the lower substrate, and the intermediate substrate are made of an organic polymer material,
Wherein the upper substrate and the lower substrate have a thickness of 0.1 to 0.5 mm and the intermediate substrate has a thickness of 0.05 to 0.2 mm.

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